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Prevalence of depressive symptoms in children and adolescents in China: A meta-analysis of observational studies
Abstract
Depressive symptoms are common in children and adolescents. The prevalence of depressive symptoms in children and adolescents in China vary significantly across studies. A meta-analysis of the prevalence of depressive symptoms in children and adolescents in China was conducted. Literature search was performed in both English (PubMed, PsycINFO and EMBASE) and Chinese (China National Knowledge Internet, WANFANG Data and SinoMed) databases. Random-effects model was used to synthesize the prevalence of depressive symptoms. Eighteen studies covering 29,626 participants were identified and analyzed. All these studies used the same measurement to identify depressive symptoms. The reported point prevalence of depressive symptoms ranged between 4% and 41% in the studies; the pooled prevalence of depressive symptoms was 19.85% (95% confidence interval: 14.75%-24.96%). In the subgroup analyses the prevalence of depressive symptoms was significantly associated with the region where the study was conducted: 17.8% in eastern, 23.7% in central, 22.7% in western, and 14.5% in northeast regions of China (P < 0.001). Considering the adverse impact of depressive symptoms on health outcomes, regular screening and effective interventions should be implemented in this population.
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“has a high prevalence of depressive symptoms or major depressive disorders30–32”
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“A recent meta-analysis shows that approximately 19.9% of Chinese adolescents experience depressive symptoms [4].”
InfluentialPlateau Environment, Gut Microbiota, and Depression: A Possible Concealed Connection?
Qiao, Y., Cheng, R., Li, X., Zheng, H., Guo, J., Wei, L., Gao, T., & Bi, H. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47070487 · Cited by 9
“[15,16].”
Family Environmental Risk and Perceived Stress in Adolescent Depressive Symptoms: A Network Analysis
Jiang, X., & Zhang, K. (2024) · Child Psychiatry & Human Development · doi:10.1007/s10578-024-01719-w · Cited by 7
Zhou, L., Ye, Y., Liu, B., Zhou, L., Sheng, J., Zhang, X.-F., Deng, X., & Ran, M. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1446727 · Cited by 9
“Studies have shown that, compared to the pre-pandemic period, the prevalence of depressive and anxiety symptoms among Chinese youth has signi fi cantly increased during and post-pandemic (32 – 34).”
BackgroundSheykhangafshe, F. B., Doost, A. M. S., Niri, V. S., Mojez, N., & Bourbour, Z. (2023) · Quarterly Journal of Child Mental Health · doi:10.61186/jcmh.10.1.9 · Cited by 9
Wu, S., Chapman, M. V., Zhu, M., & Wang, X. (2020) · Social Indicators Research · doi:10.1007/s11205-019-02251-4 · Cited by 7
You, Q., Ou, Y. H., Meng, N., Guo, L., Ye, Y., Xing, X., Yuan, W., Liao, Q., & Chen, J. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-06185-1 · Cited by 6
“Globally, 25.2% of adolescents were depressed during the COVID-19 pandemic, according to a recent meta-analysis, while in China, the prevalence is 19.85% [2].”
InfluentialChen, P., Jiang, P., Cui, Y., Yuan, X., Ren, J., Gong, J., Liao, Y., Li, Y., Pan, Q., Zhang, H., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119941 · Cited by 7
Yang, Y., & Ma, Z. (2025) · International Journal of Social Psychiatry · doi:10.1177/00207640251370514 · Cited by 6
“Moreover, children residing in relatively economically underdeveloped regions exhibit significantly elevated levels of depression and anxiety (H. Liu et al., 2018; Rao et al., 2019).”
Klettner, A. M., Luo, S., White, T. D., Elkin, T. B., Hersey, G. C., & Wu, H. (2023) · Psychological Reports · doi:10.1177/00332941231203576 · Cited by 7
“Recent evidence has shown that approximately 20% of children and adolescents in China experience symptoms of depression (Rao et al., 2019).”
Long, Z., Wang, K., Wang, H., Yao, W., & Liu, C. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1277139 · Cited by 12
Jin, L., Pan, C., Li, D., Zhang, T., Zhao, C.-H., & Wu, Y. (2025) · International Journal of Mental Health Promotion · doi:10.32604/ijmhp.2025.057962 · Cited by 6
“A study published in 2019 showed that the aggregate prevalence of depressive symptoms among Chinese children and adolescents stood at 19.85% [4].”
InfluentialLi, J., Zhang, Y., Yang, N., Du, J., Liu, P., Dai, W., & Dong, Q. (2025) · Psychiatry Investigation · doi:10.30773/pi.2024.0295 · Cited by 8
Cai, J. C., Wang, Y., Wang, C., Deng, Z.-Y., Mu, Y.-F., Deng, A.-P., Song, H.-J., Huang, Y., Fang, D.-Z., Liu, G.-L., et al. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06588-8 · Cited by 8
“The overall prevalence of depression symptoms and anxiety symptoms before the COVID-19 pandemic among Chinese students was reported to be 15.4–32.7% and 13.7–27.2%, respectively [27–30].”
