Prevention and early intervention in youth mental health: is it time for a multidisciplinary and trans-diagnostic model for care?
Open accessAbstract
Background: Similar to other health care sectors, mental health has moved towards the secondary prevention, with the effort to detect and treat mental disorders as early as possible. However, converging evidence sheds new light on the potential of primary preventive and promotion strategies for mental health of young people. We aimed to reappraise such evidence. Methods: We reviewed the current state of knowledge on delivering promotion and preventive interventions addressing youth mental health. Results: Half of all mental disorders start by 14 years and are usually preceded by non-specific psychosocial disturbances potentially evolving in any major mental disorder and accounting for 45% of the global burden of disease across the 0–25 age span. While some action has been taken to promote the implementation of services dedicated to young people, mental health needs during this critical period are still largely unmet. This urges redesigning preventive strategies in a youth-focused multidisciplinary and trans-diagnostic framework which might early modify possible psychopathological trajectories. Conclusions: Evidence suggests that it would be unrealistic to consider promotion and prevention in mental health responsibility of mental health professionals alone. Integrated and multidisciplinary services are needed to increase the range of possible interventions and limit the risk of poor long-term outcome, with also potential benefits in terms of healthcare system costs. However, mental health professionals have the scientific, ethical, and moral responsibility to indicate the direction to all social, political, and other health care bodies involved in the process of meeting mental health needs during youth years.
AI snapshot
Written from the paper’s full text.
TL;DR
This narrative review argues that youth mental health care should move beyond secondary prevention toward primary prevention and early intervention, using a trans-diagnostic clinical staging model and integrated multidisciplinary services for ages 0–25. It synthesizes evidence on risk factors, prevention stages, and service models to support a youth-focused framework.
Key findings
- Half of all mental disorders start by age 14, and mental health problems account for 45% of the global burden of disease across the 0–25 age span; up to 1 in 5 people experience clinically relevant mental health problems before age 25, with 50% already symptomatic by age 14.
- Childhood adversities are shared risk factors across disorders; a WHO survey of 51,945 adults in 21 countries estimated that eradicating childhood adversities would reduce any lifetime mental disorder by 29.8%, adolescence-onset disorders by 32.3%, and childhood-onset disorders by 38.2%.
- The paper proposes a trans-diagnostic clinical high-risk mental state (CHARMS) paradigm to intercept a wider range of lower-risk cases beyond ultra-high risk for psychosis, including sub-threshold bipolar and borderline personality symptoms and mild-moderate depression.
- Integrated youth services such as Headspace expanded from 10 to more than 110 centers, reaching about 100,000 young people per year, and models like MCPAP, MHSPY, Jigsaw, and Youth space show positive access, satisfaction, and functional outcomes, though long-term efficacy evidence remains limited.
Methods
- Narrative review with a literature search in MEDLINE, Web of Science, and Scopus using terms describing risk factors, clinical staging, and multidisciplinary prevention and early interventions in youth mental health, with special attention to research from the past 25 years; some additional evidence was included if considered appropriate by all authors.
- Studies were eligible if they assessed preventing strategies in youth in a trans-diagnostic and multidisciplinary approach; exclusions were studies not applying a clinical staging model for youth mental health in a trans-diagnostic framework, not investigating youth mental health service provision in a multidisciplinary framework, or primarily assessing older populations.
- Main analysis was a narrative synthesis across the at-risk mental state concept, early-life psychosocial risk factors, prevention stages (promotion, universal/selective/indicated, secondary, tertiary), and integrated service models.
Limitations
- The paper does not state a limitations section. Evident from the text: as a narrative review, it lacks systematic review elements such as PRISMA reporting, full search strings, and formal quality appraisal, so selection and synthesis may be non-exhaustive.
- The paper itself notes evidence gaps: lack of studies assessing longer-term efficacy of collaborative care, especially in preventing poor outcome, treatment disengagement, and relapse; and absence of validated interventions to prevent multiple relapses.
- It also states that vertical and horizontal integration of the enhanced primary care model with more specialized and intensive services is not covered in this reappraisal.
Model-written summary. Check it against the paper before relying on it.
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Cites
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Claims the paper makes
0 of 102 cited sources checked · 0 supported · 0 flagged
- Premisecitation
Half of all mental disorders start by 14 years.
“Half of all mental disorders start by 14 years”
- Also stated in: § The need for implementing prevention and early intervention in youth mental health · plain
“50% of whom being already symptomatic by the age of 14 [14]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [14] Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):593–602. source
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- Also stated in: § The need for implementing prevention and early intervention in youth mental health · plain
- Premisecitation
Stressful life events produce the most 'toxic' effect on children's stress system, raising the risk of subsequent development of stress-related mental difficulties, when experienced in the absence of a stable and supporting environment.
“stressful life events produce the most ‘toxic’ effect on children’s stress system, raising the risk of subsequent development of stress-related mental difficulties, when experienced in the absence of a stable and supporting environment [34]”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [34] Shonkoff JP. Building a new biodevelopmental framework to guide the future of early childhood policy. Child Dev. 2010;81(1):357–67. source
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- Premisecitation
The relation between attachment difficulties and youth psychological problems is most likely bidirectional.
“The relation between attachment difficulties and youth psychological problems is most likely bidirectional”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [38] Kobak R, Zajac K, Herres J, Krauthamer Ewing ES. Attachment based treatments for adolescents: the secure cycle as a framework for assessment, treatment and evaluation. Attach Hum Dev. 2015;17(2):220–39. source
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- Premisecitation
50% of people who experience clinically relevant mental health problems before age 25 are already symptomatic by age 14.
“50% of whom being already symptomatic by the age of 14 [14]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [14] Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):593–602. source
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- Premisecitation
Meta-analytic work strongly supports the effectiveness of youth prevention programs addressing child abuse, negative consequences of parents' divorce on children, substance abuse, and school-related problematic behaviors in reducing rates of psychosocial difficulties later in life.
“Meta-analytic work strongly supports the effectiveness of youth prevention programs addressing child abuse [44], negative consequences of parents’ divorce on children [45], substance abuse [46], and school-related problematic behaviors [47] in reducing rates of psychosocial difficulties later in life [48].”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [44] Davis MK, Gidycz CA. Child sexual abuse prevention programs: a meta-analysis. J Clin Child Psychol. 2000;29(2):257–65. source
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Cross-prediction between anxiety and depression occurs from adolescence to adulthood.
“cross-prediction between anxiety and depression from adolescence to adulthood”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [40] Lancefield KS, Raudino A, Downs JM, Laurens KR. Trajectories of childhood internalizing and externalizing psychopathology and psychotic-like experiences in adolescence: a prospective population-based cohort study. Dev Psychopathol. 2016;28(2):527–36. source
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- Premisecitation
Stigma represents a major barrier to initial contact with mental health services for young individuals.
“stigma represents a major barrier in this regards [19]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [19] Gronholm PC, Thornicroft G, Laurens KR, Evans-Lacko S. Mental health-related stigma and pathways to care for people at risk of psychotic disorders or experiencing first-episode psychosis: a systematic review. Psychol Med. 2017;47(11):1867–79. source
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- Premisecitation
Most mental health services, as traditionally developed, have proven ineffective to provide healthcare during the youth critical period.
