FMRI visualization of brain activity during a monetary incentive delay task

Knutson, Brian; Westdorp, Andrew; Kaiser, Erica; Hommer, Daniel

doi:10.1006/nimg.2000.0593

Cited by 1,414Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorGambling Behavior and Treatments

FMRI visualization of brain activity during a monetary incentive delay task

Knutson, Brian, Westdorp, Andrew, Kaiser, Erica, Hommer, Daniel·2000·NeuroImage

DOI 10.1006/nimg.2000.0593

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Abstract

Comparative studies have implicated striatal and mesial forebrain circuitry in the generation of autonomic, endocrine, and behavioral responses for incentives. Using blood oxygen level-dependent functional magnetic resonance imaging, we sought to visualize functional activation of these regions in 12 normal volunteers as they anticipated and responded for monetary incentives. Both individual and group analyses of time-series data revealed significant activation of striatal and mesial forebrain structures (including insula, caudate, putamen, and mesial prefrontal cortex) during trials involving both monetary rewards and punishments. In addition to these areas, during trials involving punishment, group analysis revealed activation foci in the anterior cingulate and thalamus. These results corroborate comparative studies which implicate striatal and mesial forebrain circuitry in the elaboration of incentive-driven behavior. This report also introduces a new paradigm for probing the functional integrity of this circuitry in humans.

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These tasks each include an anticipation phase and a delivery phase; brain activity during these phases is used to infer motivation and reward responsiveness, respectively.
“Both tasks have two phases, an anticipation phase, in which the subject is given information about the potential for reward, and a delivery phase, in which the reward is received. By measuring brain activity during the anticipation and delivery phases, a motivational component and a reward responsiveness component can be inferred, respectively (Knutson et al., 2000; Lutz and Widmer, 2014; Wang et”
From The effects of early life stress on reward processing (2018) · cites this paper as Knutson et al., 2000
The ventral striatum plays a role in affective reactivity.
“The VS plays a role in affective reactivity (Knutson, Westdorp, Kaiser, & Hommer, 2000; Sescousse, Caldu, Segura, & Dreher, 2013; Jensen et al., 2003; Levita et al., 2009)”
From Feeling left out or just surprised? Neural correlates of social exclusion and overinclusion in adolescence (2020) · cites this paper as Knutson, Westdorp, Kaiser, & Hommer, 2000
The VS is known for processing both rewarding and aversive stimuli, and increases in VS responses to social stimuli have been associated with reduced susceptibility to peer influences.
“This region is known for processing both rewarding (Knutson et al., 2000; Sescousse et al., 2013) and aversive stimuli (Jensen et al., 2003; Levita et al., 2009), and increases in VS responses to social stimuli have been associated with reduced susceptibility to peer influences (Pfeifer et al., 2011).”
From Feeling left out or just surprised? Neural correlates of social exclusion and overinclusion in adolescence (2020) · cites this paper as Knutson et al., 2000

Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798 · see citing works
AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913 · see citing works
A neural substrate of prediction and reward
Schultz, W., Dayan, P., & Montague, P. R. (1997) · Science · doi:10.1126/science.275.5306.1593 · Cited by 9,388 · see citing works
Untitled work
(1998) · Cited by 4,012 · see citing works
The functional neuroanatomy of emotion and affective style
Davidson, R. J., & Irwin, W. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(98)01265-0 · Cited by 1,684 · see citing works
The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking
Ikemoto, S., & Panksepp, J. (1999) · Brain Research Reviews · doi:10.1016/s0165-0173(99)00023-5 · Cited by 1,450 · see citing works
Human amygdala activation during conditioned fear acquisition and extinction: a mixed-trial fMRI study
LaBar, K. S., Gatenby, J. C., Gore, J. C., LeDoux, J. E., & Phelps, E. A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80475-4 · Cited by 1,402 · see citing works
Evidence for striatal dopamine release during a video game
Koepp, M. J., Gunn, R. N., Lawrence, A. D., Cunningham, V. J., Dagher, A., Jones, T., Brooks, D. J., Bench, C. J., & Grasby, P. M. (1998) · Nature · doi:10.1038/30498 · Cited by 1,279 · see citing works
Acute effects of cocaine on human brain activity and emotion
Breiter, H. C., Gollub, R. L., Weisskoff, R. M., Kennedy, D. N., Makris, N., Berke, J. D., Goodman, J. M., Kantor, H. L., Gastfriend, D. R., Riorden, J. P., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80374-8 · Cited by 1,270 · see citing works
Dissociating pain from its anticipation in the human brain
Ploghaus, A., Tracey, I., Gati, J. S., Clare, S., Menon, R. S., Matthews, P. M., & Rawlins, J. N. P. (1999) · Science · doi:10.1126/science.284.5422.1979 · Cited by 1,151 · see citing works
Central regulation of autonomic functions
(1991) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(91)90107-h · Cited by 1,115 · see citing works
Preferential activation of midbrain dopamine neurons by appetitive rather than aversive stimuli
Mirenowicz, J., & Schultz, W. (1996) · Nature · doi:10.1038/379449a0 · Cited by 829 · see citing works
Functional organization of human supplementary motor cortex studied by electrical stimulation
Fried, I., Katz, A., McCarthy, G., Sass, K., Williamson, P., Spencer, S., & Spencer, D. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-11-03656.1991 · Cited by 791 · see citing works
The involvement of nucleus accumbens dopamine in appetitive and aversive motivation
Salamone, J. D. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90153-8 · Cited by 584 · see citing works
The supplementary motor area in the cerebral cortex
Tanji, J. (1994) · Neuroscience Research · doi:10.1016/0168-0102(94)90038-8 · Cited by 583 · see citing works
Chemoarchitecture of the Brain
Nieuwenhuys, R. (1985) · Springer eBooks · doi:10.1007/978-3-642-70426-0 · Cited by 500 · see citing works
Chemoarchitecture of the brain
(1987) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(87)90305-7 · Cited by 416 · see citing works
Amygdala–Hippocampal Involvement in Human Aversive Trace Conditioning Revealed through Event-Related Functional Magnetic Resonance Imaging
Büchel, C., Dolan, R. J., Armony, J. L., & Friston, K. J. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-24-10869.1999 · Cited by 404 · see citing works
Prefrontal Cortical Networks Related to Visceral Function and Mood
Price, J. L. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09278.x · Cited by 397 · see citing works
Human Cerebral Cortex: Localization, Parcellation, and Morphometry with Magnetic Resonance Imaging
Rademacher, J., Galaburda, A. M., Kennedy, D. N., Filipek, P. A., & Caviness, V. S. (1992) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1992.4.4.352 · Cited by 376 · see citing works
Dissociation of dopamine release in the nucleus accumbens from intracranial self-stimulation
Garris, P. A., Kilpatrick, M., Bunin, M. A., Michael, D., Walker, Q. D., & Wightman, R. M. (1999) · Nature · doi:10.1038/18019 · Cited by 327 · see citing works
Reward prediction in primate basal ganglia and frontal cortex
Schultz, W., Tremblay, L., & Hollerman, J. R. (1998) · Neuropharmacology · doi:10.1016/s0028-3908(98)00071-9 · Cited by 318 · see citing works
Sustained activity in the medial wall during working memory delays
Petit, L., Courtney, S. M., Ungerleider, L. G., & Haxby, J. V. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-22-09429.1998 · Cited by 274 · see citing works
Activation of the human brain by monetary reward
Thut, G., Schultz, W., Roelcke, U., Nienhusmeier, M., Missimer, J. H., Maguire, R. P., & Leenders, K. L. (1997) · Neuroreport · doi:10.1097/00001756-199703240-00033 · Cited by 273 · see citing works
The role of affective processes in learning and motivation.
Young, P. T. (1959) · Psychological Review · doi:10.1037/h0045997 · Cited by 229 · see citing works
An fMRI Version of the Farnsworth-Munsell 100-Hue Test Reveals Multiple Color-selective Areas in Human Ventral Occipitotemporal Cortex
Beauchamp, M. S. (1999) · Cerebral Cortex · doi:10.1093/cercor/9.3.257 · Cited by 214 · see citing works
Functional neuroanatomical correlates of electrodermal activity: A positron emission tomographic study
Fredrikson, M. G., Furmark, T., Olsson, M. T., Fischer, H., Andersson, J., & Långström, B. (1998) · Psychophysiology · doi:10.1111/1469-8986.3520179 · Cited by 198 · see citing works
A multivariate analysis of PET activation studies
Friston, K. J., Poline, J., Holmes, A. P., Frith, C., & Frackowiak, R. S. J. (1996) · Human Brain Mapping · doi:10.1002/(sici)1097-0193(1996)4:2 · Cited by 166 · see citing works
Behavior-Relevant Changes in Nucleus Accumbens Dopamine Transmission Elicited by Food Reinforcement: An Electrochemical Study in Rat
Richardson, N. R., & Gratton, A. P. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-24-08160.1996 · Cited by 160 · see citing works
Evoked Extracellular Dopamine In Vivo in the Medial Prefrontal Cortex
Garris, P. A., Collins, L. B., Jones, S. R., & Wightman, R. M. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb02168.x · Cited by 160 · see citing works
Central regulation of autonomic functions
Loewyand, A. D. (1991) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(91)90165-9 · Cited by 152 · see citing works
Quantifying and Comparing Region-of-Interest Activation Patterns in Functional Brain MR Imaging: Methodology Considerations
Constable, R. T., Skudlarski, P., Mencl, E., Pugh, K. R., Fulbright, R. K., Lacadie, C., Shaywitz, S. E., & Shaywitz, B. A. (1998) · Magnetic Resonance Imaging · doi:10.1016/s0730-725x(97)00278-6 · Cited by 54 · see citing works
Involvement of prefrontal dopamine neurones in behavioural blockade induced by controllable vs uncontrollable negative events in rats
Ravard, S., Carnoy, P., Hervé, D., Tassin, J., Thiébot, M.-H., & Soubrié, P. (1990) · Behavioural Brain Research · doi:10.1016/0166-4328(90)90067-o · Cited by 42 · see citing works
Activation of striatum and amygdala during reward conditioning: An FMRI study
Breiter, H. C., Berke, J. D., Kennedy, W. A., et al. (1996) · NeuroImage · doi:10.1016/s1053-8119(96)80222-9 · Cited by 14 · see citing works
Identifying global anatomical differences: Deformation-based morphometry
(1998) · doi:10.1002/(sici)1097-0193(1998)6:5/6
Prefrontal cortical projections to longitudinal columns in the midbrain periaqueductal gray in Macaque monkeys
An, X., Bandler, R., �ng�r, D., & Price, J. L. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19981130)401:4

