Administration of N,N-dimethyltryptamine (DMT) in psychedelic therapeutics and research and the study of endogenous DMT
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As with all drugs, the route, form, and/or dose of a substance administered or applied can play a defining role in its overall pharmacology and use as a therapeutic. This review will focus on these factors as they relate to the psychedelic N,N-dimethyltryptamine (DMT). It will examine the positive and negative aspects of different formulations and routes of administration of DMT and the observed effects from such administrations in the form of ayahuasca teas; oral “pharmahuasca”; injections by intravenous (IV) and intramuscular (IM) routes; inhalation, insufflation; and other routes; and high-dose, low-dose, and “micro-dose” effects. The review will consider possible oral route of administration alternatives that would not require concomitant use of a monoamine oxidase inhibitor. The review will then address the current research findings for DMT from in vivo and in vitro studies as well as the possibility that these findings may be revealing the role of endogenous DMT in normal brain function.
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MAO-Is prevent the degradation of DMT, making it orally bioavailable.
“The MAO-Is prevent the degradation of the N,N-dimethyltryptamine (DMT) contained in the Psychotria viridis leaves or other additional plants, thereby DMT becomes orally bioavailable (7–9).”
From Potential therapeutic effects of an ayahuasca-inspired N,N-DMT and harmine formulation: a controlled trial in healthy subjects (2024) · cites this paper as [8]
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Nichols, D. E. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011478 · Cited by 1,762 · see citing works
Nichols, D. E. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2003.11.002 · Cited by 1,211 · see citing works
Psychedelics promote structural and functional neural plasticity
Ly, C., Greb, A. C., Cameron, L. P., Wong, J. M., Barragan, E. V., Wilson, P. C., Burbach, K. F., Soltanzadeh Zarandi, S., Sood, A., Paddy, M. R., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.022 · Cited by 1,207 · see citing works
BDNF and synaptic plasticity, cognitive function, and dysfunction
Lu, B., Nagappan, G., & Lu, Y. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-45106-5_9 · Cited by 1,043 · see citing works
González-Maeso, J., Weisstaub, N. V., Zhou, M., Chan, P., Ivic, L., Ang, R., Lira, A., Bradley-Moore, M., Ge, Y., Zhou, Q., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.008 · Cited by 925 · see citing works
Jones, M. W., Errington, M. L., French, P. J., Fine, A., Bliss, T., Garel, S., Charnay, P., Bozon, B., Laroche, S., & Davis, S. (2001) · Nature Neuroscience · doi:10.1038/85138 · Cited by 899 · see citing works
Palhano-Fontes, F., Barreto, D., Onias, H., Andrade, K. C., Novaes, M. M., Pessoa, J. A., Mota-Rolim, S. A., Osório, F. L., Sanches, R., dos Santos, R. G., et al. (2019) · Psychological Medicine · doi:10.1017/s0033291718001356 · Cited by 852 · see citing works
The Therapeutic Potential of Psychedelic Drugs: Past, Present, and Future
Carhart-Harris, R. L., & Goodwin, G. M. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.84 · Cited by 706 · see citing works
The subjective effects of psychedelics are necessary for their enduring therapeutic effects
Yaden, D. B., & Griffiths, R. R. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00194 · Cited by 541 · see citing works
The Hallucinogen <i>N,N</i> -Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator
Fontanilla, D., Johannessen, M., Hajipour, A. R., Cozzi, N. V., Jackson, M. B., & Ruoho, A. E. (2009) · Science · doi:10.1126/science.1166127 · Cited by 535 · see citing works
Osório, F. D. L., Sanches, R. F., Macedo, L. R., dos Santos, R. G., Maia-de-Oliveira, J. P., Wichert-Ana, L., de Araujo, D. B., Riba, J., Crippa, J. A., & Hallak, J. E. (2015) · Revista Brasileira de Psiquiatria · doi:10.1590/1516-4446-2014-1496 · Cited by 488 · see citing works
Vaidya, V. A., Marek, G. J., Aghajanian, G. K., & Duman, R. S. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02785.1997 · Cited by 479 · see citing works
Osmond, H., & Smythies, J. (1952) · Journal of Mental Science · doi:10.1192/bjp.98.411.309 · Cited by 474 · see citing works
O’Donovan, K. J., Tourtellotte, W. G., Milbrandt, J., & Baraban, J. M. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01343-5 · Cited by 457 · see citing works
Strassman, R. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020022002 · Cited by 453 · see citing works
Regulation of hippocampal synaptic plasticity by BDNF
Leal, G., Afonso, P. M., Salazar, I. L., & Duarte, C. B. (2015) · Brain Research · doi:10.1016/j.brainres.2014.10.019 · Cited by 410 · see citing works
McKenna, D. J., Towers, G. H. N., & Abbott, F. (1984) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(84)90003-5 · Cited by 398 · see citing works
Neurobiology of BDNF in fear memory, sensitivity to stress, and stress-related disorders
Notaras, M. J., & van den Buuse, M. (2020) · Molecular Psychiatry · doi:10.1038/s41380-019-0639-2 · Cited by 395 · see citing works
Riba, J., Valle, M., Urbano, G., Yritia, M., Morte, A., & Barbanoj, M. J. (2003) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.049882 · Cited by 390 · see citing works
Bekinschtein, P., Cammarota, M., & Medina, J. H. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.024 · Cited by 351 · see citing works
Andersen, K. A. A., Carhart‐Harris, R., Nutt, D. J., & Erritzoe, D. (2021) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13249 · Cited by 347 · see citing works
The subjective effects of psychedelics may not be necessary for their enduring therapeutic effects
Olson, D. E. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.0c00192 · Cited by 329 · see citing works
McKenna, D. J. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.03.002 · Cited by 321 · see citing works
Pharmacokinetics of Hoasca alkaloids in healthy humans
Callaway, J. C., McKenna, D. J., Grob, C. S., Brito, G. S., Raymon, L. P., Poland, R. E., Andrade, E. O., Andrade, E. O., & Mash, D. C. (1999) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(98)00168-8 · Cited by 318 · see citing works
Recent advances in the neuropsychopharmacology of serotonergic hallucinogens
Halberstadt, A. L. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.07.016 · Cited by 312 · cited 1× · see citing works
“Indeed, 5-HT2C and 5-HT1A receptors may also play a role (see reviews by Nichols 2004, 2016; Halberstadt 2015; Carbonaro and Gatch 2016) as well as other known and, perhaps, unknown receptors or compounds yet to be identified in what may be a far more complex system than we know.”
