Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat
Abstract
The current study assessed whether various co-administered serotonin (5-HT) receptor antagonists could prevent some of the acute behavioral effects of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") in rats. In the social interaction test, MDMA (5 mg/kg) significantly increased the duration of total social interaction between two conspecifics meeting for the first time. Microanalysis showed that MDMA increased adjacent lying and approach behaviours while reducing anogenital sniffing. MDMA (5 mg/kg) also caused elements of the serotonin syndrome including low body posture and piloerection. In the emergence test, MDMA significantly increased hide time and emergence latency indicating increased anxiety-like behavior. Pretreatment with the 5HT 1A receptor antagonist, WAY 100635 (1 mg/kg), prevented MDMA-induced increases in social interaction and markers of the serotonin syndrome while the 5-HT 1B receptor antagonist GR 55562 (1 mg/kg) and 5-HT 2A receptor antagonist ketanserin (1 mg/kg) were ineffective. The 5-HT 2B/2C receptor antagonist, SB 206553 (2 mg/kg), prevented MDMA-induced prosocial effects but caused pronounced thigmotaxis (hyperactivity at the periphery of the testing chamber). The anxiogenic effect of MDMA on the emergence test was not prevented by pretreatment with any of the 5-HT receptor antagonists tested. These results indicate that prosocial effect of MDMA may involve 5-HT 1A and possibly 5-HT 2B/2C receptors. In contrast, MDMA-induced generalised anxiety, as measured by the emergence test, seems unlikely to involve the 5-HT 1A, 5-HT 1B or 5-HT 2A, 5-HT 2B or 5-HT 2C receptors.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In rats, moderate MDMA doses increase social interaction.
“In rats, moderate MDMA doses increase social interaction (Morley et al. 2005; Thompson et al. 2007).”
From Effects of MDMA on sociability and neural response to social threat and social reward (2009) · cites this paper as Morley et al. 2005
MDMA increases rats' tendency to lie adjacent to one another, which is thought to indicate sociability.
“Notably, MDMA increases rats’ tendency to lie adjacent to each other, which is thought to indicate sociability (Morley et al. 2005; Thompson et al. 2007).”
From Effects of MDMA on sociability and neural response to social threat and social reward (2009) · cites this paper as Morley et al. 2005
Cites
Molecular, pharmacological and functional diversity of 5-HT receptors
Hoyer, D., Hannon, J. P., & Martin, G. R. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00746-8 · Cited by 1,869 · see citing works
The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)
Green, A. R., Mechan, A. O., Elliott, J. M., O’Shea, E., & Colado, M. I. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.3.3 · Cited by 1,272 · see citing works
A Comparison of the Social Postures of Some Common Laboratory Rodents
Grant, E. C., & Mackintosh, J. H. (1963) · Behaviour · doi:10.1163/156853963x00185 · Cited by 1,167 · see citing works
File, S. E. (1980) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(80)90012-6 · Cited by 820 · see citing works
A review of 25 years of the social interaction test
File, S. E., & Seth, P. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01273-1 · Cited by 744 · see citing works
Increased anxiety of mice lacking the serotonin 1A receptor
Parks, C. L., Robinson, P. S., Sibille, E. L., Shenk, T. E., & Tóth, M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10734 · Cited by 691 · see citing works
Tricklebank, M. D., Forler, C., & Fozard, J. R. (1984) · European Journal of Pharmacology · doi:10.1016/0014-2999(84)90714-3 · Cited by 677 · see citing works
Rudnick, G., & Wall, S. C. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.5.1817 · Cited by 535 · see citing works
Charney, D. S., Woods, S. W., Goodman, W. K., & Heninger, G. R. (1987) · Psychopharmacology · doi:10.1007/bf00215473 · Cited by 462 · see citing works
Vollenweider, F. X., Gamma, A., Liechti, M., & Huber, T. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(98)00013-x · Cited by 448 · see citing works
Recreational MDMA use in Sydney: a profile of ‘Ecstasy’ users and their experiences with the drug
Solowij, N., Hall, W., & Lee, N. (1992) · British Journal of Addiction · doi:10.1111/j.1360-0443.1992.tb02003.x · Cited by 416 · see citing works
Attack and defense in rodents as ethoexperimental models for the study of emotion
Blanchard, R. J., & Blanchard, D. C. (1989) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(89)90105-x · Cited by 296 · see citing works
Pharmacology and neurochemistry of buspirone.
