Imipramine protects against the deleterious effects of chronic corticosterone on depression-like behavior, hippocampal reelin expression, and neuronal maturation

Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants

Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., et al. (2003) · Science · doi:10.1126/science.1083328 · Cited by 4,321 · see citing works

Behavioural despair in rats: A new model sensitive to antidepressant treatments

Porsolt, R. D., Anton, G., Blavet, N., & Jalfre, M. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90118-8 · Cited by 3,138 · see citing works

Transient expression of doublecortin during adult neurogenesis

Brown, J. P., Couillard‐Després, S., Cooper‐Kuhn, C. M., Winkler, J., Aigner, L., & Kuhn, H. G. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10874 · Cited by 1,494 · see citing works

GABA regulates synaptic integration of newly generated neurons in the adult brain

Ge, S., Goh, E. L. K., Sailor, K. A., Kitabatake, Y., Ming, G., & Song, H. (2005) · Nature · doi:10.1038/nature04404 · Cited by 1,261 · see citing works

Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test

Cryan, J. F., Valentino, R. J., & Lucki, I. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.008 · Cited by 1,115 · see citing works

Course of illness, hippocampal function, and hippocampal volume in major depression

MacQueen, G. M., Campbell, S., McEwen, B. S., Macdonald, K., Amano, S., Joffe, R. T., Nahmias, C., & Young, L. T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337481100 · Cited by 980 · see citing works

The forced swimming test as a model for core and component behavioral effects of antidepressant drugs

Lucki, I. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199711000-00010 · Cited by 803 · see citing works

Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning

Weeber, E. J., Beffert, U., Jones, C., Christian, J. M., Förster, E., Sweatt, J. D., & Herz, J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205147200 · Cited by 623 · see citing works

The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling

Bessa, J. M., Ferreira, D., Melo, I., Marques, F., Cerqueira, J. J., Palha, J. A., Almeida, O. F. X., & Sousa, N. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.119 · Cited by 598 · see citing works

The neurobiology of depression and antidepressant action

Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works

Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2

Beffert, U., Weeber, E. J., Durudas, A., Qiu, S., Masiulis, I., Sweatt, J. D., Li, W.-P., Adelmann, G., Frotscher, M., Hammer, R. E., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.07.007 · Cited by 497 · see citing works

Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression

Fatemi, S. H., Earle, J. A., & McMenomy, T. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000783 · Cited by 447 · see citing works

Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats

Gregus, A., Wintink, A. J., Davis, A. C., & Kalynchuk, L. E. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.05.013 · Cited by 435 · see citing works

The Reelin signaling pathway promotes dendritic spine development in hippocampal neurons

Niu, S., Yabut, O., & D'Arcangelo, G. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.1917-08.2008 · Cited by 266 · see citing works

Behavioral and neurobiological consequences of prolonged glucocorticoid exposure in rats: Relevance to depression

Sterner, E. Y., & Kalynchuk, L. E. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.03.005 · Cited by 259 · see citing works

Neuronal plasticity and antidepressant actions

Castrén, E., & Hen, R. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2012.12.010 · Cited by 243 · see citing works

Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation

Pujadas, L., Gruart, A., Bosch, C., Delgado, L., Teixeira, C. M., Rossi, D., de Lecea, L., Martínez, A., Delgado-García, J. M., & Soriano, E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5284-09.2010 · Cited by 219 · see citing works

Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam

Brummelte, S., & Galea, L. A. M. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.07.012 · Cited by 211 · see citing works

Acute Hippocampal Brain-Derived Neurotrophic Factor Restores Motivational and Forced Swim Performance After Corticosterone

Gourley, S. L., Kiraly, D. D., Howell, J. L., Olausson, P., & Taylor, J. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.016 · Cited by 209 · see citing works

Cognitive disruption and altered hippocampus synaptic function in Reelin haploinsufficient mice

QIU, S., KORWEK, K., PRATTDAVIS, A., PETERS, M., BERGMAN, M., & WEEBER, E. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.11.001 · Cited by 202 · see citing works

Reelin Controls Granule Cell Migration in the Dentate Gyrus by Acting on the Radial Glial Scaffold

Frotscher, M. (2003) · Cerebral Cortex · doi:10.1093/cercor/13.6.634 · Cited by 197 · see citing works

Corticosterone Increases Depression-Like Behavior, With Some Effects on Predator Odor-Induced Defensive Behavior, in Male and Female Rats.

