The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
Electrospraying of polymers with therapeutic molecules: State of the art
Open accessAbstract
Abstract The encapsulation and release of bioactive molecules from polymeric vehicles represents the holy grail of drug and growth factor delivery therapies, whereby sustained and controlled release is crucial in eliciting a positive therapeutic effect. To this end, electrospraying is rapidly emerging as a popular technology for the production of polymeric particles containing bioactive molecules. Compared with traditional emulsion fabrication techniques, electrospraying has the potential to reduce denaturation of protein drugs and affords tighter regulation over particle size distribution and morphology. In this article, we review the importance of the electrospraying parameters that enable reproducible tailoring of the particles’ physical and in vitro drug release characteristics, along with discussion of existing in vivo data. Controlled morphology and monodispersity of particles can be achieved with electrospraying, with high encapsulation efficiencies and without unfavorable denaturation of bioactive molecules throughout the process. Finally, the combination of electrospraying with electrospun scaffolds, with an emphasis on tissue regeneration is reviewed, depicting a technique in its relative infancy but holding great promise for the future of regenerative medicine.
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1 retracted
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Cited by
Ghorani, B., & Tucker, N. (2015) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2015.05.024 · Cited by 493
Drug delivery systems for programmed and on-demand release
Davoodi, P., Lee, L. Y., Xu, Q., Sunil, V., Sun, Y., Soh, S., & Wang, C.-H. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.07.002 · Cited by 353
Xie, J., Jiang, J., Davoodi, P., Srinivasan, M. P., & Wang, C.-H. (2015) · Chemical Engineering Science · doi:10.1016/j.ces.2014.08.061 · Cited by 317
Electrosprays in the cone-jet mode: From Taylor cone formation to spray development
Rosell-Llompart, J., Grifoll, J., & Loscertales, I. G. (2018) · Journal of Aerosol Science · doi:10.1016/j.jaerosci.2018.04.008 · Cited by 300
Electrospinning and electrospray of bio-based and natural polymers for biomaterials development
Soares, R. M. D., Siqueira, N. M., Prabhakaram, M. P., & Ramakrishna, S. (2018) · Materials Science and Engineering: C · doi:10.1016/j.msec.2018.08.004 · Cited by 265
Metadata
- Authors
- Bock, N., Dargaville, T. R., & Woodruff, M. A.
- Venue
- Progress in Polymer Science
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 37
- Issue
- 11
- Pages
- 1510-1551
- ISSN
- 0079-6700 (ISSN-L)
- OpenAlex
- W2076463247
- Cited by
- 440
- References
- 124
- FWCI
- 15.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Bock, N., Dargaville, T. R., & Woodruff, M. A. (2012). Electrospraying of polymers with therapeutic molecules: State of the art. Progress in Polymer Science. https://doi.org/10.1016/j.progpolymsci.2012.03.002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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