“most mental health services, as traditionally developed, have proven to be ineffective to provide healthcare during this critical period [16]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [16] Andrews G, Sanderson K, Corry J, Lapsley HM. Using epidemiological data to model efficiency in reducing the burden of depression*. J Ment Health Policy Econ. 2000;3(4):175–86. source
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- Premisecitation
Childhood adversities seem to impact negatively on a number of disorders.
“childhood adversities seem to impact negatively on a number of disorders [28]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [28] Kessler RC, McLaughlin KA, Green JG, Gruber MJ, Sampson NA, Zaslavsky AM, et al. Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. Br J Psychiatry. 2010;197(5):378–85. source
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- Interpretationnone given
Neurodevelopmental changes occurring during youth make it a period of both vulnerability and opportunity for mental health.
“Neurodevelopmental changes occurring during youth make it a period of both vulnerability and opportunity for mental health.”
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Environmental determinants, whether risk or protective factors, may differentially modulate gene expression and stress response, with enduring health effects.
“depending on their nature, whether risk or protective factors, such environmental determinants may differentially modulate gene expression and stress response, with enduring health effects [32]”
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When treatments are finally offered, the majority are not evidence-based.
“When treatments are finally offered, the majority are not evidence-based [16]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [16] Andrews G, Sanderson K, Corry J, Lapsley HM. Using epidemiological data to model efficiency in reducing the burden of depression*. J Ment Health Policy Econ. 2000;3(4):175–86. source
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- Premisecitation
Use of mental health services is modest despite high prevalence of mental health problems among young individuals.
“with a modest use of mental health services despite the high prevalence of mental health problems among young individuals [17]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [17] Costello EJ, Copeland W, Cowell A, Keeler G. Service costs of caring for adolescents with mental illness in a rural community, 1993–2000. Am J Psychiatry. 2007;164(1):36–42. source
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Early indicators of later risk are often dimensional.
“early indicators of later risk are often dimensional [27]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [27] Cuthbert B. The RDoC framework: facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology. World Psychiatry. 2014;13(1):28–35. source
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Young individuals, especially male, socioeconomically disadvantaged, and of ethnic minority, are less likely to establish initial contact with mental health services.
“young individuals, especially male, socioeconomically disadvantaged, and of ethnic minority, are less likely to establish initial contact with mental health services”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [19] Gronholm PC, Thornicroft G, Laurens KR, Evans-Lacko S. Mental health-related stigma and pathways to care for people at risk of psychotic disorders or experiencing first-episode psychosis: a systematic review. Psychol Med. 2017;47(11):1867–79. source
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- Premisecitation
Children carrying specific genetic variants are at increased risk for behavioral problems in later life, but only when raised in dysfunctional families.
“children carrying specific genetic variants are at increased risk for behavioral problems in later life, but only when raised in dysfunctional families [33]”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [33] Taylor A, Kim-Cohen J. Meta-analysis of gene-environment interactions in developmental psychopathology. Dev Psychopathol. 2007;19(4):1029–37. source
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- Premisecitation
A WHO survey among 51,945 adults in 21 countries reported that eradication of childhood adversities, especially those associated with maladaptive family functioning, would lead to a 29.8% reduction of any mental disorder lifetime.
“A large survey conducted by the World Health Organization (WHO) among 51,945 adults in 21 countries reported that eradication of childhood adversities, especially those associated with maladaptive family functioning (e.g. parental mental illness, child abuse, neglect), would lead to a 29.8% reduction of any mental disorder lifetime”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [28] Kessler RC, McLaughlin KA, Green JG, Gruber MJ, Sampson NA, Zaslavsky AM, et al. Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. Br J Psychiatry. 2010;197(5):378–85. source
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Meeting the child's physical, psychological, and social needs is a key element to support optimal brain development, emotional regulation, and higher order cognitive function, with long-lasting health benefits.
“Meeting the child’s physical (i.e. healthy nutrition), psychological (i.e. stable and responsive attachment relationships), and social (i.e. supportive and safe environments) needs is key element to support optimal brain development, emotional regulation, and higher order cognitive function, with long-lasting health benefits [30]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [30] Maggi S, Irwin LJ, Siddiqi A, Hertzman C. The social determinants of early child development: an overview. J Paediatr Child Health. 2010;46(11):627–35. source
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- Premisecitation
In addition to transition to psychosis, longer-term psychotic disorder, or persistent sub-threshold psychotic symptoms, progression to persistent mood, anxiety, personality and/or substance use disorders is also a very common outcome.
“in addition to transition to psychosis, longer-term psychotic disorder, or persistent sub-threshold psychotic symptoms, progression to persistent mood, anxiety, personality and/or substance use disorders is also a very common outcome [25, 26]”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [25] Lin A, Wood SJ, Nelson B, Beavan A, McGorry P, Yung AR. Outcomes of nontransitioned cases in a sample at ultra-high risk for psychosis. Am J Psychiatry. 2015;172(3):249–58. source
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- Premisecitation
The experience of a mental disorder "kindles" a cascade of events which make recurrence later in life more likely.
“the experience of a mental disorder “kindles” a cascade of events which make recurrence later in life more likely [41]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [41] Rutter M, Kim-Cohen J, Maughan B. Continuities and discontinuities in psychopathology between childhood and adult life. J Child Psychol Psychiatry. 2006;47(3–4):276–95. source
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- Premisecitation
Prevention and early intervention is still largely unexplored in the context of common mental disorders, such as depression, anxiety, substance abuse, and eating disorders.
“this is still largely unexplored in the context of common mental disorders, such as depression, anxiety, substance abuse, and eating disorders [23]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [23] Das JK, Salam RA, Lassi ZS, Khan MN, Mahmood W, Patel V, et al. Interventions for adolescent mental health: an overview of systematic reviews. J Adolesc Health. 2016;59(4S):S49–60. source
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- Premisecitation
Up to 1 in 5 people experience clinically relevant mental health problems before the age of 25.
“with up to 1 in 5 people experiencing clinically relevant mental health problems before the age of 25”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [14] Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):593–602. source
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- Premisecitation
Progress has been made for psychotic disorders due to successful application of an at-risk mental state concept.
“While progress has been made for psychotic disorders, also due to the successful application of an at-risk mental state concept [22]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [22] McGorry PD, Mei C. Ultra-high-risk paradigm: lessons learnt and new directions. Evid Based Ment Health. 2018;21(4):131–3. source
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- Premisecitation
The development of a secure attachment between the child and a protective primary caregiver is particularly relevant to facilitate adaptive emotional and behavioral responses to stressful events.
“it appears particularly relevant the development of a secure attachment between the child and a protective primary caregiver, in order to facilitate adaptive emotional and behavioral responses to stressful events [35]”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [35] Sroufe LA. Attachment and development: a prospective, longitudinal study from birth to adulthood. Attach Hum Dev. 2005;7(4):349–67. source
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- Premisecitation
Following symptom onset, people aged 0-25 experience the greatest delay to initial treatment.
