Increased levels of plasma brain-derived neurotrophic factor (BDNF) in children with attention deficit-hyperactivity disorder (ADHD)
Abstract
Background Recent reports have suggested a pathophysiological role of brain-derived neurotrophic factor (BDNF) in attention deficit-hyperactivity disorder (ADHD). We evaluated the plasma levels of BDNF in patients with ADHD. Methods Plasma BDNF levels were measured in 41 drug naive ADHD patients and 107 normal controls. The severity of ADHD symptoms was determined by patient scores on the ADHD rating scale (ARS) and the computerized ADHD diagnostic system (ADS). Results ANCOVA with age and gender as covariates showed that the mean plasma BDNF levels were significantly higher in ADHD patients than in normal controls (F=16.968, p Conclusions Our study suggests that there is an increase of plasma BDNF levels in untreated ADHD patients, and that plasma BDNF levels had a significant positive correlation with the severity of inattention symptoms. Further studies are required to elucidate the source and role of circulating BDNF in ADHD.
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BDNF stimulates neuronal development and maintenance, regulates NT function and contributes in neuronal plasticity processes, such as long-term potentiation and learning.
“One such protein involved is BDNF, which stimulates neuronal development and maintenance, regulates NT function and contributes in neuronal plasticity processes, such as long-term potentiation and learning [122].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [122]
BDNF has a relevant role in synaptogenesis regulation and stimulates neuronal development and maintenance.
“BDNF has a relevant role in synaptogenesis regulation and stimulates neuronal development and maintenance [122, 217].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [122]
Higher levels of BDNF could compensate dysfunctions of DA and 5-HT systems observed in neurodevelopmental disorders, suggesting that higher levels of BDNF in subjects with ADHD are related to more profound NT dysfunction.
“It has been postulated that higher levels of BDNF could compensate dysfunctions of DA and 5-HT systems observed in neurodevelopmental disorders [122, 220], suggesting that higher levels of BDNF in subjects with ADHD are related to more profound NT dysfunction [146].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [122]
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Brain-derived Neurotrophic Factor Is Stored in Human Platelets and Released by Agonist Stimulation
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- Authors
- Shim, S.-H., Hwangbo, Y., Kwon, Y.-J., Jeong, H.-Y., Lee, B.-H., Lee, H.-J., & Kim, Y.-K.
- Affiliations
- Soonchunhyang University (KR)
- Korea University (KR)
- Corresponding author
- Kim, Yong-Ku
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 32
- Issue
- 8
- Pages
- 1824-1828
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2038198220
- Cited by
- 128
- References
- 3
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 14 · 2021: 11 · 2020: 3 · 2019: 5 · 2018: 3 · 2017: 13 · 2016: 14 · 2015: 8 · 2014: 11 · 2013: 10 · 2012: 6
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- brain-derived neurotrophic factor, attention deficit hyperactivity disorder, plasma BDNF levels, inattentive symptoms, sex differences, untreated children, ADHD pathophysiology, omission errors
- MeSH terms
- Adolescent, Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Child, Female, Humans, Male, Regression Analysis, Sex Factors, Brain-Derived Neurotrophic Factor
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