Kalynchuk, L. E., Gregus, A., Boudreau, D., & Perrot-Sinal, T. S. (2004) · Behavioral Neuroscience · doi:10.1037/0735-7044.118.6.1365 · Cited by 188 · see citing works

Dependent Stressful Life Events and Prior Depressive Episodes in the Prediction of Major Depression

Kendler, K. S., & Gardner, C. O. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.136 · Cited by 156 · cited 1× · see citing works

Sustained remission from depressive-like behavior depends on hippocampal neurogenesis

Mateus-Pinheiro, A., Pinto, L., Bessa, J. M., Morais, M., Alves, N. D., Monteiro, S., Patrício, P., Almeida, O. F. X., & Sousa, N. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.141 · Cited by 149 · see citing works

Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission

Bal, M., Leitz, J., Reese, A. L., Ramirez, D. M. O., Durakoglugil, M., Herz, J., Monteggia, L. M., & Kavalali, E. T. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.024 · Cited by 131 · see citing works

Beneficial behavioural and neurogenic effects of agomelatine in a model of depression/anxiety

Rainer, Q., Xia, L., Guilloux, J., Gabriel, C., Mocaër, E., Hen, R., Enhamre, E., Gardier, A. M., & David, D. J. P. (2011) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145711000356 · Cited by 123 · see citing works

Extracellular matrix functions during neuronal migration and lamination in the mammalian central nervous system

Franco, S. J., & Müller, U. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20946 · Cited by 117 · see citing works

Repeated exposure to corticosterone increases depression-like behavior in two different versions of the forced swim test without altering nonspecific locomotor activity or muscle strength

Marks, W. N., Fournier, N. M., & Kalynchuk, L. E. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.04.014 · Cited by 114 · see citing works

Overexpression of Reelin Prevents the Manifestation of Behavioral Phenotypes Related to Schizophrenia and Bipolar Disorder

Teixeira, C. M., Martín, E. D., Sahún, I., Masachs, N., Pujadas, L., Corvelo, A., Bosch, C., Rossi, D. P., Martı́nez, A., Maldonado, R. J., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.153 · Cited by 102 · see citing works

Cell-autonomous inactivation of the reelin pathway impairs adult neurogenesis in the hippocampus

Teixeira, C. M., Kron, M. M., Masachs, N., Zhang, H., Lagace, D. C., Martinez, A., Reillo, I., Duan, X., Bosch, C., Pujadas, L., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1857-12.2012 · Cited by 97 · see citing works

The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrus.

Lussier, A. L., Lebedeva, K., Fenton, E. Y., Guskjolen, A., Caruncho, H., & Kalynchuk, L. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.012 · Cited by 88 · see citing works

Repeated exposure to corticosterone, but not restraint, decreases the number of reelin-positive cells in the adult rat hippocampus

Lussier, A. L., Caruncho, H. J., & Kalynchuk, L. E. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.05.050 · Cited by 84 · see citing works

Corticosterone attenuates the antidepressant-like effects elicited by melatonin in the forced swim test in both male and female rats

Hill, M. N., Brotto, L. A., Lee, T. T.-Y., & Gorzalka, B. B. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00149-0 · Cited by 81 · see citing works

Role for Reelin in neurotransmitter release

Hellwig, S., Hack, I., Kowalski, J., Brunne, B., Jarowyj, J., Unger, A., Bock, H. H., Junghans, D., & Frotscher, M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3984-10.2011 · Cited by 74 · see citing works

Reelin as a putative vulnerability factor for depression: Examining the depressogenic effects of repeated corticosterone in heterozygous reeler mice

Lussier, A. L., Romay-Tallón, R., Kalynchuk, L. E., & Caruncho, H. J. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.09.007 · Cited by 69 · see citing works

