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Cited by 44Bipolar Disorder and TreatmentTreatment of Major DepressionSchizophrenia research and treatment

Sodium butyrate has an antimanic effect and protects the brain against oxidative stress in an animal model of mania induced by ouabain

Valvassori, Samira S., Dal-Pont, Gustavo C., Steckert, Amanda V., Varela, Roger B., Lopes-Borges, Jéssica, Mariot, Edemilson, Resende, Wilson R., Arent, Camila O. +2 more·2016·Psychiatry Research
DOI 10.1016/j.psychres.2015.11.017
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Abstract

Studies have consistently reported the participation of oxidative stress in bipolar disorder (BD). Evidence indicates that epigenetic regulations have been implicated in the pathophysiology of mood disorders. Considering these evidences, the present study aimed to investigate the effects of sodium butyrate (SB), a histone deacetylase (HDAC)inhibitor, on manic-like behavior and oxidative stress parameters (TBARS and protein carbonyl content and SOD and CAT activities) in frontal cortex and hippocampus of rats subjected to the animal model of mania induced by intracerebroventricular (ICV) ouabain administration.The results showed that SB reversed ouabain-induced hyperactivity, which represents a manic-like behavior in rats. In addition, the ouabain ICV administration induced oxidative damage to lipid and protein and alters antioxidant enzymes activity in all brain structures analyzed. The treatment with SB was able to reversesboth behavioral and oxidative stress parameters alteration induced by ouabain.In conclusion, we suggest that SB can be considered a potential new mood stabilizer by acts on manic-like behavior and regulatesthe antioxidant enzyme activities, protecting the brain against oxidative damage.

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  • Butyrate has an antimanic effect on a rat model of bipolar disorder induced by intracerebroventricular administration of ouabain.

    “There is also evidence for butyrate's antimanic effect on a rat model of bipolar disorder induced by intracerebroventricular administration of ouabain (157).”

    From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [157]

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Authors
Valvassori, S. S., Dal-Pont, G. C., Steckert, A. V., Varela, R. B., Lopes-Borges, J., Mariot, E., Resende, W. R., Arent, C. O., Carvalho, A. F., & Quevedo, J.
Affiliations
Universidade do Extremo Sul Catarinense (BR)
Corresponding author
Valvassori, Samira S.
ORCID
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2016-01
Volume
235
Pages
154-159
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/j.psychres.2015.11.017
OpenAlex
W2145746227
Cited by
44
References
4
Citations by year
2026: 3 · 2025: 6 · 2024: 2 · 2023: 4 · 2022: 8 · 2021: 2 · 2020: 6 · 2019: 1 · 2018: 3 · 2017: 6 · 2016: 3
FWCI
3.24
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • CNPq
  • FAPESC
  • CAPES
  • UNESC
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
sodium butyrate, mania, bipolar disorder, ouabain, oxidative stress, histone deacetylase inhibitors, mood stabilizers, hyperactivity, lipid peroxidation, protein carbonylation, antioxidant enzymes, superoxide dismutase, catalase, frontal cortex, hippocampus, epigenetic regulation
MeSH terms
Animals, Antioxidants, Bipolar Disorder, Brain, Catalase, Disease Models, Animal, Hippocampus, Hyperkinesis, Male, Ouabain, Superoxide Dismutase, Rats, Wistar, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Antimanic Agents, Butyric Acid, Protein Carbonylation, Rats

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