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An altered neural response to reward may contribute to alcohol problems among late adolescents with an evening chronotype
Open accessAbstract
Evening chronotypes not only differ from morning-types in their sleep and circadian timing, but they are prone to problematic outcomes involving reward function, including affective disturbance, sensation seeking, and substance involvement. We explored the neural mechanisms underlying these chronotype differences by comparing the neural response to reward in morning- and evening-types. Using a monetary reward fMRI paradigm, we compared the neural response to reward in 13 morning-types and 21 evening-types (all 20 y/o males). Region-of-interest (ROI) analyses focused on the medial prefrontal cortex (mPFC) and ventral striatum (VS), comparing the chronotype groups in these ROIs during anticipation and outcome conditions, and adjusting for time of scan. Chronotype groups were also compared on measures of sensation-seeking, substance involvement, and sleep quality. Evening-types reported significantly greater levels of alcohol dependence and worse sleep quality. Furthermore, evening-types showed an altered neural response to reward relative to morning-types, specifically, reduced mPFC reactivity during reward anticipation and increased VS reactivity during win outcome. In turn, less activation in the mPFC region in response to reward was associated with greater alcohol consumption, while increased activation in the VS in response to reward was associated with more symptoms of alcohol dependence. Increased reward-related problems among evening-types may be accompanied by altered neural responses to reward.
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“In an age-matched cohort of late adolescents, greater VS responses to reward outcome and reduced mPFC responses to reward anticipation are associated with eveningness179 and may predict alcohol dependence167, further suggesting that certain circadian phenotypes emerging during early to late adolescence could contribute to vulnerability to substance use.”
From Rhythms of life: circadian disruption and brain disorders across the lifespan (2019) · cites this paper as [179]
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“These changes in sleep timing and chronotype are associated with altered reward-related brain function in adolescents (80–82).”
From Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents (2018) · cites this paper as [80]
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Metadata
- Authors
- Hasler, B. P., Sitnick, S. L., Shaw, D. S., & Forbes, E. E.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 214
- Issue
- 3
- Pages
- 357-364
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC3852171
- OpenAlex
- W2050982997
- Cited by
- 130
- References
- 51
- Citations by year
- 2026: 4 · 2025: 11 · 2024: 18 · 2023: 9 · 2022: 13 · 2021: 11 · 2020: 9 · 2019: 10 · 2018: 9 · 2017: 12 · 2016: 11 · 2015: 9 · 2014: 4
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Pittsburgh
- National Institutes of Health
- National Heart, Lung, and Blood Institute (T32HL082610)
- National Institute on Drug Abuse (K01DA032557, R01DA026222, DA026222)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- chronotype, evening chronotype, reward processing, alcoholism, alcohol consumption, sensation seeking, sleep quality, circadian rhythm, medial prefrontal cortex, ventral striatum, reward anticipation, late adolescence, substance use
- MeSH terms
- Activity Cycles, Alcohol Drinking, Brain Mapping, Corpus Striatum, Female, Humans, Magnetic Resonance Imaging, Male, Motivation, Reward, Sleep, Time Factors, Prefrontal Cortex, Alcohol-Related Disorders, Young Adult, Anticipation, Psychological
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