Riblet, L. A., Taylor, D. P., Eison, M. S., & Stanton, H. C. (1982) · PubMed · Cited by 287 · see citing works
Altered Emotional States in Knockout Mice Lacking 5-HT1A or 5-HT1B Receptors
Zhuang, X. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00047-0 · Cited by 276 · see citing works
File, S. E., Gonzalez, L. E., & Andrews, N. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-15-04810.1996 · Cited by 230 · see citing works
Goodwin, G. M., Souza, R. J. D., Green, A. R., & Heal, D. J. (1987) · Psychopharmacology · doi:10.1007/bf00216019 · Cited by 200 · see citing works
Spanos, L. J., & Yamamoto, B. K. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90044-0 · Cited by 200 · see citing works
Callaway, C. W., Wing, L., & Geyer, M. A. (1990) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)12637-2 · Cited by 192 · see citing works
Rodgers, R. J., Perrault, G., Sanger, D. J., & Griebel, G. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00402-9 · Cited by 190 · see citing works
Neurochemistry and Neurotoxicity of 3,4‐Methylenedioxymethamphetamine (MDMA, “Ecstasy”)
McKenna, D. J., & Peroutka, S. J. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb13277.x · Cited by 183 · see citing works
A bitter pill. Overview of ecstasy (MDMA, MDA) related fatalities
Schifano, F. (2004) · Psychopharmacology · doi:10.1007/s00213-003-1730-5 · Cited by 181 · see citing works
Anxiety, motor activation, and maternal–infant interactions in 5HT1B knockout mice.
Brunner, D., Buhot, M.-C., Hen, R., & Hofer, M. A. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.3.587 · Cited by 168 · see citing works
Anxiety, motor activation, and maternal-infant interactions in 5HT-sub(1B ) knockout mice.
Brunner, D., Buhot, M.-C., Hen, R., & Hofer, M. A. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.3.587 · Cited by 164 · see citing works
MDMA induced dopamine release in vivo: role of endogenous serotonin
Koch, S., & Galloway, M. P. (1997) · Journal of Neural Transmission · doi:10.1007/bf01273176 · Cited by 163 · see citing works
Andrews, N., Hogg, S., Gonzalez, L. E., & File, S. E. (1994) · European Journal of Pharmacology · doi:10.1016/0014-2999(94)00473-0 · Cited by 148 · see citing works
McCreary, A. C., Bankson, M. G., & Cunningham, K. A. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)34994-8 · Cited by 137 · see citing works
Phenomenology and Sequelae of 3,4-Methylenedioxymethamphetamine Use
Liester, M. B., Grob, C. S., BRAVO, G. L., & WALSH, R. N. (1992) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-199206000-00001 · Cited by 128 · see citing works
Shankaran, M., & Gudelsky, G. A. (1999) · Psychopharmacology · doi:10.1007/s002130051143 · Cited by 122 · see citing works
Gold, L. H., Koob, G. F., & Geyer, M. A. (1988) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)13399-5 · Cited by 120 · see citing works
Selective labeling of 5-HT1A and 5-HT1B binding sites in bovine brain
Peroutka, S. J. (1985) · Brain Research · doi:10.1016/0006-8993(85)91204-1 · Cited by 113 · see citing works
(±)-3,4-Methylenedioxymethamphetamine (MDMA, ‘Ecstasy’) increases social interaction in rats
Morley, K. C., & McGregor, I. S. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00749-4 · Cited by 111 · see citing works
Self-citationDíaz‐Véliz, G. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(97)90004-6 · Cited by 110 · see citing works
Duxon, M. S., Kennett, G. A., Lightowler, S., Blackburn, T. P., & Fone, K. C. F. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00042-7 · Cited by 103 · see citing works
Bankson, M. G. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00345-1 · Cited by 102 · see citing works