BackgroundReviews: BDNF and Memory Formation and Storage
Bekinschtein, P., Cammarota, M., Izquierdo, I., & Medina, J. H. (2007) · The Neuroscientist · doi:10.1177/1073858407305850 · Cited by 309 · see citing works
dos Santos, R. G., Osório, F. L., Crippa, J. A. S., Riba, J., Zuardi, A. W., & Hallak, J. E. C. (2016) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125316638008 · Cited by 306 · see citing works
Riba, J., Rodríguez-Fornells, A., Urbano, G., Morte, A., Antonijoan, R., Montero, M., Callaway, J. C., & Barbanoj, M. J. (2001) · Psychopharmacology · doi:10.1007/s002130000606 · Cited by 303 · see citing works
Dose-Response Study of N,N-Dimethyltryptamine in Humans
Strassman, R. J. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950020009001 · Cited by 291 · see citing works
ADVERSE REACTIONS TO PSYCHEDELIC DRUGS. A REVIEW OF THE LITERATURE
Strassman, R. (1984) · Journal of Nervous and Mental Disease · doi:10.1097/00005053-198410000-00001 · Cited by 280 · see citing works
The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain
Nagai, F., Nonaka, R., & Satoh Hisashi Kamimura, K. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.11.075 · Cited by 279 · see citing works
Neuropharmacology of N,N-dimethyltryptamine
Carbonaro, T. M., & Gatch, M. B. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.04.016 · Cited by 268 · see citing works
Human psychopharmacology of N,N-dimethyltryptamine
Strassman, R. J. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(96)00081-2 · Cited by 261 · see citing works
Psychoplastogens: A promising class of plasticity-promoting neurotherapeutics
Olson, D. E. (2018) · Journal of Experimental Neuroscience · doi:10.1177/1179069518800508 · Cited by 257 · see citing works
Classical psychedelics for the treatment of depression and anxiety: A systematic review
Muttoni, S., Ardissino, M., & John, C. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.07.076 · Cited by 256 · see citing works
The sigma-1 receptor: roles in neuronal plasticity and disease
Kourrich, S., Su, T.-P., Fujimoto, M., & Bonci, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.09.007 · Cited by 245 · see citing works
The therapeutic potentials of Ayahuasca: possible effects against various diseases of civilization
Frecska, E., Bokor, P., & Winkelman, M. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00035 · Cited by 242 · see citing works
Psychedelics in Psychiatry: Neuroplastic, Immunomodulatory, and Neurotransmitter Mechanisms
Inserra, A., De Gregorio, D., & Gobbi, G. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000056 · Cited by 232 · see citing works
SANTOS, R. G. D., Bouso, J. C., Alcázar‐Córcoles, M. Á., & Hallak, J. E. C. (2018) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2018.1511424 · Cited by 228 · see citing works
Aday, J. S., Davis, A. K., Mitzkovitz, C. M., Bloesch, E. K., & Davoli, C. C. (2021) · ACS Pharmacology & Translational Science · doi:10.1021/acsptsci.1c00014 · Cited by 224 · see citing works
Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases
Ryskamp, D. A., Korban, S. A., Zhemkov, V., Kraskovskaya, N., & Борисович, Б. И. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00862 · Cited by 221 · see citing works
Recreational Use, Analysis and Toxicity of Tryptamines
Tittarelli, R., Mannocchi, G., Pantano, F., & Romolo, F. S. (2014) · Current Neuropharmacology · doi:10.2174/1570159x13666141210222409 · Cited by 220 · see citing works
Surge of neurophysiological coherence and connectivity in the dying brain
Borjigin, J., Lee, U., Liu, T., Pal, D., Huff, S., Klarr, D., Sloboda, J., Hernandez, J., Wang, M. M., & Mashour, G. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308285110 · Cited by 219 · see citing works
The mysterious trace amines: Protean neuromodulators of synaptic transmission in mammalian brain
Burchett, S. A., & Hicks, T. P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.07.003 · Cited by 218 · see citing works
A Meta-Analysis of Placebo-Controlled Trials of Psychedelic-Assisted Therapy
Luoma, J. B., Chwyl, C., Bathje, G. J., Davis, A. K., & Lancelotta, R. (2020) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2020.1769878 · Cited by 212 · see citing works
Szára, S. (1956) · Cellular and Molecular Life Sciences · doi:10.1007/bf02157378 · Cited by 203 · see citing works
Ayahuasca enhances creative divergent thinking while decreasing conventional convergent thinking
Kuypers, K. P. C., Riba, J., de la Fuente Revenga, M., Barker, S., Theunissen, E. L., & Ramaekers, J. G. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4377-8 · Cited by 201 · see citing works
Self-citationSzabo, A., Kovacs, A., Frecska, E., & Rajnavolgyi, E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106533 · Cited by 191 · see citing works
Kuypers, K., Ng, L., Erritzoe, D., Knudsen, G., Nichols, C. D., Nichols, D. E., Pani, L., Soula, A., & Nutt, D. (2019) · Journal of Psychopharmacology · doi:10.1177/0269881119857204 · Cited by 188 · see citing works
Psychedelic medicine: a re-emerging therapeutic paradigm
Tupper, K. W., Wood, E., Yensen, R., & Johnson, M. W. (2015) · Canadian Medical Association Journal · doi:10.1503/cmaj.141124 · Cited by 187 · see citing works