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The neural basis of human error processing: Reinforcement learning, dopamine, and the error-related negativity.
Holroyd, C. B., & Coles, M. G. H. (2002) · Psychological Review · doi:10.1037/0033-295x.109.4.679 · Cited by 4,027 · see citing works
The reward circuit: linking primate anatomy and human imaging
Haber, S. N., & Knutson, B. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.129 · Cited by 3,718 · see citing works
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Steinberg, L. (2008) · Developmental Review · doi:10.1016/j.dr.2007.08.002 · Cited by 3,644 · see citing works
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749 · see citing works
A framework for studying the neurobiology of value-based decision making
Rangel, A., Camerer, C., & Montague, P. R. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2357 · Cited by 2,184 · see citing works
Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens
Knutson, B., Adams, C. M., Fong, G. W., & Hommer, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-j0002.2001 · Cited by 2,244 · see citing works
Self-citation
Cortical substrates for exploratory decisions in humans
Daw, N. D., O'Doherty, J. P., Dayan, P., Seymour, B., & Dolan, R. J. (2006) · Nature · doi:10.1038/nature04766 · Cited by 2,224 · see citing works
The integration of negative affect, pain and cognitive control in the cingulate cortex
Shackman, A. J., Salomons, T. V., Slagter, H. A., Fox, A. S., Winter, J. J., & Davidson, R. J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2994 · Cited by 2,082 · see citing works
Model-based influences on humans’ choices and striatal prediction errors
Daw, N. D., Gershman, S. J., Seymour, B., Dayan, P., & Dolan, R. J. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.027 · Cited by 1,779 · see citing works
The Medial Frontal Cortex and the Rapid Processing of Monetary Gains and Losses
Gehring, W. J., & Willoughby, A. R. (2002) · Science · doi:10.1126/science.1066893 · Cited by 1,884 · see citing works
The Neural Basis of Altruistic Punishment
de Quervain, D. J.-F., Fischbacher, U., Treyer, V., Schellhammer, M., Schnyder, U., Buck, A., & Fehr, E. (2004) · Science · doi:10.1126/science.1100735 · Cited by 1,768 · see citing works
Functional imaging of neural responses to expectancy and experience of monetary gains and losses
Breiter, H. C., Aharon, I., Kahneman, D., Dale, A., & Shizgal, P. (2001) · Neuron · doi:10.1016/s0896-6273(01)00303-8 · Cited by 1,404 · see citing works
Dissociation of reward anticipation and outcome with event-related fMRI
Knutson, B., Fong, G. W., Adams, C. M., Varner, J. L., & Hommer, D. (2001) · Neuroreport · doi:10.1097/00001756-200112040-00016 · Cited by 1,300 · see citing works
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Aharon, I., Etcoff, N., Ariely, D., Chabris, C. F., O'Connor, E., & Breiter, H. C. (2001) · Neuron · doi:10.1016/s0896-6273(01)00491-3 · Cited by 1,087 · see citing works
Neural responses during anticipation of a primary taste reward
O'Doherty, J. P., Deichmann, R., Critchley, H. D., & Dolan, R. J. (2002) · Neuron · doi:10.1016/s0896-6273(02)00603-7 · Cited by 1,076 · see citing works
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Common and distinct networks underlying reward valence and processing stages: A meta-analysis of functional neuroimaging studies
Liu, X., Hairston, J., Schrier, M., & Fan, J. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.12.012 · Cited by 916 · see citing works
The Wick in the Candle of Learning: Epistemic Curiosity Activates Reward Circuitry and Enhances Memory
Kang, M. J., Hsu, M., Krajbich, I. M., Loewenstein, G., McClure, S. M., Wang, J. T.-Y., & Camerer, C. F. (2009) · Psychological Science · doi:10.1111/j.1467-9280.2009.02402.x · Cited by 882 · see citing works
“This interpretation is consistent with the recent finding that unexpected punishments and unexpected rewards produce very similar BOLD responses in the putamen at the time of outcomes (Knutson et al., 2000; Seymour, Daw, Dayan, Singer, & Dolan, 2007).”
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Izuma, K., Saito, D. N., & Sadato, N. (2008) · Neuron · doi:10.1016/j.neuron.2008.03.020 · Cited by 855 · see citing works
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Schacter, D. L., Addis, D. R., & Buckner, R. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.001 · Cited by 840 · see citing works
Functional magnetic resonance imaging of reward prediction
Knutson, B., & Cooper, J. C. (2005) · Current Opinion in Neurology · doi:10.1097/01.wco.0000173463.24758.f6 · Cited by 736 · see citing works
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Wittmann, B. C., Schott, B. H., Guderian, S., Frey, J. U., Heinze, H.-J., & Düzel, E. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.010 · Cited by 698 · see citing works
