Decreased serum angiogenin level in Alzheimer's disease
Abstract
Background It has been suggested that Alzheimer's disease (AD) is mediated by pathological angiogenesis. Vascular endothelial growth factor (VEGF), transforming growth factor β (TGF-β), and tumor necrosis factor α (TNF -α) may play important roles in inflammation and angiogenesis through effects on inflammatory cell infiltration or neovascularization in AD pathogenesis. A few studies on the roles of VEGF in AD have been reported recently. But, the results were inconsistent. Angiogenin, which is suspected to have a similar function as VEGF, however, has not yet been studied in patients with AD.Objective This study was performed to investigate the levels of angiogenin and vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptorI (VEGFR I), and vascular endothelial growth factor receptor II (VEGFR II) in serums of patients with AD, to compare their levels with control subjects, and to determine whether serum angiogenin, VEGF, VEGFR I, and VEGFR II levels are associated with Alzheimer's disease (AD).Methods Serum angiogenin, VEGF, VEGFR I, and VEGFR II levels were quantified at the time of diagnosis in 20 patients with definite AD, and 18 healthy controls, using a commercial ELISA kit.Results Patients with AD exhibited lower serum angiogenin (p=0.003) and higher VEGF (p=0.008) levels than control subjects. No difference in serum VEGFR I and VEGFR II concentrations was observed between AD patients and controls. There was a correlation between serum levels of angiogenin and cognitive function (MMSE-KC and CDR) in AD patients.Conclusion The increased serum level of VEGF and decreased serum angiogenin level were founded. Cognitive function was correlated with serum levels of angiogenin. Angiogenin may be involved in the pathogenesis of AD. Further study should be needed to evaluate the possibility of serum angiogenin as a biomarker of AD and as a predictor of disease progression.
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One study has previously reported no difference in serum Flt-1 levels between patients with AD and healthy controls.
“One study has previously reported no difference in serum Flt-1 levels between patients with AD and healthy controls.37”
From CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease (2018) · cites this paper as [37]
Cites
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works
Signal Transduction by Vascular Endothelial Growth Factor Receptors
Koch, S., Tugues, S., Li, X., Gualandi, L., & Claesson, L. (2011) · Biochemical Journal · doi:10.1042/bj20110301 · Cited by 1,629 · see citing works
VEGF links hippocampal activity with neurogenesis, learning and memory
Cao, L., Jiao, X., Zuzga, D. S., Liu, Y., Fong, D. M., Young, D., & During, M. J. (2004) · Nature Genetics · doi:10.1038/ng1395 · Cited by 850 · see citing works
Lee, J. H., Lee, K. U., Lee, D. Y., Kim, K. W., Jhoo, J. H., Kim, J. H., Lee, K. H., Kim, S. Y., Han, S., & Woo, J. I. (2002) · The Journals of Gerontology Series B · doi:10.1093/geronb/57.1.p47 · Cited by 774 · see citing works
The vascular endothelial growth factor family of polypeptides
Ferrara, N., Houck, K. A., Jakeman, L. B., Winer, J., & Leung, D. W. (1991) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240470305 · Cited by 641 · see citing works
Differential Roles of Vascular Endothelial Growth Factor Receptor-1 and Receptor-2 in Angiogenesis
Shibuya, M. (2006) · BMB Reports · doi:10.5483/bmbrep.2006.39.5.469 · Cited by 623 · see citing works
From angiogenesis to neuropathology
Greenberg, D. A., & Jin, K. (2005) · Nature · doi:10.1038/nature04481 · Cited by 532 · see citing works
Tarkowski, E., Issa, R., Sjögren, M., Wallin, A., Blennow, K., Tarkowski, A., & Kumar, P. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00285-8 · Cited by 360 · see citing works
Brain Infarction and the Clinical Expression of Alzheimer Disease
Román, G. C. (1997) · JAMA · doi:10.1001/jama.1997.03550020045023 · Cited by 350 · see citing works
Cerebral vessels in ageing and Alzheimer's disease
Kalaria, R. N. (1996) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(96)00116-7 · Cited by 336 · see citing works
