Meta-analysis of the P300 and P50 waveforms in schizophrenia

BRAMON, E

doi:10.1016/j.schres.2004.01.004

Cited by 569Schizophrenia research and treatmentMental Health and PsychiatryNeural and Behavioral Psychology Studies

Meta-analysis of the P300 and P50 waveforms in schizophrenia

BRAMON, E·2004·Schizophrenia Research

DOI 10.1016/j.schres.2004.01.004

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Abstract

Objective To determine whether patients with schizophrenia have abnormalities in the P300 and P50 waves and to quantify the magnitude of any differences from controls.Method We conducted a systematic search for articles published between January 1994 and August 2003 that reported P50 or P300 measures in schizophrenic patients and controls. Metaregression analyses were performed using a random effects model. The pooled standardised effect size (PSES) was calculated as the difference between the means of the two groups divided by the common standard deviation.Results We identified 46 studies suitable for analysis of P300 measures, including 1443 patients and 1251 controls. There were 20 P50 studies including 421 patients and 401 controls. The PSES for the P300 amplitude was 0.85 (95% CI: 0.65 to 1.05; p<0.001), and for the P300 latency was -0.57 (95% CI: -0.75 to -0.38; p<0.001). The PSES of the P50 ratio was -1.56 (95% CI: -2.05 to -1.06; p<0.001). There were no significant differences between patients and controls in P50 latency. Across-study variations in filters, task difficulty, antipsychotic medication and duration of illness did not influence the PSES significantly.Conclusions This meta-analysis confirms the existence of ERP deficits in schizophrenia. The magnitude of these deficits is similar to the most robust findings reported in neuroimaging and neuropsychology in schizophrenia.

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“Acutely psychotic and nonpsychotic SCZ patients exhibit larger P50 gating ratios than healthy controls (especially when SOA = 500 ms), irrespective of medication status.66,67”
From Are hallucinations due to an imbalance between excitatory and inhibitory influences on the brain? (2016) · cites this paper as [66]

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Authors: BRAMON, E.
Affiliations: King's College London (GB)
Corresponding author: BRAMON, E
ORCID: BRAMON, E
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2004-10
Volume: 70
Issue: 2-3
Pages: 315-329
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2004.01.004
OpenAlex: W2132218777
Cited by: 569
References: 111
Citations by year: 2026: 13 · 2025: 16 · 2024: 14 · 2023: 11 · 2022: 21 · 2021: 24 · 2020: 27 · 2019: 25 · 2018: 25 · 2017: 25 · 2016: 36 · 2015: 28 · 2014: 36 · 2013: 41 · 2012: 33
FWCI: 2.26
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Schizophrenia Research (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
Research Portal (King's College London) (submittedVersion)
Funders: Schizophrenia Research Fund
Wellcome Trust
National Institute for Health and Care Research (PDA/02/06/016)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: schizophrenia, P300
MeSH terms: Brain, Evoked Potentials, Humans, Schizophrenia, Antipsychotic Agents, Event-Related Potentials, P300

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Meta-analysis of the P300 and P50 waveforms in schizophrenia

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