Neural differentiation of expected reward and risk in human subcortical structures
Preuschoff, K., Bossaerts, P., & Quartz, S. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.06.024 · Cited by 692 · see citing works
BOLD responses reflecting dopaminergic signals in the human ventral tegmental area
D'Ardenne, K., McClure, S. M., Nystrom, L. E., & Cohen, J. D. (2008) · Science · doi:10.1126/science.1150605 · Cited by 661 · see citing works
Amygdala and nucleus accumbens in responses to receipt and omission of gains in adults and adolescents.
Ernst, M., Nelson, E. E., Jazbec, S., McClure, E. B., Monk, C. S., Leibenluft, E., Blair, J., & Pine, D. S. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.12.038 · Cited by 635 · see citing works
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Rizvi, S. J., Pizzagalli, D. A., Sproule, B. A., & Kennedy, S. H. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.03.004 · Cited by 571 · see citing works
The Neural Signature of Social Norm Compliance
Spitzer, M., Fischbacher, U., Herrnberger, B., Grön, G., & Fehr, E. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.011 · Cited by 584 · see citing works
Basal ganglia functional connectivity based on a meta-analysis of 126 positron emission tomography and functional magnetic resonance imaging publications
Postuma, R. B., & Dagher, A. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj088 · Cited by 579 · see citing works
Disclosing information about the self is intrinsically rewarding
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Incentive-elicited brain activation in adolescents: Similarities and differences from young adults
Bjork, J. M., Knutson, B., Fong, G. W., Caggiano, D. M., Bennett, S. M., & Hommer, D. W. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4862-03.2004 · Cited by 567 · see citing works
Self-citation
Reinforcement-related brain potentials from medial frontal cortex: Origins and functional significance
Nieuwenhuis, S., Holroyd, C. B., Mol, N., & Coles, M. G. H. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.05.003 · Cited by 557 · see citing works
Reward Processing in Depression: A Conceptual and Meta-Analytic Review Across fMRI and EEG Studies
Keren, H., O’Callaghan, G., Vidal-Ribas, P., Buzzell, G. A., Brotman, M. A., Leibenluft, E., Pan, P. M., Meffert, L., Kaiser, A., Wolke, S., et al. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17101124 · Cited by 521 · see citing works
Diffusion tensor fiber tracking shows distinct corticostriatal circuits in humans
Lehéricy, S., Ducros, M., Van De Moortele, P., Francois, C., Thivard, L., Poupon, C., Swindale, N., Ugurbil, K., & Kim, D. (2004) · Annals of Neurology · doi:10.1002/ana.20030 · Cited by 542 · see citing works
Placebo Analgesia: A Predictive Coding Perspective
Büchel, C., Geuter, S., Sprenger, C., & Eippert, F. (2014) · Neuron · doi:10.1016/j.neuron.2014.02.042 · Cited by 505 · see citing works
ERP Correlates of Feedback and Reward Processing in the Presence and Absence of Response Choice
Yeung, N., Holroyd, C. B., & Cohen, J. D. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhh153 · Cited by 520 · see citing works
Neural Responses to Monetary Incentives in Major Depression
Knutson, B., Bhanji, J. P., Cooney, R. E., Atlas, L. Y., & Gotlib, I. H. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.07.023 · Cited by 496 · see citing works
Self-citation
The neural substrates of reward processing in humans: the modern role of FMRI
McClure, S. M., York, M. K., & Montague, P. R. (2004) · The Neuroscientist · doi:10.1177/1073858404263526 · Cited by 480 · see citing works
Sleep deprivation amplifies reactivity of brain reward networks, biasing the appraisal of positive emotional experiences
Gujar, N., Yoo, S.-S., Hu, P., & Walker, M. P. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3220-10.2011 · Cited by 491 · see citing works
Age differences in affective decision making as indexed by performance on the Iowa gambling task
Cauffman, E., Shulman, E. P., Steinberg, L., Claus, E., Banich, M. T., Graham, S., & Woolard, J. (2010) · Developmental Psychology · doi:10.1037/a0016128 · Cited by 488 · see citing works
Individual differences in reward responding explain placebo-induced expectations and effects
Scott, D. J., Stohler, C. S., Egnatuk, C. M., Wang, H., Koeppe, R. A., & Zubieta, J.-K. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.028 · Cited by 466 · see citing works
Ventral–striatal responsiveness during reward anticipation in ADHD and its relation to trait impulsivity in the healthy population: A meta-analytic review of the fMRI literature