“following symptom onset, people aged 0–25 experience the greatest delay to initial treatment [18]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [18] Catania LS, Hetrick SE, Newman LK, Purcell R. Prevention and early intervention for mental health problems in 0–25 year olds: are there evidence-based models of care? Adv Ment Health. 2011;10(1):6–19. source
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- Premisecitation
Internalizing and externalizing disorders of childhood are associated with an increased likelihood to develop a psychiatric disorder later in adulthood.
“internalizing and externalizing disorders of childhood are associated with an increased likelihood to develop a psychiatric disorder later in adulthood [39]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [39] Copeland WE, Shanahan L, Costello EJ, Angold A. Childhood and adolescent psychiatric disorders as predictors of young adult disorders. Arch Gen Psychiatry. 2009;66(7):764–72. source
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- Premisecitation
During development, risk factors may contribute to a range of psychopathologies.
“during development risk factors may contribute to a range of psychopathologies”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [27] Cuthbert B. The RDoC framework: facilitating transition from ICD/DSM to dimensional approaches that integrate neuroscience and psychopathology. World Psychiatry. 2014;13(1):28–35. source
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- Interpretationcitation
Mental health needs during youth are still largely unmet.
“mental health needs during this critical period are still largely unmet”
- Also stated in: § The need for implementing prevention and early intervention in youth mental health · plain
“with a modest use of mental health services despite the high prevalence of mental health problems among young individuals [17]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [17] Costello EJ, Copeland W, Cowell A, Keeler G. Service costs of caring for adolescents with mental illness in a rural community, 1993–2000. Am J Psychiatry. 2007;164(1):36–42. source
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- Also stated in: § The need for implementing prevention and early intervention in youth mental health · plain
- Interpretationcitation
A trans-diagnostic clinical high-risk mental state (CHARMS) paradigm may increase capacity to intercept a wider range of lower risk cases than those with attenuated psychotic symptoms only, including people with sub-threshold bipolar and borderline personality symptoms as well as mild-moderate depression.
“a trans-diagnostic clinical high-risk mental state (CHARMS) paradigm may increase capacity to intercept a wider range of lower risk cases than those with attenuated psychotic symptoms only, including people with sub-threshold bipolar and borderline personality symptoms as well as mild-moderate depression [22]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [22] McGorry PD, Mei C. Ultra-high-risk paradigm: lessons learnt and new directions. Evid Based Ment Health. 2018;21(4):131–3. source
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- Premisecitation
Adversities during pregnancy and early childhood such as inadequate care, neglect, and trauma have been shown to negatively impact academic trajectories, psychosocial skills, physical resilience, and the possibility of healthy aging.
“adversities during pregnancy and early childhood such as inadequate care, neglect, and trauma, have been shown to negatively impact on academic trajectories, psychosocial skills, physical resilience and the possibility of healthy aging [29, 31]”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [29] Mustard JF. Brain development, child development—adult health and well-being and paediatrics. Paediatr Child Health. 1999;4(8):519–20. source
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- cites [31] Fonagy P, Target M. Attachment and reflective function: their role in self-organization. Dev Psychopathol. 1997;9(4):679–700. source
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- Premisecitation
Significant delays in receiving care are attributable to reduced ability of services to rapidly deliver specialist mental healthcare for youth in need after a first primary care consultation.
“significant delays in receiving care are also attributable to the reduced ability of services to rapidly deliver specialist mental healthcare for youth in need after a first primary care consultation [21]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [21] Fusar-Poli P. Integrated mental health services for the developmental period (0 to 25 Years): a critical review of the evidence. Front Psychiatry. 2019;10:355. source
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- Premisecitation
Adolescent oppositional defiant disorder, anxiety and substance disorders entirely account for the homotypic prediction pattern of depression over time.
“adolescent oppositional defiant disorder, anxiety and substance disorders entirely accounting for the homotypic prediction pattern of depression overtime”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [40] Lancefield KS, Raudino A, Downs JM, Laurens KR. Trajectories of childhood internalizing and externalizing psychopathology and psychotic-like experiences in adolescence: a prospective population-based cohort study. Dev Psychopathol. 2016;28(2):527–36. source
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- Premisecitation
Young individuals who do establish contact with mental health services show high rates of disengagement.
“When they do, they show high rates of disengagement [20]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [20] Kim DJ, Brown E, Reynolds S, Geros H, Sizer H, Tindall R, et al. The rates and determinants of disengagement and subsequent re-engagement in young people with first-episode psychosis. Soc Psychiatry Psychiatr Epidemiol. 2019;54:945–53. source
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- Premisecitation
Most mental disorders have their peak of incidence during the transition from childhood to young adulthood.
“most mental disorders have their peak of incidence during the transition from childhood to young adulthood”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [14] Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. 2005;62(6):593–602. source
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- Premisecitation
The reduction would be higher when considering exclusively adolescence-onset (32.3%) and childhood-onset (38.2%) cases.
“and an even higher reduction when considering exclusively adolescence- (32.3%) and childhood-onset (38.2%) cases [28]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [28] Kessler RC, McLaughlin KA, Green JG, Gruber MJ, Sampson NA, Zaslavsky AM, et al. Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys. Br J Psychiatry. 2010;197(5):378–85. source
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- Interpretationreasoning
Single disorder-oriented trajectories offer limited prospects for preventive interventions.
“Overall, these findings highlight how single disorder-oriented trajectories offer limited prospects for preventive interventions.”
Quote in the paperSubstantial claim - Premisecitation
Most risk factors are shared across multiple mental disorders.
“most risk factors are shared across multiple mental disorders”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [85] Uher R, Zwicker A. Etiology in psychiatry: embracing the reality of poly-gene-environmental causation of mental illness. World Psychiatry. 2017;16(2):121–9. source
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- Premisecitation
Early intervention models, initially designed to assist people with psychotic disorders, have expanded their area of intervention to mood, personality, eating, and substance use disorders.
“Parallel, early intervention models, initially designed to assist people with psychotic disorders, have expanded their area of intervention to mood, personality, eating, and substance use disorders [128].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [128] Malla A, Iyer S, McGorry P, Cannon M, Coughlan H, Singh S, et al. From early intervention in psychosis to youth mental health reform: a review of the evolution and transformation of mental health services for young people. Soc Psychiatry Psychiatr Epidemiol. 2016;51(3):319–26. source
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- Premisecitation
A Cochrane systematic review has confirmed the need for greater collaboration between primary care sector and specialist mental healthcare services to improve the effectiveness of early intervention in mental health.
“a Cochrane systematic review has confirmed the need for greater collaboration between primary care sector and specialist mental healthcare services [100]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [100] Bower P, Sibbald B. Systematic review of the effect of on-site mental health professionals on the clinical behaviour of general practitioners. BMJ. 2000;320(7235):614–7. source
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- Premisecitation
About a third of individuals at clinical high risk are only in remission.
