Cited by 71Retinal Diseases and TreatmentsComplement system in diseasesOcular Diseases and Behçet’s Syndrome

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Implications of genetic variation in the complement system in age-related macular degeneration

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de Jong, Sarah, Gagliardi, Giuliana, Garanto, Alejandro, de Breuk, Anita, Lechanteur, Yara T.E., Katti, Suresh, van den Heuvel, Lambert P., Volokhina, Elena B., den Hollander, Anneke I.·2021·Progress in Retinal and Eye Research

DOI 10.1016/j.preteyeres.2021.100952

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Abstract

Age-related macular degeneration (AMD) is the main cause of vision loss among the elderly in the Western world. While AMD is a multifactorial disease, the complement system was identified as one of the main pathways contributing to disease risk. The strong link between the complement system and AMD was demonstrated by genetic associations, and by elevated complement activation in local eye tissue and in the systemic circulation of AMD patients. Several complement inhibitors have been and are being explored in clinical trials, but thus far with limited success, leaving the majority of AMD patients without treatment options to date. This indicates that there is still a gap of knowledge regarding the functional implications of the complement system in AMD pathogenesis and how to bring these towards clinical translation. Many different experimental set-ups and disease models have been used to study complement activation in vivo and in vitro, and recently emerging patient-derived induced pluripotent stem cells and genome-editing techniques open new opportunities to study AMD disease mechanisms and test new therapeutic strategies in the future. In this review we provide an extensive overview of methods employed to understand the molecular processes of complement activation in AMD pathogenesis. We discuss the findings, advantages and challenges of each approach and conclude with an outlook on how recent, exciting developments can fill in current knowledge gaps and can aid in the development of effective complement-targeting therapeutic strategies in AMD.

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McLaughlin, B. J., Fan, W., Zheng, J. J., Cai, H., Priore, L. V. D., Bora, N. S., & Kaplan, H. J. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0813 · Cited by 48
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Human iPSC-Derived Retinal Pigment Epithelium: A Model System for Prioritizing and Functionally Characterizing Causal Variants at AMD Risk Loci
Smith, E. N., D’Antonio‐Chronowska, A., Greenwald, W. W. Y., Borja, V., Aguiar, L. R., Pogue, R. E., Matsui, H., Benaglio, P., Borooah, S., D’Antonio, M., et al. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2019.04.012 · Cited by 48
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Nishiguchi, K. M., Yasuma, T. R., Tomida, D., Nakamura, M., Ishikawa, K., Kikuchi, M., Ohmi, Y., Niwa, T., Hamajima, N., Furukawa, K., et al. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8425 · Cited by 47
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Silva, A. S., Teixeira, A., Bavia, L., Lin, F. L. H., Velletri, R., Belfort, R., & Isaac, L. (2012) · Europe PMC (PubMed Central) · Cited by 46
Mitochondrial decline precedes phenotype development in the complement factor H mouse model of retinal degeneration but can be corrected by near infrared light
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Trakkides, T.-O., Schäfer, N., Reichenthaler, M., Kühn, K., Brandwijk, R. J. M. G. E., Toonen, E. J. M., Urban, F., Wegener, J., Enzmann, V., & Pauly, D. (2019) · Antioxidants · doi:10.3390/antiox8110548 · Cited by 45
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Warwick, A., Khandhadia, S., Ennis, S., & Lotery, A. J. (2014) · Journal of Clinical Medicine · doi:10.3390/jcm3041234 · Cited by 42
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Lyzogubov, V., Wu, X., Jha, P., Tytarenko, R., Triebwasser, M., Kolar, G., Bertram, P., Bora, P. S., Atkinson, J. P., & Bora, N. S. (2014) · The American Journal of Pathology · doi:10.1016/j.ajpath.2014.06.001 · Cited by 41
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Emri, E., Körtvely, E., Dammeier, S., Klose, F., Simpson, D. A. C., den Hollander, A. I., Ueffing, M., & Lengyel, I. (2020) · Nutrients · doi:10.3390/nu12103051 · Cited by 41
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Recalde, S., Tortajada, A., Subias, M., Anter, J., Blasco, M., Maranta, R., Coco, R., Pinto, S., Noris, M., García-Layana, A., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015050580 · Cited by 32
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Borras, C., Delaunay, K., Slaoui, Y., Abache, T., Jorieux, S., Naud, M., Sanharawi, M. E., Gélizé, E., Lassiaz, P., An, N., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00443 · Cited by 16
Complement C3 inhibitor POT-4: Clinical Safety of Intravitreal Administration
Kaushal, S., Grossi, F. V., Francois, C. G., & Slakter, J. S. (2009) · Investigative Ophthalmology & Visual Science · Cited by 13
Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration
Arya, S., Emri, E., Synowsky, S. A., Shirran, S. L., Barzegar-Befroei, N., Pető, T., Botting, C. H., Lengyel, I., & Stewart, A. J. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.03.023 · Cited by 11
Ablation of C3 modulates macrophage reactivity in the outer retina during photo-oxidative damage.
Jiao, H., Provis, J. M., Natoli, R., & Rutar, M. (2020) · PubMed Central · Cited by 11
Human Complement Factor H and Factor H-Like Protein 1 Are Expressed in Human Retinal Pigment Epithelial Cells
Weinberger, A. W. A., Eddahabi, C., Carstesen, D., Zipfel, P. F., Walter, P., & Skerka, C. (2013) · Ophthalmic Research · doi:10.1159/000351624 · Cited by 10
Functional Evaluation of AMD-Associated Risk Variants of Complement Factor B
Pilotti, C., Greenwood, J., & Moss, S. E. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.5.19 · Cited by 10
NEI-Supported Age-Related Macular Degeneration Research: Past, Present, and Future
Wright, C. B., Mazzucco, A. E., Becker, S. M., Sieving, P. A., & Tumminia, S. J. (2020) · Translational Vision Science & Technology · doi:10.1167/tvst.9.7.49 · Cited by 8
Treatment with interleukin‐33 is non‐toxic and protects retinal pigment epithelium in an ageing model of outer retinal degeneration
Clare, A. J., Copland, D. A., Nicholson, L. B., Liu, J., Neal, C., Moss, S. E., Dick, A. D., & Theodoropoulou, S. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16000 · Cited by 7
Adaptive and Maladaptive Complement Activation in the Retina
Silverman, S. M., & Wong, W. T. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-27378-1_6 · Cited by 3
Lampalizumab inhibits ocular alternative complement activity in patients with geographic atrophy secondary to age-related macular degeneration
Chang, M., Steffen, V., Honigberg, L. A., & Edmonds, R. (2020) · Investigative Ophthalmology & Visual Science · Cited by 1

