The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration–Like Phenotype
Open accessAbstract
In the mouse, membrane cofactor protein (CD46), a key regulator of the alternative pathway of the complement system, is only expressed in the eye and on the inner acrosomal membrane of spermatozoa. We noted that although Cd46(-/-) mice have normal systemic alternative pathway activating ability, lack of CD46 leads to dysregulated complement activation in the eye, as evidenced by increased deposition of C5b-9 in the retinal pigment epithelium (RPE) and choroid. A knockout of CD46 induced the following cardinal features of human dry age-related macular degeneration (AMD) in 12-month-old male and female mice: accumulation of autofluorescent material in and hypertrophy of the RPE, dense deposits in and thickening of Bruch's membrane, loss of photoreceptors, cells in subretinal space, and a reduction of choroidal vessels. Collectively, our results demonstrate spontaneous age-related degenerative changes in the retina, RPE, and choroid of Cd46(-/-) mice that are consistent with human dry AMD. These findings provide the exciting possibility of using Cd46(-/-) mice as a convenient and reliable animal model for dry AMD. Having such a relatively straight-forward model for dry AMD should provide valuable insights into pathogenesis and a test model system for novel drug targets. More important, tissue-specific expression of CD46 gives the Cd46(-/-) mouse model of dry AMD a unique advantage over other mouse models using knockout strains.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Inhibition of CD46 by gene knockout in mouse models led to increased VEGF production in the retina and choroid, increased MAC deposition on these tissues, increased susceptibility to laser-induced CNV, and degenerative changes in retinal tissues resembling an AMD phenotype.
“In addition, the inhibition of CD46 by gene knockout in mouse models led to increased VEGF production in the retina and choroid, increased MAC deposition on these tissues, increased susceptibility to laser-induced CNV, and degenerative changes in retinal tissues resembling an AMD phenotype [166,167].”
From Bruch’s Membrane: A Key Consideration with Complement-Based Therapies for Age-Related Macular Degeneration (2023) · cites this paper as [167]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works
The Retinal Pigment Epithelium in Visual Function
Strauss, O. (2005) · Physiological Reviews · doi:10.1152/physrev.00021.2004 · Cited by 2,828 · see citing works
Prevalence of Age-Related Macular Degeneration in the United States
The Eye Diseases Prevalence Research Group* (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.4.564 · Cited by 2,742 · see citing works
Autophagy in Human Health and Disease
Choi, A. M. K., Ryter, S. W., & Levine, B. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1205406 · Cited by 2,583 · see citing works
A role for local inflammation in the formation of drusen in the aging eye
Anderson, D. H., Mullins, R. F., Hageman, G. S., & Johnson, L. V. (2002) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)01624-0 · Cited by 1,087 · see citing works
Risk factors for age-related macular degeneration
Smith, W., Assink, J., Klein, R., Mitchell, P., Klaver, C. C. W., Klein, B. E. K., Hofman, A., Jensen, S., Wang, J. J., & de Jong, P. T. V. M. (2001) · Ophthalmology · doi:10.1016/s0161-6420(00)00580-7 · Cited by 1,071 · see citing works
Mechanisms of Age-Related Macular Degeneration
Ambati, J., & Fowler, B. J. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.018 · Cited by 1,029 · see citing works
Bhutto, I. A., & Lutty, G. A. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.04.005 · Cited by 1,005 · see citing works