Unifying Theories of Psychedelic Drug Effects
Swanson, L. R. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00172 · Cited by 181 · see citing works
Barker, S. A. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00536 · Cited by 177 · see citing works
Self-citationAlmeida, R. N. D., Galvão, A. C. D. M., da Silva, F. S., Silva, E. A. D. S., Palhano-Fontes, F., Maia-de-Oliveira, J. P., de Araújo, L.-S. B., Lobão-Soares, B., & Galvão-Coelho, N. L. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.01234 · Cited by 177 · see citing works
Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting
Prochazkova, L., Lippelt, D. P., Colzato, L. S., Kuchar, M., Sjoerds, Z., & Hommel, B. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5049-7 · Cited by 177 · see citing works
The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke
Ruscher, K., Shamloo, M., Rickhag, M., Ladunga, I., Soriano, L., Gisselsson, L., Toresson, H., Ruslim-Litrus, L., Oksenberg, D., Urfer, R., et al. (2011) · Brain · doi:10.1093/brain/awq367 · Cited by 176 · see citing works
Bershad, A. K., Schepers, S. T., Bremmer, M. P., Lee, R., & de Wit, H. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.019 · Cited by 175 · see citing works
Brain-derived neurotrophic factor and control of synaptic consolidation in the adult brain
Soule, J. D., Messaoudi, E., & Bramham, C. R. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340600 · Cited by 172 · see citing works
Effects of <i>N</i>,<i>N</i>-Dimethyltryptamine on Rat Behaviors Relevant to Anxiety and Depression
Cameron, L. P., Benson, C. J., Dunlap, L. E., & Olson, D. E. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00134 · Cited by 171 · see citing works
Ayahuasca, dimethyltryptamine, and psychosis: a systematic review of human studies
SANTOS, R. G. D., Bouso, J. C., & Hallak, J. E. C. (2017) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125316689030 · Cited by 168 · see citing works
Cameron, L. P., Benson, C. J., DeFelice, B. C., Fiehn, O., & Olson, D. E. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00692 · Cited by 168 · see citing works
Yanakieva, S., Polychroni, N., Family, N., Williams, L. T. J., Luke, D. P., & Terhune, D. B. (2018) · Psychopharmacology · doi:10.1007/s00213-018-5119-x · Cited by 167 · see citing works
Tsai, S., Hayashi, T., Harvey, B. K., Wang, Y., Wu, W. W., Shen, R., Zhang, Y., Becker, K. G., Hoffer, B. J., & Su, T. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909089106 · Cited by 160 · see citing works
Psychedelics and Immunomodulation: Novel Approaches and Therapeutic Opportunities
Szabo, A. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00358 · Cited by 150 · see citing works
Davis, A. K., Clifton, J. M., Weaver, E. G., Hurwitz, E. S., Johnson, M. W., & Griffiths, R. R. (2020) · Journal of Psychopharmacology · doi:10.1177/0269881120916143 · Cited by 148 · see citing works
Cozzi, N. V., Gopalakrishnan, A., Anderson, L. L., Feih, J. T., Shulgin, A. T., Daley, P. F., & Ruoho, A. E. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0308-8 · Cited by 144 · see citing works
Barker, S. A., McIlhenny, E. H., & Strassman, R. (2012) · Drug Testing and Analysis · doi:10.1002/dta.422 · Cited by 142 · cited 1× · see citing works
“There have also been some 70 published studies conducted that reported the detection and/or quantitation of DMT in human blood and urine (Barker et al. 2012).”
BackgroundSelf-citationPharmahuasca: Human Pharmacology of Oral DMT Plus Harmine
Ott, J. (1999) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1999.10471741 · Cited by 140 · see citing works
Morales-Garcia, J. A., Calleja-Conde, J., Lopez-Moreno, J. A., Alonso-Gil, S., Sanz-SanCristobal, M., Riba, J., & Perez-Castillo, A. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01011-0 · Cited by 138 · see citing works
Developments in harmine pharmacology — Implications for ayahuasca use and drug-dependence treatment
Brierley, D. I., & Davidson, C. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.06.001 · Cited by 137 · see citing works
Autonomic, Neuroendocrine, and Immunological Effects of Ayahuasca
SANTOS, R. G. D., Valle, M., Bouso, J. C., Nomdedeu, J. F., Rodrı́guez-Espinosa, J., McIlhenny, E. H., Barker, S. A., Barbanoj, M. J., & Riba, J. (2011) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0b013e31823607f6 · Cited by 136 · see citing works
Self-citationStrassman, R. J., Qualls, C. R., & Berg, L. M. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00200-6 · Cited by 130 · see citing works
Shim, S.-H., Hwangbo, Y., Kwon, Y.-J., Jeong, H.-Y., Lee, B.-H., Lee, H.-J., & Kim, Y.-K. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.08.005 · Cited by 128 · see citing works
Motives and Side-Effects of Microdosing With Psychedelics Among Users
Hutten, N. R. P. W., Mason, N. L., Dolder, P. C., & Kuypers, K. P. C. (2019) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyz029 · Cited by 126 · see citing works
dos Santos, R. G., Balthazar, F. M., Bouso, J. C., & Hallak, J. E. (2016) · Journal of Psychopharmacology · doi:10.1177/0269881116652578 · Cited by 125 · see citing works
