Cited by 302Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCancer-related cognitive impairment studies

Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment

Arnáiz, E., Jelic, V., Almkvist, O., Wahlund, L-O., Winblad, B., Valind, S., Nordberg, A.·2001·Neuroreport

Abstract

The objective of this study was to assess whether reduced glucose metabolism (rCMRGlu) and cognitive functioning could predict development of Alzheimer's disease (AD) in subjects with mild cognitive impairment (MCI). Twenty MCI patients underwent baseline and follow-up investigations of rCMRGlu, as measured by PET, and cognitive function measured by neuropsychological test assessments. Subjects were clinically followed up with an average interval of 36.5 months. Two groups were obtained after the second clinical assessment. Nine patients were diagnosed as AD and classified as progressive MCI (P-MCI), whereas 11 patients remained clinically stable and were classified as stable MCI (S-MCI). There were no differences in demographic variables or baseline MMSE between the two subgroups. Logistic regression indicated the two variables that most effectively predicted future development of AD were rCMRGlu from the left temporoparietal area and performance on the block design. These combined measures gave an optimal 90% correct classification rate, whereas only rCMRGlu or neuropsychology alone gave 75% and 65% correct classification, respectively. Measures of temporoparietal cerebral metabolism and visuospatial function may aid in predicting the evolution to AD for patients with MCI.

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Crossref · 10.1097/00001756-200103260-00045

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Authors
Arnáiz, E., Jelic, V., Almkvist, O., Wahlund, L.-O., Winblad, B., Valind, S., & Nordberg, A.
Affiliations
  • Karolinska Institutet (SE)
  • Uppsala University (SE)
Venue
Neuroreport
Published
2001-03
Volume
12
Issue
4
Pages
851-855
ISSN
0959-4965 (ISSN-L)
OpenAlex
W2084550552
Cited by
302
References
27
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 1 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 10 · 2015: 12 · 2014: 12 · 2013: 9 · 2012: 14
FWCI
16.53
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroreport (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
Keywords
mild cognitive impairment, Alzheimer's disease, brain glucose metabolism, disease progression prediction, visuospatial ability, block designs, FDG-PET, cognitive decline
MeSH terms
Aged, Alzheimer Disease, Cerebral Cortex, Cognition Disorders, Female, Glucose, Humans, Male, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Tomography, Emission-Computed, Logistic Models

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