Age-related deficits in fronto-temporal connections in schizophrenia: A diffusion tensor imaging study
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Objective Impairment of white matter connecting frontal and temporal cortices has been reported in schizophrenia. Yet, not much is known about the effects of age on fibers connecting these brain regions. Using diffusion tensor imaging tractography, we investigated the relationship between age and fiber integrity in patients with schizophrenia vs. healthy adults.Methods DTI tractography was used to create 3D reconstructions of the cingulum, uncinate and inferior occipito-frontal fasciculi in 27 patients with schizophrenia and 34 healthy volunteers (23-56 years of age, group-matched on age). Fractional anisotropy (FA), describing fiber integrity, was then calculated along the entire length of these tracts, and correlated with subjects' age.Results Patients revealed a significant decline in FA with age in both the cingulum and uncinate, but not in the inferior occipito-frontal fasciculi. No statistically significant correlations were found in these fiber bundles in controls.Conclusions These results suggest an age-associated reduction of frontal-temporal connectivity in schizophrenia, but not in healthy controls.
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Patients with schizophrenia exhibit structural abnormalities in the cerebral white matter.
“After more than 2 decades of neuroimaging research, it is now well established that patients with schizophrenia exhibit structural abnormalities in the cerebral white matter.”
From Schizophrenia, myelination, and delayed corollary discharges: a hypothesis (2012) · cites this paper as [23]
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- Authors
- ROSENBERGER, G., KUBICKI, M., NESTOR, P., CONNOR, E., BUSHELL, G., MARKANT, D., NIZNIKIEWICZ, M., WESTIN, C., KIKINIS, R., & JSAYKIN, A.
- Affiliations
- Brigham and Women's Hospital (US)
- Harvard University (US)
- Venue
- Schizophrenia Research
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 102
- Issue
- 1-3
- Pages
- 181-188
- ISSN
- 0920-9964 (ISSN-L)
- PMC
- PMC2684860
- OpenAlex
- W2030553916
- Cited by
- 89
- References
- 34
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 2 · 2020: 4 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 10 · 2013: 9 · 2012: 12
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Schizophrenia Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs
- National Alliance for Research on Schizophrenia and Depression
- National Institutes of Health (R01 MH 50747, EB005149)
- National Institute of Mental Health (R01MH058704, R01 MH40799, K05MH070047, K02 K05 MH070047, R01MH050740, R03MH068464, R01MH040799, R01MH 50747)
- National Institute of Biomedical Imaging and Bioengineering (U54EB005149)
- National Center for Research Resources (P41RR013218)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- schizophrenia, age-related decline
- MeSH terms
- Adult, Age Factors, Female, Frontal Lobe, Humans, Functional Laterality, Male, Neural Pathways, Schizophrenia, Schizophrenic Psychology, Temporal Lobe, Anisotropy, Control Groups, Diffusion Magnetic Resonance Imaging
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