Might microdosing psychedelics be safe and beneficial? An initial exploration
Fadiman, J., & Korb, S. (2019) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2019.1593561 · Cited by 125 · see citing works
The psychedelic model of schizophrenia: the case of N,N- dimethyltryptamine
Gillin, J. C., Kaplan, J., Stillman, R. C., & Wyatt, R. J. (1976) · American Journal of Psychiatry · doi:10.1176/ajp.133.2.203 · Cited by 123 · see citing works
Szabo, A., Kovacs, A., Riba, J., Djurovic, S., Rajnavolgyi, E., & Frecska, E. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00423 · Cited by 121 · see citing works
Microdosing psychedelics: Motivations, subjective effects and harm reduction
Lea, T., Amada, N. M., Jungaberle, H., Schecke, H., & Klein, M. (2019) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2019.11.008 · Cited by 121 · see citing works
Nguyen, L., Lucke-Wold, B. P., Mookerjee, S. A., Kaushal, N., & Matsumoto, R. R. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-50174-1_10 · Cited by 119 · see citing works
Making psychedelics into medicines: The politics and paradoxes of medicalization
Noorani, T. N. (2019) · Journal of Psychedelic Studies · doi:10.1556/2054.2019.018 · Cited by 119 · see citing works
N,N-Dimethyltryptamine: An Endogenous Hallucinogen
Barker, S. A., Monti, J. A., & Christian, S. T. (1981) · International review of neurobiology · doi:10.1016/s0074-7742(08)60291-3 · Cited by 113 · see citing works
Self-citationWhen the Endogenous Hallucinogenic Trace AmineN,N-Dimethyltryptamine Meets the Sigma-1 Receptor
Su, T., Hayashi, T., & Vaupel, D. B. (2009) · Science Signaling · doi:10.1126/scisignal.261pe12 · Cited by 110 · see citing works
Psychedelic Microdosing: Prevalence and Subjective Effects
Cameron, L. P., Nazarian, A., & Olson, D. E. (2020) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2020.1718250 · Cited by 110 · see citing works
Frecska, E., Szabo, A., Winkelman, M. J., Luna, L. E., & McKenna, D. J. (2013) · Journal of Neural Transmission · doi:10.1007/s00702-013-1024-y · Cited by 109 · see citing works
Biosynthesis and Extracellular Concentrations of N,N-dimethyltryptamine (DMT) in Mammalian Brain
Dean, J. G., Liu, T., Huff, S., Sheler, B., Barker, S. A., Strassman, R. J., Wang, M. M., & Borjigin, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-45812-w · Cited by 107 · see citing works
Self-citationBlough, B. E., Landavazo, A., Decker, A. M., Partilla, J. S., Baumann, M. H., & Rothman, R. B. (2014) · Psychopharmacology · doi:10.1007/s00213-014-3557-7 · Cited by 101 · see citing works
Jordi Riba, A., McIlhenny, E. H., Bouso, J. C., & Barker, S. A. (2014) · Drug Testing and Analysis · doi:10.1002/dta.1685 · Cited by 98 · see citing works
Self-citationHow are Biogenic Amines Metabolized by Monoamine Oxidases?
Vianello, R., Repič, M., & Mavri, J. (2012) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201201122 · Cited by 98 · see citing works
Samorini, G. (2019) · Journal of Psychedelic Studies · doi:10.1556/2054.2019.008 · Cited by 96 · see citing works
Dunlap, L. E., Azinfar, A., Ly, C., Cameron, L. P., Viswanathan, J., Tombari, R. J., Myers-Turnbull, D., Taylor, J. C., Grodzki, A. C., Lein, P. J., et al. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01404 · Cited by 95 · see citing works
Nardai, S., László, M., Szabó, A., Alpár, A., Hanics, J., Zahola, P., Merkely, B., Frecska, E., & Nagy, Z. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113245 · Cited by 94 · see citing works
Effect of some indolealkylamines on man
TURNER, W. J. (1959) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1959.02340130141020 · Cited by 88 · see citing works
Thompson, M. A., Moon, E., Kim, U.-J., Xu, J., Siciliano, M. J., & Weinshilboum, R. M. (1999) · Genomics · doi:10.1006/geno.1999.5960 · Cited by 87 · see citing works
Yritia, M., Jordi Riba, A., Ortuño, J., Ramirez, A., Castillo, A., Alfaro, Y., de la Torre, R., & Barbanoj, M. J. (2002) · Journal of Chromatography B · doi:10.1016/s1570-0232(02)00397-5 · Cited by 85 · see citing works
The therapeutic potential of microdosing psychedelics in depression
Kuypers, K. P. C. (2020) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125320950567 · Cited by 85 · see citing works
Neural and subjective effects of inhaled N,N-dimethyltryptamine in natural settings
Pallavicini, C., Cavanna, F., Zamberlán, F., de la Fuente, L. A., Ilksoy, Y. A., Perl, Y. S., Arias, M., Romero, C., Carhart-Harris, R. L., Timmermann, C., et al. (2021) · Journal of Psychopharmacology · doi:10.1177/0269881120981384 · Cited by 83 · see citing works
Mavlyutov, T. A., Epstein, M. L., Liu, P., Verbny, Y., Ziskind‐Conhaim, L., & Ruoho, A. E. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.040 · Cited by 80 · see citing works
Barker, S. A., Borjigin, J., Lomnicka, I., & Strassman, R. (2013) · Biomedical Chromatography · doi:10.1002/bmc.2981 · Cited by 72 · see citing works
Self-citationDimethyltryptamine (DMT): Subjective effects and patterns of use among Australian recreational users
Cakic, V., Potkonyak, J., & Marshall, A. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.03.015 · Cited by 72 · see citing works