Anderson, D. H., Radeke, M. J., Gallo, N. B., Chapin, E. A., Johnson, P. T., Curletti, C. R., Hancox, L. S., Hu, J., Ebright, J. N., Malek, G., et al. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.11.003 · Cited by 727 · see citing works
Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts
Gehrs, K. M., Anderson, D. H., Johnson, L. V., & Hageman, G. S. (2006) · Annals of Medicine · doi:10.1080/07853890600946724 · Cited by 633 · see citing works
An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice
Ambati, J., Anand, A., Fernandez, S., Sakurai, E., Lynn, B. C., Kuziel, W. A., Rollins, B. J., & Ambati, B. K. (2003) · Nature Medicine · doi:10.1038/nm950 · Cited by 631 · see citing works
Johnson, L. V., Leitner, W. P., Staples, M. K., & Anderson, D. H. (2001) · Experimental Eye Research · doi:10.1006/exer.2001.1094 · Cited by 621 · see citing works
Immunology of age-related macular degeneration
Ambati, J., Atkinson, J. P., & Gelfand, B. D. (2013) · Nature reviews. Immunology · doi:10.1038/nri3459 · Cited by 591 · see citing works
Self-citationWebvision: The Organization of the Retina and Visual System
Kolb, H., Fernández, E., & Nelson, R. (1995) · Cited by 544 · see citing works
Age-related macular degeneration
Coleman, H. R., Chan, C.-C., Ferris, F. L., & Chew, E. Y. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61759-6 · Cited by 542 · see citing works
Pickering, M. C., Cook, H. T., Warren, J. A., Bygrave, A. E., Moss, J., Walport, M. J., & Botto, M. (2002) · Nature Genetics · doi:10.1038/ng912 · Cited by 516 · see citing works
Imamura, Y., Noda, S., Hashizume, K., Shinoda, K., Yamaguchi, M., Uchiyama, S., Shimizu, T., Mizushima, Y., Shirasawa, T., & Tsubota, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602131103 · Cited by 420 · see citing works
The bisretinoids of retinal pigment epithelium
Sparrow, J. R., Gregory-Roberts, E., Yamamoto, K., Blonska, A., Ghosh, S. K., Ueda, K., & Zhou, J. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.12.001 · Cited by 392 · see citing works
Mehalow, A. K. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg232 · Cited by 377 · see citing works
Wang, A. L., Lukas, T. J., Yuan, M., Du, N. Y., Tso, M. O. M., & Neufeld, A. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004160 · Cited by 357 · see citing works
Seddon, J. M., Yu, Y., Miller, E. C., Reynolds, R. C., Tan, P. L., Gowrisankar, S., Goldstein, J. I., Triebwasser, M. P., Anderson, H. E., Zerbib, J., et al. (2013) · Nature Genetics · doi:10.1038/ng.2741 · Cited by 345 · see citing works
Self-citationForecasting Age-Related Macular Degeneration Through the Year 2050
Rein, D. B. (2009) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2009.58 · Cited by 345 · see citing works
Risk Factors for Age-related Macular Degeneration
Evans, J. R. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(00)00023-9 · Cited by 337 · see citing works
Age-Related Retinopathy in NRF2-Deficient Mice
Zhao, Z., Chen, Y., Wang, J., Sternberg, P., Freeman, M. L., Grossniklaus, H. E., & Cai, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019456 · Cited by 303 · see citing works
Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration
Malek, G., Johnson, L. V., Mace, B. E., Saloupis, P., Schmechel, D. E., Rickman, D. W., Toth, C. A., Sullivan, P. M., & Rickman, C. B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503015102 · Cited by 284 · see citing works
Spraul, C. W., Lang, G., Grossniklaus, H. E., & Lang, G. K. (1999) · Survey of Ophthalmology · doi:10.1016/s0039-6257(99)00086-7 · Cited by 258 · see citing works
Bora, P. S., Sohn, J.-H., Cruz, J. M. C., Jha, P., Nishihori, H., Wang, Y., Kaliappan, S., Kaplan, H. J., & Bora, N. S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.1.491 · Cited by 249 · see citing works
Self-citationSOD2 knockdown mouse model of early AMD
