Cited by 360Alzheimer's disease research and treatmentsNeurological Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

Increased intrathecal levels of the angiogenic factors VEGF and TGF-β in Alzheimer’s disease and vascular dementia

Tarkowski, Elisabeth, Issa, Razao, Sjögren, Magnus, Wallin, Anders, Blennow, Kaj, Tarkowski, Andrej, Kumar, Pat·2002·Neurobiology of Aging

Abstract

The aim of the present study was to investigate, in patients with Alzheimer's disease (AD), and vascular dementia (VAD), patterns of local release of vascular endothelial growth factor (VEGF) and transforming growth factor-beta (TGF-beta), two cytokines having a pivotal role in hypoxia-induced angiogenesis. The intrathecal levels of these molecules were related to the clinical severity of these diseases and to the intrathecal levels of beta-amyloid protein. Significantly increased cerebrospinal fluid (CSF) levels of both VEGF and TGF-beta were observed in 20 patients with AD and in 26 patients with VAD compared to healthy controls. Interestingly, there was significant correlation between the CSF levels of TGF-beta and VEGF in all the individuals studied. Our study demonstrates, both in patients with AD and in patients with VAD, an intrathecal production of VEGF, a cytokine which plays a pivotal role in angiogenesis. These results suggest that vascular factors might not only play a role in the pathogenesis of VAD but also in the pathogenesis of AD. In addition, we show in AD and VAD an intrathecal production of TGF-beta, a cytokine exerting on one hand anti-inflammatory and angiogenic properties, but on the other promoting amyloidogenesis.

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Crossref · 10.1016/s0197-4580(01)00285-8

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Authors
Tarkowski, E., Issa, R., Sjögren, M., Wallin, A., Blennow, K., Tarkowski, A., & Kumar, P.
Affiliations
  • University of Gothenburg (SE)
  • Manchester Metropolitan University (GB)
Corresponding author
Tarkowski, Elisabeth
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2002-03
Volume
23
Issue
2
Pages
237-243
ISSN
0197-4580 (ISSN-L)
OpenAlex
W2168897511
Cited by
360
References
45
Citations by year
2026: 12 · 2025: 13 · 2024: 20 · 2023: 17 · 2022: 20 · 2021: 16 · 2020: 10 · 2019: 17 · 2018: 16 · 2017: 13 · 2016: 14 · 2015: 20 · 2014: 15 · 2013: 19 · 2012: 14
FWCI
7.79
Type
journal article
Language
en
Open access
closed
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
  • e-space (Manchester Metropolitan University) (submittedVersion)
Funders
Göteborgs Läkaresällskap
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, vascular dementia, vascular endothelial growth factor, TGF-beta, cerebrospinal fluid, angiogenesis, hypoxia, amyloid-beta, amyloidogenesis, disease severity
MeSH terms
Aged, Albumins, Alzheimer Disease, Enzyme-Linked Immunosorbent Assay, Female, Humans, Lymphokines, Magnetic Resonance Imaging, Male, Middle Aged, Tomography, X-Ray Computed, Dementia, Vascular, Transforming Growth Factor beta, Endothelial Growth Factors, Amyloid beta-Peptides, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A

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