Shared genetic risk factors for depression and stroke
Abstract
Background The comorbidity of major depressive disorder (MDD) and stroke are common in clinic. There is a growing body of evidence suggesting a bi-directional relationship between stroke and depression. However, the mechanisms underlying the relationship between MDD and stroke are poorly investigated. Considering that both MDD and stroke can be heritable and are influenced by multiple risk genes, shared genetic risk factors between MDD and stroke may exist. Objective The objective is to review the existing evidence for common genetic risk factors for both MDD and stroke and to outline the possible pathophysiological mechanisms mediating this association. Methods A systematic review and meta-analysis was performed. Gene association studies regarding stroke and depression were searched in the database PubMed, CNKI, and Chinese Biomedical Literature Database before December 2018. Statistical analysis was performed using the software Revman 5.3. Results Genetic polymorphisms of 4 genes, methylenetetrahydrofolate reductase (MTHFR) and apolipoprotein E (ApoE) have been demonstrated to associate with the increased risk for both MDD and stroke, while the association between identified polymorphisms in angiotensin converting enzyme (ACE) and serum paraoxonase (PON1) with depression is still under debate, for the existing studies are insufficient in sample size. These results suggest the possible pathophysiological mechanisms that are common to these two disorders, including immune-inf…
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The APOE ε4 allele is associated with late-life depression in humans.
“Population-based studies reveal that apolipoprotein E (APOE) ε4 gene allele is closely associated with late-life depression (LLD).”
From APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline (2021) · cites this paper as [3]
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Systematic review and meta-analysis of genetic studies of late-life depression
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APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline
Fang, W., Xiao, N., Zeng, G., Bi, D., Dai, X., Mi, X., Ye, Q., Chen, X., & Zhang, J. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01631-0 · Cited by 42 · see citing works
- Authors
- Zhao, F., Yue, Y., Jiang, H., & Yuan, Y.
- Affiliations
- Zhongda Hospital Southeast University (CN)
- Corresponding author
- Yuan, Yonggui
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 93
- Pages
- 55-70
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2925222320
- Cited by
- 45
- References
- 9
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 6 · 2023: 11 · 2022: 3 · 2021: 6 · 2020: 5 · 2019: 1
- FWCI
- 0.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Key Technology R&D Program (2015BAI13B01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- major depressive disorder, stroke, shared genetic risk, MTHFR polymorphisms, apolipoprotein E, angiotensin-converting enzyme, paraoxonase 1, post-stroke depression, oxidative stress, nitrative stress, lipid metabolism, cerebrovascular function
- MeSH terms
- Apolipoproteins E, Depression, Humans, Peptidyl-Dipeptidase A, Risk Factors, Genetic Predisposition to Disease, Stroke, Methylenetetrahydrofolate Reductase (NADPH2), Aryldialkylphosphatase
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