Justilien, V., Pang, J.-J., Renganathan, K., Zhan, X., Crabb, J. W., Kim, S. R., Sparrow, J. R., Hauswirth, W. W., & Lewin, A. S. (2007) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.07-0432 · Cited by 234 · see citing works
Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction
Coffey, P. J., Gias, C., McDermott, C. J., Lundh, P., Pickering, M. C., Sethi, C., Bird, A., Fitzke, F. W., Maass, A., Chen, L. L., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705079104 · Cited by 231 · see citing works
VEGF Expression and Receptor Activation in the Choroid during Development and in the Adult
Saint‐Geniez, M., Maldonado, A. E., & D'Amore, P. A. (2006) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-1229 · Cited by 226 · see citing works
Mata, N. L., Tzekov, R. T., Liu, X., Weng, J., Birch, D. G., & Travis, G. H. (2001) · PubMed · Cited by 219 · see citing works
Abrogation of the alternative complement pathway by targeted deletion of murine factor B
Matsumoto, M., Fukuda, W., Circolo, A., Goellner, J. J., Strauss‐Schoenberger, J., Wang, X., Fujita, S., Hidvégi, T., Chaplin, D., & Colten, H. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8720 · Cited by 216 · see citing works
Tuo, J., Bojanowski, C. M., Zhou, M., Shen, D., Ross, R. J., Rosenberg, K. I., Cameron, D. J., Yin, C., Kowalak, J. A., Zhuang, Z., et al. (2007) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.07-0051 · Cited by 205 · see citing works
Luhmann, U. F. O., Robbie, S. J., Munro, P., Barker, S. E., Durán, Y., Luong, V., Fitzke, F. W., Bainbridge, J. W., Ali, R. R., & MacLaren, R. E. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3462 · Cited by 205 · see citing works
Karan, G., Lillo, C., Yang, Z., Cameron, D. J., Locke, K. G., Zhao, Y., Thirumalaichary, S., Li, C., Birch, D. G., Vollmer-Snarr, H. R., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407698102 · Cited by 182 · see citing works
Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD)
Ramkumar, H. L., Zhang, J., & Chan, C.-C. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2010.02.002 · Cited by 163 · see citing works
Circolo, A., Garnier, G., Fukuda, W., Wang, X., Hidvégi, T., Szalai, A. J., Briles, D. E., Volanakis, J. E., Wetsel, R. A., & Colten, H. R. (1999) · Immunopharmacology · doi:10.1016/s0162-3109(99)00021-1 · Cited by 162 · see citing works
Viiri, J., Amadio, M., Marchesi, N., Hyttinen, J. M. T., Kivinen, N., Sironen, R. K., Rilla, K. J., Akhtar, S., Provenzani, A., D’Agostino, V., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069563 · Cited by 158 · see citing works
Fujihara, M., Nagai, N., Sussan, T. E., Biswal, S. S., & Handa, J. T. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003119 · Cited by 150 · see citing works
Animal models in research on retinal degenerations: past progress and future hope
Chader, G. J. (2002) · Vision Research · doi:10.1016/s0042-6989(01)00212-7 · Cited by 147 · see citing works
The R345W mutation in EFEMP1 is pathogenic and causes AMD-like deposits in mice
Fu, L., Garland, D. L., Yang, Z., Shukla, D., Rajendran, A., Pearson, E., Stone, E. M., Zhang, K., & Pierce, E. A. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm198 · Cited by 142 · see citing works
Liszewski, M. K., Leung, M. K., Cui, W., Subramanian, V. B., Parkinson, J., Barlow, P. N., Manchester, M., & Atkinson, J. P. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004650200 · Cited by 141 · see citing works
Self-citationPATHWAY-BASED THERAPIES FOR AGE-RELATED MACULAR DEGENERATION
Zarbin, M. A., & Rosenfeld, P. J. (2010) · Retina · doi:10.1097/iae.0b013e3181f57e30 · Cited by 140 · see citing works
Helgason, H., Sulem, P., Duvvari, M. R., Luo, H., Þorleifsson, G., Stefánsson, H., Jónsdóttir, I., Másson, G., Gudbjartsson, D. F., Walters, G. B., et al. (2013) · Nature Genetics · doi:10.1038/ng.2740 · Cited by 137 · see citing works