Research works printed but not linked: 3

Cipriani, 2020, Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration, Nat. Commun., 11, 778, 10.1038/s41467-020-14499-3 · DOI
Gallemore, 2016, A proof of concept study of intravitreal (IVT) LFG316 in patients with neovascular age realted macular degeneration (nAMD), Invest. Ophthalmol. Vis. Sci., 57
Weismann, 2011, Complement factor H binds malondialdehyde epitopes and protects from oxidative stress, Nature, 478, 76, 10.1038/nature10449 · DOI · Paper page

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Authors: de Jong, S., Gagliardi, G., Garanto, A., de Breuk, A., Lechanteur, Y. T. E., Katti, S., van den Heuvel, L. P., Volokhina, E. B., & den Hollander, A. I.
Affiliations: Radboud University Medical Center (NL)
Radboud University Nijmegen (NL)
ORCID: de Jong, Sarah
Gagliardi, Giuliana
Garanto, Alejandro
Lechanteur, Yara T.E.
Volokhina, Elena B.
Venue: Progress in Retinal and Eye Research
Publisher: Elsevier BV
Published: 2021-09
Volume: 84
Pages: 100952
ISSN: 1350-9462 (ISSN-L)
DOI: 10.1016/j.preteyeres.2021.100952
OpenAlex: W3131044740
Cited by: 71
References: 273
Citations by year: 2026: 10 · 2025: 11 · 2024: 12 · 2023: 14 · 2022: 17 · 2021: 7
FWCI: 2.15
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Progress in Retinal and Eye Research (publishedVersion, cc-by)
PubMed (publishedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion, other-oa)
Funders: Foundation Fighting Blindness Inc
Dutch Research Council
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords: age-related macular degeneration, complement system, complement activation, genetic variation, genetic association, complement inhibitors, AMD pathogenesis, induced pluripotent stem cells, genome editing, disease models
MeSH terms: Aged, Complement System Proteins, Complement Activation, Humans, Macular Degeneration, Genetic Variation

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Implications of genetic variation in the complement system in age-related macular degeneration

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