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Cited by 440

The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.

Electrospraying of polymers with therapeutic molecules: State of the art

Open access
Bock, N., Dargaville, T.R., Woodruff, M.A.·2012·Progress in Polymer Science

Abstract

Abstract The encapsulation and release of bioactive molecules from polymeric vehicles represents the holy grail of drug and growth factor delivery therapies, whereby sustained and controlled release is crucial in eliciting a positive therapeutic effect. To this end, electrospraying is rapidly emerging as a popular technology for the production of polymeric particles containing bioactive molecules. Compared with traditional emulsion fabrication techniques, electrospraying has the potential to reduce denaturation of protein drugs and affords tighter regulation over particle size distribution and morphology. In this article, we review the importance of the electrospraying parameters that enable reproducible tailoring of the particles’ physical and in vitro drug release characteristics, along with discussion of existing in vivo data. Controlled morphology and monodispersity of particles can be achieved with electrospraying, with high encapsulation efficiencies and without unfavorable denaturation of bioactive molecules throughout the process. Finally, the combination of electrospraying with electrospun scaffolds, with an emphasis on tissue regeneration is reviewed, depicting a technique in its relative infancy but holding great promise for the future of regenerative medicine.

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Crossref · 10.1016/j.progpolymsci.2012.03.002

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Metadata

Authors
Bock, N., Dargaville, T. R., & Woodruff, M. A.
Venue
Progress in Polymer Science
Publisher
Elsevier BV
Published
2012-11
Volume
37
Issue
11
Pages
1510-1551
ISSN
0079-6700 (ISSN-L)
OpenAlex
W2076463247
Cited by
440
References
124
FWCI
15.06
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Electrospraying of polymers with therapeutic molecules: State of the art. https://app.cochat.ai/papers/10.1016/j.progpolymsci.2012.03.002
The paper
Bock, N., Dargaville, T. R., & Woodruff, M. A. (2012). Electrospraying of polymers with therapeutic molecules: State of the art. Progress in Polymer Science. https://doi.org/10.1016/j.progpolymsci.2012.03.002

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.