“with about a third only in remission [92]”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [92] Simon AE, Borgwardt S, Riecher-Rössler A, Velthorst E, de Haan L, Fusar-Poli P. Moving beyond transition outcomes: meta-analysis of remission rates in individuals at high clinical risk for psychosis. Psychiatry Res. 2013;209(3):266–72. source
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- Premisecitation
A narrowed psychosis-risk approach guarantees a limited detection, approximately 5%, even for those patients who will eventually develop a first episode of psychosis.
“a so narrowed approach guarantees a limited detection, approximately 5%, even for those patients who will eventually develop a first episode of psychosis [93]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [93] Fusar-Poli P, Rutigliano G, Stahl D, Davies C, Bonoldi I, Reilly T, et al. Development and validation of a clinically based risk calculator for the transdiagnostic prediction of psychosis. JAMA Psychiatry. 2017;74(5):493–500. source
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- Premisecitation
Reducing the duration of untreated illness has been robustly shown to impact positively on the outcome of first-episode psychosis and schizophrenia in many ways.
“reducing the duration of untreated illness has been robustly shown to impact positively on the outcome of first-episode psychosis and schizophrenia in many ways [95]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [95] Oliver D, Davies C, Crossland G, Lim S, Gifford G, McGuire P, et al. Can we reduce the duration of untreated psychosis? A systematic review and meta-analysis of controlled interventional studies. Schizophr Bull. 2018;44(6):1362–72. source
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- Premisecitation
The Massachusetts Child Psychiatry Access Project (MCPAP) promoted the creation of a statewide service favoring collaborations between primary care practices and specialized child and adolescent psychiatry services.
“In the USA, the Massachusetts Child Psychiatry Access Project (MCPAP) promoted the creation of a statewide service favoring collaborations between primary care practices and specialized child and adolescent psychiatry services.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [129] Connor DF, McLaughlin TJ, Jeffers-Terry M, O’Brien WH, Stille CJ, Young LM, et al. Targeted child psychiatric services: a new model of pediatric primary clinician–child psychiatry collaborative care. Clin Pediatr (Phila). 2006;45(5):423–34. source
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- Premisecitation
The Massachusetts Mental Health Services Program for Youth (MHSPY) has implemented home-based integrated clinical interventions to assist severely impaired youth with mental, social, and substance use problems as well as their families in the community.
“With the aim of productively integrating and enhancing collaborative care at all levels of prevention, the Massachusetts Mental Health Services Program for Youth (MHSPY) has also implemented home-based integrated clinical interventions to assist severely impaired youth with mental, social, and substance use problems as well as their families in the community.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [131] Grimes KE, Mullin B. MHSPY: a children’s health initiative for maintaining at-risk youth in the community. J Behav Health Serv Res. 2006;33(2):196–212. source
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- Premisecitation
Some undesired outcomes, such as decreased social functioning, quality of life, and occupational performance, are shared across mental disorders.
“some undesired outcomes, such as decreased social functioning, quality of life, and occupational performance, are shared across mental disorders [98, 99]”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [98] Filho AS, Hetem LA, Ferrari MC, Trzesniak C, Martín-Santos R, Borduqui T, et al. Social anxiety disorder: what are we losing with the current diagnostic criteria? Acta Psychiatr Scand. 2010;121(3):216–26. source
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- Premisecitation
Disappointing evidence from studies of the effect of collaborative care on depression indicates that clinical improvement may not be maintained after discontinuing multidisciplinary treatment.
“disappointing evidence from studies of the effect of collaborative care on depression indicate that the clinical improvement may not be maintained after discontinuing the multidisciplinary treatment [101]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [101] Asarnow J, Jaycox L, Tang L, Duan N, LaBorde A, Zeledon L, et al. Long-term benefits of short-term quality improvement interventions for depressed youths in primary care. Am J Psychiatry. 2009;166(9):1002–10. source
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- Premisecitation
A hybrid strategy in at-risk states involving symptom relief coupled to a reduction of transition has been suggested.
“a hybrid strategy has been suggested in at-risk states involving symptom relief coupled to a reduction of transition [97]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [97] Millan MJ, Andrieux A, Bartzokis G, Cadenhead K, Dazzan P, Fusar-Poli P, et al. Altering the course of schizophrenia: progress and perspectives. Nat Rev Drug Discov. 2016;15(7):485–515. source
Not checked in the free run.
- Premisecitation
Multimodal preventing programs combining preschool intervention and family support have been associated with the most enduring beneficial effects on social outcomes, including better overall academic performances and lower delinquency and antisocial behavior rates.
“multimodal preventing programs combining preschool intervention and family support have been associated to the most enduring beneficial effects on a number of social outcomes, including significant better overall academic performances and lower delinquency and antisocial behavior rates [49]”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [49] Yoshikawa H. Long term effects of early childhood programs on social outcomes and delinquency. Future Child. 1995;5(3):51–75. source
Not checked in the free run.
- Premisecitation
Some pre-diagnostic symptoms and neurobiological correlates are not specific for psychosis.
“some pre-diagnostic symptoms and neurobiological correlates are not specific for psychosis [97]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [97] Millan MJ, Andrieux A, Bartzokis G, Cadenhead K, Dazzan P, Fusar-Poli P, et al. Altering the course of schizophrenia: progress and perspectives. Nat Rev Drug Discov. 2016;15(7):485–515. source
Not checked in the free run.
- Premisecitation
Exercise training is an effective universal prevention intervention to support brain plasticity, structure, connectivity, and cognitive functioning.
“exercise training to support brain plasticity [66], structure [67] and connectivity [68] as well as cognitive functioning [69]”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites [66] Cotman CW, Berchtold NC. Exercise: a behavioral intervention to enhance brain health and plasticity. Trends Neurosci. 2002;25(6):295–301. source
Not checked in the free run.
- cites [67] Draganski B, Gaser C, Busch V, Schuierer G, Bogdahn U, May A. Neuroplasticity: changes in grey matter induced by training. Nature. 2004;427(6972):311–2. source
Not checked in the free run.
- cites [68] Douw L, Nieboer D, van Dijk BW, Stam CJ, Twisk JW. A healthy brain in a healthy body: brain network correlates of physical and mental fitness. PLoS ONE. 2014;9(2):e88202. source
Not checked in the free run.
- Premisecitation
Perinatal phosphatidylcholine and N-acetylcysteine administration are effective universal prevention interventions to support infants' brain development and anti-inflammatory neuroprotection.
“perinatal phosphatidylcholine [54] and N-acetylcysteine [55] administration to support infants’ brain development and anti-inflammatory neuroprotection”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [54] Ross RG, Hunter SK, McCarthy L, Beuler J, Hutchison AK, Wagner BD, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290–8. source
Not checked in the free run.
- cites [55] Jenkins DD, Wiest DB, Mulvihill DM, Hlavacek AM, Majstoravich SJ, Brown TR, et al. Fetal and neonatal effects of N-acetylcysteine when used for neuroprotection in maternal chorioamnionitis. J Pediatr. 2016;168(67–76):e6.
Not checked in the free run.
- Premisecitation
In psychosis studies, the first 2 years following the manifestation of functional impairment is a period of particular risk for transition to full-blown disorder.
