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Cited by 37Medication Adherence and ComplianceDiabetes Management and EducationSchizophrenia research and treatment

Are people with schizophrenia adherent to diabetes medication? A comparative meta-analysis

Open access
Gorczynski, Paul, Firth, Joseph, Stubbs, Brendon, Rosenbaum, Simon, Vancampfort, Davy·2017·Psychiatry Research
DOI 10.1016/j.psychres.2017.01.049
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Abstract

Individuals living with schizophrenia are 2-3 times more likely to experience type 2 diabetes mellitus. Diabetes medication adherence is essential to reduce morbidity and mortality in this population. We conducted a meta-analysis of diabetes medication adherence among people with schizophrenia, and compared this to those without schizophrenia. A systematic search strategy was used to identify all articles reporting adherence to diabetes medications among patients with schizophrenia. In total, 10 unique studies reporting data from 33,910 people with schizophrenia were included. Random effects meta-analysis showed people with schizophrenia adhered to medication on 77.3% of days prescribed (n=32080, 95%CI=73.6-81%, I 2=99.2%,), and adhered on 4.6% more days per year than those without schizophrenia (p<0.01, 95%CI=2.4-6.7%, I 2=92.5%, schizophrenia n=19367, controls=170,853). Furthermore, 56% of individuals with schizophrenia (n=33680) were considered "adherent" (i.e. >80% adherence over 12-24 month) to diabetes medication, which was significantly more than those without schizophrenia (OR=1.34, 95%CI: 1.18-1.52, p<0.01). Factors which were positively associated with diabetes medication adherence were age, number of outpatient visits, along with multiple medication administration variables. Future prospective research should examine diabetes monitoring, medication prescription, and subsequent adherence in fully representative samples. Novel interventions for maximizing compliance to diabetes medication in this vulnerable population should also be explored.

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Authors
Gorczynski, P., Firth, J., Stubbs, B., Rosenbaum, S., & Vancampfort, D.
Affiliations
  • University of Portsmouth (GB)
  • University of Manchester (GB)
  • King's College London (GB)
  • UNSW Sydney (AU)
  • KU Leuven (BE)
Corresponding author
Gorczynski, Paul
ORCID
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2017-04
Volume
250
Pages
17-24
ISSN
0165-1781 (ISSN-L)
DOI
10.1016/j.psychres.2017.01.049
OpenAlex
W2579309537
Cited by
37
References
36
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 14 · 2021: 3 · 2020: 2 · 2019: 4 · 2018: 3 · 2017: 2
FWCI
3.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (publishedVersion, cc-by-nc-nd)
  • Lirias (KU Leuven) (submittedVersion)
  • Research Explorer (The University of Manchester) (submittedVersion)
Topics
  • Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
schizophrenia, diabetes medication adherence, type 2 diabetes, medication adherence, psychiatric comorbidity, outpatient visits, age
MeSH terms
Age Factors, Diabetes Mellitus, Type 2, Humans, Hypoglycemic Agents, Prospective Studies, Schizophrenia, Schizophrenic Psychology, Medication Adherence

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