Stephenson, C. P., Hunt, G. E., Topple, A. N., & McGregor, I. S. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00049-4 · Cited by 95 · see citing works
Self-citationLocomotor response to MDMA is attenuated in knockout mice lacking the 5-HT 1B receptor
Scearce-Levie, K. A., Viswanathan, S. S., & Hen, R. (1999) · Psychopharmacology · doi:10.1007/s002130050819 · Cited by 93 · see citing works
Callaway, C. W., Rempel-Clower, N., Ry, P., & Geyer, M. A. (1992) · PubMed · Cited by 92 · see citing works
Serotonin1B Receptor Activation Mimics Behavioral Effects of Presynaptic Serotonin Release
Rempel, N. L., Callaway, C. W., & Geyer, M. A. (1993) · Neuropsychopharmacology · doi:10.1038/npp.1993.22 · Cited by 91 · see citing works
Anxiogenic-like effect of serotonin1B receptor stimulation in the rat elevated plus-maze
Lin, D. C.-H., & Parsons, L. H. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00712-2 · Cited by 91 · see citing works
Zanoveli, J. M., Nogueira, R. L., & Zangrossi, H. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01970-8 · Cited by 89 · see citing works
Fletcher, P. J., Korth, K. M., Robinson, S. K., & Baker, G. B. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1104-4 · Cited by 89 · see citing works
de Boer, S. F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00092-0 · Cited by 88 · see citing works
Collinson, N., & Dawson, G. R. (1997) · Psychopharmacology · doi:10.1007/s002130050317 · Cited by 87 · see citing works
Lin, H. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(98)00191-9 · Cited by 85 · see citing works
Heat increases 3,4-methylenedioxymethamphetamine self-administration and social effects in rats
Cornish, J. L., Shahnawaz, Z., Thompson, M. R., Wong, S., Morley, K. C., Hunt, G. E., & McGregor, I. S. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.09.060 · Cited by 83 · see citing works
Self-citationWinslow, J., & Insel, T. R. (1991) · Psychopharmacology · doi:10.1007/bf02244372 · Cited by 82 · see citing works
MDMA (“Ecstasy”) and panic disorder: Induction by a single dose
McCann, U. D., & Ricaurte, G. A. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90185-3 · Cited by 81 · see citing works
Self-Organized Huddles of Rat Pups Modeled by Simple Rules of Individual Behavior
Schank, J. C., & Alberts, J. R. (1997) · Journal of Theoretical Biology · doi:10.1006/jtbi.1997.0488 · Cited by 80 · see citing works
Amphetamine derivatives induce locomotor hyperactivity by acting as indirect serotonin agonists
Callaway, C. W., Johnson, M. P., Gold, L. H., Nichols, D. E., & Geyer, M. A. (1991) · Psychopharmacology · doi:10.1007/bf02246026 · Cited by 70 · see citing works
"Ecstasy" (MDMA)-induced panic
Whitaker‐Azmitia, P. M., & Aronson, T. A. (1989) · American Journal of Psychiatry · doi:10.1176/ajp.146.1.119b · Cited by 62 · see citing works
Picazo, O., López‐Rubalcava, C., & Fernández‐Guasti, A. (1995) · Brain Research Bulletin · doi:10.1016/0361-9230(94)00273-4 · Cited by 52 · see citing works
MDMA (‘ecstasy’) exhibits an anxiogenic-like activity in social encounters between male mice
Maldonado, E., & Navarro, J. F. (2001) · Pharmacological Research · doi:10.1006/phrs.2001.0824 · Cited by 50 · see citing works
Navarro, J. F., & Maldonado, E. (1999) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(98)00100-6 · Cited by 49 · see citing works
On the anxiogenic and anxiolytic nature of long-term cerebral 5-HT depletion following MDMA
Green, A. R., & McGregor, I. S. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1158-3 · Cited by 48 · see citing works
