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Cited by 107Treatment of Major DepressionTryptophan and brain disordersLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.

LDL cholesterol relates to depression, its severity, and the prospective course

Wagner, Claudia Johanna, Musenbichler, Cornelia, Böhm, Lea, Färber, Katharina, Fischer, Anna-Isabell, von Nippold, Felicitas, Winkelmann, Merle, Richter-Schmidinger, Tanja, Mühle, Christiane, Kornhuber, Johannes, Lenz, Bernd·2019·Progress in Neuro-Psychopharmacology and Biological Psychiatry
DOI 10.1016/j.pnpbp.2019.01.010
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Abstract

Background Major depressive disorder (MDD) is a highly prevalent and burdening mental illness. Approximately 30% of the major depressive episodes (MDE) are classified as therapy-refractory. Further knowledge of the pathophysiological mechanisms underlying MDD and predictive biomarkers are needed to improve treatment options.Methods Serum lipid levels were compared between patients with a current MDE (n = 130) or remitted MDD (n = 39) and healthy control subjects (n = 61) and associated with the severity (17-item Hamilton Depression Rating Scale [HAMD] scores) and the prospective course of depression (direct follow-up of at median 20 days post-inclusion).Results We found higher levels of LDL cholesterol (152.5 vs. 134.0 mg/dl, U = 3021, P = 0.008) and LDL/HDL ratio (2.82 vs. 2.21, U = 2912, P = 0.003) in patients with a current MDE than in healthy control subjects. In patients with a current MDE, higher HAMD scores correlated also with higher values of triglycerides (ρ = 0.213, P = 0.015), total cholesterol (ρ = 0.199, P = 0.023), LDL cholesterol (ρ = 0.224, P = 0.010), and LDL/HDL ratio (ρ = 0.196, P = 0.026). Moreover, higher total cholesterol (ρ = -0.233, P = 0.010), LDL cholesterol (ρ = -0.235, P = 0.010), and LDL/HDL ratio (ρ = -0.199, P = 0.029) were associated with a stronger decline in HAMD score between study inclusion and direct follow-up.Limitations We employed an associational study design, performed only a short-term follow-up, and excluded suicidal study subjects.Conclusions Serum lipid levels are associated with depression per se, the depression severity, and the prospective 3-week course. These observations build the basis for future investigations on individualized lipid metabolism-related treatment strategies in depressed patients.

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Authors
Wagner, C. J., Musenbichler, C., Böhm, L., Färber, K., Fischer, A.-I., von Nippold, F., Winkelmann, M., Richter-Schmidinger, T., Mühle, C., Kornhuber, J., & Lenz, B.
Affiliations
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Corresponding author
Wagner, Claudia Johanna
ORCID
Venue
Progress in Neuro-Psychopharmacology and Biological Psychiatry
Publisher
Elsevier BV
Published
2019-06
Volume
92
Pages
405-411
ISSN
0278-5846 (ISSN-L)
DOI
10.1016/j.pnpbp.2019.01.010
OpenAlex
W2913860542
Cited by
106
References
21
Citations by year
2026: 11 · 2025: 14 · 2024: 17 · 2023: 26 · 2022: 18 · 2021: 9 · 2020: 7 · 2019: 4
FWCI
5.88
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Bundesministerium für Bildung und Forschung (01EE1401C)
  • Friedrich-Alexander-Universität Erlangen-Nürnberg
  • Deutsche Forschungsgemeinschaft (GRK2162/1, KO 947/13-1)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords
LDL cholesterol, major depressive disorder, serum lipids, LDL/HDL ratio, depression severity, triglycerides, total cholesterol, remitted depression, course of depression, predictive biomarkers, lipid metabolism
MeSH terms
Adolescent, Adult, Aged, Major Depressive Disorder, Female, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Prospective Studies, Remission Induction, Triglycerides, Biomarkers, Case-Control Studies, Disease Progression, Young Adult

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