Postpartum Corticosterone Administration Reduces Dendritic Complexity and Increases the Density of Mushroom Spines of Hippocampal CA 3 Arbours in Dams

Workman, J. L., Brummelte, S., & Galea, L. A. M. (2012) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2012.02380.x · Cited by 66 · see citing works

Comparison of the antidepressant sertraline on differential depression-like behaviors elicited by restraint stress and repeated corticosterone administration

Ulloa, J. L., Castañeda, P., Berríos, C., Díaz‐Véliz, G., Mora, S., Bravo, J. A., Araneda, K., Menares, C., Morales, P., & Fiedler, J. L. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.08.001 · Cited by 64 · see citing works

Novel Insights into Depression and Antidepressants: A Synergy Between Synaptogenesis and Neurogenesis?

Bambico, F. R., & Belzung, C. (2012) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_234 · Cited by 57 · see citing works

Persistent effects of prior chronic exposure to corticosterone on reward-related learning and motivation in rodents

Olausson, P., Kiraly, D. D., Gourley, S. L., & Taylor, J. R. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2844-4 · Cited by 55 · see citing works

The effect of amygdala kindling on hippocampal neurogenesis coincides with decreased reelin and DISC1 expression in the adult dentate gyrus

Fournier, N. M., Andersen, D., Botterill, J. J., Sterner, E. Y., Lussier, A. L., Caruncho, H. J., & Kalynchuk, L. E. (2009) · Hippocampus · doi:10.1002/hipo.20653 · Cited by 50 · see citing works

Prolog to Special Issue

Neff, N. H. (2004) · Critical Reviews in Neurobiology · doi:10.1615/critrevneurobiol.v16.i12.20 · Cited by 38 · see citing works

Peony glycosides reverse the effects of corticosterone on behavior and brain BDNF expression in rats

Mao, Q., Huang, Z., Ip, S., Xian, Y., & Che, C. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.11.016 · Cited by 35 · see citing works

Effects of brief pulse and ultrabrief pulse electroconvulsive stimulation on rodent brain and behaviour in the corticosterone model of depression

O'Donovan, S. M., Dalton, V. S., Harkin, A., & McLoughlin, D. M. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000200 · Cited by 26 · see citing works

Elevated Corticosterone Levels During the First Postpartum Period Influence Subsequent Pregnancy Outcomes and Behaviours of the Dam

Wong, J. H. K., Brummelte, S., & Galea, L. A. M. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02169.x · Cited by 19 · see citing works

Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse

Van Pett, K., Viau, V., Bittencourt, J. C., Chan, R. K. W., Li, H.-Y., Arias, C., Prins, G. S., Perrin, M., Vale, W., & Sawchenko, P. E. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20001211)428:2

Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy

Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works

Mitochondria and Mood: Mitochondrial Dysfunction as a Key Player in the Manifestation of Depression

Allen, J., Romay-Tallón, R., Brymer, K. J., Caruncho, H. J., & Kalynchuk, L. E. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00386 · Cited by 350 · see citing works

Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice

Du Preez, A., Onorato, D., Eiben, I., Musaelyan, K., Egeland, M., Zunszain, P. A., Fernandes, C., Thuret, S., & Pariante, C. M. (2021) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2020.07.015 · Cited by 285 · see citing works

The exercise-glucocorticoid paradox: How exercise is beneficial to cognition, mood, and the brain while increasing glucocorticoid levels

Chen, C., Nakagawa, S., An, Y., Ito, K., Kitaichi, Y., & Kusumi, I. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.001 · Cited by 191 · see citing works

Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice

Schiavon, A. P., Bonato, J. M., Milani, H., Guimarães, F. S., & Weffort de Oliveira, R. M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.06.017 · Cited by 135 · see citing works

DNA methylation and antipsychotic treatment mechanisms in schizophrenia: Progress and future directions

Ovenden, E. S., McGregor, N. W., Emsley, R. A., & Warnich, L. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.10.004 · Cited by 85 · see citing works

Epigenetic RELN Dysfunction in Schizophrenia and Related Neuropsychiatric Disorders

Guidotti, A., Grayson, D. R., & Caruncho, H. J. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00089 · Cited by 83 · see citing works

