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Cited by 146Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMedical Imaging Techniques and Applications

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Reduced cerebral glucose metabolism in patients at risk for Alzheimer's disease

Hunt, Aoife, Schönknecht, Peter, Henze, Marcus, Seidl, Ulrich, Haberkorn, Uwe, Schröder, Johannes·2007·Psychiatry Research: Neuroimaging
DOI 10.1016/j.pscychresns.2006.12.003
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Abstract

While significantly reduced glucose metabolism in fronto-temporo-parietal and cingulate cortices has been demonstrated in Alzheimer's disease (AD) compared with controls, cerebral glucose metabolism in patients with mild cognitive impairment who subsequently develop AD is less well-defined. In the present study we measured cerebral glucose metabolism by positron emission tomography (PET) with (18)F-2-fluoro-2-deoxy-D-glucose in 14 patients with aging-associated cognitive decline (AACD), 44 patients with AD, and 14 healthy control subjects at baseline. The AACD patients were clinically followed up, and conversion to AD was determined. Compared with controls, AACD patients had significantly reduced glucose metabolism in the right precuneus, posterior cingulate, right angular gyrus, and bilateral middle temporal cortices, while the respective deficits were more pronounced in AD patients and also involved the frontal cortices. AACD patients who subsequently converted to AD (AACD-converters) showed more extended metabolic changes which also involved the frontal and temporal cortices, right cingulate gyrus, right thalamus, and bilateral precuneus.

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Metadata

Authors
Hunt, A., Schönknecht, P., Henze, M., Seidl, U., Haberkorn, U., & Schröder, J.
Affiliations
  • Heidelberg University (DE)
  • German Cancer Research Center (DE)
Corresponding author
Schröder, Johannes
ORCID
Schröder, Johannes
Venue
Psychiatry Research: Neuroimaging
Publisher
Elsevier BV
Published
2007-07
Volume
155
Issue
2
Pages
147-154
ISSN
0925-4927 (ISSN-L)
DOI
10.1016/j.pscychresns.2006.12.003
OpenAlex
W2037603765
Cited by
146
References
41
Citations by year
2026: 4 · 2025: 6 · 2024: 9 · 2023: 16 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 9 · 2018: 9 · 2017: 7 · 2016: 10 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 8
FWCI
4.03
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords
Alzheimer's disease, brain glucose metabolism, mild cognitive impairment, conversion to Alzheimer's disease, precuneus, posterior cingulate cortex, angular gyrus, middle temporal cortex, frontal cortex, thalamus, FDG-PET
MeSH terms
Aged, Alzheimer Disease, Brain, Brain Mapping, Cerebral Cortex, Cognition Disorders, Female, Follow-Up Studies, Frontal Lobe, Glucose, Gyrus Cinguli, Humans, Image Processing, Computer-Assisted, Functional Laterality, Male, Severity of Illness Index, Temporal Lobe, Tissue Distribution, Disease Progression, Fluorodeoxyglucose F18, Positron-Emission Tomography

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