Cortical asymmetries in unaffected siblings of patients with obsessive–compulsive disorder
Open accessAbstract
Obsessive-compulsive disorder (OCD) is considered to be associated with atypical brain asymmetry. However, no study has examined the asymmetry in OCD from the perspective of cortical morphometry. This study is aimed to describe the characteristics of cortical asymmetry in OCD patients, and to investigate whether these features exist in their unaffected siblings - a vital step in identifying putative endophenotypes for OCD. A total of 48 subjects (16 OCD patients, 16 unaffected siblings, and 16 matched controls) were recruited who had complete magnetic resonance imaging scans. Left-right hemispheric asymmetries of cortical thickness were measured using a surface-based threshold-free cluster enhancement method. OCD patients and siblings both showed leftward asymmetries of cortical thickness in the anterior cingulate cortex (ACC), which showed a significant positive correlation with compulsive subscale scores. In addition, siblings and healthy controls showed significantly decreased leftward asymmetries in the orbitofrontal cortex (OFC), and the decreased leftward bias in the OFC was accompanied by lower scales on the Yale-Brown Obsessive-Compulsive Scale. To sum up, leftward asymmetries of cortical thickness in the ACC may represent an endophenotype of increased hereditary risk for OCD, while decreased leftward asymmetries of cortical thickness in the OFC may represent a protective factor.
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Patients and their unaffected first-degree relatives show leftward asymmetry of cortical thickness in the anterior cingulate cortex.
“Specifically, patients and their UFDR show leftward asymmetry of cortical thickness in the anterior cingulate cortex (ACC) (Peng et al., 2015).”
From Imbalance between the caudate and putamen connectivity in obsessive–compulsive disorder (2022) · cites this paper as Peng et al., 2015
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- Authors
- Peng, Z., Li, G., Shi, F., Shi, C., Yang, Q., Chan, R. C. K., & Shen, D.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- South China Normal University (CN)
- First Affiliated Hospital of Jinan University (CN)
- Guangzhou Psychiatric Hospital (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Shen, Dinggang
- Venue
- Psychiatry Research: Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 234
- Issue
- 3
- Pages
- 346-351
- ISSN
- 0925-4927 (ISSN-L)
- PMC
- PMC5546124
- OpenAlex
- W1820433113
- Cited by
- 18
- References
- 47
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health (EB006733, EB008374, EB009634, AG041721)
- National Science Fund China Young Investigator Award (81088001)
- National Key Technologies R&D Program (2012BAI36B01)
- National Natural Science Foundation of China (81201049)
- Knowledge Innovation Project of the Chinese Academy of Sciences (KSCX2-EW-J-8)
- CAS/SAFEA International Partnership Programme for Creative Research
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- obsessive-compulsive disorder, hemispheric lateralization, cortical thickness, endophenotypes, unaffected siblings, anterior cingulate cortex, orbitofrontal cortex, compulsive symptoms, heritability, protective factors
- MeSH terms
- Adult, Brain, Brain Mapping, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Obsessive-Compulsive Disorder, Case-Control Studies, Prefrontal Cortex, Siblings, Endophenotypes
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