Self-citationRazzoli, M., Cushing, B. S., Carter, C. S., & Valsecchi, P. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(03)00064-3 · Cited by 47 · see citing works
Navarro, J. F., & Maldonado, E. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00250-6 · Cited by 46 · see citing works
Wallis, C. J., & Lal, H. (1998) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(98)00024-4 · Cited by 43 · see citing works
Effects of 3,4-methylenedioxy-methamphetamine (MDMA) on anxiety in mice tested in the light-dark box
Maldonado, E., & Navarro, J. F. (2000) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(99)00112-8 · Cited by 43 · see citing works
Methysergide potentiates the hyperactivity produced by MDMA in rats
Gold, L. H., & Koob, G. F. (1988) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(88)90034-2 · Cited by 42 · see citing works
Hiramatsu, M., NABESHIMA, T., Kameyama, T., Maeda, Y., & Cho, A. K. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90511-x · Cited by 38 · see citing works
Effects of single and repeated restraint on the social behavior of male rats
Albonetti, M. E., & Farabollini, F. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90272-h · Cited by 38 · see citing works
Meert, T. F., Melis, W., Aerts, N., & Clincke, G. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199708000-00008 · Cited by 31 · see citing works
Eguchi, J., Inomata, Y., & Saito, K.-I. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00485-3 · Cited by 30 · see citing works
Anxiogenic activity of methylenedioxymethamphetamine (Ecstasy): An experimental study
Bhattacharya, S. K., Bhattacharya, A., & Ghosal, S. (1998) · Biogenic Amines · Cited by 29 · see citing works
Bickerdike, M. J., Fletcher, A., & Marsden, C. A. (1995) · Neuropharmacology · doi:10.1016/0028-3908(95)00037-7 · Cited by 27 · see citing works
Filip, M., Nowak, E., Papla, I., & Przegaliński, E. (2001) · PubMed · Cited by 26 · see citing works
Sramek, J. J., Frackiewicz, E. J., & Cutlet, N. R. (1997) · Clinical Therapeutics · doi:10.1016/s0149-2918(97)80134-8 · Cited by 25 · see citing works
Zhang, Z.-J., Schmidt, D. E., de Paulis, T., Trivedi, B., Onaivi, E. S., Ebert, M. H., & Hewlett, W. A. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00566-4 · Cited by 24 · see citing works
Effects of cocaine and putative atypical antipsychotics on rat social behavior
Rademacher, D. J., Schuyler, A. L., Kruschel, C. K., & Steinpreis, R. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00904-8 · Cited by 21 · see citing works
Capurro, A., Reyes-Parada, M. I., Olazábal, D. E., Perrone, R., Silveira, R., & Macadar, O. (1997) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/s0300-9629(97)00132-1 · Cited by 17 · see citing works
Takahashi, R. N., Berton, O., Mormède, P., & Chaouloff, F. (2001) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2001000500017 · Cited by 17 · see citing works
Kutscher, C. L., & Yamamoto, B. K. (1979) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(79)90251-x · Cited by 15 · see citing works
Flagged first, then by citations
5 of the 77 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Molecular and Cellular Mechanisms of Ecstasy-Induced Neurotoxicity: An Overview
Capela, J. P., Carmo, H., Remião, F., Bastos, M. D. L., Meisel, A., & Carvalho, F. D. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8064-1 · Cited by 285 · see citing works
Gregorio, D. D., Aguilar‐Valles, A., Preller, K. H., Heifets, B. D., Hibicke, M., Mitchell, J., & Gobbi, G. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1659-20.2020 · Cited by 261 · see citing works