Adult hippocampal neuroplasticity triggers susceptibility to recurrent depression

Alves, N. D., Correia, J. S., Patrício, P., Mateus-Pinheiro, A., Machado-Santos, A. R., Loureiro-Campos, E., Morais, M., Bessa, J. M., Sousa, N., & Pinto, L. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.29 · Cited by 79 · see citing works

Schisandra chinensis produces the antidepressant-like effects in repeated corticosterone-induced mice via the BDNF/TrkB/CREB signaling pathway

Yan, T., Xu, M., Wan, S., Wang, M., Wu, B., Xiao, F., Bi, K., & Jia, Y. (2016) · Psychiatry Research · doi:10.1016/j.psychres.2016.06.037 · Cited by 76 · see citing works

Connecting Dots between Mitochondrial Dysfunction and Depression

Khan, M., Baussan, Y., & Hébert-Chatelain, É. (2023) · Biomolecules · doi:10.3390/biom13040695 · Cited by 77 · see citing works

Baicalin decreases SGK1 expression in the hippocampus and reverses depressive-like behaviors induced by corticosterone

Li, Y.-C., Wang, L.-L., Pei, Y.-Y., Shen, J.-D., Li, H.-B., Wang, B.-Y., & Bai, M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.10.023 · Cited by 64 · see citing works

Severe life stress, mitochondrial dysfunction, and depressive behavior: A pathophysiological and therapeutic perspective

Allen, J., Caruncho, H. J., & Kalynchuk, L. E. (2020) · Mitochondrion · doi:10.1016/j.mito.2020.11.010 · Cited by 60 · see citing works

Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade, Promotes Neurogenesis, and Attenuates Emotional and Olfactory Dysfunctions in Chronic Corticosterone-Induced Depression

Gao, C., Du, Q., Li, W., Deng, R., Wang, Q., Xu, A., & Shen, J. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1042-8 · Cited by 54 · see citing works

Peripheral Etanercept Administration Normalizes Behavior, Hippocampal Neurogenesis, and Hippocampal Reelin and GABAA Receptor Expression in a Preclinical Model of Depression

Brymer, K. J., Fenton, E. Y., Kalynchuk, L., & Caruncho, H. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00121 · Cited by 49 · see citing works

Exploring the Potential Antidepressant Mechanisms of TNFα Antagonists

Brymer, K. J., Romay-Tallón, R., Allen, J., Caruncho, H. J., & Kalynchuk, L. E. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00098 · Cited by 52 · see citing works

Antidepressant effects of curcumin-coated iron oxide nanoparticles in a rat model of depression

Khadrawy, Y. A., Hosny, E. N., Magdy, M., & Mohammed, H. S. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174384 · Cited by 51 · see citing works

High-throughput virtual screening and quantum mechanics approach to develop imipramine analogues as leads against trypanothione reductase of leishmania

Pandey, R. K., Verma, P., Sharma, D., Bhatt, T. K., Sundar, S., & Prajapati, V. K. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.06.010 · Cited by 49 · see citing works

How Stress Influences the Dynamic Plasticity of the Brain’s Extracellular Matrix

Laham, B. J., & Gould, E. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.814287 · Cited by 47 · see citing works

Antidepressant and pro-neurogenic effects of agmatine in a mouse model of stress induced by chronic exposure to corticosterone

Olescowicz, G., Neis, V. B., Fraga, D. B., da Rosa, P. B., Azevedo, D., Melleu, F. F., Brocardo, P. S., Gil‐Mohapel, J., & Rodrigues, A. L. S. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.08.017 · Cited by 44 · see citing works

Reelin-Related Disturbances in Depression: Implications for Translational Studies

Caruncho, H. J., Brymer, K. J., Romay-Tallón, R., Mitchell, M. A., Baltanás, T. R., Botterill, J. J., Olivares, J. M., & Kalynchuk, L. E. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00048 · Cited by 42 · see citing works

Fast-acting antidepressant-like effects of Reelin evaluated in the repeated-corticosterone chronic stress paradigm

