Circadian rhythms, refractive development, and myopia
Open accessAbstract
Purpose: Despite extensive research, mechanisms regulating postnatal eye growth and those responsible for ametropias are poorly understood. With the marked recent increases in myopia prevalence, robust and biologically‐based clinical therapies to normalize refractive development in childhood are needed. Here, we review classic and contemporary literature about how circadian biology might provide clues to develop a framework to improve the understanding of myopia etiology, and possibly lead to rational approaches to ameliorate refractive errors developing in children. Recent findings: Increasing evidence implicates diurnal and circadian rhythms in eye growth and refractive error development. In both humans and animals, ocular length and other anatomical and physiological features of the eye undergo diurnal oscillations. Systemically, such rhythms are primarily generated by the ‘master clock’ in the surpachiasmatic nucleus, which receives input from the intrinsically photosensitive retinal ganglion cells (ip RGC s) through the activation of the photopigment melanopsin. The retina also has an endogenous circadian clock. In laboratory animals developing experimental myopia, oscillations of ocular parameters are perturbed. Retinal signaling is now believed to influence refractive development; dopamine, an important neurotransmitter found in the retina, not only entrains intrinsic retinal rhythms to the light:dark cycle, but it also modulates refractive development. Circadian clocks comprise a transcription/translation feedback control mechanism utilizing so‐called clock genes that have now been associated with experimental ametropias. Contemporary clinical research is also reviving ideas first proposed in the nineteenth century that light exposures might impact refraction in children. As a result, properties of ambient lighting are being investigated in refractive development. In other areas of medical science, circadian dysregulation is now thought to impact many non‐ocular disorders, likely because the patterns of modern artificial lighting exert adverse physiological effects on circadian pacemakers. How, or if, such modern light exposures and circadian dysregulation contribute to refractive development is not known. Summary: The premise of this review is that circadian biology could be a productive area worthy of increased investigation, which might lead to the improved understanding of refractive development and improved therapeutic interventions.
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Recent reviews shed light on the complex interaction and the interdependence of the disruption of circadian rhythm on the onset and progression of myopia.
“Recent reviews shed light on this complex interaction and the interdependence of the disruption of circadian rhythm on the onset and progression of myopia 112, 113.”
From The inner clock-Blue light sets the human rhythm (2019) · cites this paper as [112]
The Abstract (Recent findings) and Summary review links between circadian rhythms, eye growth, and refractive development. But the review says it is not known whether circadian dysregulation contributes to refractive development, and describes its role in myopia as a hypothesis; it does not establish an interdependent effect on myopia onset and progression. Page numbers were not available in our copy. (LLM, conf=0.86)
Experimental — accuracy not yet measuredEvidence is rising that circadian rhythm and both the irradiance dosis and the spectral irradiance of light impact eye growth, or emmetropization.
“Evidence is also rising that circadian rhythm and both, the irradiance dosis and the spectral irradiance of light, impact eye growth, or emmetropization.”
From The inner clock-Blue light sets the human rhythm (2019) · cites this paper as [112]
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Self-citationIncrease in choroidal thickness after blue light stimulation of the blind spot in young adults
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RNA-sequencing analysis reveals the long noncoding RNA profile in the mouse myopic retina
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Additive effects of narrowband light and optical defocus on chick eye growth and refraction
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Mice Lacking Gpr179 with Complete Congenital Stationary Night Blindness Are a Good Model for Myopia
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- Authors
- Chakraborty, R., Ostrin, L. A., Nickla, D. L., Iuvone, P. M., Pardue, M. T., & Stone, R. A.
- Affiliations
- Flinders University (AU)
- University of Houston (US)
- New England College of Optometry (US)
- Emory University (US)
- Georgia Institute of Technology (US)
- University of Pennsylvania (US)
- Corresponding author
- Chakraborty, Ranjay
- ORCID
- Venue
- Ophthalmic and Physiological Optics
- Published
- 2018-04-24
- Volume
- 38
- Issue
- 3
- Pages
- 217-245
- ISSN
- 0275-5408 (ISSN-L)
- 1475-1313
- PMC
- PMC6038122
- OpenAlex
- W2802569724
- Cited by
- 235
- References
- 345
- Citations by year
- 2026: 36 · 2025: 20 · 2024: 31 · 2023: 41 · 2022: 32 · 2021: 26 · 2020: 21 · 2019: 20 · 2018: 6 · 2013: 1
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Ophthalmic and Physiological Optics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01 EY016435, R01 EY004864, R01 EY027711, P30 EY006360, R01 EY022342, EY001583, EY013636, EY025307)
- Research to Prevent Blindness
- Topics
- Health Sciences › Medicine › Epidemiology › Ophthalmology and Visual Impairment Studies
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- circadian rhythm, refractive development, myopia, eye growth, diurnal cycle, suprachiasmatic nucleus, intrinsically photosensitive retinal ganglion cells, melanopsin, dopamine, clock genes, experimental myopia, ambient lighting, artificial light exposure, circadian dysfunction, refractive error, children
- MeSH terms
- Circadian Rhythm, Eye, Humans, Myopia, Refraction, Ocular, Disease Progression
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