The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Dopamine signaling and myopia development: What are the key challenges
Open accessAbstract
In the face of an "epidemic" increase in myopia over the last decades and myopia prevalence predicted to reach 2.5 billion people by the end of this decade, there is an urgent need to develop effective and safe therapeutic interventions to slow down this "myopia booming" and prevent myopia-related complications and vision loss. Dopamine (DA) is an important neurotransmitter in the retina and mediates diverse functions including retina development, visual signaling, and refractive development. Inspired by the convergence of epidemiological and animal studies in support of the inverse relationship between outdoor activity and risk of developing myopia and by the close biological relationship between light exposure and dopamine release/signaling, we felt it is timely and important to critically review the role of DA in myopia development. This review will revisit several key points of evidence for and against DA mediating light control of myopia: 1) the causal role of extracellular retinal DA levels, 2) the mechanism and action of dopamine D1 and D2 receptors and 3) the roles of cellular/circuit retinal pathways. We examine the experiments that show causation by altering DA, DA receptors and visual pathways using pharmacological, transgenic, or visual environment approaches. Furthermore, we critically evaluate the safety issues of a DA-based treatment strategy and some approaches to address these issues. The review identifies the key questions and challenges in translating basic knowledge on DA signaling and myopia from animal studies into effective pharmacological treatments for myopia in children.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Global Prevalence of Myopia and High Myopia and Temporal Trends from 2000 through 2050
Holden, B. A., Fricke, T. R., Wilson, D. A., Jong, M., Naidoo, K. S., Sankaridurg, P., Wong, T. Y., Naduvilath, T. J., & Resnikoff, S. (2016) · Ophthalmology · doi:10.1016/j.ophtha.2016.01.006 · Cited by 5,500
Millisecond-timescale, genetically targeted optical control of neural activity
Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 4,861
The physiology, signaling, and pharmacology of dopamine receptors
Beaulieu, J.-M., & Gainetdinov, R. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.002642 · Cited by 2,763
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046
Optogenetics in neural systems
Yizhar, O., Fenno, L. E., Davidson, T. J., Mogri, M., & Deisseroth, K. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.004 · Cited by 1,881
Morgan, I. G., Ohno-Matsui, K., & Saw, S.-M. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60272-4 · Cited by 1,871
Multimodal fast optical interrogation of neural circuitry
Zhang, F., Wang, L.-P., Brauner, M., Liewald, J. F., Kay, K., Watzke, N., Wood, P. G., Bamberg, E., Nagel, G., Gottschalk, A., et al. (2007) · Nature · doi:10.1038/nature05744 · Cited by 1,738
Outdoor Activity Reduces the Prevalence of Myopia in Children
Rose, K. A., Morgan, I. G., Ip, J., Kifley, A., Huynh, S., Smith, W., & Mitchell, P. (2008) · Ophthalmology · doi:10.1016/j.ophtha.2007.12.019 · Cited by 1,335
He, M., Xiang, F., Zeng, Y., Mai, J., Chen, Q., Zhang, J., Smith, W., Rose, K., & Morgan, I. G. (2015) · JAMA · doi:10.1001/jama.2015.10803 · Cited by 1,076
Dolgin, E. (2015) · Nature · doi:10.1038/519276a · Cited by 967
Cited by
IMI – Report on Experimental Models of Emmetropization and Myopia
Troilo, D., Smith, E. L., Nickla, D. L., Ashby, R., Tkatchenko, A. V., Ostrin, L. A., Gawne, T. J., Pardue, M. T., Summers, J. A., Kee, C.-S., et al. (2019) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.18-25967 · Cited by 487
Self-citationA Review of Current Concepts of the Etiology and Treatment of Myopia
Cooper, J., & Tkatchenko, A. V. (2018) · Eye & Contact Lens: Science & Clinical Practice · doi:10.1097/icl.0000000000000499 · Cited by 293
Circadian rhythms, refractive development, and myopia
Chakraborty, R., Ostrin, L. A., Nickla, D. L., Iuvone, P. M., Pardue, M. T., & Stone, R. A. (2018) · Ophthalmic and Physiological Optics · doi:10.1111/opo.12453 · Cited by 235
Self-citation
Metadata
- Authors
- Zhou, X., Pardue, M. T., Iuvone, P. M., & Qu, J.
- Venue
- Progress in Retinal and Eye Research
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 61
- Pages
- 60-71
- ISSN
- 1350-9462 (ISSN-L)
- OpenAlex
- W2622037061
- Cited by
- 395
- References
- 120
- FWCI
- 14.84
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Dopamine signaling and myopia development: What are the key challenges. https://app.cochat.ai/papers/10.1016/j.preteyeres.2017.06.003
- The paper
- Zhou, X., Pardue, M. T., Iuvone, P. M., & Qu, J. (2017). Dopamine signaling and myopia development: What are the key challenges. Progress in Retinal and Eye Research. https://doi.org/10.1016/j.preteyeres.2017.06.003
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