Bora, N. S., Kaliappan, S., Jha, P., Xu, Q., Sohn, J.-H., Dhaulakhandi, D. B., Kaplan, H. J., & Bora, P. S. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1872 · Cited by 124 · see citing works
Self-citationKavanagh, D., Yu, Y., Schramm, E. C., Triebwasser, M. P., Wagner, E. K., Raychaudhuri, S., Daly, M. J., Atkinson, J. P., & Seddon, J. M. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv091 · Cited by 124 · see citing works
Self-citationCeruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD
Hadziahmetovic, M., Dentchev, T., Song, Y., Haddad, N., He, X., Hahn, P., Pratico, D., Wen, R., Harris, Z. L., Lambris, J. D., et al. (2008) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.07-1472 · Cited by 121 · see citing works
Retinal Dysfunction and Progressive Retinal Cell Death in SOD1-Deficient Mice
Hashizume, K., Hirasawa, M., Imamura, Y., Noda, S., Shimizu, T., Shinoda, K., Kurihara, T., Noda, K., Ozawa, Y., Ishida, S., et al. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070730 · Cited by 114 · see citing works
Yu, Y., Triebwasser, M. P., Wong, E. K. S., Schramm, E. C., Thomas, B., Reynolds, R. C., Mardis, E. R., Atkinson, J. P., Daly, M. J., Raychaudhuri, S., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu226 · Cited by 108 · see citing works
Self-citationMouse models of age-related macular degeneration
Elizabeth Rakoczy, P., Yu, M. J. T., Nusinowitz, S., Chang, B., & Heckenlively, J. R. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2005.10.012 · Cited by 107 · see citing works
Transgenic Mice Expressing Variants of Complement Factor H Develop AMD-like Retinal Findings
Ufret-Vincenty, R. L., Aredo, B., Liu, X., McMahon, A., Chen, P. W., Sun, H., Niederkorn, J. Y., & Kędzierski, W. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4457 · Cited by 104 · see citing works
Emerging roles and new functions of CD46
Liszewski, M. K., Kemper, C., Price, J. D., et al. (2005) · Springer Seminars in Immunopathology · doi:10.1007/s00281-005-0002-3 · Cited by 103 · see citing works
REVIEW PAPER: Animals as Models of Age-Related Macular Degeneration
Zeiss, C. J. (2010) · Veterinary Pathology · doi:10.1177/0300985809359598 · Cited by 103 · see citing works
Molecular genetics of AMD and current animal models
Edwards, A. O., & Malek, G. (2007) · Angiogenesis · doi:10.1007/s10456-007-9064-2 · Cited by 98 · see citing works
Survey of common eye diseases in laboratory mouse strains.
Chang, B., Hurd, R., Wang, J., & Nishina, P. (2013) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.13-12289 · Cited by 97 · see citing works
Age-Related Macular Degeneration
Khandhadia, S., Cherry, J., & Lotery, A. J. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0653-2_2 · Cited by 97 · see citing works
Bora, N. S., Kaliappan, S., Jha, P., Xu, Q., Sivasankar, B., Harris, C. L., Morgan, B. P., & Bora, P. S. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1783 · Cited by 91 · see citing works
Self-citationGenetic susceptibility to age related macular degeneration
Yates, J. R. W., & Moore, A. T. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.2.83 · Cited by 88 · see citing works
Espinosa‐Heidmann, D. G., Sall, J. C., Hernandez, E. P., & Cousins, S. W. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.03-0910 · Cited by 82 · see citing works
Properdin Plays a Protective Role in Polymicrobial Septic Peritonitis
Stover, C. M., Luckett, J., Echtenacher, B., Dupont, A., Figgitt, S. E., Brown, J., Männel, D. N., & Schwaeble, W. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3313 · Cited by 82 · see citing works
Cho, K. S., Yoon, Y. H., Choi, J. A., Lee, S.-J., & Koh, J. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-9827 · Cited by 77 · see citing works
The Human Complement System in Health and Disease.
