Cited by 20Sleep and related disordersCircadian rhythm and melatoninTreatment of Major Depression

Nocturnal motor activity and light exposure: objective actigraphy-based marks of melancholic and non-melancholic depressive disorder. Brief report

Open access
Tonon, André Comiran, Fuchs, Daniel Fernando Paludo, Barbosa Gomes, William, Levandovski, Rosa, Pio de Almeida Fleck, Marcelo, Hidalgo, Maria Paz Loayza, da Silva Alencastro, Luciano·2017·Psychiatry Research

Abstract

Differentiation of melancholic (MEL) and non-melancholic (N-MEL) depression results from subjective assessment of psychomotor disturbance, which obscures their accurate diagnosis. CORE instrument assigned participants with severe or refractory depression to MEL or N-MEL group. Participants underwent 7 days of actigraphy. Data was fitted to a cosinusoidal curve corresponding to a 24-h rhythm. Nocturnal activity was significantly higher in N-MEL. ROC curve shows that average night activity discriminate participants with 71% sensitivity and 100% specificity (area under the curve = 0.84). Actigraphy contribute to the objective differentiation of depression subtypes, and have implications for research on their neurobiology and clinical management.

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Crossref · 10.1016/j.psychres.2017.08.025

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  • Several digital biomarkers have been investigated for MDD characterization and diagnosis, including physical activity patterns, voice features, light exposure measurements, mobile phone GPS, and normal smartphone usage duration and frequency.

    “In the recent years, several digital biomarkers have been investigated for MDD characterization and diagnosis such as measure patterns of physical activity (24, 25) features from voice samples (26, 27), light exposure measurements (25), mobile phone global positioning systems (GPS) and normal usage of smartphones such as usage duration and frequency (22).”

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Authors
Tonon, A. C., Fuchs, D. F. P., Barbosa Gomes, W., Levandovski, R., Pio de Almeida Fleck, M., Hidalgo, M. P. L., & da Silva Alencastro, L.
Affiliations
Universidade Federal do Rio Grande do Sul (BR)
Corresponding author
Tonon, André Comiran
Venue
Psychiatry Research
Publisher
Elsevier BV
Published
2017-12
Volume
258
Pages
587-590
ISSN
0165-1781 (ISSN-L)
OpenAlex
W2748311435
Cited by
20
References
18
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 4 · 2019: 1
FWCI
1.77
Type
journal article
Language
en
Open access
Locations
  • Psychiatry Research (publishedVersion)
  • PubMed (publishedVersion)
  • Lume (Universidade Federal do Rio Grande do Sul) (submittedVersion, cc-by-nc-sa)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Keywords
endogenous depression, non-melancholic depression, depression subtypes, actigraphy, light exposure, circadian rhythm, psychomotor disorders
MeSH terms
Adult, Circadian Rhythm, Darkness, Depressive Disorder, Female, Humans, Male, Middle Aged, Motor Activity, Psychomotor Disorders, ROC Curve, Sensitivity and Specificity, Area Under Curve, Actigraphy, Depressive Disorder, Treatment-Resistant

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