Plichta, M. M., & Scheres, A. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.07.012 · Cited by 424 · see citing works
Dorsal striatum responses to reward and punishment: effects of valence and magnitude manipulations
DELGADO, M. R., LOCKE, H. M., STENGER, V. A., & FIEZ, J. A. (2003) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.3.1.27 · Cited by 431 · see citing works
Anticipation of monetary and social reward differently activates mesolimbic brain structures in men and women
Spreckelmeyer, K. N., Krach, S., Kohls, G., Rademacher, L., Irmak, A., Konrad, K., Kircher, T., & Gründer, G. (2009) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsn051 · Cited by 425 · see citing works
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Schönberg, T., Daw, N. D., Joel, D., & O'Doherty, J. P. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2496-07.2007 · Cited by 390 · see citing works
Having a word with yourself: neural correlates of self-criticism and self-reassurance.
Longe, O., Maratos, F. A., Gilbert, P., Evans, G., Volker, F., Rockliff, H., & Rippon, G. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.09.019 · Cited by 403 · see citing works
Orbitofrontal cortex tracks positive mood in mothers viewing pictures of their newborn infants
Nitschke, J. B., Nelson, E. E., Rusch, B. D., Fox, A. S., Oakes, T. R., & Davidson, R. J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2003.10.005 · Cited by 371 · see citing works
Social Influence Modulates the Neural Computation of Value
Zaki, J., Schirmer, J., & Mitchell, J. P. (2011) · Psychological Science · doi:10.1177/0956797611411057 · Cited by 359 · see citing works
Dissociation of neural networks for anticipation and consumption of monetary and social rewards
Rademacher, L., Krach, S., Kohls, G., Irmak, A., Gründer, G., & Spreckelmeyer, K. N. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.089 · Cited by 347 · see citing works
Smoking and structural brain deficits: a volumetric MR investigation
Gallinat, J., Meisenzahl, E., Jacobsen, L. K., Kalus, P., Bierbrauer, J., Kienast, T., Witthaus, H., Leopold, K., Seifert, F., Schubert, F., et al. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05050.x · Cited by 330 · see citing works
Diminished Frontostriatal Activity During Processing of Monetary Rewards and Losses in Pathological Gambling
Balodis, I. M., Kober, H., Worhunsky, P. D., Stevens, M. C., Pearlson, G. D., & Potenza, M. N. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.006 · Cited by 305 · see citing works
Reward circuitry function in autism spectrum disorders
Dichter, G. S., Felder, J. N., Green, S. R., Rittenberg, A. M., Sasson, N. J., & Bodfish, J. W. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq095 · Cited by 296 · see citing works
Entering adolescence: resistance to peer influence, risky behavior, and neural changes in emotion reactivity
Pfeifer, J. H., Masten, C. L., Moore, W. E., Oswald, T. M., Mazziotta, J. C., Iacoboni, M., & Dapretto, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.02.019 · Cited by 294 · see citing works
Striatum-medial prefrontal cortex connectivity predicts developmental changes in reinforcement learning
van den Bos, W., Cohen, M. X., Kahnt, T., & Crone, E. A. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhr198 · Cited by 276 · see citing works
Learning-related changes in reward expectancy are reflected in the feedback-related negativity
Bellebaum, C., & Daum, I. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06138.x · Cited by 299 · see citing works
Striatal activity underlies novelty-based choice in humans
Wittmann, B. C., Daw, N. D., Seymour, B., & Dolan, R. J. (2008) · Neuron · doi:10.1016/j.neuron.2008.04.027 · Cited by 277 · see citing works
Processing of the incentive for social approval in the ventral striatum during charitable donation
Izuma, K., Saito, D. N., & Sadato, N. (2010) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2009.21228 · Cited by 276 · see citing works
Anticipatory reward processing in addicted populations: a focus on the monetary incentive delay task
Balodis, I. M., & Potenza, M. N. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.08.020 · Cited by 267 · see citing works
Is Decreased Prefrontal Cortical Sensitivity to Monetary Reward Associated With Impaired Motivation and Self-Control in Cocaine Addiction?
Goldstein, R. Z., Alia-Klein, N., Tomasi, D., Zhang, L., Cottone, L. A., Maloney, T., Telang, F., Caparelli, E. C., Chang, L., Ernst, T., et al. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.1.43 · Cited by 258 · see citing works
The stress-buffering effect of acute exercise: evidence for HPA axis negative feedback
Zschucke, E., Renneberg, B., Dimeo, F., Wüstenberg, T., & Ströhle, A. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.10.019 · Cited by 253 · see citing works
