Are candidate neurocognitive endophenotypes of OCD present in paediatric patients? A systematic review
Abstract
To-date it has been difficult to ascertain the exact cognitive profile of childhood OCD as studies report variable results. Adult OCD research lately utilises the endophenotype approach; studying cognitive traits that are present in both patients and their unaffected first-degree relatives, and are thought to lie closer to the genotype than the full-blown disorder. By observing whether candidate endopenotypes of adult OCD are present in child patients, we can determine whether the two subtypes show cognitive overlap. We conducted a systematic review of the paediatric OCD literature focussing on proposed neurocognitive endophenotypes of OCD: cognitive flexibility, response inhibition, memory, planning, decision-making, action monitoring, and reversal learning. We found that paediatric patients present robust increases in brain error related negativity associated with abnormal action monitoring, impaired decision-making under uncertainty, planning, and visual working memory, but there is less evidence for deficits in other cognitive domains. This implies that children with OCD show some cognitive similarities with adult patients, but other dysfunctions may only manifest later in the disorder trajectory.
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Impairments of inhibitory control may manifest only later in the trajectory of the disorder.
“and impairments of inhibitory control may manifest only later in the trajectory of the disorder (Marzuki et al., 2020).”
From Inhibitory control in obsessive compulsive disorder: a systematic review and activation likelihood estimation meta-analysis of functional magnetic resonance imaging studies (2022) · cites this paper as Marzuki et al., 2020
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Obsessive-compulsive disorder: Etiology, neuropathology, and cognitive dysfunction
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- Authors
- Marzuki, A. A., Pereira de Souza, A. M. F. L., Sahakian, B. J., & Robbins, T. W.
- Affiliations
- University of Cambridge (GB)
- Corresponding author
- Marzuki, Aleya A.
- Sahakian, Barbara J.
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2020-01
- Volume
- 108
- Pages
- 617-645
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W2995683224
- Semantic Scholar
- 9fa887f777cb3d96e84d1a6026568798d6e6e272
- Cited by
- 39
- References
- 200
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 12 · 2020: 3
- FWCI
- 0.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cambridge Coordination for the Improvement of Higher Education Personnel
- NIHR Cambridge Biomedical Research Centre
- Wallitt Foundation and Eton College
- Wellcome Trust Senior Investigator
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- pediatric obsessive-compulsive disorder, neurocognitive endophenotypes, cognitive flexibility, response inhibition, visual working memory, planning, decision making under uncertainty, action monitoring, reversal learning, error-related negativity, cognitive profile
- MeSH terms
- Adolescent, Child, Humans, Obsessive-Compulsive Disorder, Endophenotypes, Cognitive Dysfunction
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