“Psychosis studies have identified in the first 2 years following the manifestation of functional impairment a period of particular risk for transition to full-blown disorder [91]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [91] Kempton MJ, Bonoldi I, Valmaggia L, McGuire P, Fusar-Poli P. Speed of psychosis progression in people at ultra-high clinical risk: a complementary meta-analysis. JAMA Psychiatry. 2015;72(6):622–3. source
Not checked in the free run.
- Interpretationcitation
The sharing of most risk factors across multiple mental disorders suggests poor validity of boundaries between diagnostic categories, at least at this stage.
“suggesting the poor validity of boundaries between diagnostic categories, at least at this stage [85]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [85] Uher R, Zwicker A. Etiology in psychiatry: embracing the reality of poly-gene-environmental causation of mental illness. World Psychiatry. 2017;16(2):121–9. source
Not checked in the free run.
- Premisecitation
Developmental anomalies and behavioral deficits observed during childhood may be, at least partially, modifiable.
“promising findings suggest that developmental anomalies and behavioral deficits observed during childhood may be, at least partially, modifiable [53]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [53] Ghosh A, Michalon A, Lindemann L, Fontoura P, Santarelli L. Drug discovery for autism spectrum disorder: challenges and opportunities. Nat Rev Drug Discov. 2013;12(10):777–90. source
Not checked in the free run.
- Premisecitation
MCPAP has a wide area of intervention including attention deficit hyperactivity disorder, depression, anxiety as well as initial psychopharmacological treatment.
“MCPAP has a wide area of intervention including attention deficit hyperactivity disorder, depression, anxiety as well as initial psychopharmacological treatment [129].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [129] Connor DF, McLaughlin TJ, Jeffers-Terry M, O’Brien WH, Stille CJ, Young LM, et al. Targeted child psychiatric services: a new model of pediatric primary clinician–child psychiatry collaborative care. Clin Pediatr (Phila). 2006;45(5):423–34. source
Not checked in the free run.
- Premisecitation
Reforming youth mental health services toward integration and collaboration between different healthcare professionals has gained increasing interest over the last decade.
“Over the last decade, reforming youth mental health services in the perspective of integration and collaboration between different healthcare professionals has gained increasing interest [127].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [127] McGorry P, Bates T, Birchwood M. Designing youth mental health services for the 21st century: examples from Australia, Ireland and the UK. Br J Psychiatry Suppl. 2013;54:s30–5. source
Not checked in the free run.
- Premisecitation
Research suggests detrimental psychosocial and functional consequences of each relapse.
“research suggests detrimental psychosocial and functional consequences of each relapse [125, 126]”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [125] Fikreyesus M, Soboka M, Feyissa G. Psychotic relapse and associated factors among patients attending health services in Southwest Ethiopia: a cross-sectional study. Bmc Psychiatry. 2016;16:354. source
Not checked in the free run.
- cites [126] Gbiri C, Badru F, Ladapo H, Gbiri A. Socio–economic correlates of relapsed patients admitted in a Nigerian mental health institution. Int J Clin Pract. 2011;15(1):19–26. source
Not checked in the free run.
- Premisecitation
Timing school-based mental health assistance, assertiveness training, and stress and anxiety management have the greatest chance to prevent maladaptive behavior and symptomatic manifestations.
“To date, timing school-based mental health assistance, assertiveness training, and stress and anxiety management have the greatest chance to prevent maladaptive behavior and symptomatic manifestations [89].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [89] Greenberg M, Weissberg R, O’Brien M, Zins J, Fredericks L, Resnik H, et al. Enhancing school-based prevention and youth development through coordinated social, emotional, and academic learning. Am Psychol. 2003;58(6–7):466–74. source
Not checked in the free run.
- Premisecitation
School-based behavioral interventions are effective universal prevention interventions to minimize risk of bullying and peer rejection as well as substance abuse.
“school-based behavioral interventions to minimize risk of bullying and peer rejection [62, 63] as well as substance abuse [64, 65]”
Quote in the paperNot a substantial claim0 of 4 sources checked- cites [62] Waasdorp TE, Bradshaw CP, Leaf PJ. The impact of schoolwide positive behavioral interventions and supports on bullying and peer rejection: a randomized controlled effectiveness trial. Arch Pediatr Adolesc Med. 2012;166(2):149–56. source
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- cites [63] Nocentini A, Menesini E. KiVa anti-bullying program in italy: evidence of effectiveness in a randomized control trial. Prev Sci. 2016;17(8):1012–23. source
Not checked in the free run.
- cites [64] Patnode CD, O’Connor E, Rowland M, Burda BU, Perdue LA, Whitlock EP. Primary care behavioral interventions to prevent or reduce illicit drug use and nonmedical pharmaceutical use in children and adolescents: a systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med. 2014;160(9):612–20. source
Not checked in the free run.
- cites [65] Vogl LE, Newton NC, Champion KE, Teesson M. A universal harm-minimisation approach to preventing psychostimulant and cannabis use in adolescents: a cluster randomised controlled trial. Subst Abuse Treat Prev Policy. 2014;9:24. source
Not checked in the free run.
- Interpretationreasoning
It has become increasingly possible to offer multidisciplinary and integrated healthcare to young people below the age of 25 with a variety of mental health difficulties as well as support their families.
“Thus, it has become increasingly possible to offer multidisciplinary and integrated healthcare to young people below the age of 25 with a variety of mental health difficulties as well as support their families.”
Quote in the paperSubstantial claim - Interpretationcitation
A promising strategy is the identification of young individuals exposed to risk factors who also have a family history of severe mental illness, in light of the higher genetic component for risk of mental disorders.
“a promising strategy has been suggested to be the identification of those young individuals exposed to these risk factors who also have a family history of severe mental illness, in light of the per se higher genetic component for risk of mental disorders [90]”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [90] Fusar-Poli P, McGorry PD, Kane JM. Improving outcomes of first-episode psychosis: an overview. World Psychiatry. 2017;16(3):251–65. source
Not checked in the free run.
- Interpretationreasoning
The absence of validated interventions to prevent multiple relapses highlights the limited protective effect of psychopharmacological treatments in the long-term.
“The absence of validated interventions to prevent multiple relapses highlights the limited protective effect of psychopharmacological treatments in the long-term”
Quote in the paperSubstantial claim - Premisenone given
Following the manifestation of a first episode of acute psychiatric symptoms, some patients may not reach full recovery, being still symptomatic or functionally impaired.
“following the manifestation of a first episode of acute psychiatric symptoms, some patients may not reach full recovery, being still symptomatic or functionally impaired.”
Quote in the paperNot a substantial claim - Premisecitation
Increasing evidence suggests a similar effect of reducing duration of untreated illness for other psychiatric disorders including major depressive disorder, bipolar disorder, panic disorder, generalized anxiety disorder, and obsessive-compulsive disorder.