Differentiating frontostriatal and fronto-cerebellar circuits in attention-deficit/hyperactivity disorder
Durston, S., van Belle, J., & de Zeeuw, P. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.07.037 · Cited by 248 · see citing works
Motivation-dependent responses in the human caudate nucleus.
Delgado, M. R. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh062 · Cited by 246 · see citing works
Monetary Incentives Enhance Processing in Brain Regions Mediating Top-down Control of Attention
Small, D. M., Gitelman, D., Simmons, K., Bloise, S. M., Parrish, T., & Mesulam, M.-M. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhi063 · Cited by 242 · see citing works
A randomized proof-of-mechanism trial applying the ‘fast-fail’ approach to evaluating κ-opioid antagonism as a treatment for anhedonia
Krystal, A. D., Pizzagalli, D. A., Smoski, M., Mathew, S. J., Nurnberger, J., Lisanby, S. H., Iosifescu, D., Murrough, J. W., Yang, H., Weiner, R. D., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0806-7 · Cited by 227 · see citing works
The maturation of incentive processing and cognitive control
Geier, C., & Luna, B. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.01.021 · Cited by 225 · see citing works
Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia
Barch, D. M., Pagliaccio, D., & Luking, K. (2015) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2015_376 · Cited by 218 · see citing works
Social Manipulation of Preference in the Human Brain
Izuma, K., & Adolphs, R. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.023 · Cited by 224 · see citing works
Lower Ventral Striatal Activation During Reward Anticipation in Adolescent Smokers
Peters, J., Bromberg, U., Schneider, S., Brassen, S., Menz, M., Banaschewski, T., Conrod, P. J., Flor, H., Gallinat, J., Garavan, H., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10071024 · Cited by 218 · see citing works
Reward circuitry function in autism during face anticipation and outcomes
Dichter, G. S., Richey, J. A., Rittenberg, A. M., Sabatino, A., & Bodfish, J. W. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-011-1221-1 · Cited by 222 · see citing works
Striatal functional alteration in adolescents characterized by early childhood behavioral inhibition
Guyer, A. E., Nelson, E. E., Perez-Edgar, K., Hardin, M. G., Roberson-Nay, R., Monk, C. S., Bjork, J. M., Henderson, H. A., Pine, D. S., Fox, N. A., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0666-06.2006 · Cited by 211 · see citing works
Characterizing anhedonia: A systematic review of neuroimaging across the subtypes of reward processing deficits in depression
Borsini, A., Wallis, A. S. J., Zunszain, P., Pariante, C. M., & Kempton, M. J. (2020) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/s13415-020-00804-6 · Cited by 207 · see citing works
Developmental changes in brain function underlying the influence of reward processing on inhibitory control
Padmanabhan, A., Geier, C. F., Ordaz, S. J., Teslovich, T., & Luna, B. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.06.004 · Cited by 202 · see citing works
Separate neural representations of prediction error valence and surprise: Evidence from an fMRI meta‐analysis
Fouragnan, E., Retzler, C., & Philiastides, M. G. (2018) · Human Brain Mapping · doi:10.1002/hbm.24047 · Cited by 176 · see citing works
The effects of early life stress on reward processing
Novick, A. M., Levandowski, M. L., Laumann, L. E., Philip, N. S., Price, L. H., & Tyrka, A. R. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.02.002 · Cited by 192 · see citing works
“By measuring brain activity during the anticipation and delivery phases, a motivational component and a reward responsiveness component can be inferred, respectively (Knutson et al., 2000; Lutz and Widmer, 2014; Wang et al., 2016).”
Background
Social “wanting” dysfunction in autism: neurobiological underpinnings and treatment implications
Kohls, G., Chevallier, C., Troiani, V., & Schultz, R. T. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-10 · Cited by 197 · see citing works
Early childhood stress exposure, reward pathways, and adult decision making
Birn, R. M., Roeber, B. J., & Pollak, S. D. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1708791114 · Cited by 197 · see citing works
Reduced functional connectivity within the limbic cortico-striato-thalamo-cortical loop in unmedicated adults with obsessive-compulsive disorder
Posner, J., Marsh, R., Maia, T. V., Peterson, B. S., Gruber, A., & Simpson, H. B. (2014) · Human Brain Mapping · doi:10.1002/hbm.22371 · Cited by 197 · see citing works
The rewarding nature of social interactions.
Krach, S. (2010) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2010.00022 · Cited by 196 · see citing works