Szabó, Í., Varga, V. É., Dvorácskó, S., Farkas, A. E., Körmöczi, T., Berkecz, R., Kecskés, S., Menyhárt, Á., Frank, R., Hantosi, D., et al. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108612 · Cited by 72 · see citing works
Sigma receptor modulators: a patent review
Collina, S., Gaggeri, R., Marra, A., Bassi, A., Negrinotti, S., Negri, F., & Rossi, D. (2013) · Expert Opinion on Therapeutic Patents · doi:10.1517/13543776.2013.769522 · Cited by 71 · see citing works
<i>N,N</i> -dimethyltryptamine and the pineal gland: Separating fact from myth
Nichols, D. E. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881117736919 · Cited by 69 · see citing works
Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia
Martin, D. A., Marona-Lewicka, D., Nichols, D. E., & Nichols, C. D. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.03.013 · Cited by 67 · see citing works
Yang, Z.-J., Carter, E. L., Torbey, M., Martin, L. J., & Koehler, R. C. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.10.019 · Cited by 62 · see citing works
DeSteno, D. A., & Schmauss, C. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.012 · Cited by 62 · see citing works
The effect of N,N-dimethyltryptamine in human subjects tolerant to lysergic acid diethylamide
Rosenberg, D. E., Isbell, H., Miner, E. J., & Logan, C. R. (1964) · Psychopharmacology · doi:10.1007/bf00413244 · Cited by 61 · see citing works
SANTOS, R. G. D., Bouso, J. C., Rocha, J. M., Rossi, G. N., & Hallak, J. E. C. (2021) · Risk Management and Healthcare Policy · doi:10.2147/rmhp.s300656 · Cited by 60 · see citing works
Sociopsychotherapeutic Functions of Ayahuasca Healing in Amazonia
Andritzky, W. (1989) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1989.10472145 · Cited by 59 · see citing works
Asphyxia-activated corticocardiac signaling accelerates onset of cardiac arrest
Li, D., Mabrouk, O. S., Liu, T., Tian, F., Xu, G., Rengifo, S., Choi, S. J., Mathur, A., Crooks, C. P., Kennedy, R. T., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1423936112 · Cited by 59 · see citing works
Chemical composition of traditional and analog Ayahuasca
Kaasik, H., Souza, R. C. Z., Zandonadi, F. S., Tófoli, L. F., & Sussulini, A. (2021) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2020.1815911 · Cited by 59 · see citing works
Christian, S. T., Harrison, R., Quayle, E., Pagel, J., & Monti, J. (1977) · Biochemical Medicine · doi:10.1016/0006-2944(77)90088-6 · Cited by 58 · see citing works
Bringing Ayahuasca to the Clinical Research Laboratory
Jordi Riba, A., & Barbanoj, M. J. (2005) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2005.10399804 · Cited by 58 · see citing works
Halberstadt, A. L., Nichols, D. E., & Geyer, M. A. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2616-6 · Cited by 57 · see citing works
The Identity of the Malpighiaceous Narcotics of South America
Schultes, R. E. (1957) · Botanical Museum leaflets Harvard University · doi:10.5962/p.168508 · Cited by 55 · see citing works
Rabbit Lung Indolethylamine N-Methyltransferase
Thompson, M. A., & Weinshilboum, R. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.51.34502 · Cited by 51 · see citing works
The Effects of Hallucinogens on Gene Expression
Martin, D. A., & Nichols, C. D. (2017) · Current topics in behavioral neurosciences · doi:10.1007/7854_2017_479 · Cited by 51 · see citing works
Griesmaier, E., Posod, A., Gross, M. J., Neubauer, V., Wegleiter, K., Hermann, M., Urbanek, M., Keller, M., & Kiechl‐Kohlendorfer, U. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.06.030 · Cited by 50 · see citing works
Kärkkäinen, J., Forsström, T., Tornaeus, J., Wähälä, K., Kiuru, P. S., Honkanen, A., Stenman, U., Turpeinen, U., & Hesso, A. (2005) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510510013604 · Cited by 50 · see citing works
Zhao, X., Zhu, L., Liu, D., Chi, T., Ji, X., Liu, P., Yang, X., Tian, X., & Zou, L. (2018) · APOPTOSIS · doi:10.1007/s10495-018-1495-2 · Cited by 50 · see citing works
Corbett, L., Christian, S. T., Morin, R. D., Benington, F., & Smythies, J. (1978) · The British Journal of Psychiatry · doi:10.1192/bjp.132.2.139 · Cited by 49 · see citing works
Halberstadt, A. L., Buell, M. R., Masten, V. L., Risbrough, V. B., & Geyer, M. A. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1247-z · Cited by 45 · see citing works
The pharmacological interaction of compounds in ayahuasca: a systematic review
Ruffell, S., Netzband, N., Bird, C., Young, A. H., & Juruena, M. F. (2020) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2020-0884 · Cited by 45 · see citing works
Nuño-Ayala, M., Guillén, N., Arnal, C., Lou-Bonafonte, J. M., Martino, A. D., García-de-Jalón, J.-A., Gascón, S., Osaba, L., Osada, J., & Navarro, M. A. J. G. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00189.2010 · Cited by 44 · see citing works
A multidisciplinary overview of intoxicating enema rituals in the western hemisphere
Smet, P. A. G. M. D. (1983) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(83)90031-4 · Cited by 44 · see citing works
Dimethyltryptamine (DMT): a biochemical Swiss Army knife in neuroinflammation and neuroprotection?
