Cited by 222Obsessive-Compulsive Spectrum DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesPsychoanalysis and Psychopathology Research

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Pharmacological Treatment of Obsessive-Compulsive Disorder

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Pittenger, Christopher, Bloch, Michael H.·2014·Psychiatric Clinics of North America

DOI 10.1016/j.psc.2014.05.006PMC PMC4143776

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Abstract

Obsessive-compulsive disorder (OCD) affects up to 2.5% of the population of the course of a lifetime and produces substantial morbidity. Approximately 70% of patients can experience significant symptomatic relief with appropriate pharmacotherapy. Selective serotonin reuptake inhibitors are the mainstay of pharmacological treatment. These drugs are typically used at higher doses and for longer periods than in depression. Proven second-line treatments include the tricyclic clomipramine and the addition of low-dose neuroleptic medications. OCD refractory to available treatments remains a profound clinical challenge.

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Authors: Pittenger, C., & Bloch, M. H.
Affiliations: Yale University (US)
Corresponding author: Pittenger, Christopher
ORCID: Pittenger, Christopher
Bloch, Michael H.
Venue: Psychiatric Clinics of North America
Publisher: Elsevier BV
Published: 2014-09
Volume: 37
Issue: 3
Pages: 375-391
ISSN: 0193-953X (ISSN-L)
DOI: 10.1016/j.psc.2014.05.006
PMC: PMC4143776
OpenAlex: W1997452831
Cited by: 222
References: 79
Citations by year: 2026: 24 · 2025: 25 · 2024: 31 · 2023: 32 · 2022: 21 · 2021: 16 · 2020: 17 · 2019: 16 · 2018: 8 · 2017: 7 · 2016: 12 · 2015: 10 · 2014: 1
FWCI: 1.52
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychiatric Clinics of North America (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (UL1TR000142)
National Institute of Mental Health (R01MH095790, R34MH083115, K23MH091240, R25MH077823)
National Center for Advancing Translational Sciences
Topics: Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
Keywords: obsessive-compulsive disorder, pharmacotherapy, selective serotonin reuptake inhibitors, clomipramine, tricyclic antidepressants, treatment-resistant OCD, second-line therapy
MeSH terms: Combined Modality Therapy, Drug Therapy, Combination, Nonprescription Drugs, Humans, Obsessive-Compulsive Disorder, Psychotherapy, Psychotropic Drugs, Precision Medicine

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Pharmacological Treatment of Obsessive-Compulsive Disorder

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