Impaired cerebral glucose metabolism and cognitive functioning predict deterioration in mild cognitive impairment
Abstract
The objective of this study was to assess whether reduced glucose metabolism (rCMRGlu) and cognitive functioning could predict development of Alzheimer's disease (AD) in subjects with mild cognitive impairment (MCI). Twenty MCI patients underwent baseline and follow-up investigations of rCMRGlu, as measured by PET, and cognitive function measured by neuropsychological test assessments. Subjects were clinically followed up with an average interval of 36.5 months. Two groups were obtained after the second clinical assessment. Nine patients were diagnosed as AD and classified as progressive MCI (P-MCI), whereas 11 patients remained clinically stable and were classified as stable MCI (S-MCI). There were no differences in demographic variables or baseline MMSE between the two subgroups. Logistic regression indicated the two variables that most effectively predicted future development of AD were rCMRGlu from the left temporoparietal area and performance on the block design. These combined measures gave an optimal 90% correct classification rate, whereas only rCMRGlu or neuropsychology alone gave 75% and 65% correct classification, respectively. Measures of temporoparietal cerebral metabolism and visuospatial function may aid in predicting the evolution to AD for patients with MCI.
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Others have observed that temporo-parietal METglu deficits predict AD.
“Others have observed that temporo-parietal METglu deficits predict AD (18–20).”
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- Authors
- Arnáiz, E., Jelic, V., Almkvist, O., Wahlund, L.-O., Winblad, B., Valind, S., & Nordberg, A.
- Affiliations
- Karolinska Institutet (SE)
- Uppsala University (SE)
- Venue
- Neuroreport
- Published
- 2001-03
- Volume
- 12
- Issue
- 4
- Pages
- 851-855
- ISSN
- 0959-4965 (ISSN-L)
- OpenAlex
- W2084550552
- Cited by
- 302
- References
- 27
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 1 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 10 · 2015: 12 · 2014: 12 · 2013: 9 · 2012: 14
- FWCI
- 16.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroreport (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- mild cognitive impairment, Alzheimer's disease, brain glucose metabolism, disease progression prediction, visuospatial ability, block designs, FDG-PET, cognitive decline
- MeSH terms
- Aged, Alzheimer Disease, Cerebral Cortex, Cognition Disorders, Female, Glucose, Humans, Male, Middle Aged, Neuropsychological Tests, Predictive Value of Tests, Tomography, Emission-Computed, Logistic Models
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