“Increasing evidence suggests a similar effect for other psychiatric disorders including major depressive disorder, bipolar disorder, panic disorder, generalized anxiety disorder, and obsessive–compulsive disorder [96].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [96] Dell’Osso B, Glick I, Baldwin D, Altamura A. Can long-term outcomes be improved by shortening the duration of untreated illness in psychiatric disorders? A Conceptual Framework. Psychopathology. 2013;46(1):14–21. source
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- Premisecitation
Biological evidence for an association between multiple relapse and further deterioration is conflicting.
“While the biological evidence for an association between multiple relapse and further deterioration is conflicting [124]”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [124] Jollans L, Whelan R. Neuromarkers for mental disorders: harnessing population neuroscience. Front Psychiatry. 2018;9:242. source
Not checked in the free run.
- Interpretationreasoning
This healthcare model is transferred to other countries at an increasingly rapid rate.
“This healthcare model is transferred to other countries at an increasingly rapid rate.”
Quote in the paperNot a substantial claim - Premisecitation
In Australia, a 2006 government-funded initiative led to creation of 'Headspace', a multidisciplinary and integrated service offering early intervention for 12-25-year-old people with emerging mental health difficulties.
“In Australia, a 2006 government-funded initiative led to creation of ‘Headspace’, a multidisciplinary and integrated service offering early intervention for 12–25-year-old people with emerging mental health difficulties.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [132] McGorry PD, Tanti C, Stokes R, Hickie IB, Carnell K, Littlefield LK, et al. headspace: Australia’s National Youth Mental Health Foundation–where young minds come first. Med J Aust. 2007;187(7 Suppl):S68–70.
Not checked in the free run.
- Premisecitation
Headspace has a wide area of intervention including mental health, physical health, vocational and educational support, and substance use.
“Headspace has a wide area of intervention including mental health, physical health, vocational and educational support, and substance use [132].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [132] McGorry PD, Tanti C, Stokes R, Hickie IB, Carnell K, Littlefield LK, et al. headspace: Australia’s National Youth Mental Health Foundation–where young minds come first. Med J Aust. 2007;187(7 Suppl):S68–70.
Not checked in the free run.
- Premisecitation
Research is following suit, with programs moving from the early identification of states immediately preceding psychosis onset in late adolescence or early adulthood to the investigation of earlier phases of illness in vulnerable children and younger adolescents (e.g. London Child Health and Development Study).
“Interestingly, research is following suit, with programs moving from the early identification of states immediately preceding psychosis onset in late adolescence or early adulthood to the investigation of earlier phases of illness in vulnerable children and younger adolescents (e.g. London Child Health and Development Study) [136].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [136] Laurens KR, Cullen AE. Toward earlier identification and preventative intervention in schizophrenia: evidence from the London Child Health and Development Study. Soc Psychiatry Psychiatr Epidemiol. 2016;51(4):475–91. source
Not checked in the free run.
- Premisecitation
Similar models have been developed or under construction in Denmark, Israel, California, Canada (the ACCESS, Adolescent/young adult Connections to Community-driven Early Strengths-based and Stigma-free services), British Columbia ('The Foundry' model), and the Netherlands (@ease).
“Similar models have been developed or under construction in Denmark, Israel, California, Canada (the ACCESS, Adolescent/young adult Connections to Community-driven Early Strengths-based and Stigma-free services), British Columbia (‘The Foundry’ model), and the Netherlands (@ease) [8].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [8] McGorry PD, Mei C. Early intervention in youth mental health: progress and future directions. Evid Based Ment Health. 2018;21(4):182–4. source
Not checked in the free run.
- Premisecitation
An independent evaluation of Headspace has shown positive effects of the service in terms of reducing suicide ideation, self-harm, and number of absent school or work days.
“An independent evaluation of Headspace has shown positive effects of the service in terms of reducing suicide ideation, self-harm, and number of absent school or work days [133].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [133] Patulny R, Muir K, Powell A, Flaxman S, Oprea I. Are we reaching them yet? Service access patterns among attendees at the headspace youth mental health initiative. Child Adolesc Ment Health. 2013;18(2):95–102. source
Not checked in the free run.
- Interpretationreasoning
A mix of services is offered among these models of care, in order to target mental health and behavior, situational problems, physical or sexual health, alcohol or other drugs use, and vocational issues.
“In summary, a mix of services is offered among these models of care, in order to target mental health and behavior, situational problems, physical or sexual health, alcohol or other drugs use, and vocational issues.”
Quote in the paperSubstantial claim - Premisecitation
In the United Kingdom, a youth-based mental health service called 'Youth space' has implemented integrated health benefits for people aged 0-25 years in the Birmingham catchment area.
“In the United Kingdom, a youth-based mental health service called ‘Youth space’ has implemented integrated health benefits for people aged 0–25 years in the Birmingham catchment area [135].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [135] Birchwood M. Youth space and youth mental health. Eur Psychiatry. 2018;48:S7.
Not checked in the free run.
- Interpretationcitation
Research evidence supports the implementation of healthcare systems integrating mental, primary, and social care in order to guarantee youth a healthy mental development through promotion, prevention, and early interventions.
“In order to guarantee youth a healthy mental development through promotion, prevention, and early interventions, research evidence supports the implementation of healthcare systems integrating mental, primary, and social care [128].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [128] Malla A, Iyer S, McGorry P, Cannon M, Coughlan H, Singh S, et al. From early intervention in psychosis to youth mental health reform: a review of the evolution and transformation of mental health services for young people. Soc Psychiatry Psychiatr Epidemiol. 2016;51(3):319–26. source
Not checked in the free run.
- Classified as probably not a substantial claim. 7
- May combine two claims. 15
- The quote only partly states this claim. 1
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationProblematic substance use including alcohol and illicit drugs is the main risk factor for incident DALY (9%) among people younger than 25.
“with problematic substance use including alcohol and illicit drugs being the main risk factor for incident DALY (9%) [15]”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [15] Gore FM, Bloem PJ, Patton GC, Ferguson J, Joseph V, Coffey C, et al. Global burden of disease in young people aged 10–24 years: a systematic analysis. Lancet. 2011;377(9783):2093–102. source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationAmong people younger than 25 years old, mental health problems, especially anxiety and mood disorders, are the main cause of disability-adjusted life-years (DALYs).
“Among people younger than 25 years old, mental health problems, especially anxiety and mood disorders, are the main cause of disability-adjusted life-years (DALYs)”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [15] Gore FM, Bloem PJ, Patton GC, Ferguson J, Joseph V, Coffey C, et al. Global burden of disease in young people aged 10–24 years: a systematic analysis. Lancet. 2011;377(9783):2093–102. source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationMental health problems account for 45% of the global burden of disease across the 0-25 age span.
“accounting for 45% of the global burden of disease across the 0–25 age span”
- Also stated in: § Results · plain
“accounting for 45% of the global burden of disease”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [15] Gore FM, Bloem PJ, Patton GC, Ferguson J, Joseph V, Coffey C, et al. Global burden of disease in young people aged 10–24 years: a systematic analysis. Lancet. 2011;377(9783):2093–102. source
Not checked in the free run.
- Also stated in: § Results · plain
May combine two claims.
PremisecitationInternalizing and externalizing psychopathology predict psychosis-like experiences and vice versa.
