Gender does not matter: add-on repetitive transcranial magnetic stimulation treatment for female methamphetamine dependents
Abstract
Background Repetitive transcranial magnetic stimulation (rTMS) targeting prefrontal cortex reduces craving in different types of drug addiction. However, most studies failed to elucidate the potential gender discrepancies for the treatment effects, due to the small percentage of female subjects enrolled. The present study prospectively recruited female methamphetamine dependents for TMS treatment.Methods Ninety female methamphetamine dependents were randomly assigned into the control group (routine addiction rehabilitation) or add-on 10 Hz group (routine addiction rehabilitation plus 20 times rTMS treatments). The craving scores to drug associated cues were examined as the primary outcome for this treatment.Results The results showed that add-on rTMS treatment was as well effective in female methamphetamine dependents, and the effect lasted for at least 30 days after treatment. Drug abuse history predicts the efficacy of chronic treatment, and the effects of TMS treatment was more pronounced in young, high-craving subjects.Conclusions Add-on high frequency rTMS treatment is as well tolerable and effective in female methamphetamine dependents.
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TMS applications to investigate and modulate SUD-related networks have grown exponentially across alcohol, cocaine, methamphetamine, opioid, cannabis, and tobacco use disorders.
“there has been an exponential growth in the application of TMS to investigate and modulate these networks in populations with SUDs including alcohol, cocaine, methamphetamine, opioid, cannabis, and tobacco use disorder [11,12,25–29].”
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- Authors
- Liu, T., Li, Y., Shen, Y., Liu, X., & Yuan, T.-F.
- Affiliations
- Nanjing Normal University (CN)
- Jiangsu Province Hospital (CN)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Yuan, Ti-Fei
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 92
- Pages
- 70-75
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2906880337
- Cited by
- 49
- References
- 27
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 14 · 2019: 4
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NSFC Grant (81822017, 31771215, 81702230)
- The Science and Technology Commission of Shanghai Municipality (18QA1403700, 18JC1420304, 18140901700)
- Shanghai Municipal Education Commission – Gaofeng Clinical Medicine (20181715)
- Hundred-talent Fund from Shanghai Municipal Commission of Health (2018BR21)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- repetitive transcranial magnetic stimulation, methamphetamine dependence, women who use drugs, gender differences, craving, drug cues, prefrontal cortex, adjunctive therapy, addiction rehabilitation, treatment efficacy
- MeSH terms
- Adolescent, Adult, Age Factors, Central Nervous System Stimulants, Feasibility Studies, Female, Humans, Male, Methamphetamine, Middle Aged, Sex Factors, Time Factors, Treatment Outcome, Prefrontal Cortex, Amphetamine-Related Disorders, Transcranial Magnetic Stimulation, Young Adult, Craving
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