InfluentialA Systematic Review and Meta-Analysis of Anxiety among Children and Youth in Ethiopia
Boru, B. B., & Guracho, Y. D. (2021) · Journal of Depression and Anxiety Disorders · doi:10.36959/362/479 · Cited by 6
Jiang, Q., Liu, P., Qin, Y., Zhao, Z., Yan, B., Jin-hai, S., Dai, Z., Qian, Y. H., & Yuan, L. (2023) · International Journal of Social Psychiatry · doi:10.1177/00207640231212090 · Cited by 5
“In China, the prevalence of depressive symptoms in children and adolescents ranges from 4% to 41%, with a pooled prevalence of 19.85% (Rao et al., 2019).”
BackgroundInfluentialYang, Y., Lin, Y., Wang, F., Wang, S. J., Wang, J., Tong, F., & Gong, Q. H. (2025) · BMC Psychiatry · doi:10.1186/s12888-025-06525-9 · Cited by 6
Yang, Q., Ai, Y., Chi, Y., Guo, X., Liu, S., Qi, Q., & Hu, Y. (2025) · Child Care Health and Development · doi:10.1111/cch.70050 · Cited by 5
Qiao, Y., Cheng, R., Zheng, H., Guo, J., Rong, L., Li, G., Wei, L., Gao, T., & Bi, H. (2025) · Behavioural Brain Research · doi:10.1016/j.bbr.2025.115782 · Cited by 5
Xu, Y., Hu, C.-J., & Zhong, B. (2025) · Psychology Research and Behavior Management · doi:10.2147/prbm.s559551 · Cited by 5
Lin, Y., Huang, J., Rankin, R., McDonald, S., Jiang, D., Li, S.-X., Lou, W.-W., Chen, Y., & Gong, Q. (2025) · Frontiers in Public Health · doi:10.3389/fpubh.2025.1691683 · Cited by 7
“A recent meta-analysis of observational studies involving 29,626 Chinese children and adolescents reported that approximately 19.9% of students had DSs, with estimates of 17.8%, 23.7%, 22.7%, and 14.5% in the eastern, central, western, and northeastern regions of China, respectively (6).”
InfluentialPeng, B., Zhu, X., Han, T., Zhao, S., Zheng, J. X., & Jia, F. (2025) · BMC Psychology · doi:10.1186/s40359-025-03710-z · Cited by 8
“Another 2019 meta-analysis of Chinese adolescents, which included 18 studies with 29,626 participants, revealed a 19.85% prevalence of depressive symptoms [24].”
InfluentialLu, J., Tan, M., Ma, Y., Li, J., Yang, F., & Zhou, X. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119424 · Cited by 7
Chen, L., Zheng, W., Wei, C.-Y., Ling, J., & Kong, Q. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1505491 · Cited by 6
Clinical and subthreshold depression in an epidemiologic sample of adolescents
Kwok, N. T., So, S. H., Chan, S. S. M., Tsoi, K. K. F., Ma, S. L., Wong, O. W. H., Chau, S. W. H., Lai, K. Y. C., Hung, S. F., & Leung, P. W. L. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120143 · Cited by 5
Hong, S., Zhang, Q., Wei, Y., Ai, M., Wang, W., Chen, J., Xu, X., Li, X., Greenshaw, A. J., & Kuang, L. (2025) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1554939 · Cited by 4
Yang, M., Yao, Y., Shen, H., Teng, F., Liu, Y., Ma, Y., Di, B., & Su, M. (2025) · Microchemical Journal · doi:10.1016/j.microc.2025.114446 · Cited by 4
Metadata
- Authors
- Rao, W.-W., Xu, D.-D., Cao, X.-L., Wen, S.-Y., Che, W.-I., Ng, C. H., Ungvari, G. S., He, F., & Xiang, Y.-T.
- Affiliations
- University of Macau (MO)
- Harbin University (CN)
- Shenzhen KangNing Hospital (CN)
- Karolinska Institutet (SE)
- The University of Melbourne (AU)
- The University of Western Australia (AU)
- Capital Medical University (CN)
- Corresponding author
- He, Fan
- Xiang, Yu-Tao
- Venue
- Psychiatry Research
- Publisher
- Elsevier BV
- Published
- 2019-02
- Volume
- 272
- Pages
- 790-796
- ISSN
- 0165-1781 (ISSN-L)
- OpenAlex
- W2906196871
- Cited by
- 165
- References
- 34
- Citations by year
- 2026: 24 · 2025: 41 · 2024: 35 · 2023: 20 · 2022: 12 · 2021: 16 · 2020: 13 · 2019: 4
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatry Research (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Funders
- niversity of Macau (MYRG2015-00230-FHS, MYRG2016-00005-FHS)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- depressive symptoms, childhood depression, adolescent depression, prevalence, China, regional variation, depression screening, mental health
- MeSH terms
- Adolescent, Child, China, Depression, Female, Humans, Male, Mass Screening, Prevalence, Databases, Factual, Observational Studies as Topic, Neurodevelopmental Disorders
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