Szabó, A., & Frecska, E. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.179041 · Cited by 44 · see citing works
Smythies, Rd, M., & Brown, G. B. (1979) · PubMed · Cited by 43 · see citing works
Strassman, R. J. (1991) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1991.10472572 · Cited by 43 · see citing works
Molecular and Functional Imaging Studies of Psychedelic Drug Action in Animals and Humans.
Cumming, P., Scheidegger, M., Dornbierer, D., Palner, M., Quednow, B. B., & Martin-Soelch, C. (2021) · Molecules · doi:10.3390/molecules26092451 · Cited by 43 · see citing works
Schindler, E., Wallace, R., Sloshower, J., & D'Souza, D. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00177 · Cited by 42 · see citing works
Frankel, P. S., & Cunningham, K. A. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03548-5 · Cited by 41 · see citing works
Dean, J. G. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00232 · Cited by 37 · see citing works
Stability Evaluation of DMT and Harmala Alkaloids in Ayahuasca Tea Samples
Silveira, G. D. O., SANTOS, R. G. D., Lourenço, F. R., Rossi, G. N., Hallak, J. E. C., & Yonamine, M. (2020) · Molecules · doi:10.3390/molecules25092072 · Cited by 37 · see citing works
Rosengarten, H., & Friedhoff, A. J. (1976) · Schizophrenia Bulletin · doi:10.1093/schbul/2.1.90 · Cited by 35 · see citing works
Sigma-1 and N-Methyl- D -Aspartate Receptors: A Partnership with Beneficial Outcomes
Pabba, M., & Sibille, E. L. (2015) · Complex Psychiatry · doi:10.1159/000376549 · Cited by 32 · see citing works
Christian, S. T., Benington, F., Morin, R. D., & Corbett, L. (1975) · Biochemical Medicine · doi:10.1016/0006-2944(75)90036-8 · Cited by 31 · see citing works
Dimethyltryptamine: Endogenous Role and Therapeutic Potential
Rodrigues, A. V., Almeida, F., & Vieira‐Coelho, M. A. (2019) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2019.1602291 · Cited by 30 · see citing works
Barker, S. A., Beaton, J. M., Christian, S. T., Monti, J. A., & Morris, P. E. (1982) · Biochemical Pharmacology · doi:10.1016/0006-2952(82)90062-4 · Cited by 26 · see citing works
Self-citationFitzgerald, P. J. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.04.003 · Cited by 26 · see citing works
Psychedelic-assisted therapies: The past, and the need to move forward responsibly
Gardner, J., Carter, A., O’Brien, K., & Seear, K. (2019) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2019.05.019 · Cited by 23 · see citing works
Szara, S. I. (2007) · PubMed · Cited by 22 · see citing works
Ontogeny of N,N-Dimethyltryptamine and related indolealkylamine levels in neonatal rats
Beaton, J. M., & Morris, P. E. (1984) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(84)90007-1 · Cited by 22 · see citing works
5-methoxy-N, N-dimethyltryptamine, a possible endogenous psychotoxin.
Benington, F., Rd, M., & Clark, L. C. (1965) · PubMed · Cited by 22 · see citing works
N,N-dimethyltryptamine Prevents Renal Ischemia-Reperfusion Injury in a Rat Model
Nemes, B., Pető, K., Németh, N., Mester, A., Magyar, Z. É., Ghanem, S., Sógor, V., Tánczos, B., Deák, Á., Kállay, M., et al. (2019) · Transplantation Proceedings · doi:10.1016/j.transproceed.2019.04.005 · Cited by 22 · see citing works
In vivo metabolism of α,α,β,β-tetradeutero-n, N-dimethyltryptamine in rodent brain
Barker, S. A., Beaton, J. M., Christian, S. T., Monti, J. A., & Morris, P. E. (1984) · Biochemical Pharmacology · doi:10.1016/0006-2952(84)90404-0 · Cited by 21 · see citing works
Self-citationIndolethylamine‐N‐methyltransferase in developing rabbit lung
Lin, R.-L., Sargeant, S., & Narasimhachari, N. (1974) · Developmental Psychobiology · doi:10.1002/dev.420070511 · Cited by 21 · see citing works
Berge, O., Chacho, D., & Hole, K. (1983) · European Journal of Pharmacology · doi:10.1016/0014-2999(83)90253-4 · Cited by 20 · see citing works
Pető, K., Németh, N., Mester, A., Magyar, Z. É., Ghanem, S., Somogyi, V., Tánczos, B., Deák, Á., Bidiga, L., Frecska, E., et al. (2018) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-170361 · Cited by 18 · see citing works
Inhibition of Synaptosomal Neurotransmitter Uptake by Hallucinogens
Whipple, M. R., Reinecke, M. G., & Gage, F. H. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb08113.x · Cited by 14 · see citing works
A comparison of the behavioral effects of proteo- and deutero-N, N-dimethyltryptamine
Beaton, J. M., Barker, S. A., & Liu, W.-F. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90240-4 · Cited by 13 · see citing works
Self-citationRuffing, D. M., Kovacic, B., Demetriou, S., & Domino, E. F. (1979) · Psychopharmacology · doi:10.1007/bf00431949 · Cited by 13 · see citing works
Ruffing, D. M., & Domino, E. F. (1981) · Psychopharmacology · doi:10.1007/bf00432428 · Cited by 12 · see citing works
Polypharmacology or “Pharmacological Promiscuity” In Psychedelic Research: What Are We Missing?
Oña, G., SANTOS, R. G. D., Hallak, J. E. C., & Bouso, J. C. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00614 · Cited by 12 · see citing works
Evidence for dimethyltryptamine (DMT) as a naturally-occurring transmitter in mammalian brain.
