Reversal learning in patients with obsessive-compulsive disorder (OCD) and their unaffected relatives: Is orbitofrontal dysfunction an endophenotype of OCD?
Abstract
It has been suggested that reversal learning deficits might be an endophenotype of OCD. To investigate this hypothesis, we administered a probabilistic reversal learning task (ProbRev) to OCD patients, their unaffected first-degree relatives, and healthy controls. Although the relatives had a performance in between OCDs and controls at the early phase of the ProbRev, their performance was similar to controls and was significantly better than OCD patients at the later stages of the test. Our findings imply that reversal learning impairment might be partly a trait-related feature of OCD but state-related factors can also contribute to observed deficits.
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Previous studies examining behavioral deficits in reversal learning in OCD patients yielded mixed outcomes.
“Previous studies examining behavioral deficits in reversal learning in OCD patients yielded mixed outcomes, with some studies observing deficits,21, 22, 23, 24, 25, 26, 27 whereas others did not.28, 29, 30”
From Behavioral flexibility in a mouse model for obsessive‐compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants (2019) · cites this paper as [22]
Previous studies examining symptom-unrelated cognitive flexibility in OCD patients yielded mixed outcomes, with some studies observing behavioral deficits in reversal learning, whereas others did not.
“However, previous studies examining symptom‐unrelated cognitive flexibility in OCD patients yielded mixed outcomes, with some studies observing behavioral deficits in reversal learning,21, 22, 23, 24, 25, 26, 27 whereas others did not.28, 29, 30, 69”
From Behavioral flexibility in a mouse model for obsessive‐compulsive disorder: Impaired Pavlovian reversal learning in SAPAP3 mutants (2019) · cites this paper as [22]
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van den Boom, B. J. G., Mooij, A. H., Misevičiūtė, I., Denys, D., & Willuhn, I. (2019) · Genes, Brain and Behavior · doi:10.1111/gbb.12557 · Cited by 55 · see citing works
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- Authors
- Tezcan, D., Tumkaya, S., & Bora, E.
- Affiliations
- Pamukkale University (TR)
- The University of Melbourne (AU)
- ORCID
- Bora, Emre
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 252
- Pages
- 231-233
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2593476122
- Cited by
- 29
- References
- 9
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 3
- FWCI
- 2.37
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- obsessive-compulsive disorder, reversal learning, endophenotypes, first-degree relatives
- MeSH terms
- Adult, Family, Female, Humans, Male, Obsessive-Compulsive Disorder, Reversal Learning, Task Performance and Analysis, Case-Control Studies, Prefrontal Cortex, Endophenotypes
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