Grey matter abnormalities in obsessive–compulsive disorder: Statistical parametric mapping of segmented magnetic resonance images
Open accessAbstract
Background: Although a number of functional imaging studies are in agreement in suggesting orbitofrontal and subcortical hyperfunction in the pathophysiology of obsessive–compulsive disorder (OCD), the structural findings have been contradictory. Aims: To investigate grey matter abnormalities in patients with OCD by employing a novel voxel-based analysis of magnetic resonance images. Method: Statistical parametric mapping was utilised to compare segmented grey matter images from 25 patients with OCD with those from 25 matched controls. Results: Increased regional grey matter density was found in multiple cortical areas, including the left orbitofrontal cortex, and in subcortical areas, including the thalamus. On the other hand, regions of reduction were confined to posterior parts of the brain, such as the left cuneus and the left cerebellum. Conclusions: Increased grey matter density of frontal–subcortical circuits, consonant with the hypermetabolic findings from functional imaging studies, seems to exist in patients with OCD, and cerebellar dysfunction may be involved in the pathophysiology of OCD.
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In adult obsessive-compulsive disorder, deficits exist during similar and even identical tasks of motor inhibition, interference inhibition and cognitive switching.
“contrast with findings in adult OCD of deficits during similar and even identical tasks of motor inhibition, interference inhibition and cognitive switching. 1,2”
From Brain activation in paediatric obsessive-compulsive disorder during tasks of inhibitory control (2008) · cites this paper as [2]
In “Parietal and cerebellar involvements in OCD” (page unavailable), the paper discusses abnormal neuropsychological performance and possible executive deficits in OCD. It does not report deficits on motor-inhibition, interference-inhibition, or cognitive-switching tasks, let alone establish that the tasks were similar or identical. (LLM, conf=0.82)
Experimental — accuracy not yet measuredDeficits in selective attention and cognitive flexibility, not only inhibitory functions, have been found in adult patients with obsessive-compulsive disorder.
“Deficits in selective attention and cognitive flexibility, not just inhibitory functions, have been found in adult patients with OCD. 1,2”
From Brain activation in paediatric obsessive-compulsive disorder during tasks of inhibitory control (2008) · cites this paper as [2]
In “Parietal and cerebellar involvements in OCD,” the paper discusses cognitive deficits in OCD, including executive dysfunction, and refers to abnormal neuropsychological performance. It does not specifically report deficits in selective attention or cognitive flexibility; its proposed link between cerebellar changes and cognitive deficits is described as speculative. (LLM, conf=0.77)
Experimental — accuracy not yet measuredIn adult obsessive-compulsive disorder, evidence indicates abnormalities in inhibitory functions such as motor and interference inhibition and task switching, as well as in frontostriatothalamic networks.
“In adult obsessive-compulsive disorder (OCD) there is evidence of abnormalities in inhibitory functions such as motor and interference inhibition and task switching, 1,2 as well as in mediating frontostriatothalamic networks. [3][4]4][5]”
From Brain activation in paediatric obsessive-compulsive disorder during tasks of inhibitory control (2008) · cites this paper as [2]
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- Authors
- Kim, J.-J., Lee, M. C., Kim, J., Kim, I. Y., Kim, S. I., Han, M. H., Chang, K.-H., & Kwon, J. S.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Kwon, Jun Soo
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2001-10
- Volume
- 179
- Issue
- 4
- Pages
- 330-334
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2040455976
- Cited by
- 217
- References
- 35
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 4 · 2019: 8 · 2018: 9 · 2017: 7 · 2016: 8 · 2015: 15 · 2014: 11 · 2013: 13 · 2012: 7
- FWCI
- 10.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- obsessive-compulsive disorder, gray matter abnormalities, gray matter density, orbitofrontal cortex, thalamus, cerebellum, cuneus, frontal-subcortical circuits, cerebellar dysfunction, brain structure
- MeSH terms
- Adult, Cerebellum, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Obsessive-Compulsive Disorder, Stereotaxic Techniques, Case-Control Studies
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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