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Cited by 25Schizophrenia research and treatmentAdvanced Neuroimaging Techniques and ApplicationsMental Health and Psychiatry

Cingulum bundle diffusivity and delusions of reference in first episode and chronic schizophrenia

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Fitzsimmons, Jennifer, Schneiderman, Jason S., Whitford, Thomas J., Swisher, Tali, Niznikiewicz, Margaret A., Pelavin, Paula E., Terry, Douglas P., Mesholam-Gately, Raquelle I. +3 more·2014·Psychiatry Research: Neuroimaging
DOI 10.1016/j.pscychresns.2014.08.002PMC PMC4195812
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Abstract

The goal of this study was to assess integrity of the cingulum bundle in patients diagnosed with first episode schizophrenia, chronic schizophrenia, and matched controls as well as to determine the relationship between diffusion measures of cingulum bundle integrity and severity of patients' delusions of reference. Participants, who comprised 18 first episode patients, 20 chronic patients, and two groups of matched controls (20 subjects in each), underwent 3 T MRI diffusion tensor imaging. Patients diagnosed with schizophrenia (chronic+first episode) showed decreased fractional anisotropy in the right cingulum bundle compared with controls. First episode patients exhibited higher trace bilaterally, compared with matched controls, and on the left compared with chronic patients. Axial diffusivity was increased in first episode patients, bilaterally, compared with matched controls and chronic patients. Radial diffusivity was also higher, bilaterally, in first episode patients compared with matched controls, and on the right compared with chronic patients. Trace diffusity and radial diffusivity in first episode patients were significantly correlated with increased severity of delusions of reference. Given that the abnormalities were present only in first episode patients and were not observed in chronic cases, it appears that they normalize over time. These abnormalities in first episode patients involved diffusivity measures in all directions (trace, radial and axial), suggesting a likely acute, partially reversible process in which there is an increase in brain water content, i.e., swelling, edema, or inflammation, that may reflect an early neuroinflammatory response in first episode patients.

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  • In 18 first episode schizophrenia cases, bilateral increases in both axial and radial cingulum diffusivity were found.

    “Similarly, bilateral increases in both axial and radial cingulum diffusivity were found in 18 first episode cases (Fitzsimmons et al., 2014)”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Fitzsimmons et al., 2014

  • In first episode schizophrenia cases, radial cingulum diffusivity correlated with the severity of delusions of reference.

    “with radial diffusivity correlating with the severity of delusions of reference.”

    From The cingulum bundle: Anatomy, function, and dysfunction (2018) · cites this paper as Fitzsimmons et al., 2014

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Authors
Fitzsimmons, J., Schneiderman, J. S., Whitford, T. J., Swisher, T., Niznikiewicz, M. A., Pelavin, P. E., Terry, D. P., Mesholam-Gately, R. I., Seidman, L. J., Goldstein, J. M., & Kubicki, M.
Affiliations
  • Brigham and Women's Hospital (US)
  • VA Boston Healthcare System (US)
  • Beth Israel Deaconess Medical Center (US)
Corresponding author
Fitzsimmons, Jennifer
ORCID
Venue
Psychiatry Research: Neuroimaging
Publisher
Elsevier BV
Published
2014-11
Volume
224
Issue
2
Pages
124-132
ISSN
0925-4927 (ISSN-L)
DOI
10.1016/j.pscychresns.2014.08.002
PMC
PMC4195812
OpenAlex
W2090847113
Cited by
25
References
2
Citations by year
2025: 2 · 2024: 3 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 2
FWCI
2.80
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research Neuroimaging (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (P50MH080272, R01MH050740, NIHP50MH080272, T32MH016259)
  • National Center for Research Resources (UL1RR025758)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
cingulum, delusions of reference, first-episode schizophrenia, chronic schizophrenia, fractional anisotropy, axial diffusivity, radial diffusivity, white matter integrity, neuroinflammation, cerebral edema, diffusion tensor imaging
MeSH terms
Adult, Brain, Brain Mapping, Chronic Disease, Corpus Callosum, Delusions, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Schizophrenia, Anisotropy, Diffusion Tensor Imaging

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