Behavioral and neurochemical effects of sodium butyrate in an animal model of mania
Abstract
The present study investigated the effect of the histone deacetylase inhibitor, sodium butyrate (SB), on locomotor behavior and on mitochondrial respiratory-chain complexes activity in the brain of rats subjected to an animal model of mania induced by d-amphetamine (d-AMPH). In the reversal treatment, Wistar rats were first treated with d-AMPH or saline (Sal) for 14 days. Thereafter, between days 8 and 14, rats were administered SB or Sal. In the prevention treatment, rats were treated with SB or Sal for 14 days and received d-AMPH or Sal between days 8 and 14. The d-AMPH treatment increased locomotor behavior in Sal-treated rats under reversion and prevention treatment, and SB reversed and prevented d-AMPH-related hyperactivity. Moreover, d-AMPH decreased the activity of mitochondrial respiratory-chain complexes in Sal-treated rats in the prefrontal cortex, hippocampus, striatum, and amygdala in both experiments, and SB was able to reverse and prevent this impairment. The present study suggests that the mechanism of action of SB involves induction of mitochondrial function in parallel with behavioral changes, reinforcing the need for more studies on histone deacetylase inhibitors as a possible target for new medications for bipolar disorder treatment.
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Sodium butyrate is capable of reversing behavioral hyperactivity and depressive-like and manic-like behaviors in rats.
“Sodium butyrate has been shown to be capable of reversing behavioral hyperactivity (155) and depressive-like and manic-like behaviors in rats (156).”
From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [155]
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- Authors
- Moretti, M., Valvassori, S. S., Varela, R. B., Ferreira, C. L., Rochi, N., Benedet, J., Scaini, G., Kapczinski, F., Streck, E. L., Zugno, A. I., & Quevedo, J.
- Affiliations
- Universidade do Sul de Santa Catarina (BR)
- Universidade Federal do Rio Grande do Sul (BR)
- Corresponding author
- Moretti, Morgana
- ORCID
- Venue
- Behavioural Pharmacology
- Published
- 2011-12
- Volume
- 22
- Issue
- 8
- Pages
- 766-772
- ISSN
- 0955-8810 (ISSN-L)
- OpenAlex
- W2314385198
- Cited by
- 84
- References
- 0
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 9 · 2020: 10 · 2019: 4 · 2018: 2 · 2017: 6 · 2016: 3 · 2015: 5 · 2014: 8 · 2013: 9
- FWCI
- 3.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Behavioural Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- sodium butyrate, histone deacetylase inhibitors, mania, d-amphetamine, locomotor hyperactivity, mitochondrial respiratory chain, brain mitochondria, prefrontal cortex, hippocampus, striatum, amygdala, bipolar disorder, animal model of mania
- MeSH terms
- Central Nervous System Stimulants, Animals, Behavior, Animal, Bipolar Disorder, Brain, Dextroamphetamine, Disease Models, Animal, Hyperkinesis, Male, Motor Activity, Rats, Wistar, Antimanic Agents, Butyric Acid, Rats, Histone Deacetylase Inhibitors
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