Cited by 284Substance Abuse Treatment and OutcomesMental Health Treatment and AccessPersonality Disorders and Psychopathology

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Co-occurring mental and substance abuse disorders: A review on the potential predictors and clinical outcomes

Najt, Pablo, Fusar-Poli, Paolo, Brambilla, Paolo·2011·Psychiatry Research

DOI 10.1016/j.psychres.2010.07.042

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Abstract

This article reviews the literature on co-occurring mental disorders and substance use disorders. The co-occurrence of mental disorders with substance use disorders presents a major challenge to those who provide psychiatric services. Despite the clinical and social burdens caused by this complex problem, research in this area is still insufficient. We found 18 studies showing potential predictors of co-occurring disorders (COD). Poor outcomes have been associated with: (i) COD compared to single disorders and (ii) COD with prior mental disorder compared to COD with prior substance use disorders. Poorer outcomes were reported for substance use disorder patients with comorbid major depressive disorder, and patients with substance use disorder and post-traumatic stress disorder. Furthermore, more negative outcomes were related to COD patients with temporally prior onset of mood disorders. Comorbidity between major depressive disorder or post-traumatic stress disorder and substance use disorder is suggested in the literature as a potential predictor of COD problems.

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Authors: Najt, P., Fusar-Poli, P., & Brambilla, P.
Affiliations: Durham University (GB)
University of Udine (IT)
Corresponding author: Najt, Pablo
ORCID: Najt, Pablo
Brambilla, Paolo
Venue: Psychiatry Research
Publisher: Elsevier BV
Published: 2011-04
Volume: 186
Issue: 2-3
Pages: 159-164
ISSN: 0165-1781 (ISSN-L)
DOI: 10.1016/j.psychres.2010.07.042
OpenAlex: W2144587812
Cited by: 284
References: 44
Citations by year: 2026: 11 · 2025: 13 · 2024: 19 · 2023: 55 · 2022: 28 · 2021: 15 · 2020: 20 · 2019: 15 · 2018: 15 · 2017: 13 · 2016: 18 · 2015: 16 · 2014: 18 · 2013: 15 · 2012: 11
FWCI: 1.02
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Psychiatry Research (publishedVersion)
PubMed (publishedVersion)
Institutional Research Information System (University of Udine) (submittedVersion)
Research Portal (King's College London) (submittedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords: co-occurring mental disorders, substance use disorders, comorbidities, clinical outcomes, major depressive disorder, post-traumatic stress disorder, mood disorders, psychiatric treatment
MeSH terms: Mental Disorders, Humans, Predictive Value of Tests, Sex Factors, Comorbidity, Treatment Outcome, Age of Onset, Substance-Related Disorders

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Co-occurring mental and substance abuse disorders: A review on the potential predictors and clinical outcomes

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