Effect of adolescent substance use and antisocial behavior on the development of early adulthood depression
Open accessAbstract
Major depressive disorder (MDD) is a prevalent and frequently comorbid psychiatric disorder. This study evaluates the development of depressive symptoms, MDD diagnosis, and suicidal ideation in a high-risk sample (N=524) diagnosed with conduct disorder (CD) and substance use disorder (SUD) symptoms as youth and re-assessed approximately 6.5 years later. Dual trajectory classes of both alcohol and other drug use (AOD) and antisocial behavior (ASB), previously identified using latent class growth analyses (LCGA), were used to predict depression outcomes. The Dual Chronic, Increasing AOD/Persistent ASB, and Decreasing Drugs/Persistent ASB classes had higher past-week depression scores, more past-year MDD symptoms, and were more likely to have past-year MDD than the Resolved class. The Dual Chronic and Decreasing Drugs/Persistent ASB classes also had more past-year MDD symptoms than the Persistent AOD/Adolescent ASB class. Youth at highest risk for developing or maintaining depression in adulthood had the common characteristic of persistent antisocial behavior. This suggests young adulthood depression is associated more with persistent antisocial behavior than with persistent substance use in comorbid youth. As such, interventions targeting high-risk youth, particularly those with persistent antisocial behavior, are needed to help reduce the risk of severe psychosocial consequences (including risk for suicide) in adulthood.
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Depression is more positively associated with antisocial behaviors in adolescence.
“and is more positively associated with antisocial behaviors (Choi et al. 2016).”
From Problematic online behaviors among adolescents and emerging adults: associations between cyberbullying perpetration, problematic social media use, and psychosocial factors (2019) · cites this paper as Choi et al. 2016
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- Authors
- Choi, T. K., Worley, M. J., Trim, R. S., Howard, D., Brown, S. A., Hopfer, C. J., Hewitt, J. K., & Wall, T. L.
- Affiliations
- CHA University Bundang Medical Center (KR)
- University of California San Diego (US)
- University of Colorado Denver (US)
- University of Colorado Boulder (US)
- Corresponding author
- Wall, Tamara L.
- ORCID
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 238
- Pages
- 143-149
- ISSN
- 0165-1781 (ISSN-L)
- PMC
- PMC5094832
- OpenAlex
- W2274955352
- Cited by
- 12
- References
- 50
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2019: 1 · 2018: 2 · 2017: 2
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute of Drug Abuse (R01 DA021692, R01 DA035804, F31 DA030861, P60 DA011015, R01 DA012845, R01 DA021913, R01 DA015522)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- adolescent substance use, antisocial behavior, conduct disorder, substance use disorders, major depressive disorder, suicidal ideation, alcohol and other drug use, at-risk youth, comorbidities
- MeSH terms
- Adolescent, Adolescent Behavior, Adult, Antisocial Personality Disorder, Depression, Major Depressive Disorder, Female, Humans, Male, Risk Factors, Suicide, United States, Comorbidity, Prevalence, Conduct Disorder, Substance-Related Disorders, Young Adult, Suicidal Ideation
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