The DOI matches its Crossref record; 68 of the 69 references it cites were found in a registry or an index.
Moving beyond transition outcomes: Meta-analysis of remission rates in individuals at high clinical risk for psychosis
Abstract
Recent evidence suggests that transition risks from initial clinical high risk (CHR) status to psychosis are decreasing. The role played by remission in this context is mostly unknown. The present study addresses this issue by means of a meta-analysis including eight relevant studies published up to January 2012 that reported remission rates from an initial CHR status. The primary effect size measure was the longitudinal proportion of remissions compared to non-remission in subjects with a baseline CHR state. Random effect models were employed to address the high heterogeneity across studies included. To assess the robustness of the results, we performed sensitivity analyses by sequentially removing each study and rerunning the analysis. Of 773 subjects who met initial CHR criteria, 73% did not convert to psychosis along a 2-year follow. Of these, about 46% fully remitted from the baseline attenuated psychotic symptoms, as evaluated on the psychometric measures usually employed by prodromal services. The corresponding clinical remission was estimated as high as 35% of the baseline CHR sample. The CHR state is associated with a significant proportion of remitting subjects that can be accounted by the effective treatments received, a lead time bias, a dilution effect, a comorbid effect of other psychiatric diagnoses.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“with about a third only in remission [92]”
From Prevention and early intervention in youth mental health: is it time for a multidisciplinary and trans-diagnostic model for care? (2020) · cites this paper as [92]
Citations
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2009.06.005 · Cited by 19,575
(2000) · Cited by 9,198
van Os, J., Linscott, R. J., Myin-Germeys, I., Delespaul, P., & Krabbendam, L. (2009) · Psychological Medicine · doi:10.1017/s0033291708003814 · Cited by 2,343
A Fail-Safe N for Effect Size in Meta-Analysis
Orwin, R. G. (1983) · Journal of Educational Statistics · doi:10.2307/1164923 · Cited by 2,064 · cited 2×
“In addition, we used the fail-safe procedure (Orwin, 1983) to generate the number of unpublished studies that would be needed to move estimates to a non-significant difference.”
Limitations of the Application of Fourfold Table Analysis to Hospital Data
Berkson, J. (1946) · Biometrics Bulletin · doi:10.2307/3002000 · Cited by 1,810 · cited 1×
“This treatment-seeking bias may account in part for the high correlation between psychosis-like and anxiety/ depression symptoms in patient populations as opposed to the general population (Berkson, 1946).”
The Psychosis High-Risk State: A Comprehensive State-of-the-Art Review
Fusar-Poli, P., Borgwardt, S., Bechdolf, A., Addington, J., Riecher-Rössler, A., Schultze-Lutter, F., Keshavan, M., Wood, S., Ruhrmann, S., Seidman, L. J., et al. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.269 · Cited by 1,483
Self-citationMild Cognitive Impairment: Ten Years Later
Petersen, R. C., Roberts, R. O., Knopman, D. S., Boeve, B. F., Geda, Y. E., Ivnik, R. J., Smith, G. E., & Jack, C. R. (2009) · Archives of Neurology · doi:10.1001/archneurol.2009.266 · Cited by 1,447
Cited by
Sorted by citations
Items 101–133 of 133
Biomarkers for predicting transition from at-risk mental state to psychosis: A systematic review
Ricci, V., Martinotti, G., Mosca, A., & Maina, G. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106612 · Cited by 3
Early Intervention in Emerging Psychosis: State of the Art and Future Perspectives
McGorry, P. D., & Goldstone, S. D. (2016) · Key issues in mental health (Online)/Key issues in mental health (Print) · doi:10.1159/000440911 · Cited by 3
Laurens, K. R., & Cullen, A. E. (2015) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-015-1161-8 · Cited by 3
Psychosis High-Risk States in Adolescents
Simon, A. E. (2016) · Key issues in mental health (Online)/Key issues in mental health (Print) · doi:10.1159/000440913 · Cited by 3
Self-citationGifford, G., Crossley, N. A., Morgan, S. E., Kempton, M. J., Dazzan, P., Modinos, G., Azis, M., Samson, C., Bonoldi, I., Quinn, B., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.25235 · Cited by 2
Hoogerheide, B., Visser, E., Maas, E. T., Booij, S. H., & Riese, H. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.02.066 · Cited by 2
Ozdemir, E., MacBeth, A. M., & GRIFFITHS, H. M. (2025) · Psychology and Psychotherapy Theory Research and Practice · doi:10.1111/papt.12589 · Cited by 3
Yu, J., Bernardo, A. B. I., & Zaroff, C. M. (2015) · Asia-Pacific Psychiatry · doi:10.1111/appy.12215 · Cited by 3
Psychotische Störungen und Schizophrenie