Morgan, B. P. (1998) · Annals of the Rheumatic Diseases · doi:10.1136/ard.57.10.581 · Cited by 75 · see citing works
Mouse models of ocular diseases
Chang, B., Hawes, N. L., Hurd, R. E., Wang, J., Howell, D., Davisson, M. T., Roderick, T. H., Nusinowitz, S., & Heckenlively, J. R. (2005) · Visual Neuroscience · doi:10.1017/s0952523805225075 · Cited by 75 · see citing works
The role of complement in ocular pathology
Bora, N. S., Jha, P., & Bora, P. S. (2008) · Seminars in Immunopathology · doi:10.1007/s00281-008-0110-y · Cited by 69 · see citing works
Self-citationTriebwasser, M. P., Roberson, E. D. O., Yu, Y., Schramm, E. C., Wagner, E. K., Raychaudhuri, S., Seddon, J. M., & Atkinson, J. P. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-17432 · Cited by 69 · see citing works
Self-citationPolyethylene Glycol (PEG)-induced Mouse Model of Choroidal Neovascularization
Lyzogubov, V. V., Tytarenko, R. G., Liu, J., Bora, N. S., & Bora, P. S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.204701 · Cited by 65 · see citing works
Self-citationFujihara, M., Bartels, E. D., Nielsen, L. B., & Handa, J. T. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.01.017 · Cited by 62 · see citing works
Molecular ophthalmology: an update on animal models for retinal degenerations and dystrophies
Hafezi, F. (2000) · British Journal of Ophthalmology · doi:10.1136/bjo.84.8.922 · Cited by 61 · see citing works
Ross, R. J., Zhou, M., Shen, D., Fariss, R. N., Ding, X., Bojanowski, C. M., Tuo, J., & Chan, C.-C. (2008) · Experimental Eye Research · doi:10.1016/j.exer.2008.01.014 · Cited by 60 · see citing works
Mechanism of age related macular degeneration
Husain, D., Ambati, B. K., ADAMIS, A., & Miller, J. W. (2002) · Ophthalmology Clinics of North America · doi:10.1016/s0896-1549(01)00009-8 · Cited by 55 · see citing works
Genomic aspects of age-related macular degeneration
Horie‐Inoue, K., & Inoue, S. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.08.013 · Cited by 54 · see citing works
Bora, N. S., Jha, P., Lyzogubov, V. V., Kaliappan, S., Liu, J., Tytarenko, R. G., Fraser, D. A., Morgan, B. P., & Bora, P. S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.153130 · Cited by 53 · see citing works
Self-citationAge related macular degeneration and visual disability
B. Christoforidis, J., Tecce, N., Dell'Omo, R., Mastropasqua, R., Verolino, M., & Costagliola, C. (2011) · Current Drug Targets · doi:10.2174/138945011794182755 · Cited by 52 · see citing works
Majji, A. B., Cao, J. M., Chang, K. Y., Hayashi, A., Aggarwal, S., Grebe, R. R., & de Juan, E. (2000) · PubMed · Cited by 51 · see citing works
Luhmann, U. F. O., Carvalho, L. S., Robbie, S. J., Cowing, J. A., Durán, Y., Munro, P., Bainbridge, J. W., & Ali, R. R. (2012) · Experimental Eye Research · doi:10.1016/j.exer.2012.11.015 · Cited by 50 · see citing works
Morphological Changes of Retinal Pigment Epithelium and Choroid in rd-mice
Neuhardt, T., May, C. A., Wilsch, C., Eichhorn, M., & Lütjen-Drecoll, E. (1999) · Experimental Eye Research · doi:10.1006/exer.1998.0589 · Cited by 50 · see citing works
Liu, J., Jha, P., Lyzogubov, V. V., Tytarenko, R. G., Bora, N. S., & Bora, P. S. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.226266 · Cited by 49 · see citing works
Self-citationBora, N. S., Matta, B., Lyzogubov, V. V., & Bora, P. S. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.07.012 · Cited by 49 · see citing works
Self-citationRole of Ocular Complement Factor H in a Murine Model of Choroidal Neovascularization
Lyzogubov, V. V., Tytarenko, R. G., Jha, P., Liu, J., Bora, N. S., & Bora, P. S. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091168 · Cited by 49 · see citing works
Self-citationRegulatory Proteins of Complement
Liszewski, M. K., & Atkinson, J. P. (1998) · CRC Press eBooks · doi:10.1201/b14212-8 · Cited by 46 · see citing works
Self-citationRadu, R. A., Hu, J., Jiang, Z., & Bok, D. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.548669 · Cited by 44 · see citing works
Complement Regulatory Protein CD46 Protects against Choroidal Neovascularization in Mice
Lyzogubov, V., Wu, X., Jha, P., Tytarenko, R., Triebwasser, M., Kolar, G., Bertram, P., Bora, P. S., Atkinson, J. P., & Bora, N. S. (2014) · The American Journal of Pathology · doi:10.1016/j.ajpath.2014.06.001 · Cited by 41 · see citing works