Brymer, K. J., Johnston, J. N., Botterill, J. J., Romay-Tallón, R., Mitchell, M. A., Allen, J., Pinna, G., Caruncho, H. J., & Kalynchuk, L. E. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-0609-z · Cited by 41 · see citing works

Myricitrin induces antidepressant-like effects and facilitates adult neurogenesis in mice

Meyer, E., Mori, M., Campos, A. C., Andreatini, R., Guimarães, F. S., Milani, H., & de Oliveira, R. M. W. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.08.048 · Cited by 39 · see citing works

The Role of MeCP2 in Regulating Synaptic Plasticity in the Context of Stress and Depression

Sánchez-Lafuente, C. L., Kalynchuk, L. E., Caruncho, H. J., & Ausió, J. (2022) · Cells · doi:10.3390/cells11040748 · Cited by 39 · see citing works

Folic acid exerts antidepressant effects by upregulating brain-derived neurotrophic factor and glutamate receptor 1 expression in brain

Gao, L., Liu, X., Li, Y., Wu, J., Xu, M., & Liu, Y. (2017) · Neuroreport · doi:10.1097/wnr.0000000000000887 · Cited by 35 · see citing works

Interaction Effect of Social Isolation and High Dose Corticosteroid on Neurogenesis and Emotional Behavior

Chan, J. N., Lee, J., Lee, S., Hui, K. K. Y., Chan, A. H. L., Fung, T., Sánchez-Vidaña, D., Lau, B., & Ngai, S. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00018 · Cited by 36 · see citing works

Reelin proteolysis affects signaling related to normal synapse function and neurodegeneration

Lussier, A. L., Weeber, E. J., & Rebeck, G. W. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00075 · Cited by 31 · see citing works

Depressive-like phenotype induced by prenatal dexamethasone in mice is reversed by desipramine

Conti, M., Spulber, S. D., Raciti, M., & Ceccatelli, S. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.09.015 · Cited by 26 · see citing works

Melanin-Concentrating Hormone (MCH) and MCH-R1 in the Locus Coeruleus May Be Involved in the Regulation of Depressive-Like Behavior

Ye, H., Cui, X., Ding, H., Cui, S., Hu, X., Liu, Y., Zhao, H., & Zhang, Y. (2018) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyy088 · Cited by 26 · see citing works

A Role for Matrix Metalloproteases in Antidepressant Efficacy

Alaiyed, S., & Conant, K. E. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00117 · Cited by 25 · see citing works

Ketamine Rescues Hippocampal Reelin Expression and Synaptic Markers in the Repeated-Corticosterone Chronic Stress Paradigm

Johnston, J. N., Thacker, J. S., Desjardins, C., Kulyk, B. D., Romay-Tallón, R., Kalynchuk, L. E., & Caruncho, H. J. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.559627 · Cited by 26 · see citing works

Longitudinal in vivo Diffusion Tensor Imaging Detects Differential Microstructural Alterations in the Hippocampus of Chronic Social Defeat Stress-Susceptible and Resilient Mice

Liu, X., Yuan, J., Guang, Y., Wang, X., & Feng, Z. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00613 · Cited by 25 · see citing works

Facilitating Granule Cell Survival and Maturation in Dentate Gyrus With Baicalin for Antidepressant Therapeutics

Zhao, F., Tao, W., Shang, Z., Zhang, W., Ruan, J., Zhang, C., Zhou, L., Aiello, H., Lai, H., & Qu, R. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.556845 · Cited by 26 · see citing works

Patient oriented research in mental health: matching laboratory to life and beyond in Canada

Johnston, J. N., Ridgway, L., Cary-Barnard, S., Allen, J., Sánchez-Lafuente, C. L., Reive, B. S., Kalynchuk, L. E., & Caruncho, H. J. (2021) · Research Involvement and Engagement · doi:10.1186/s40900-021-00266-1 · Cited by 23 · see citing works

Cyclical corticosterone administration sensitizes depression-like behavior in rats

Lebedeva, K. A., Caruncho, H. J., & Kalynchuk, L. E. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.04.023 · Cited by 23 · see citing works

Reelin has antidepressant-like effects after repeated or singular peripheral injections

