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Cited by 15Treatment of Major DepressionSchizophrenia research and treatmentBipolar Disorder and Treatment

The DOI matches its Crossref record; 33 of the 34 references it cites were found in a registry or an index.

Combination therapy with amisulpride and antidepressants: Clinical observations in case series of elderly patients with psychotic depression

Politis, Antonis M., Papadimitriou, George N., Theleritis, Christos G., Psarros, Constantin, Soldatos, Constantin R.·2008·Progress in Neuro-Psychopharmacology and Biological Psychiatry
DOI 10.1016/j.pnpbp.2008.03.011
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Abstract

Psychotic depression is classified as a clinical subtype of major depressive disorder. The combination of an antidepressant with an antipsychotic agent has been demonstrated to be efficacious for the treatment of psychotic depression. However, in elderly patients with psychotic depression, little information is available on the efficacy of such combinations. Therefore, we have evaluated combination treatment for 5 weeks with amisulpride and antidepressants in non-demented elderly patients with psychotic depression. Eleven patients were treated with either citalopram 20-40 mg/day (n=5) or mirtazapine 30-60 mg/day (n=6), and amisulpride 75-100 mg/day for 5 weeks. Clinical status was evaluated at baseline and after 3 and 5 weeks using the Brief Psychiatric Rating Scale (BPRS), the Hamilton Depression Rating Scale--17 items (HDRS) and the Clinical Global Impression Scale (CGI-S). In 5 of the 11 patients there was remission of depression, while in another 5 patients there was partial remission of depression and in one patient there was no remission. Finally, there was resolution of psychotic symptoms in all the patients involved. One patient developed tremor and rigidity but insisted on continuing with the drug since her psychopathology has improved considerably after the addition of amisulpride to antidepressant treatment. In conclusion, some of the elderly patients with psychotic depression may benefit from the combination of amisulpride and antidepressant pharmacotherapy.

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1 of the 34 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

  1. Alexopoulos, 2004, The Expert Consensus Guideline Series using antipsychotic agents in older patients, J Clin Psychiatry, 65, 4
  2. Möller, 2005, A six-week, double-blind, randomized trial comparing the safety and efficacy of amisulpride and risperidone in elderly patients with schizophrenia, Eur Neuropsychopharmacol, 15, 511

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Metadata

Authors
Politis, A. M., Papadimitriou, G. N., Theleritis, C. G., Psarros, C., & Soldatos, C. R.
Affiliations
National and Kapodistrian University of Athens (GR)
Corresponding author
Papadimitriou, George N.
ORCID
Venue
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher
Elsevier BV
Published
2008-07
Volume
32
Issue
5
Pages
1227-1230
ISSN
0278-5846 (ISSN-L)
DOI
10.1016/j.pnpbp.2008.03.011
OpenAlex
W1976000144
Cited by
15
References
34
Citations by year
2025: 1 · 2024: 1 · 2022: 1 · 2021: 2 · 2019: 1 · 2017: 1 · 2016: 1 · 2014: 2
FWCI
1.16
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Keywords
psychotic depression, amisulpride, antidepressants, combination therapy, elderly patients, citalopram, mirtazapine, antipsychotic augmentation, depression remission, psychotic symptoms, adverse effects
MeSH terms
Amisulpride, Aged, Aged, 80 and over, Antidepressive Agents, Depression, Drug Therapy, Combination, Female, Humans, Male, Psychotic Disorders, Sulpiride, Antipsychotic Agents

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