Self-citationTreatment of Dry Age-Related Macular Degeneration
Querques, G., Rosenfeld, P. J., Cavallero, E., Borrelli, E., Corvi, F., Querques, L., Bandello, F. M., & Zarbin, M. A. (2014) · Ophthalmic Research · doi:10.1159/000363187 · Cited by 39 · see citing works
Schmidt-Erfurth, U. M., Rudolf, M., Funk, M., Hofmann-Rummelt, C., Franz-Haas, N.-S., Aherrahrou, Z., & Schlo¨tzer-Schrehardt, U. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0227 · Cited by 32 · see citing works
Polyethylene glycol induced mouse model of retinal degeneration
Lyzogubov, V. V., Bora, N. S., Tytarenko, R. G., & Bora, P. S. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.07.021 · Cited by 26 · see citing works
Self-citationSallo, F. B., Bereczki, E., Csont, T., Luthert, P. J., Munro, P., Ferdinandy, P., Sántha, M., & Lengyel, I. (2009) · Experimental Eye Research · doi:10.1016/j.exer.2009.03.006 · Cited by 25 · see citing works
Ethen, C. M., Feng, X., Olsen, T. W., & Ferrington, D. A. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-0810 · Cited by 25 · see citing works
Autophagy Regulating Kinases As Potential Therapeutic Targets For Age-Related Macular Degeneration
Kaarniranta, K., Kauppinen, A., Błasiak, J., & Salminen, A. (2012) · Future Medicinal Chemistry · doi:10.4155/fmc.12.169 · Cited by 23 · see citing works
Kaliappan, S., Jha, P., Lyzogubov, V. V., Tytarenko, R. G., Bora, N. S., & Bora, P. S. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.09.009 · Cited by 21 · see citing works
Self-citationBertram, P. G., Akk, A. M., Zhou, H., et al. (2015) · Monoclonal Antibodies in Immunodiagnosis and Immunotherapy · doi:10.1089/mab.2014.0066 · Cited by 17 · see citing works
Wang, A. L., & Neufeld, A. H. (2009) · Vision Research · doi:10.1016/j.visres.2009.08.029 · Cited by 16 · see citing works
Emerging Role of Complement in Ocular Diseases
Bora, N. S., Jha, P., Lyzogubov, V. V., et al. (2011) · Current Immunology Reviews · doi:10.2174/157339511796196656 · Cited by 4 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- Morgan BP, Harris CL (Eds): Complement Regulatory Proteins. San Diego, London: Academic Press, 1999
Cited by
Sorted by citations
Implications of genetic variation in the complement system in age-related macular degeneration
de Jong, S., Gagliardi, G., Garanto, A., de Breuk, A., Lechanteur, Y. T. E., Katti, S., van den Heuvel, L. P., Volokhina, E. B., & den Hollander, A. I. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2021.100952 · Cited by 71 · see citing works
Hammadi, S., Tzoumas, N., Ferrara, M., Meschede, I. P., Lo, K., Harris, C., Lako, M., & Steel, D. H. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12082870 · Cited by 44 · see citing works
- Authors
- Lyzogubov, V. V., Bora, P. S., Wu, X., Horn, L. E., de Roque, R., Rudolf, X. V., Atkinson, J. P., & Bora, N. S.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- Washington University in St. Louis (US)
- Corresponding author
- Bora, Nalini S.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 186
- Issue
- 8
- Pages
- 2088-2104
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC4973660
- OpenAlex
- W2415663312
- Cited by
- 45
- References
- 92
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 8 · 2023: 6 · 2021: 5 · 2020: 6 · 2019: 3 · 2018: 6 · 2017: 6 · 2016: 2
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal Of Pathology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- The Edward N. and Della L. Thome Memorial Foundation
- Lions of Arkansas Foundation, Inc.
- Pat and Willard Walker Eye Research Center
- Jones Eye Institute
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Keywords
- CD46, membrane cofactor protein, dry age-related macular degeneration, complement regulation, alternative complement pathway, retinal pigment epithelium, choroid, C5b-9 deposition, Bruch's membrane, photoreceptor loss, choroidal vasculature, knockout mouse models, tissue-specific gene expression
- MeSH terms
- Animals, Disease Models, Animal, Female, Macular Degeneration, Male, Blotting, Western, Mice, Knockout, Mice, Membrane Cofactor Protein, Geographic Atrophy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