Allen, J., Romay-Tallón, R., Mitchell, M. A., Brymer, K. J., Johnston, J. N., Sánchez-Lafuente, C. L., Pinna, G., Kalynchuk, L. E., & Caruncho, H. J. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109043 · Cited by 22 · see citing works

New Strategies for the Treatment of Neuropsychiatric Disorders Based on Reelin Dysfunction

Tsuneura, Y., NAKAI, T., Mizoguchi, H., & Yamada, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031829 · Cited by 19 · see citing works

Early psilocybin intervention alleviates behavioral despair and cognitive impairment in stressed Wistar rats

Wang, Z., Robbins, B., Zhuang, R., Sandini, T. M., van Bruggen, R., Li, X., & Zhang, Y. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111243 · Cited by 17 · see citing works

Cyclical administration of corticosterone results in aggravation of depression-like behaviors and accompanying downregulations in reelin in an animal model of chronic stress relevant to human recurrent depression

Lebedeva, K. A., Allen, J., Kulhawy, E. Y., Caruncho, H. J., & Kalynchuk, L. E. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113070 · Cited by 17 · see citing works

Reelin Rescues Behavioral, Electrophysiological, and Molecular Metrics of a Chronic Stress Phenotype in a Similar Manner to Ketamine

Johnston, J. N., Allen, J., Shkolnikov, I., Sánchez-Lafuente, C. L., Reive, B. S., Scheil, K., Liang, S., Christie, B. R., Kalynchuk, L. E., & Caruncho, H. J. (2023) · eNeuro · doi:10.1523/eneuro.0106-23.2023 · Cited by 18 · see citing works

Chronic corticosterone-induced impaired cognitive flexibility is not due to suppressed adult hippocampal neurogenesis

Lui, E., Salim, M., Chahal, M., Puri, N., Marandi, E., Quadrilatero, J., & Satvat, E. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.05.060 · Cited by 16 · see citing works

Intravenous Reelin Treatment Rescues Atrophy of Spleen White Pulp and Correlates to Rescue of Forced Swim Test Immobility and Neurochemical Alterations Induced by Chronic Stress

Reive, B. S., Johnston, J. N., Sánchez-Lafuente, C. L., Zhang, L., Chang, A., Zhang, J., Allen, J., Romay-Tallón, R., Kalynchuk, L. E., & Caruncho, H. J. (2023) · Chronic Stress · doi:10.1177/24705470231164920 · Cited by 15 · see citing works

Molecular Mechanisms of Reelin in the Enteric Nervous System and the Microbiota–Gut–Brain Axis: Implications for Depression and Antidepressant Therapy

Halvorson, C. S., Sánchez-Lafuente, C. L., Johnston, J. N., Kalynchuk, L. E., & Caruncho, H. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020814 · Cited by 16 · see citing works

Regional alterations of cerebral [18F]FDG metabolism in the chronic unpredictable mild stress- and the repeated corticosterone depression model in rats

Laeken, N. V., Pauwelyn, G., Dockx, R., Descamps, B., Brans, B. T., Peremans, K. Y., Baeken, C., Goethals, I., Vanhove, C., & Vos, F. D. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1899-8 · Cited by 14 · see citing works

Interaction of reelin and stress on immobility in the forced swim test but not dopamine-mediated locomotor hyperactivity or prepulse inhibition disruption: Relevance to psychotic and mood disorders

Notaras, M. J., Vivian, B., Wilson, C., & van den Buuse, M. (2017) · Schizophrenia Research · doi:10.1016/j.schres.2017.07.016 · Cited by 14 · see citing works

Maternal Deprivation in Rats Decreases the Expression of Interneuron Markers in the Neocortex and Hippocampus

Aksić, M., Poleksić, J., Aleksić, D., Petronijević, N., Radonjić, N. V., Jakovcevski, M., Kapor, S., Divac, N., Filipović, B., & Jakovčevski, I. (2021) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2021.670766 · Cited by 13 · see citing works

Sex differences in basal reelin levels in the paraventricular hypothalamus and in response to chronic stress induced by repeated corticosterone in rats