St, C., Harrison, R. J., & Pagel, J. (1976) · PubMed · Cited by 9 · see citing works
Indolealkylamine metabolism: Synthesis of deuterated indolealkylamines as metabolic probes
Morris, P. E., & Chiao, C. (1993) · Journal of Labelled Compounds and Radiopharmaceuticals · doi:10.1002/jlcr.2580330603 · Cited by 7 · see citing works
Ruffing, D. M., & Domino, E. F. (1983) · Psychopharmacology · doi:10.1007/bf00432112 · Cited by 6 · see citing works
N,N-dimethyltryptamine facts and myths
Barker, S. A. (2018) · Journal of Psychopharmacology · doi:10.1177/0269881118767648 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 7
- Liechti ME Psychedelics: what are low doses and ‘microdoses’? Commentary on Kuypers et al. (2019) Journal of Psychopharmacology 2019 33 1052 1053
- McKenna DJ Callaway JC Grob CS The scientific investigation of ayahuasca: a review of past and current research Heffter Rev Psychedel Res 1998 1 65 77
- Nichols DE N, N-dimethyltryptamine facts and myths: author’s reply J Psychopharmacol 2018 32 820 822 10.1177/0269881118767648 29991341 · DOI
- Passie T The science of microdosing psychedelics 2019 London Psychedelic Press
- Riba J (2003) Human pharmacology of ayahuasca. Dissertation. University of Barcelona, Spain.
- Shulgin A Shulgin A Joy D Tihkal: The Continuation 1997 USA Transform Press
- Strassman RJ (2001) DMT: the spirit molecule: a doctor’s revolutionary research into the biology of near-death and mystical experiences. Park Street Press
Cited by
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Drug–drug interactions involving classic psychedelics: A systematic review
Halman, A., Kong, G., Sarris, J. J., & Perkins, D. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811231211219 · Cited by 74 · see citing works
Exploring DMT: Endogenous role and therapeutic potential
Schimmelpfennig, J., & Jankowiak-Siuda, K. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110314 · Cited by 54 · see citing works
Cheng, D., Lei, Z., Chu, K., Lam, O. J. H., Chiang, C. Y., & Zhang, Z.-J. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01462-3 · Cited by 46 · see citing works
The risk of chronic psychedelic and MDMA microdosing for valvular heart disease
Tagen, M., Mantuani, D., van Heerden, L., Holstein, A., Klumpers, L. E., & Knowles, R. G. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811231190865 · Cited by 41 · see citing works
Aicher, H. D., Mueller, M. J., Dornbierer, D. A., Suay, D., Elsner, C., Wicki, I., Meling, D., Caflisch, L., Hempe, A., Steinhart, C., et al. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1302559 · Cited by 33 · see citing works
Egger, K., Aicher, H., Cumming, P. D., & Scheidegger, M. (2024) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-024-05353-6 · Cited by 36 · see citing works
Dornbierer, D. A., Marten, L., Mueller, J., Aicher, H. D., Mueller, M. J., Boxler, M., Kometer, M., Kosanic, D., von Rotz, R., Puchkov, M., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1246892 · Cited by 32 · see citing works
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Ramaekers, J. G., Reckweg, J. T., & Mason, N. L. (2025) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230890 · Cited by 32 · see citing works
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Mahmood, D., Alenezi, S. K., Anwar, M. J., Azam, F., Qureshi, K. A., & Jaremko, M. (2022) · Pharmaceuticals · doi:10.3390/ph15050640 · Cited by 29 · see citing works
Luethi, D., Kolaczynska, K. E., Vogt, S. B., Ley, L., Erne, L., Liechti, M. E., & Duthaler, U. (2022) · Journal of Chromatography B · doi:10.1016/j.jchromb.2022.123534 · Cited by 27 · see citing works
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Werle, I., Nascimento, L. M. M., dos Santos, A. L. A., Soares, L. A., SANTOS, R. G. D., Hallak, J. E. C., & Bertoglio, L. J. (2024) · British Journal of Pharmacology · doi:10.1111/bph.16315 · Cited by 28 · see citing works
Laszlo, M. J., Vigh, J. P., Kocsis, A. E., Porkoláb, G., Hoyk, Z., Polgár, T. F., Walter, F. R., Szabó, A., Djurovic, S., Merkely, B. P., et al. (2025) · Science Advances · doi:10.1126/sciadv.adx5958 · Cited by 18 · see citing works
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Kargbo, R. B. (2022) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.2c00354 · Cited by 12 · see citing works
Varani, A. M., Silva, S. R., Lopes, S. S. D. S., Barbosa, J. B. F., de Oliveira, D. R., Corrêa, M. A., Moraes, A. P., Miranda, V. F. O., & Prosdocimi, F. (2022) · PeerJ · doi:10.7717/peerj.14114 · Cited by 11 · see citing works
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Schmautz, B., Fuchshuber, J., Andres, D., Prandstätter, T., Roithmeier, L., Freund, A., Schwerdtfeger, A. R., & Unterrainer, . (2024) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2024.1329226 · Cited by 7 · see citing works
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Singh, R. P., Singh, S., Naskar, K. S., & Kundu, A. (2023) · Synthesis · doi:10.1055/a-2112-2353 · Cited by 5 · see citing works
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Butt, N.-U.-H., & Baytaş, S. N. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104471 · Cited by 4 · see citing works
