Mild cognitive impairment – Beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment.
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Abstract.: The First Key Symposium was held in Stockholm, Sweden, 2–5 September 2003. The aim of the symposium was to integrate clinical and epidemiological perspectives on the topic of Mild Cognitive Impairment (MCI). A multidisciplinary, international group of experts discussed the current status and future directions of MCI, with regard to clinical presentation, cognitive and functional assessment, and the role of neuroimaging, biomarkers and genetics. Agreement on new perspectives, as well as recommendations for management and future research were discussed by the international working group. The specific recommendations for the general MCI criteria include the following: (i) the person is neither normal nor demented; (ii) there is evidence of cognitive deterioration shown by either objectively measured decline over time and/or subjective report of decline by self and/or informant in conjunction with objective cognitive deficits; and (iii) activities of daily living are preserved and complex instrumental functions are either intact or minimally impaired.
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Dementia severity in AD patients and the pattern of cognitive deficits in MCI patients have a great impact on the expected pattern of hippocampal regional atrophy.
“It seems quite obvious that both the dementia severity in AD patients and the pattern of cognitive deficits in MCI patients (only amnestic, amnestic plus other domains, or not amnestic at all [41]) have a great impact on the expected pattern of hippocampal regional atrophy.”
From Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease (2015) · cites this paper as [41]
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Assessing cognitive decline in the aging brain: lessons from rodent and human studies
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- Authors
- Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L. ‐., Nordberg, A., Bäckman, L., Albert, M., Almkvist, O., Arai, H., Basun, H., Blennow, K., De Leon, M., DeCarli, C., Erkinjuntti, T., Giacobini, E., Graff, C., Hardy, J., Jack, C., Jorm, A., Ritchie, K., Van Duijn, C., Visser, P., & Petersen, R. C.
- Affiliations
- Karolinska Institutet (SE)
- Johns Hopkins University (US)
- Tohoku University (JP)
- Uppsala University (SE)
- University of Gothenburg (SE)
- University of California, Davis (US)
- University of Helsinki (FI)
- University of Geneva (CH)
- National Institutes of Health (US)
- Mayo Clinic (US)
- Australian National University (AU)
- Inserm (FR)
- Maastricht University (NL)
- Corresponding author
- Winblad, B.
- ORCID
- Venue
- Journal of Internal Medicine
- Publisher
- Wiley
- Published
- 2004-08-20
- Volume
- 256
- Issue
- 3
- Pages
- 240-246
- ISSN
- 0954-6820 (ISSN-L)
- 1365-2796
- OpenAlex
- W2055649795
- Cited by
- 4,946
- References
- 0
- Citations by year
- 2026: 157 · 2025: 234 · 2024: 272 · 2023: 228 · 2022: 267 · 2021: 271 · 2020: 306 · 2019: 292 · 2018: 248 · 2017: 263 · 2016: 267 · 2015: 284 · 2014: 256 · 2013: 263 · 2012: 254
- FWCI
- 54.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Max Planck Digital Library (submittedVersion)
- ANU Open Research (Australian National University) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- mild cognitive impairment, diagnostic criteria, cognitive decline, activities of daily living, functional assessment, neuroimaging, biomarkers, dementia prevention, clinical management guidelines
- MeSH terms
- Aged, Cognition Disorders, Diagnostic Imaging, Humans, Neuropsychological Tests, Biomarkers, Biomedical Research
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