Sánchez-Lafuente, C. L., Romay-Tallón, R., Allen, J., Johnston, J. N., Kalynchuk, L. E., & Caruncho, H. J. (2022) · Hormones and Behavior · doi:10.1016/j.yhbeh.2022.105267 · Cited by 9 · see citing works

Patterns of Membrane Protein Clustering in Peripheral Lymphocytes as Predictors of Therapeutic Outcomes in Major Depressive Disorder

Caruncho, H. J., Baltanás, T. R., Romay-Tallón, R., Kalynchuk, L. E., & Olivares, J. M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00190 · Cited by 9 · see citing works

BKM120 alters the migration of doublecortin-positive cells in the dentate gyrus of mice

Hwang, Y., Kim, H., & Shin, E. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106226 · Cited by 8 · see citing works

Changes in Membrane Protein Clustering in Peripheral Lymphocytes in an Animal Model of Depression Parallel Those Observed in Naïve Depression Patients: Implications for the Development of Novel Biomarkers of Depression

Romay-Tallón, R., Kulhawy, E. Y., Brymer, K. J., Allen, J., Baltanás, T. R., Olivares, J. M., Kalynchuk, L. E., & Caruncho, H. J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01149 · Cited by 8 · see citing works

Psilocybin mitigates behavioral despair and cognitive impairment in treatment-resistant depression model using wistar kyoto rats

Wang, Z., Robbins, B., Zhuang, R., van Bruggen, R., Sandini, T. M., Li, X., & Zhang, Y. (2025) · Scientific Reports · doi:10.1038/s41598-025-03383-z · Cited by 8 · see citing works

Altered acoustic startle, prepulse facilitation, and object recognition memory produced by corticosterone withdrawal in male rats

Brymer, K. J., Kulhaway, E. Y., Howland, J. G., Caruncho, H. J., & Kalynchuk, L. E. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113291 · Cited by 6 · see citing works

The impact of body mass index in gene expression of reelin pathway mediators in individuals with schizophrenia and mood disorders: A post-mortem study

Brietzke, E. M., Trevizol, A. P., Fries, G. R., Subramaniapillai, M., Kapczinski, F. P., McIntyre, R. S., & Mansur, R. B. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.04.012 · Cited by 6 · see citing works

Gastrodin enhances stress resilience through promoting Wnt/β-Catenin-dependent neurogenesis

Zhang, H., Zhao, Z., Liu, P., Wang, M., Liu, Y., He, H., Ge, Y., Zhou, T., Xiao, C., You, Z., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.04.017 · Cited by 5 · see citing works

The effects of neonatal procedural pain and maternal isolation on hippocampal cell proliferation and reelin concentration in neonatal and adult male and female rats

Timmerman, B. M., Mooney‐Leber, S. M., & Brummelte, S. (2021) · Developmental Psychobiology · doi:10.1002/dev.22212 · Cited by 5 · see citing works

Antidepressant-like activity of red wine phenolic extracts in repeated corticosterone-induced depression mice via BDNF/TrkB/CREB signaling pathway

Jia, Y., Dong, Z., Yan, T., Wu, B., Liao, Z., Bi, K., Gong, P., & Suna, B. (2016) · BIO Web of Conferences · doi:10.1051/bioconf/20160704009 · Cited by 5 · see citing works

Sex-dependent effects of early life stress on network and behavioral statesPreprint

Scarpa, G. B., Antonoudiou, P., Weiss, G. L., Stone, B. T., & Maguire, J. L. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.10.593547 · Cited by 5 · see citing works

Emotional behaviors as well as the hippocampal reelin expression in C57BL/6N male mice chronically treated with corticosterone

Ibi, D., Nakasai, G., Sawahata, M., Takaba, R., Kinoshita, M., Yamada, K., & Hiramatsu, M. (2023) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2023.173617 · Cited by 4 · see citing works

Reelin, the HPA Axis, and Chronic Stress: Implications for the Neurobiology of Depression

Thom, S. A., Halvorson, C. S., Reive, B. S., Sánchez-Lafuente, C. L., Kalynchuk, L. E., & Caruncho, H. J. (2026) · Chronic Stress · doi:10.1177/24705470261427267 · Cited by 3 · see citing works

