Cited by 47Cardiac Health and Mental HealthTreatment of Major DepressionStress Responses and Cortisol

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Link between depression and cardiovascular diseases due to epigenomics and proteomics: Focus on energy metabolism

Kahl, Kai G., Stapel, Britta, Frieling, Helge·2019·Progress in Neuro-Psychopharmacology and Biological Psychiatry

DOI 10.1016/j.pnpbp.2018.09.004

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Abstract

Major depression is the most common mental disorder and a leading cause of years lived with disability. In addition to the burden attributed to depressive symptoms and reduced daily life functioning, people with major depression are at increased risk of premature mortality, particularly due to cardiovascular diseases. Several studies point to a bi-directional relation between major depression and cardiovascular diseases, thereby indicating that both diseases may share common pathophysiological pathways. These include lifestyle factors (e.g. physical activity, smoking behavior), dysfunctions of endocrine systems (e.g. hypothalamus-pituitary adrenal axis), and a dysbalance of pro- and anti-inflammatory factors. Furthermore, recent research point to the role of epigenomic and proteomic factors, that are reviewed here with a particular focus on the mitochondrial energy metabolism.

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See all 47

Authors: Kahl, K. G., Stapel, B., & Frieling, H.
Affiliations: Medizinische Hochschule Hannover (DE)
Corresponding author: Kahl, Kai G.
ORCID: Kahl, Kai G.
Stapel, Britta
Frieling, Helge
Venue: Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher: Elsevier BV
Published: 2019-03
Volume: 89
Pages: 146-157
ISSN: 0278-5846 (ISSN-L)
DOI: 10.1016/j.pnpbp.2018.09.004
OpenAlex: W2892142660
Cited by: 47
References: 234
Citations by year: 2026: 4 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 8 · 2021: 7 · 2020: 6 · 2019: 6
FWCI: 0.89
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: major depressive disorder, cardiovascular disease, epigenomics, proteomics, energy metabolism, mitochondrial metabolism, bidirectional relationship, hypothalamic-pituitary-adrenal axis, inflammation, premature mortality, lifestyle factors
MeSH terms: Animals, Cardiovascular Diseases, Major Depressive Disorder, Depressive Disorder, Major, Energy Metabolism, Humans, Proteomics, Epigenesis, Genetic, Epigenomics

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Link between depression and cardiovascular diseases due to epigenomics and proteomics: Focus on energy metabolism

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