The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Early motherhood in rats is associated with a modification of hippocampal function
Abstract
The transition to motherhood results in a number of hormonal, neurological and behavioral changes necessary to ensure offspring survival. However, little attention has been paid to changes not directly linked to reproductive function in the early mother. In this study, we demonstrate that spatial performances during the learning phase were impaired after the delivery in rats, while spatial retention ability was improved 2 weeks later. In addition, we also report that early motherhood reduced the cell proliferation in the dentate gyrus of the hippocampus without inducing a decrease in the newborn cells 2 weeks later. The decrease of estradiol levels and high levels of glucocorticoids after delivery could in part explain the changes in the hippocampal function. In summary, our findings suggest that early postpartum period is associated with a modification of hippocampal function. This may reflect a homeostatic form of hippocampal plasticity in response to the onset of the maternal experience.
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“In both mothers and fathers, parenting has suppressive effects on adult neurogenesis (Darnaudéry et al., 2007; Glasper et al., 2011; Hyer et al., 2016; Leuner et al., 2007; Pawluski and Galea, 2007; Mahmoud et al., 2016).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as Darnaudéry et al., 2007
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Postpartum depression: Etiology, treatment and consequences for maternal care
Brummelte, S., & Galea, L. A. M. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.08.008 · Cited by 567
Sex differences in depression: Insights from clinical and preclinical studies
Eid, R. S., Gobinath, A. R., & Galea, L. A. M. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.01.006 · Cited by 486
Pawluski, J. L., Brummelte, S., Barha, C. K., Crozier, T. M., & Galea, L. A. M. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.03.007 · Cited by 316
Galea, L. A. M., Wainwright, S. R., Roes, M., Duarte‐Guterman, P., Chow, C., & Hamson, D. K. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12070 · Cited by 247
Adult neurogenesis, glia, and the extracellular matrix
Cope, E. C., & Gould, E. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.03.023 · Cited by 236
Metadata
- Authors
- Darnaudéry, M., Perez-Martin, M., Del Favero, F., Gomez-Roldan, C., Garcia-Segura, L. M., & Maccari, S.
- Affiliations
- Université de Lille (FR)
- Universidad de Málaga (ES)
- Corresponding author
- Darnaudéry, Muriel
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 32
- Issue
- 7
- Pages
- 803-812
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2088366321
- Cited by
- 128
- References
- 56
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 12 · 2018: 8 · 2017: 4 · 2016: 11 · 2015: 10 · 2014: 9 · 2013: 9 · 2012: 4
- FWCI
- 1.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Université de Lille
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Keywords
- early motherhood, postpartum period, hippocampus, spatial learning, dentate gyrus, cell proliferation, estradiol, glucocorticoids, maternal behavior, hippocampal plasticity, rats
- MeSH terms
- Animals, Antimetabolites, Bromodeoxyuridine, Cell Survival, Cognition, Corticosterone, Estradiol, Female, Hippocampus, Immunohistochemistry, Mothers, Neuronal Plasticity, Pregnancy, Space Perception, Rats, Sprague-Dawley, Maze Learning, Dentate Gyrus, Cell Proliferation, Rats
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