Fandiño, O. E., Hutton, A. R. J., Zhang, C., Abbate, M. T. A., Naser, Y. A., Li, Y., Paredes, A. J., & Donnelly, R. F. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114603 · Cited by 4 · see citing works
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Gold, N. D., Podrebarac, S. K., White, L. A., Marini, C., Simon, N. M., Mittelman, M. S., Ross, S., Bogenschutz, M. P., & Petridis, P. D. (2023) · Psychedelic Medicine · doi:10.1089/psymed.2022.0011 · Cited by 3 · see citing works
Silva, G. A. E., Wakui, V. G., Kato, L., & Marquezin, C. A. (2024) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2024.184304 · Cited by 3 · see citing works
Lima, G., Soares, C., Teixeira, M., & Castelo-Branco, M. S. (2024) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.16264 · Cited by 3 · see citing works
Engel, L. B., Thal, S. B., Bright, S. J., & Low, M. (2024) · Journal of Psychedelic Studies · doi:10.1556/2054.2024.00377 · Cited by 3 · see citing works
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Lima, G., Soares, C., Teixeira, M., Pais, M. L., Cabral, C., Rijo, P. M., & Castelo-Branco, M. S. (2025) · Scientific Reports · doi:10.1038/s41598-025-31431-1 · Cited by 2 · see citing works
Schimmelpfennig, J., & Jankowiak-Siuda, K. (2023) · Neuropsychiatria i Neuropsychologia · doi:10.5114/nan.2023.129068 · Cited by 2 · see citing works
Videira, N. B., Nair, V., Paquet, V., & Calhoun, D. (2023) · Journal of Applied Toxicology · doi:10.1002/jat.4533 · Cited by 2 · see citing works
de Oliveira, L. C., Galdino, T. P., Pedro, M. D. S., da Luz, M. A., Castro, I. D. M., Filho, E. A. C., Gonçalves, J. D. D. S., de Lima, A. G. B., Afonso, V. I., Fook, M. V. L., et al. (2025) · ACS Omega · doi:10.1021/acsomega.5c06560 · Cited by 1 · see citing works
Hosie, W. C., Banerjee, A., Egbuta, M. A., Razmkhah, K., Bolandi, B., Dehvari, K., Homon, A. A., Kappadakunnel, A., Simone, J. J., & Trant, J. F. (2025) · Advanced Therapeutics · doi:10.1002/adtp.202500333 · Cited by 1 · see citing works
Baumann, M. H., Glatfelter, G. C., Walton, S. E., Krotulski, A. J., Witowski, C. G., & von Salm, J. L. (2025) · Psychopharmacology · doi:10.1007/s00213-025-06879-8 · Cited by 1 · see citing works
Greene, S. L. (2025) · Comprehensive analytical chemistry · doi:10.1016/bs.coac.2024.12.002 · Cited by 1 · see citing works
The Ontological Status of Visions and Hallucinations.Preprint
Blaber, R. M. (2022) · doi:10.31235/osf.io/vmakg · Cited by 1 · see citing works
Application of machine learning and complex network measures to an EEG dataset from DMT experimentsPreprint
Alves, C. L., Toutain, T. G. L. D. O., Porto, J. A. M., Pineda, A. M., de Sena, E. P., Rodrigues, F. A., Thielemann, C., & Ciba, M. (2022) · medRxiv · doi:10.1101/2022.06.14.22276410
Schimmelpfennig, J., & Jankowiak-Siuda, K. (2023) · Pharmacotherapy in Psychiatry and Neurology · doi:10.5114/fpn.2023.131979
The Ghosts of Ayahuasca: Conceptual Limits and Spectral Residues
Glazier, J. W., & O'Donnell, S. J. (2025) · Anthropology of Consciousness · doi:10.1111/anoc.70013
Kolesnikov, A. (2024) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.10825356
Cheng, D., Lei, Z.-G., Chu, K., Lam, O. J. H., Chiang, C. Y., & Zhang, Z.-J. (2024) · Figshare · doi:10.6084/m9.figshare.25734511
Psychedelics and Respiratory Health: A Literature Review
Alanazi, M. M., & Alqahtani, M. Μ. (2025) · Psychedelic Medicine · doi:10.1177/28314425251404458
Happawana, K. (2025) · Springer eBooks · doi:10.1007/978-3-032-06290-1_6
Santos, F. P., Paranhos, B. A. P. B., Sandini, T. M., Bruno, V., & Yonamine, M. (2026) · Talanta · doi:10.1016/j.talanta.2026.129455
Csonka, M., Damenija, G., Stengl, R., Bálint, T., Nagy, D. G., Budai, A., Eröss, B., Șulea, C. M., Frecska, E., Merkely, B., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10180849/v1
Salvinorin A in humans: A systematic review of pharmacokinetics, pharmacodynamics, and safety
Zürrer, W. E., Liesner, J., Brüschweiler, D., Aicher, H., Scheidegger, M., & Ineichen, B. V. (2026) · Journal of Psychopharmacology · doi:10.1177/02698811261473385
- Authors
- Barker, S. A.
- Affiliations
- Louisiana State University (US)
- Corresponding author
- Barker, Steven A.
- ORCID
- Barker, Steven A.
- Venue
- Psychopharmacology
- Published
- 2022-01-22
- Volume
- 239
- Issue
- 6
- Pages
- 1749-1763
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC8782705
- OpenAlex
- W4207030820
- Semantic Scholar
- 91c073b0b79e94b887b764e30d93b74963e40b7a
- Cited by
- 58
- References
- 156
- Citations by year
- 2026: 4 · 2025: 19 · 2024: 17 · 2023: 12 · 2022: 6
- FWCI
- 2.25
- Type
- journal article
- Language
- en
- Update notices
- correction (2022-02-11)
- Open access
- bronze
- doi.org
- Licence
- Locations
- Psychopharmacology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Alkaloids: synthesis and pharmacology
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Keywords
- N,N-dimethyltryptamine, ayahuasca, intravenous injection, intramuscular injection, insufflation, microdosing, monoamine oxidase inhibitors
- MeSH terms
- Administration, Oral, N,N-Dimethyltryptamine, Hallucinogens, Monoamine Oxidase Inhibitors, Banisteriopsis
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