Bedi, G., Hyman, D., & de Wit, H. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.003 · Cited by 247 · see citing works
Thompson, M. R., Callaghan, P. D., Hunt, G. E., Cornish, J. L., & McGregor, I. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.02.032 · Cited by 237 · see citing works
Self-citationEffects of MDMA on sociability and neural response to social threat and social reward
Bedi, G., Phan, K. L., Angstadt, M., & de Wit, H. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1635-z · Cited by 206 · see citing works
Kamilar-Britt, P., & Bedi, G. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.08.016 · Cited by 163 · see citing works
The social brain: Neurobiological basis of affiliative behaviours and psychological well-being
Walker, S. C., & McGlone, F. P. (2013) · Neuropeptides · doi:10.1016/j.npep.2013.10.008 · Cited by 138 · see citing works
Baumann, M. H., Clark, R. D., & Rothman, R. B. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.02.018 · Cited by 135 · see citing works
MDMA-assisted therapy: A new treatment model for social anxiety in autistic adults
Danforth, A. L., Struble, C. M., Yazar‐Klosinski, B., & Grob, C. S. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.03.011 · Cited by 110 · see citing works
Young, M. B., Norrholm, S. D., Khoury, L. M., Jovanovic, T., Rauch, S. A. M., Reiff, C. M., Dunlop, B. W., Rothbaum, B. O., & Howell, L. L. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4684-8 · Cited by 108 · see citing works
Challis, C., & Berton, O. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00007 · Cited by 81 · see citing works
Effects of MDMA on attention to positive social cues and pleasantness of affective touch
Bershad, A. K., Mayo, L. M., Hedger, K. V., McGlone, F. P., Walker, S. C., & de Wit, H. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0402-z · Cited by 73 · see citing works
Therapeutic mechanisms of psychedelics and entactogens
Heifets, B. D., & Olson, D. E. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01666-5 · Cited by 67 · see citing works
Perspectives on Zebrafish Models of Hallucinogenic Drugs and Related Psychotropic Compounds
Neelkantan, N., Mikhaylova, A., Stewart, A., Arnold, R., Gjeloshi, V., Kondaveeti, D., Poudel, M. K., & Kalueff, A. V. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn400090q · Cited by 65 · see citing works
Developmental effects of 3,4-methylenedioxymethamphetamine: a review
Skelton, M. R., Williams, M. T., & Vorhees, C. V. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282f62c76 · Cited by 64 · see citing works
Clemens, K. J., McGregor, I. S., Hunt, G. E., & Cornish, J. L. (2007) · Drug and Alcohol Review · doi:10.1080/09595230601036945 · Cited by 55 · see citing works
Self-citationAcute behavioural and neurotoxic effects of MDMA plus cocaine in adolescent mice
Daza‐Losada, M., Rodríguez‐Arias, M., Maldonado, C., Aguilar, M. A., Guerri, C., & Miñarro, J. (2008) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2008.07.005 · Cited by 53 · see citing works
Wardle, M. C., Kirkpatrick, M. G., & de Wit, H. (2014) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu035 · Cited by 52 · see citing works
Investigation of serotonin-1A receptor function in the human psychopharmacology of MDMA
Hasler, F., Studerus, E., Lindner, K., Ludewig, S., & Vollenweider, F. X. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108094650 · Cited by 52 · see citing works
Hunt, G. E., McGregor, I. S., Cornish, J. L., & Callaghan, P. D. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.06.011 · Cited by 51 · see citing works
Self-citationAdult Attachment System Links With Brain Mu Opioid Receptor Availability In Vivo.