Clamor, A., Frantz, I., & Lincoln, T. M. (2020) · Springer eBooks · doi:10.1007/978-3-662-61814-1_44 · Cited by 3
Smesny, S., Gussew, A., Schack, S., Langbein, K., Wagner, G., & Reichenbach, J. R. (2020) · Schizophrenia Research · doi:10.1016/j.schres.2020.04.021 · Cited by 2
Repurposing medications to prevent psychosis
Cohen, B. M., McPhie, D. L., Sonntag, K., Lopes, C., & Babb, S. M. (2025) · npj Mental Health Research · doi:10.1038/s44184-025-00169-z · Cited by 2
Rodriguez-Sanchez, J., Hauke, D. J., Pinotsis, D. A., Berndt, L. C. S., Oloye, H., Nicholas, S., Hamilton, H., Roach, B. J., Bachman, P., Belger, A., et al. (2026) · Biological Psychiatry · doi:10.1016/j.biopsych.2026.04.007 · Cited by 3
Freudenreich, O. (2019) · Current clinical psychiatry · doi:10.1007/978-3-030-29450-2_11 · Cited by 1
Früherkennung und Frühbehandlung von Menschen mit erhöhtem Psychoserisiko
Müller, H., & Bechdolf, A. (2020) · Springer eBooks · doi:10.1007/978-3-662-45995-9_26-1 · Cited by 1
Bhattacharyya, S., Davies, C., Carter, B., McGuire, P. K., Brammer, M. J., Fusar‐Poli, P., Broome, M. R., Watson, S., Pérez, J., & Yung, A. R. (2024) · Efficacy and Mechanism Evaluation · doi:10.3310/ynfh9826 · Cited by 1
Self-citationBartholomeusz, C. F., & Pantelis, C. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139839518.006 · Cited by 1
Symptomatic Remission Along the Clinical Psychosis Spectrum: A Historical and Conceptual Review
Binbay, T., Ergül, C., & van Os, J. (2021) · Nöro Psikiyatri Arşivi · doi:10.29399/npa.27701 · Cited by 1
Koike, S., Fujioka, M., Satomura, Y., Koshiyama, D., Tada, M., Sakakibara, E., Okada, N., Takano, Y., Iwashiro, N., Natsubori, T., et al. (2021) · Schizophrenia · doi:10.1038/s41537-021-00186-9 · Cited by 1
Lee, T. Y., Kim, S. N., Chon, M., & Kwon, J. S. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.08.002 · Cited by 1
Rodriguez-Sanchez, J., Hauke, D. J., Pinotsis, D. A., Berndt, L. C. S., Oloye, H., Nicholas, S., Hamilton, H., Roach, B. J., Bachman, P., Belger, A., et al. (2025) · medRxiv · doi:10.1101/2025.09.16.25335778 · Cited by 1
Early Detection of Psychosis - Helpful or Stigmatizing Experience for Those Concerned?
Uttinger, M., Papmeyer, M., & Riecher‐Rössler, A. (2016) · Key issues in mental health (Online)/Key issues in mental health (Print) · doi:10.1159/000440915
Self-citationS9-3．児童思春期の統合失調症とその周辺の標準的治療と支援について
純一, 藤. (2017) · 児童青年精神医学とその近接領域 · doi:10.20615/jscap.58.1_64
純一, 藤. (2019) · 児童青年精神医学とその近接領域 · doi:10.20615/jscap.60.1_96
Ross, R. G. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.09.009
L’état mental à risque : au-delà de la prévention de la psychose
Morin, J., Daneault, J.-G., Krebs, M., Shah, J. L., & Solida-Tozzi, A. (2021) · Santé mentale au Québec · doi:10.7202/1088179ar
Psychotic experiences: Gift or illness?
van der Zeijst, M. C. E. (2023) · doi:10.33612/diss.806987620
Importance of Early Detection in Early Psychosis
Joo, S. W. (2024) · Korean Journal of Schizophrenia Research · doi:10.16946/kjsr.2024.27.1.14
Maeve, H., Alliende, L. M., Pokorny, V., Williams, T. F., Gold, J. M., Waltz, J. A., Schiffman, J., Ellman, L. M., Strauss, G., Walker, E. F., et al. (2025) · Schizophrenia Bulletin Open · doi:10.1093/schizbullopen/sgaf031
Marqueurs neurodéveloppementaux en psychiatrie : intérêt dans les troubles schizophréniques
Gay, O. (2016) · theses.fr (ABES) · doi:10.70675/b0e8f0f3ze67bz4340z9b3cz01b56b6184f0
Lu, Y., Todesco, B., Hawke, L. D., Kozloff, N., Strudwick, G., Michael Kiang, A., Wang, W., Castle, D. J., Foussias, G., & Husain, M. O. (2026) · The Canadian Journal of Psychiatry · doi:10.1177/07067437261436536
van der Gaag, M., Mei, C., Nelson, B., Berger, M., Krcmar, M., Amminger, G. P., Bechdolf, A., Hutton, P., Cuijpers, P. J., Yung, A. R., et al. (2026) · Early Intervention in Psychiatry · doi:10.1111/eip.70185
Metadata
- Authors
- Simon, A. E., Borgwardt, S., Riecher-Rössler, A., Velthorst, E., de Haan, L., & Fusar-Poli, P.
- Affiliations
- University of Bern (CH)
- University of Basel (CH)
- Amsterdam UMC Location University of Amsterdam (NL)
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 209
- Issue
- 3
- Pages
- 266-272
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2010348239
- Cited by
- 133
- References
- 69
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 4 · 2023: 9 · 2022: 6 · 2021: 15 · 2020: 15 · 2019: 18 · 2018: 4 · 2017: 12 · 2016: 16 · 2015: 10 · 2014: 11
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- BORIS (University Library Bern) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Keywords
- clinical high risk for psychosis, remission, transition to psychosis, attenuated psychotic symptoms, prodromal psychosis, lead-time bias, dilution effect, comorbidities, treatment effects
- MeSH terms
- Humans, Psychotic Disorders, Remission, Spontaneous, Risk Factors, Databases, Factual, Prodromal Symptoms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
