The brain‐derived neurotrophic‐factor ( BDNF ) val66met polymorphism is associated with geriatric depression: A meta‐analysis
Open accessAbstract
Depression has been associated with reduced expression of brain‐derived neurotrophic factor ( BDNF ) in the hippocampus. Genetic association studies of the BDNF Val66Met polymorphism (rs6265) in geriatric depression have produced inconsistent results. A meta‐analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age‐matched controls. A total of five studies involving 523 cases with geriatric depression and 1,220 psychiatrically healthy controls was included. Met allele carriers had an increased risk for geriatric depression when compared to Val/Val homozygotes ( P = 0.004, OR = 1.48, 95% CI = 1.13–1.93). Our findings suggest the BDNF Met allele may confer increased risk for depression as individual age. © 2012 Wiley Periodicals, Inc.
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APOE-e4 is associated with increased risk for late-life depression.
“At least three genes have been associated with increased risk for LLD: the methionine (Met) allele of the neurotrophic factor BDNF199, APOE-e4 (involved in myelin repair and Aβ metabolism), and SLC6A4 (the short allele of the serotonin transporter 5-HTTLPR)200.”
From Psychobiological factors of resilience and depression in late life (2019) · cites this paper as [199]
The methionine allele of BDNF is associated with increased risk for late-life depression.
“At least three genes have been associated with increased risk for LLD: the methionine (Met) allele of the neurotrophic factor BDNF199, APOE-e4 (involved in myelin repair and Aβ metabolism), and SLC6A4 (the short allele of the serotonin transporter 5-HTTLPR)200.”
From Psychobiological factors of resilience and depression in late life (2019) · cites this paper as [199]
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- Authors
- Pei, Y., Smith, A. K., Wang, Y., Pan, Y., Yang, J., Chen, Q., Pan, W., Bao, F., Zhao, L., Tie, C., Wang, Y., Wang, J., Zhen, W., Zhou, J., & Ma, X.
- Affiliations
- Capital Medical University (CN)
- Emory University (US)
- UNSW Sydney (AU)
- Corresponding author
- Ma, Xin
- ORCID
- Venue
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
- Publisher
- Wiley
- Published
- 2012-05-18
- Volume
- 159B
- Issue
- 5
- Pages
- 560-566
- ISSN
- 1552-4841 (ISSN-L)
- 1552-485X
- PMC
- PMC3549636
- OpenAlex
- W1973114890
- Cited by
- 67
- References
- 79
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 7 · 2016: 11 · 2015: 6 · 2014: 6 · 2013: 4 · 2012: 1
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Medical Genetics Part B Neuropsychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K01MH085806, MH085806)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- brain-derived neurotrophic factor, BDNF Val66Met polymorphism, geriatric depression, genetic susceptibility, Met allele, hippocampus, genetic association
- MeSH terms
- Aged, Depression, Humans, Publication Bias, Brain-Derived Neurotrophic Factor, Amino Acid Substitution, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Genetic Association Studies
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