Turtonen, O., Saarinen, A., Nummenmaa, L., Tuominen, L., Tikka, M., Armio, R., Hautamäki, A., Laurikainen, H., Raitakari, O., Keltikangas-Järvinen, L., et al. (2020) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.10.013 · Cited by 81 · see citing works
Oppong‐Damoah, A., Zaman, R. U., D’Souza, M. J., & Murnane, K. S. (2018) · Hormones and Behavior · doi:10.1016/j.yhbeh.2018.12.011 · Cited by 49 · see citing works
Neural correlates of MDMA (“Ecstasy”)-induced social interaction in rats
Thompson, M. R., Hunt, G. E., & McGregor, I. S. (2008) · Social Neuroscience · doi:10.1080/17470910802045042 · Cited by 48 · see citing works
Self-citationColussi‐Mas, J., & Schenk, S. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06467.x · Cited by 47 · see citing works
Andó, R. D., Benkő, A., Ferrington, L., Kirilly, E., Kelly, P. A. T., & Bagdy, G. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2005.12.010 · Cited by 46 · see citing works
Dystrophic Serotonin Axons in Postmortem Brains from Young Autism Patients
Azmitia, E. C., Singh, J. S., Hou, X. P., & Węgiel, J. (2011) · The Anatomical Record · doi:10.1002/ar.21243 · Cited by 46 · see citing works
Hargreaves, G. A., Hunt, G. E., Cornish, J. L., & McGregor, I. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.023 · Cited by 45 · see citing works
Self-citationSáez‐Briones, P., & Hernández, A. (2013) · Current Neuropharmacology · doi:10.2174/1570159x11311050007 · Cited by 40 · see citing works
Broadbear, J. H., Tunstall, B. J., & Beringer, K. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00267.x · Cited by 38 · see citing works
Bradbury, S., Gittings, D., & Schenk, S. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2726-9 · Cited by 37 · see citing works
Effect of drugs of abuse on social behaviour
Blanco-Gandía, M. C., Mateos-García, A., García-Pardo, M. P., Montagud‐Romero, S., Rodríguez‐Arias, M., Miñarro, J., & Aguilar, M. A. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000162 · Cited by 35 · see citing works
MDMA, cortisol, and heightened stress in recreational ecstasy users
Parrott, A. C., Montgomery, C., Wetherell, M. A., Downey, L. A., Stough, C. K. K., & Scholey, A. B. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000060 · Cited by 34 · see citing works
Liu, J., Decatur, J. D., Proni, G., & Champeil, É. (2009) · Forensic Science International · doi:10.1016/j.forsciint.2009.10.022 · Cited by 32 · see citing works
Tryptophan Promotes Interpersonal Trust
Colzato, L. S., Steenbergen, L., de Kwaadsteniet, E. W., Sellaro, R., Liepelt, R., & Hommel, B. (2013) · Psychological Science · doi:10.1177/0956797613500795 · Cited by 31 · see citing works
Arrant, A. E., Jemal, H., & Kuhn, C. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.10.010 · Cited by 31 · see citing works
Molla, H. M., Lee, R., Lyubomirsky, S., & de Wit, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-43156-0 · Cited by 30 · see citing works
Serotonin and Serotonin Receptors in Hallucinogen Action
Halberstadt, A. L., & Nichols, D. E. (2010) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(10)70103-x · Cited by 25 · see citing works
Reduced sensitivity to MDMA-induced facilitation of social behaviour in MDMA pre-exposed rats
Thompson, M. R., Callaghan, P. D., Hunt, G. E., & McGregor, I. S. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.01.014 · Cited by 25 · see citing works
Self-citationRamos, L., Hicks, C., Caminer, A., Couto, K., Narlawar, R., Kassiou, M., & McGregor, I. S. (2016) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2016.10.002 · Cited by 25 · see citing works
Self-citationPonzoni, L., Sala, M., & Braida, D. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.08.009 · Cited by 23 · see citing works
Differential effects of modafinil, methamphetamine, and MDMA on agonistic behavior in male mice