“internalizing and externalizing psychopathology predicting psychosis-like experiences and vice versa [40]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [40] Lancefield KS, Raudino A, Downs JM, Laurens KR. Trajectories of childhood internalizing and externalizing psychopathology and psychotic-like experiences in adolescence: a prospective population-based cohort study. Dev Psychopathol. 2016;28(2):527–36. source
Not checked in the free run.
May combine two claims.
PremisecitationA number of factors influence the person's mental health from before birth until early adulthood, after which mental health can still be significantly modulated but to a lesser extent.
“Research evidence indicates that a number of factors influence the person’s mental health from before birth until early adulthood, after which mental health can still be significantly modulated but to a lesser extent [29]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [29] Mustard JF. Brain development, child development—adult health and well-being and paediatrics. Paediatr Child Health. 1999;4(8):519–20. source
Not checked in the free run.
May combine two claims.
InterpretationreasoningInterventions addressing multiple co-occurring problems are more likely to impact positively on youth mental health, potentially interrupting the continuity between childhood internalizing and externalizing psychopathology and psychiatric disorders in adulthood.
“interventions addressing multiple co-occurring problems are more likely to impact positively on youth mental health, potentially interrupting the continuity between childhood internalizing and externalizing psychopathology that may also co-occur with psychosis-like experiences on one hand, and psychiatric disorders in adulthood on the other.”
Quote in the paperSubstantial claimMay combine two claims.
PremisecitationIn the absence of secure attachment, neurodevelopment may be undermined, making the person more vulnerable to further environmental insults and subsequent development of both internalizing and externalizing behavioral problems, including anxiety, depression, substance misuse, maladaptive eating patterns, sexual risk behavior, and suicidality.
“In its absence, neurodevelopment may be undermined, making that person more vulnerable to further environmental insults and subsequent development of both internalizing [36] and externalizing [37] behavioral problems, including anxiety, depression, substance misuse, maladaptive eating patterns, sexual risk behavior, and suicidality.”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [36] Groh AM, Roisman GI, van Ijzendoorn MH, Bakermans-Kranenburg MJ, Fearon RP. The significance of insecure and disorganized attachment for children’s internalizing symptoms: a meta-analytic study. Child Dev. 2012;83(2):591–610. source
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- cites [37] Fearon RP, Bakermans-Kranenburg MJ, van Ijzendoorn MH, Lapsley AM, Roisman GI. The significance of insecure attachment and disorganization in the development of children’s externalizing behavior: a meta-analytic study. Child Dev. 2010;81(2):435–56. source
Not checked in the free run.
May combine two claims. The quote only partly states this claim.
PremisecitationLifetime omega-3 fatty acid, vitamin, sulforaphane, and prebiotic supplementation are effective universal prevention interventions to support good mental health by reducing neuroinflammation, oxidative stress, and microbiota dysbiosis.
“lifetime omega-3 fatty acid [56–58], vitamin [57–59], sulforaphane [60], and prebiotic [61] supplementation to support good mental health by reducing neuroinflammation, oxidative stress, and microbiota dysbiosis”
Quote in the paperNot a substantial claim0 of 5 sources checked- cites [56] Pusceddu MM, Kelly P, Stanton C, Cryan JF, Dinan TG. N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology. Int J Neuropsychopharmacol. 2016;19(12):pyw078. source
Not checked in the free run.
- cites [57] Dawson SL, Bowe SJ, Crowe TC. A combination of omega-3 fatty acids, folic acid and B-group vitamins is superior at lowering homocysteine than omega-3 alone: a meta-analysis. Nutr Res. 2016;36(6):499–508. source
Not checked in the free run.
- cites [58] Kurtys E, Eisel ULM, Verkuyl JM, Broersen LM, Dierckx RAJO, de Vries EFJ. The combination of vitamins and omega-3 fatty acids has an enhanced anti-inflammatory effect on microglia. Neurochem Int. 2016;99:206–14. source
Not checked in the free run.
- cites [59] Eryilmaz H, Dowling KF, Huntington FC, Rodriguez-Thompson A, Soare TW, Beard LM, et al. Association of prenatal exposure to population-wide folic acid fortification with altered cerebral cortex maturation in youths. JAMA Psychiatry. 2018;75(9):918–28. source
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- cites [60] Do KQ, Cuenod M, Hensch TK. Targeting oxidative stress and aberrant critical period plasticity in the developmental trajectory to schizophrenia. Schizophr Bull. 2015;41(4):835–46. source
Not checked in the free run.
May combine two claims.
PremisecitationSome health and social domains such as education, housing, nutrition, and healthcare have pervasive influence on low income settings, while lack of supportive environments and community networks may have more detrimental effects in urban areas with high population density or ethnic minorities.
“some health and social domains such as education, housing, nutrition, and healthcare, have pervasive influence on low income settings, while lack of supportive environments and community networks may have more detrimental effects in urban areas with high population density or ethnic minorities [50, 51]”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites [50] Castillo EG, Ijadi-Maghsoodi R, Shadravan S, Moore E, Mensah MO, Docherty M, et al. Community interventions to promote mental health and social equity. Curr Psychiatry Rep. 2019;21(5):35. source
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- cites [51] Jané-Llopis E, Barry M, Hosman C, Patel V. Mental health promotion works: a review. Promot Educ. 2005; 12(Suppl 2):9–25, 61, 7.
Not checked in the free run.
May combine two claims.
PremisecitationIndicated interventions have positive effects not only in reducing the presenting problem but also in improving other areas of psychosocial adjustment among at-risk students.
“Results suggested that indicated interventions have positive effects not only in reducing the presenting problem but also in improving other areas of psychosocial adjustment [94].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [94] Conley CS, Shapiro JB, Kirsch AC, Durlak JA. A meta-analysis of indicated mental health prevention programs for at-risk higher education students. J Couns Psychol. 2017;64(2):121–40. source
Not checked in the free run.
May combine two claims.
PremisecitationPathways to mental disorders are pluripotent and trans-diagnostic.
“increasingly clear evidence that pathways to mental disorders are pluripotent and trans-diagnostic [22]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [22] McGorry PD, Mei C. Ultra-high-risk paradigm: lessons learnt and new directions. Evid Based Ment Health. 2018;21(4):131–3. source
Not checked in the free run.
May combine two claims.
PremisecitationThe development of services for indicated prevention has met the objectives of strengthening service engagement, reducing the duration of untreated illness, and liaising with secondary prevention interventions.
“Research evidence suggests that the development of services for indicated prevention has met the objectives of strengthening service engagement, reducing the duration of untreated illness, and liaising with secondary prevention interventions [42].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [42] WHO. Prevention of mental disorders. Effective interventions and policy options. Geneva: World Health Organisation; 2004.
Not checked in the free run.
Probably not a substantial claim: may not pass S2 (checkable), S3 (load-bearing).
InterpretationreasoningPromotion programs require tailoring to the specific socio-cultural setting.
“Most likely, promotion programs require tailoring to the specific socio-cultural setting.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationStudies have shown that most primary care practices have enrolled in MCPAP, increasing young individuals' access to psychiatric services and overall satisfaction.