Kishimoto, K., Liu, S.-M., Tsuji, T., Olson, K., & Hu, G. (2005) · Oncogene · doi:10.1038/sj.onc.1208223 · Cited by 325 · see citing works
Pitfalls in the Measurement of Circulating Vascular Endothelial Growth Factor
JELKMANN, W. E. B. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.4.617 · Cited by 324 · see citing works
Han, C., Jo, S. A., Jo, I., Kim, E., Park, M. H., & Kang, Y. (2007) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2007.08.012 · Cited by 290 · see citing works
Alzheimer's disease and angiogenesis
Vagnucci, A. H., & Li, W. W. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12521-4 · Cited by 267 · see citing works
SLEVIN, M. A., Krupiński, J., Słowik, A., Kumar, P., Szczudlik, A., & Gaffney, J. J. (2000) · Stroke · doi:10.1161/01.str.31.8.1863 · Cited by 233 · see citing works
Alzheimer's disease and angiogenesis
Agorogiannis, E. I., & Agorogiannis, G. I. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13000-0 · Cited by 224 · see citing works
Peers, C., Dallas, M. L., Boycott, H. E., Scragg, J. L., Pearson, H. A., & Boyle, J. P. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05026.x · Cited by 166 · see citing works
Perlmutter, L. S., Chui, H. C., Saperia, D., & Athanikar, J. N. (1990) · Brain Research · doi:10.1016/0006-8993(90)91111-s · Cited by 131 · see citing works
Low serum VEGF levels are associated with Alzheimer's disease
Mateo, I., Llorca, J., Infante, J., Rodríguez‐Rodríguez, E., Fernández‐Viadero, C., Peña, N., Berciano, J., & Combarros, O. (2006) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2006.00775.x · Cited by 128 · see citing works
Achen, M. G., & Stacker, S. A. (1998) · International Journal of Experimental Pathology · doi:10.1046/j.1365-2613.1998.700404.x · Cited by 121 · see citing works
Effects of hypoxia on glial cell expression of angiogenesis-regulating factors VEGF and TGF-beta.
Behzadian, M. A., Wang, X., Al‐Shabrawey, M., Shabrawey, M., & Caldwell, R. B. (1998) · PubMed · Cited by 118 · see citing works
Elevated serum angiogenin levels in ALS
Cronin, S., Greenway, M. J., Ennis, S., Kieran, D., Green, A., Prehn, J. H. M., & Hardiman, O. M. (2006) · Neurology · doi:10.1212/01.wnl.0000244466.46020.47 · Cited by 72 · see citing works
Hu, B., Yip, H. K.-F., & So, K. (1998) · Glia · doi:10.1002/(sici)1098-1136(199810)24:2 · Cited by 58 · see citing works
Gunsilius, E., Petzer, A. L., Stockhammer, G., et al. (2001) · Stroke · doi:10.1161/01.str.32.1.275-b · Cited by 27 · see citing works
Saver, J. L., Kidwell, C. S., Liebeskind, D. S., & Starkman, S. (2001) · Stroke · doi:10.1161/01.str.32.1.275-c · Cited by 19 · see citing works
Genetic and environmental determinants of circulating levels of angiogenin in community‐based sample
Pantsulaia, I., Trofimov, S., Kobyliansky, E. D., et al. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02456.x · Cited by 17 · see citing works
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CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease
Janelidze, S., Mattsson, N., Stomrud, E., Lindberg, O., Palmqvist, S., Zetterberg, H., Blennow, K., & Hansson, O. (2018) · Neurology · doi:10.1212/wnl.0000000000006082 · Cited by 359 · see citing works
- Authors
- Kim, Y. N., & Kim, D. H.
- Affiliations
- Hallym University (KR)
- Corresponding author
- Kim, Do Hoon
- ORCID
- Kim, Do Hoon
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 38
- Issue
- 2
- Pages
- 116-120
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W1990096485
- Cited by
- 55
- References
- 26
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 1 · 2018: 5 · 2017: 1 · 2016: 4 · 2015: 9 · 2014: 5 · 2013: 3
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Korea Healthcare technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- Alzheimer's disease, angiogenin, vascular endothelial growth factor, serum biomarkers, pathological angiogenesis, cognitive function, disease progression
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cognition, Female, Humans, Male, Neovascularization, Pathologic, Neuropsychological Tests, Ribonuclease, Pancreatic, Vascular Endothelial Growth Factor Receptor-1, Vascular Endothelial Growth Factor Receptor-2, Vascular Endothelial Growth Factor A
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