Máchalová, A., Šlais, K., Vršková, D., & Šulcová, A. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.04.013 · Cited by 21 · see citing works
Carlyle, M., Stevens, T., Fawaz, L., Marsh, B., Kosmider, S., & Morgan, C. J. A. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119826594 · Cited by 21 · see citing works
Jones, K. L., Brennan, K. A., Colussi‐Mas, J., & Schenk, S. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00217.x · Cited by 20 · see citing works
Esaki, H., Sasaki, Y., Nishitani, N., Kamada, H., Mukai, S., Ohshima, Y., Nakada, S., Ni, X., Deyama, S., & Kaneda, K. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175653 · Cited by 18 · see citing works
Popik, P., Cyrano, E., Piotrowska, D., Hołuj, M., Gołębiowska, J., Malikowska‐Racia, N., Potasiewicz, A., & Nikiforuk, A. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1329424 · Cited by 18 · see citing works
Oxytocin and the Role of Fluid Restriction in MDMA-Induced Hyponatremia
Atila, C., Straumann, I., Vizeli, P., Beck, J., Monnerat, S., Holze, F., Liechti, M. E., & Christ‐Crain, M. (2024) · JAMA Network Open · doi:10.1001/jamanetworkopen.2024.45278 · Cited by 17 · see citing works
Procópio‐Souza, R., Fukushiro, D. F., Trombin, T. F., Wuo‐Silva, R., Zanlorenci, L. H. F., Lima, A. J. O., Ribeiro, L. T. C., Corrêa, J. M. R. M., Marinho, E. A. V., Kameda, S. R., et al. (2011) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2011.04.017 · Cited by 17 · see citing works
van den Buuse, M., Becker, T., Kwek, P., Martin, S., Ruimschotel, E., & Risbrough, V. B. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000101 · Cited by 17 · see citing works
Sensitization to the Prosocial Effects of 3,4-Methylenedioxymethamphetamine (MDMA)
Curry, D. W., Berro, L. F., Belkoff, A. R., Sulima, A., Rice, K. C., & Howell, L. L. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.017 · Cited by 13 · see citing works
Espinosa‐Velasco, M., Reguilón, M. D., Bellot, M., Nadal‐Gratacós, N., Berzosa, X., Gómez‐Canela, C., Rodríguez‐Arias, M., Camarasa, J., Escubedo, E., Pubill, D., et al. (2022) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2022.110562 · Cited by 13 · see citing works
Effects of psychostimulants on social interaction in adult male rats
Šlamberová, R., Mikulecká, A., Macuchova, E., HREBÍČKOVÁ, I., Ševčíková, M., Nohejlová, K., & Pometlová, M. (2015) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000148 · Cited by 13 · see citing works
Khorana, N., Young, R., & Glennon, R. A. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.08.013 · Cited by 11 · see citing works
Sharp, J. L., & Smith, M. A. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.805139 · Cited by 10 · see citing works
Lettfuss, N. Y., Seeger-Armbruster, S., & von Ameln-Mayerhofer, A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.01.033 · Cited by 9 · see citing works
Wronikowska‐Denysiuk, O., Zykubek, M., Kurach, Ł., Michalak, A., Boguszewska‐Czubara, A., & Budzyńska, B. (2021) · Psychopharmacology · doi:10.1007/s00213-021-05910-y · Cited by 9 · see citing works
Ponzoni, L., Braida, D., Bondiolotti, G., & Sala, M. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00146 · Cited by 9 · see citing works
Smith, M. A., Schmidt, K. T., Sharp, J. L., Pearson, T., Davis, A. L., Gibson, A. N., & Potter, K. M. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174646 · Cited by 8 · see citing works
A Systematic Review of the MDMA Model to Address Social Impairment in Autism
Chaliha, D. R., Mamo, J. C. L., Albrecht, M. A., Lam, V., Takechi, R., & Vaccarezza, M. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210101130258 · Cited by 7 · see citing works
Román, V., Kedves, R., Kelemen, K., Némethy, Z., Sperlágh, B., Lendvai, B., & Vizi, E. S. (2021) · Physiological Reports · doi:10.14814/phy2.15088 · Cited by 7 · see citing works
