HMGA1 proteins in human atherosclerotic plaques

Schlueter, Claudia; Hauke, Sven; Loeschke, Siegfried; Hans Wenk, Heiner; Bullerdiek, Jörn

doi:10.1016/j.prp.2004.11.010

Cited by 21Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismCerebrovascular and Carotid Artery Diseases

HMGA1 proteins in human atherosclerotic plaques

Schlueter, Claudia, Hauke, Sven, Loeschke, Siegfried, Hans Wenk, Heiner, Bullerdiek, Jörn·2005·Pathology - Research and Practice

DOI 10.1016/j.prp.2004.11.010

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Abstract

One of the major characteristics of atherosclerosis is the migration of smooth muscle cells (SMC) from the tunica media to the intima, caused by alterations in the environment, e.g. mechanical, chemical, or immunologic injuries of the arterial walls. A group of molecules that may act as a main regulator of SMC phenotype switching is formed by the so-called HMGA1 high-mobility group proteins. One target gene of the HMGA1 protein, playing a major role in the development of atherosclerotic lesions, is CD44. The expression of CD44 is regulated by IL-1beta, but binding of HMGA1 potentiates the transactivation of the CD44 promoter. In this study, the HMGA1 expression of human atherosclerotic plaque samples was examined. Compared to the non-active components, all major components of the well-developed atherosclerotic plaques showed strong positivity of the high-mobility group protein HMGA1 in their activated areas, e.g. neointimal SMCs, macrophages, newly built blood vessels. This report is the first to describe HMGA1 as one of the first mediators in the development of human atherosclerotic plaques.

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HMGA1 is a master regulator of the vascular SMC phenotypic switch following vessel wall injury and release of proinflammatory cytokines.
“The architectural transcription factor HMGA1 is a master regulator of the vascular SMCs phenotypic switch that follows vessel wall injury and release of proinflammatory cytokines [6,190,191].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [190]

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Authors: Schlueter, C., Hauke, S., Loeschke, S., Hans Wenk, H., & Bullerdiek, J.
Affiliations: University of Bremen (DE)
Corresponding author: Bullerdiek, Jörn
Venue: Pathology - Research and Practice
Publisher: Elsevier BV
Published: 2005-04
Volume: 201
Issue: 2
Pages: 101-107
ISSN: 0344-0338 (ISSN-L)
DOI: 10.1016/j.prp.2004.11.010
OpenAlex: W1987684274
Cited by: 21
References: 27
Citations by year: 2025: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 3 · 2016: 2 · 2014: 1 · 2013: 1 · 2012: 1
FWCI: 0.36
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pathology - Research and Practice (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cerebrovascular and Carotid Artery Diseases
Keywords: HMGA1, high mobility group proteins, atherosclerosis, atherosclerotic plaque, smooth muscle cell migration, CD44, IL-1β, neointima, macrophages, vascular remodeling, gene expression
MeSH terms: Coronary Artery Disease, Humans, Immunohistochemistry, Muscle, Smooth, Vascular, Blotting, Southern, Biomarkers, Carotid Stenosis, In Situ Hybridization, Reverse Transcriptase Polymerase Chain Reaction, HMGA Proteins, Endothelial Cells

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HMGA1 proteins in human atherosclerotic plaques

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