Risk taking and the adolescent reward system: A potential common link to substance abuse
Schneider, S., Peters, J., Bromberg, U., Brassen, S., Miedl, S. F., Banaschewski, T., Barker, G. J., Conrod, P., Flor, H., Garavan, H., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11030489 · Cited by 186 · see citing works
Overlapping Responses for the Expectation of Juice and Money Rewards in Human Ventromedial Prefrontal Cortex
Kim, H., Shimojo, S., & O'Doherty, J. P. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq145 · Cited by 176 · see citing works
Individuals Family History Positive for Alcoholism Show Functional Magnetic Resonance Imaging Differences in Reward Sensitivity That Are Related to Impulsivity Factors
Andrews, M. M., Meda, S. A., Thomas, A. D., Potenza, M. N., Krystal, J. H., Worhunsky, P., Stevens, M. C., O'Malley, S., Book, G. A., Reynolds, B., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.049 · Cited by 181 · see citing works
Social and monetary reward processing in autism spectrum disorders
Delmonte, S., Balsters, J. H., McGrath, J., Fitzgerald, J., Brennan, S., Fagan, A. J., & Gallagher, L. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-7 · Cited by 180 · see citing works
Remitted major depression is characterized by reward network hyperactivation during reward anticipation and hypoactivation during reward outcomes
Dichter, G. S., Kozink, R. V., McClernon, F. J., & Smoski, M. J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.09.048 · Cited by 170 · see citing works
Amphetamine modulates human incentive processing
Knutson, B., Bjork, J. M., Fong, G. W., Hommer, D., Mattay, V. S., & Weinberger, D. R. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.030 · Cited by 174 · see citing works
Self-citation
The nucleus accumbens is involved in both the pursuit of social reward and the avoidance of social punishment
Kohls, G., Perino, M. T., Taylor, J. M., Madva, E. N., Cayless, S. J., Troiani, V., Price, E., Faja, S., Herrington, J. D., & Schultz, R. T. (2013) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2013.07.020 · Cited by 170 · see citing works
Imaging brain response to reward in addictive disorders
Hommer, D. W., Bjork, J. M., & Gilman, J. M. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05898.x · Cited by 163 · see citing works
Self-citation
Neural mechanism of intertemporal choice: From discounting future gains to future losses
Xu, L., Liang, Z.-Y., Wang, K., Li, S., & Jiang, T. (2009) · Brain Research · doi:10.1016/j.brainres.2008.12.061 · Cited by 161 · see citing works
Locus Coeruleus Activity Strengthens Prioritized Memories Under Arousal
Clewett, D. V., Huang, R., Velasco, R., Lee, T.-H., & Mather, M. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.2097-17.2017 · Cited by 152 · see citing works
An Initial Study of Neural Responses to Monetary Incentives as Related to Treatment Outcome in Cocaine Dependence
Jia, Z., Worhunsky, P. D., Carroll, K. M., Rounsaville, B. J., Stevens, M. C., Pearlson, G. D., & Potenza, M. N. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.008 · Cited by 147 · see citing works
The Role of the Amygdala in Signaling Prospective Outcome of Choice
Kahn, I., Yeshurun, Y., Rotshtein, P., Fried, I., Ben-Bashat, D., & Hendler, T. (2002) · Neuron · doi:10.1016/s0896-6273(02)00626-8 · Cited by 141 · see citing works
Reward-related processing in the human brain: developmental considerations
Fareri, D. S., Martin, L. N., & Delgado, M. R. (2008) · Development and Psychopathology · doi:10.1017/s0954579408000576 · Cited by 141 · see citing works
The psychology of internet fraud victimisation: A systematic review
Norris, G., Brookes, A., & Dowell, D. (2019) · Journal of Police and Criminal Psychology · doi:10.1007/s11896-019-09334-5 · Cited by 143 · see citing works
An altered neural response to reward may contribute to alcohol problems among late adolescents with an evening chronotype
Hasler, B. P., Sitnick, S. L., Shaw, D. S., & Forbes, E. E. (2013) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2013.08.005 · Cited by 130 · see citing works
Neuropsychological Sequelae of PTSD and TBI Following War Deployment among OEF/OIF Veterans
Dolan, S., Martindale, S., Robinson, J., Kimbrel, N. A., Meyer, E. C., Kruse, M. I., Morissette, S. B., Young, K. A., & Gulliver, S. B. (2012) · Neuropsychology Review · doi:10.1007/s11065-012-9190-5 · Cited by 126 · see citing works
Blunted ventral striatal responses to anticipated rewards foreshadow problematic drug use in novelty-seeking adolescents
Büchel, C., Peters, J., Banaschewski, T., Bokde, A. L. W., Bromberg, U., Conrod, P. J., Flor, H., Papadopoulos, D., Garavan, H., Gowland, P., et al. (2017) · Nature Communications · doi:10.1038/ncomms14140 · Cited by 118 · see citing works
Self-citation

