Reelin regulates postnatal neurogenesis and enhances spine hypertrophy and long-term potentiation
Open accessAbstract
Reelin, an extracellular protein essential for neural migration and lamination, is also expressed in the adult brain. To unravel the function of this protein in the adult forebrain, we generated transgenic mice that overexpress Reelin under the control of the CaMKIIalpha promoter. Overexpression of Reelin increased adult neurogenesis and impaired the migration and positioning of adult-generated neurons. In the hippocampus, the overexpression of Reelin resulted in an increase in synaptic contacts and hypertrophy of dendritic spines. Induction of long-term potentiation (LTP) in alert-behaving mice showed that Reelin overexpression evokes a dramatic increase in LTP responses. Hippocampal field EPSP during a classical conditioning paradigm was also increased in these mice. Our results indicate that Reelin levels in the adult brain regulate neurogenesis and migration, as well as the structural and functional properties of synapses. These observations suggest that Reelin controls developmental processes that remain active in the adult brain.
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Reelin enhances hippocampal synaptic plasticity by altering the composition of NMDA receptor subunits and promoting surface clustering of AMPA receptors.
“Reelin is also known to enhance hippocampal synaptic plasticity (Pujadas et al., 2010; Weeber et al., 2002) by altering the composition of NMDA receptor subunits and promoting surface clustering of AMPA receptors (Qiu et al., 2006) (Figure 3B).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Pujadas et al., 2010
In the adult mouse hippocampus, reelin deficiency reduces neurogenesis, while reelin overexpression increases neurogenesis.
“In the adult mouse hippocampus, reelin deficiency reduces neurogenesis (Won et al., 2006), while reelin overexpression increases neurogenesis (Pujadas et al., 2010) (Figure 3A).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Pujadas et al., 2010
In the developing and adult brain, reelin is an important mediator of circuit formation by regulating dendritic tree maturation, spine formation and stability, glutamatergic neurotransmission, and synaptic plasticity.
“In the developing and adult brain, evidence suggests that reelin is an important mediator of circuit formation by regulating dendritic tree maturation, spine formation and stability, glutamatergic neurotransmission, and synaptic plasticity (Pujadas et al., 2010) (Figure 3B).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Pujadas et al., 2010
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- Authors
- Pujadas, L., Gruart, A., Bosch, C., Delgado, L., Teixeira, C. M., Rossi, D., de Lecea, L., Martínez, A., Delgado-García, J. M., & Soriano, E.
- Affiliations
- Universidad Pablo de Olavide (ES)
- Instituto de Salud Carlos III (ES)
- Institute for Research in Biomedicine (ES)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-03-31
- Volume
- 30
- Issue
- 13
- Pages
- 4636-4649
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6632327
- OpenAlex
- W2039954704
- Cited by
- 219
- References
- 62
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 8 · 2023: 10 · 2022: 14 · 2021: 18 · 2020: 16 · 2019: 9 · 2018: 11 · 2017: 9 · 2016: 21 · 2015: 19 · 2014: 12 · 2013: 16 · 2012: 12
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministerio de Ciencia e Innovación
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- reelin, adult neurogenesis, postnatal neurogenesis, long-term potentiation, hippocampus, neuronal migration, synaptic structure, transgenic mice, classical conditioning, synaptic plasticity
- MeSH terms
- Reelin Protein, Animals, Cell Movement, Conditioning, Classical, Hippocampus, Mice, Transgenic, Nerve Tissue Proteins, Neurons, Promoter Regions, Genetic, Serine Endopeptidases, Synapses, Cell Adhesion Molecules, Neuronal, Extracellular Matrix Proteins, Prosencephalon, Long-Term Potentiation, Dendritic Spines, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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