The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
P50 sensory gating ratios in schizophrenics and controls: A review and data analysis
Open accessAbstract
Many studies have found that the P50 sensory gating ratio in a paired click task is smaller in normal control subjects than in patients with schizophrenia, indicating more effective sensory gating. However, a wide range of gating ratios has been reported in the literature for both groups. The purpose of this study was to compile these findings and to compare reported P50 gating ratios in controls and patients with schizophrenia. Current data collected from individual controls in eight studies from the University of California, Irvine (UCI), Indiana University (IU), and Yale University also are reported. The IU, UCI, and Yale data showed that approximately 40% of controls had P50 ratios within 1 S.D. below the mean of means for patients with schizophrenia. The meta-analysis rejected the null hypothesis that all studies showed no effect. The meta-analysis also showed that the differences were not the same across all studies. The mean ratios in 45 of the 46 group comparisons were smaller for controls than for patients, and the observed difference in means was significant for 35 of those studies. Reported gating ratios for controls from two laboratories whose findings were reported in the literature differed from all the other control groups. Variables affecting the gating ratio included band pass filter setting, rules regarding the inclusion of P30, sex, and age. Standards of P50 collection and measurement would help determine whether the gating ratio can be sufficiently reliable to be labeled an endophenotype, and suggestions are made toward this goal.
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Cites
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Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus
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“Although 1 participant in the current sample had a P50 ratio more than 3 SD above the mean (178%), that participant was not excluded due to evidence than approximately 3% of subjects in healthy samples could have a P50 gating ratio exceeding 180% (Patterson et al., 2008).”
Self-citationSchizophrenia, “just the facts”: What we know in 2008Part 3: Neurobiology
KESHAVAN, M., TANDON, R., BOUTROS, N., & NASRALLAH, H. (2008) · Schizophrenia Research · doi:10.1016/j.schres.2008.07.020 · Cited by 347
Self-citationRemoving Obstacles in Neuroscience Drug Discovery: The Future Path for Animal Models
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Gone to Pot – A Review of the Association between Cannabis and Psychosis
Radhakrishnan, R., Wilkinson, S. T., & D’Souza, D. C. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00054 · Cited by 310
Metadata
- Authors
- Patterson, J. V., Hetrick, W. P., Boutros, N. N., Jin, Y., Sandman, C., Stern, H., Potkin, S., & Bunney, W. E.
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2008-03
- Volume
- 158
- Issue
- 2
- Pages
- 226-247
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W1994037263
- Cited by
- 352
- References
- 122
- FWCI
- 17.76
- Type
- journal article
- Language
- en
- Open access
- green
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