Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: A 24-week follow-up study
Abstract
Purpose Major depressive disorder (MDD) is a devastating disease that afflicts large populations and has also been accepted to be an independent risk factor for cardiovascular disease (CVD). Oxidative stress seems to play an essential role in the relationship of MDD and CVD. We aimed to determine the level of oxidative stress in patients with MDD and to investigate the effects of long-term antidepressant (AD) treatment on the oxidative-antioxidative system parameters and CVD risk factors.Method Fifty patients who fully met the fourth Diagnostic and Statistical Manual of Mental Disorders criteria for MDD and 44 healthy control subjects were included in the study. Control visits of the patients were repeated 6weeks, 12weeks and 24weeks after beginning of the AD treatment. Lipid profiles, oxidation and oxidizability of apolipoprotein B-containing lipoproteins (expressed as apo B-b-MDA and apo B-Δ-MDA, respectively), levels of plasma malondialdehyde (p-MDA), total antioxidative capacity (TAOC), antioxidant molecules and antioxidant enzyme activities including paraoxonase/arylesterase, red blood cell superoxide dismutase (RBC-SOD) and glutathione peroxidase were determined during 24-week of follow-up period.Results According to the results of the study, p-MDA, apo B-b-MDA and RBC-SOD activity were increased and arylesterase activity was decreased in MDD patients. Body mass index (BMI), vitamin A and total cholesterol levels in MDD patients increased after 24-weeks of AD treatment. RBC-SOD activity, TAOC, p-MDA and apo B-b-MDA levels were decreased; paraoxonase/arylesterase activities and apo B-Δ-MDA were increased at the end of 24th week.Conclusion Oxidative stress, demonstrated in MDD patients, was partly improved during 24weeks of AD treatment. Increase in paraoxonase/arylesterase activities and decrease in p-MDA and apo B-b-MDA levels after 24weeks seem to be beneficial for reduction of CVD risk in MDD patients. However increased BMI and apo B-Δ-MDA levels are negative cardiovascular effects of long-term AD treatment.
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TAC was found decreased after 24-week treatment with antidepressants in MDD patients.
“However, TAC was also found decreased after 24-week treatment with antidepressants”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [33]
In a 24-week follow-up study, plasmatic MDA, serum OxLDL levels, and erythrocyte SOD activity were increased in MDD patients before treatment.
“Plasmatic MDA, serum oxidized LDL (OxLDL) levels, and erythrocyte SOD activity were increased in MDD patients before treatment”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [33]
After 24 weeks of treatment, MDA and SOD levels decreased in MDD patients.
“After 24-weeks of treatment, MDA and SOD levels decreased.”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [33]
MDA levels were positively correlated with the severity of MDD in that 24-week follow-up study.
“and MDA levels were positively correlated with the severity of MDD.”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [33]
No significant differences in oxidative stress parameters were found between patients on venlafaxine and patients on SSRIs during the follow-up period.
“Patients on venlafaxine were also compared with patients on SSRIs in the aspect of oxidative stress parameters in the follow-up period, but no significant differences were found [33].”
From Preclinical and Clinical Evidence of Antioxidant Effects of Antidepressant Agents: Implications for the Pathophysiology of Major Depressive Disorder (2012) · cites this paper as [33]
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- Authors
- Kotan, V. O., Sarandol, E., Kirhan, E., Ozkaya, G., & Kirli, S.
- Corresponding author
- Kotan, Vahap Ozan
- ORCID
- Kotan, Vahap Ozan
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 35
- Issue
- 5
- Pages
- 1284-1290
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2016056242
- Cited by
- 149
- References
- 53
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 9 · 2023: 8 · 2022: 6 · 2021: 11 · 2020: 16 · 2019: 9 · 2018: 5 · 2017: 16 · 2016: 11 · 2015: 13 · 2014: 11 · 2013: 11 · 2012: 9
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Bursa Uludag University - AVESIS (submittedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- major depressive disorder, antidepressant treatment, oxidative stress, malondialdehyde, apolipoprotein B, lipid peroxidation, superoxide dismutase, glutathione peroxidase, total antioxidant capacity, cardiovascular risk, body mass index, vitamin A, cholesterol
- MeSH terms
- Adult, Antidepressive Agents, Antioxidants, Apolipoproteins, Blood Cell Count, Carboxylic Ester Hydrolases, Cardiovascular Diseases, Major Depressive Disorder, Female, Follow-Up Studies, Hormones, Humans, Lipids, Liver Function Tests, Long-Term Care, Male, Malondialdehyde, Psychiatric Status Rating Scales, Risk Factors, Superoxide Dismutase, Body Mass Index, Oxidative Stress, Aryldialkylphosphatase, Young Adult
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