“Studies have shown that most primary care practices have enrolled in the program, increasing young individuals’ access to psychiatric services and overall satisfaction [130].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [130] Straus JH, Sarvet B. Behavioral health care for children: the massachusetts child psychiatry access project. Health Aff (Millwood). 2014;33(12):2153–61. source
Not checked in the free run.
Probably not a substantial claim: may not pass S2 (checkable).
InterpretationreasoningResearch evidence summarized in this review suggests that health researchers and professionals as well as health service institutions and governments have to join forces to deliver integrated and multidisciplinary actions in mental health, especially in the early steps of the prevention chain.
“Research evidence summarized in this review suggests that health researchers and professionals as well as health service institutions and governments have to join forces to deliver integrated and multidisciplinary actions in mental health, especially in the early steps of the prevention chain.”
Quote in the paperNot a substantial claim- Rests on an assumption: Promotion and prevention in mental health are not necessarily the responsibility of mental health professionals alone.
- Rests on an assumption: The mental health care sector has among its prerogatives the provision of effective interventions from early stages of illness to long-lasting conditions.
May combine two claims.
PremisecitationIn Ireland, services called 'Headstrong' and 'Jigsaw' have developed, proving to be effective in facilitating access to community care to people aged 12-25 with emerging mental health difficulties.
“In Ireland, services called ‘Headstrong’ and ‘Jigsaw’ have developed, proving to be effective in facilitating access to community care to people aged 12–25 with emerging mental health difficulties [134].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [134] O’Keeffe L, O’Reilly A, O’Brien G, Buckley R, Illback R. Description and outcome evaluation of Jigsaw: an emergent Irish mental health early intervention programme for young people. Ir J Psychol Med. 2015;32(1):71–7. source
Not checked in the free run.
May combine two claims.
PremisecitationDepending on the presenting concern, the proportion of each delivered service can vary as well as the main service provider (general practitioner, psychologist, allied mental health etc.) and funding source.
“Depending on the presenting concern, the proportion of each delivered service can vary as well as the main service provider (general practitioner, psychologist, allied mental health etc.) and funding source [137].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [137] Rickwood DJ, Telford NR, Mazzer KR, Parker AG, Tanti CJ, McGorry PD. The services provided to young people through the headspace centres across Australia. Med J Aust. 2015;202(10):533–6. source
Not checked in the free run.
May combine two claims.
PremisecitationStudies have shown benefits of MHSPY interventions in terms of higher psychosocial functioning and family satisfaction as well as lower burden on services and risk to self and others.
“Studies have shown benefits of MHSPY interventions in terms of higher psychosocial functioning and family satisfaction as well as lower burden on services and risk to self and others [131].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [131] Grimes KE, Mullin B. MHSPY: a children’s health initiative for maintaining at-risk youth in the community. J Behav Health Serv Res. 2006;33(2):196–212. source
Not checked in the free run.
May combine two claims.
PremisecitationIn a decade, thanks to the creation of 'communities of youth services' (CYSs), Headspace has seen growing the number of its centers from 10 to more than 110, granting access to services to about 100,000 young people per year, including vulnerable, marginalized, and at-risk groups.
“In a decade, thanks to the creation of ‘communities of youth services’ (CYSs), Headspace has seen growing the number of its centers from 10 to more than 110, granting access to services to about 100,000 young people per year, including vulnerable, marginalized, and at-risk groups [8].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [8] McGorry PD, Mei C. Early intervention in youth mental health: progress and future directions. Evid Based Ment Health. 2018;21(4):182–4. source
Not checked in the free run.
Classified as probably not a substantial claim.
PremisecitationElements indicating best practice have been identified, including being highly accessible, acceptable, appropriate, and sustainable.
“elements indicating best practice have been identified, including being highly accessible (affordable, convenient, timely, non-stigmatizing, flexible, inclusive, and awareness raising), acceptable (youth-friendly, confidential, respectful, engaging, responsive, competent, and collaborative), appropriate (early intervention focused, comprehensive, developmentally-appropriate, suitable to early st”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [138] Hetrick SE, Bailey AP, Smith KE, Malla A, Mathias S, Singh SP, et al. Integrated (one-stop shop) youth health care: best available evidence and future directions. Med J Aust. 2017;207(10):S5–18.
Not checked in the free run.
Probably not a substantial claim: may not pass S2 (checkable). May combine two claims.
InterpretationreasoningThe continuity of youth mental health needs from an early age seems to go beyond the boundaries of what falls within the mental health professionals' competences and duties, putting at stake the epistemological status of psychiatry.
“The continuity of youth mental health needs from an early age seems to go beyond the boundaries of what falls within the mental health professionals’ competences and duties, putting at stake the epistemological status of psychiatry.”
Quote in the paperNot a substantial claim
The paper relies on this without support.
Promotion and prevention in mental health are not necessarily the responsibility of mental health professionals alone.
“Promotion and prevention in mental health are not necessarily responsibility of mental health professionals alone.”
The paper relies on this without support.
The mental health care sector has among its prerogatives the provision of effective interventions from early stages of illness to long-lasting conditions.
“The mental health care sector has among its prerogatives the provision of effective interventions from early stages of illness to long-lasting conditions.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The marked benefits of early detection of STBs include acute suicide prevention and identification of at-risk children for early intervention.
“the marked benefits of early detection of STBs, ranging from acute suicide prevention to identification of at-risk children for early intervention, when such interventions are potentially most effective18”
From Asking Preadolescents About Suicide Is Not Associated With Increased Suicidal Thoughts (2026) · cites this paper as [18]
The Background (page not provided) says screening and early detection may enable intervention before health problems worsen or begin. The Primary prevention section also describes identifying young people at clinical high risk for mental disorders. Neither passage establishes a benefit specifically for early detection of suicidal thoughts and behaviors (STBs) or acute suicide prevention. (LLM, conf=0.85)
Experimental — accuracy not yet measured
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- Authors
- Colizzi, M., Lasalvia, A., & Ruggeri, M.
- Affiliations
- University of Verona (IT)
- Corresponding author
- Colizzi, Marco
- Venue
- International Journal of Mental Health Systems
- Published
- 2020-03-24
- Volume
- 14
- Issue
- 1
- Pages
- 23-23
- ISSN
- 1752-4458 (ISSN-L)
- PMC
- PMC7092613
- OpenAlex
- W3013568653
- Semantic Scholar
- 3bc453fe077f87269b72f8b873fceffbdf36ae4f
- Cited by
- 727
- References
- 140
- Citations by year
- 2026: 153 · 2025: 185 · 2024: 188 · 2023: 101 · 2022: 70 · 2021: 22 · 2020: 8
- FWCI
- 8.10
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Journal of Mental Health Systems (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Trento) (submittedVersion, cc-by)
- Institutional Research Information System (University of Udine) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Health Professions › Speech and Hearing › School Health and Nursing Education
- Keywords
- youth mental health, mental health prevention, early intervention, primary prevention, mental health promotion, multidisciplinary care, psychosocial problems, unmet mental health needs, integrated mental health services
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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