Mukai, S., Nakada, S., Kamada, H., Yaguchi, R., Deyama, S., & Kaneda, K. (2020) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12124 · Cited by 6 · see citing works
Popik, P., Cyrano, E., Gołębiowska, J., Malikowska‐Racia, N., Potasiewicz, A., & Nikiforuk, A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0307794 · Cited by 6 · see citing works
History, pharmacology and therapeutic mechanisms of 3,4‐methylenedioxymethamphetamine (MDMA)
Casey, A. B., & Heifets, B. D. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70225 · Cited by 4 · see citing works
Sáez‐Briones, P., Castro-Castillo, V., Díaz‐Véliz, G., Valladares, L., Barra, R., Hernández, A., & Cassels, B. K. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00157 · Cited by 4 · see citing works
Serotonin and serotonin receptors in hallucinogen action
Halberstadt, A. L., & Nichols, D. E. (2020) · Handbook of behavioral neuroscience · doi:10.1016/b978-0-444-64125-0.00043-8 · Cited by 4 · see citing works
Palacios-Lagunas, D. A., Hernández-Mondragón, J. C., Fuxé, K., Borroto‐Escuela, D. O., Crespo‐Ramírez, M., Pérez-Eugenio, F., & de la Mora, M. P. (2025) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2025.174135 · Cited by 1 · see citing works
Psilocybin modulates social behaviour in male and female mice in a time-dependent manner
Shadani, S., McCoy, K., Ong, L., Greaves, E., Conn, K., Andrews, Z. B., & Foldi, C. J. (2026) · Neuropsychopharmacology · doi:10.1038/s41386-026-02450-x · Cited by 1 · see citing works
Vervaeke, H. (2008) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-6554-8_9 · Cited by 1 · see citing works
Neurobiological Research on Addiction
Carter, A., Hall, W., Capps, B., & Daglish, M. R. C. (2009) · Cited by 1 · see citing works
Deep Learning Algorithms Reveal Increased Social Activity of Rats at the Start of Evening TwilightPreprint
Popik, P., Cyrano, E., Gołębiowska, J., Malikowska‐Racia, N., Potasiewicz, A., & Nikiforuk, A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.14.603464 · Cited by 1 · see citing works
Kanarik, M. (2007) · DSpace repository (University of Tartu)
Brain and Peripheral Organ Toxicity of "Ecstasy" in Adolescent Rats in Human Relevant Doses
Gomes, A. T. (2014) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/wbf2-1943
Atila, C., Straumann, I., Vizeli, P., Beck, J., Monnerat, S., Holze, F., Liechti, M. E., & Christ‐Crain, M. (2024) · SSRN Electronic Journal · doi:10.2139/ssrn.4819307
MDMA modulates human sensorimotor cortical pathways during gentle touch
Molla, H. M., Novembre, G., Bershad, A. K., Handlin, L., Perini, I., de Wit, H., & Morrison, I. (2024) · Imaging Neuroscience · doi:10.1162/imag_a_00316
Morley, K. C., Arunogiri, S., Mills, K. L., Watt, J., Teesson, M., Baillie, A., Lee, Y. Y., Morse, A. R., Back, S. E., Lubman, D. I., et al. (2026) · BMJ Open · doi:10.1136/bmjopen-2025-114896
Self-citation
- Authors
- Morley, K. C., Arnold, J. C., & McGregor, I. S.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- McGregor, Iain S.
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2005-06
- Volume
- 29
- Issue
- 5
- Pages
- 648-657
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W1973287358
- Cited by
- 79
- References
- 77
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 3 · 2013: 5 · 2012: 3
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- MDMA, ecstasy, 5-HT1A receptor, 5-HT1B receptor, 5-HT2A receptor, prosocial behavior, social interaction, serotonin syndrome, anxiety-like behavior, thigmotaxis, WAY-100635, ketanserin, acute drug effects
- MeSH terms
- Animals, Hallucinogens, Indoles, Interpersonal Relations, Ketanserin, Male, Piperazines, Pyridines, Serotonin Antagonists, Rats, Wistar, Serotonin Agents, N-Methyl-3,4-methylenedioxyamphetamine, Serotonin Syndrome, Receptor, Serotonin, 5-HT1A, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
