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Link between depression and cardiovascular diseases due to epigenomics and proteomics: Focus on energy metabolism
Abstract
Major depression is the most common mental disorder and a leading cause of years lived with disability. In addition to the burden attributed to depressive symptoms and reduced daily life functioning, people with major depression are at increased risk of premature mortality, particularly due to cardiovascular diseases. Several studies point to a bi-directional relation between major depression and cardiovascular diseases, thereby indicating that both diseases may share common pathophysiological pathways. These include lifestyle factors (e.g. physical activity, smoking behavior), dysfunctions of endocrine systems (e.g. hypothalamus-pituitary adrenal axis), and a dysbalance of pro- and anti-inflammatory factors. Furthermore, recent research point to the role of epigenomic and proteomic factors, that are reviewed here with a particular focus on the mitochondrial energy metabolism.
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“The findings show that raised levels of inflammation (because of factors such as pro-inflammatory cytokines) have been associated with depression [60,161,174,175,178].”
From Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature (2021) · cites this paper as [60]
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Metadata
- Authors
- Kahl, K. G., Stapel, B., & Frieling, H.
- Affiliations
- Medizinische Hochschule Hannover (DE)
- Corresponding author
- Kahl, Kai G.
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 89
- Pages
- 146-157
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2892142660
- Cited by
- 47
- References
- 234
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 6
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- major depressive disorder, cardiovascular disease, epigenomics, proteomics, energy metabolism, mitochondrial metabolism, bidirectional relationship, hypothalamic-pituitary-adrenal axis, inflammation, premature mortality, lifestyle factors
- MeSH terms
- Animals, Cardiovascular Diseases, Major Depressive Disorder, Depressive Disorder, Major, Energy Metabolism, Humans, Proteomics, Epigenesis, Genetic, Epigenomics
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