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Co-occurring mental and substance abuse disorders: A review on the potential predictors and clinical outcomes
Abstract
This article reviews the literature on co-occurring mental disorders and substance use disorders. The co-occurrence of mental disorders with substance use disorders presents a major challenge to those who provide psychiatric services. Despite the clinical and social burdens caused by this complex problem, research in this area is still insufficient. We found 18 studies showing potential predictors of co-occurring disorders (COD). Poor outcomes have been associated with: (i) COD compared to single disorders and (ii) COD with prior mental disorder compared to COD with prior substance use disorders. Poorer outcomes were reported for substance use disorder patients with comorbid major depressive disorder, and patients with substance use disorder and post-traumatic stress disorder. Furthermore, more negative outcomes were related to COD patients with temporally prior onset of mood disorders. Comorbidity between major depressive disorder or post-traumatic stress disorder and substance use disorder is suggested in the literature as a potential predictor of COD problems.
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“In a review of the literature, a diagnosis of either posttraumatic stress disorder (PTSD) or major depressive disorder (MDD) was found to be a major factor associated with poorer outcomes for individuals with a comorbid substance use disorder, and there was some evidence that these effects were especially pronounced for males (Najt et al., 2011).”
From Influences of victimization and comorbid conditions on latency to illicit drug use among adolescents and young adults (2020) · cites this paper as Najt et al., 2011
In the citing paper
“In a review of the literature, a diagnosis of either posttraumatic stress disorder (PTSD) or major depressive disorder (MDD) was found to be a major factor associated with poorer outcomes for individuals with a comorbid substance use disorder, and there was some evidence that these effects were especially pronounced for males (Najt et al., 2011).”
From Influences of victimization and comorbid conditions on latency to illicit drug use among adolescents and young adults (2020) · cites this paper as Najt et al., 2011
In the citing paper
“These findings were surprising in light of evidence that the effects of co-occurring disorders on SUD outcomes are especially pronounced for males (Najt et al., 2011).”
From Influences of victimization and comorbid conditions on latency to illicit drug use among adolescents and young adults (2020) · cites this paper as Najt et al., 2011
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Metadata
- Authors
- Najt, P., Fusar-Poli, P., & Brambilla, P.
- Affiliations
- Durham University (GB)
- University of Udine (IT)
- Corresponding author
- Najt, Pablo
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 186
- Issue
- 2-3
- Pages
- 159-164
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2144587812
- Cited by
- 284
- References
- 44
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 19 · 2023: 55 · 2022: 28 · 2021: 15 · 2020: 20 · 2019: 15 · 2018: 15 · 2017: 13 · 2016: 18 · 2015: 16 · 2014: 18 · 2013: 15 · 2012: 11
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (University of Udine) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Keywords
- co-occurring mental disorders, substance use disorders, comorbidities, clinical outcomes, major depressive disorder, post-traumatic stress disorder, mood disorders, psychiatric treatment
- MeSH terms
- Mental Disorders, Humans, Predictive Value of Tests, Sex Factors, Comorbidity, Treatment Outcome, Age of Onset, Substance-Related Disorders
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