Repeated corticosterone enhances the acquisition and recall of trace fear conditioning

Marks, W. N., & Kalynchuk, L. E. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.09.022 · Cited by 3 · see citing works

Mozart K488 Addition Can Improve Depressive-Like Behavior in Rats: In Search of Better Management

Pangemanan, L., Irwanto, I., & Maramis, M. M. (2024) · Pharmacognosy Journal · doi:10.5530/pj.2024.16.53 · Cited by 2 · see citing works

The Signature of the Serotonin System in the Chronic Corticosterone Depression Model: A Study with [18F] MPPF, [18F] Altanserin and [11C] DASB

Pauwelyn, G., Laeken, N. V., Verhoeven, J., Vos, F. D., Peremans, K. Y., Dockx, R., Baeken, C., Descamps, B., Vanhove, C., Kersemans, K., et al. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000468 · Cited by 2 · see citing works

Sirtuin 3, a mitochondrial metabolic enzyme, links the mitochondrial function to neurophysiology in depression

Chen, C.-Y., Wang, Y., Liu, L., & Zhang, Y. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111563 · Cited by 1 · see citing works

Fetal exposure to high levels of maternal glucocorticoids alters reelin signaling in the prefrontal cortex of rat pups

Kolaka, R., Chotwiwatthanakun, C., & Chutabhakdikul, N. (2019) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2019.04.004 · Cited by 1 · see citing works

Red wine polyphenols reverse depressive-like behaviors in mice induced by repeated corticosterone treatment

Yan, T., Sun, Y., Wu, B., Xiao, F., Bi, K., Sun, B., & Jia, Y. (2019) · Ciência e técnica vitivinícola/Ciência e técnica vitivinícola · doi:10.1051/ctv/201934020115 · Cited by 1 · see citing works

Receptor-Associated Protein (RAP) Models In Vivo Reelin Haploinsufficiency: Implications in Schizophrenia

Ahmed, J. J. (2017) · Digital Commons - University of South Florida (University of South Florida)

Effects of excess glucocorticoids on neural cell fate : long lasting consequences of adverse prenatal factors

Conti, M. (2017) · Figshare

Sex Differences in Basal Hypothalamic Reelin Levels and in Response to Chronic Stress Induced by Repeated Corticosterone in RatsPreprint

Sánchez-Lafuente, C. L., Romay-Tallón, R., Allen, J., Johnston, J. N., Kalynchuk, L. E., & Caruncho, H. J. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4115799

Impact of CBG deficiency on emotional and cognitive processes

de Medeiros, G. F. (2016) · doi:10.70675/5068781bzb1fez4551z99eez04f240a93ed0 · Cited by 1 · see citing works

Stratégies non pharmacologiques et réponse aux antidépresseurs dans un modèle murin de dépression : effets comportementaux et mécanismes neurobiologiques

Coutens, B. (2022) · doi:10.70675/7ffbfd7ezefb5z4e4ez82f4z42a6ac0ff754

256 – Heterozygous reeler mice exhibit alterations in sensorimotor gating, but not presynaptic proteins

Barr, A. M., Fish, K. N., Markou, A., & Honer, W. G. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2007.12.323

The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrus.

Lussier, A. L., Lebedeva, K., Fenton, E. Y., Guskjolen, A., Caruncho, H., & Kalynchuk, L. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.012 · Cited by 88 · see citing works

The crucial role of reelin in a preclinical model of depression

Allen, J. E. (2017) · University Library - University of Saskatchewan (University of Saskatchewan)

Antidepressant-like Effects of Peripheral Reelin Administration in a Preclinical Model of Depression

Mitchell, M. A. (2017) · University Library - University of Saskatchewan (University of Saskatchewan)

Reelin-Related Disturbances in Depression: Implications for Translational Studies

Caruncho, H. J., Brymer, K. J., Romay-Tallón, R., Mitchell, M. A., Baltanás, T. R., Botterill, J. J., Olivares, J. M., & Kalynchuk, L. E. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00048 · Cited by 42 · see citing works