Sequential bilateral transplantation in Parkinson's
Hagell, P., Schrag, A. E., Piccini, P. P., et al. (1999)
Statistical shape analysis of putamen in early-onset Parkinson’s disease
Sığırlı, D., Özdemir, S. T., Erer, S., Şahin, İ., Ercan, İ., Özpar, R., Örün, M. O., & Hakyemez, B. (2021) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2021.106936 · Cited by 14 · see citing works
Forebrain Development: Holoprosencephaly (HPE)
Monuki, E. S. (2009) · Elsevier eBooks · doi:10.1016/b978-008045046-9.01077-9 · Cited by 2 · see citing works
Regional changes in [18F]dopa metabolism in the striatum in Parkinson's disease
Morrish, P., Sawle, G. V., & Brooks, D. J. (1996) · Brain · doi:10.1093/brain/119.6.2097 · Cited by 153 · see citing works
[MRI scan of striatum volume in healthy adults].
Xu, J., Xu, X., Wang, Q., et al. (2010) · PubMed · doi:10.3785/j.issn.1008-9292.2010.02.004 · Cited by 3 · see citing works

Authors: Knutson, B., Westdorp, A., Kaiser, E., & Hommer, D.
Affiliations: National Institutes of Health (US)
ORCID: Knutson, Brian
Venue: NeuroImage
Publisher: Elsevier BV
Published: 2000-07
Volume: 12
Issue: 1
Pages: 20-27
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1006/nimg.2000.0593
OpenAlex: W1967922673
Cited by: 1,414
References: 36
Citations by year: 2026: 65 · 2025: 62 · 2024: 68 · 2023: 103 · 2022: 101 · 2021: 82 · 2020: 85 · 2019: 86 · 2018: 71 · 2017: 68 · 2016: 64 · 2015: 56 · 2014: 67 · 2013: 55 · 2012: 59
FWCI: 6.01
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
Keywords: monetary incentive delay task, incentive processing, striatum, insula, caudate nucleus, putamen, anterior cingulate cortex, thalamus, reward, punishment, brain activation
MeSH terms: Adult, Brain, Brain Mapping, Cerebrovascular Circulation, Corpus Striatum, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Oxygen, Photic Stimulation, Punishment, Reaction Time, Reward, Thalamus, Prosencephalon

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FMRI visualization of brain activity during a monetary incentive delay task

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