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Cited by 2,157Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Learning enhances adult neurogenesis in the hippocampal formation

Gould, Elizabeth, Beylin, Anna, Tanapat, Patima, Reeves, Alison, Shors, Tracey J.·1999·Nature Neuroscience
DOI 10.1038/6365
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Abstract

Thousands of hippocampal neurons are born in adulthood, suggesting that new cells could be important for hippocampal function. To determine whether hippocampus-dependent learning affects adult-generated neurons, we examined the fate of new cells labeled with the thymidine analog bromodeoxyuridine following specific behavioral tasks. Here we report that the number of adult-generated neurons doubles in the rat dentate gyrus in response to training on associative learning tasks that require the hippocampus. In contrast, training on associative learning tasks that do not require the hippocampus did not alter the number of new cells. These findings indicate that adult-generated hippocampal neurons are specifically affected by, and potentially involved in, associative memory formation.

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  • Recent epidemiological evidence in twin pairs suggests that socially engaging cognitive activities in midlife and early late-life may reduce risk for AD and dementia decades later and may be indicative of an enriched environment, which enhances the proliferation of new brain cells and promotes brain repair in animal models.

    “Recent epidemiological evidence in twin pairs suggests that socially engaging cognitive activities in midlife and early late-life may reduce risk for AD and dementia decades later (30) and may be indicative of an enriched environment, which enhances the proliferation of new brain cells and promotes brain repair in animal models (31–33).”

    From Evidence for Neurocognitive Plasticity in At-Risk Older Adults: The Experience Corps Program (2009) · cites this paper as [30]

  • Manipulating the rate of proliferation in rodents selectively affects hippocampus dependent task performance, such as spatial and contextual memory or pattern separation tasks, but not less hippocampus dependent tasks such as delay conditioning.

    “Furthermore, manipulating the rate of proliferation in rodents has been shown to selectively effect hippocampus dependent task performance, such as in spatial and contextual memory or pattern separation tasks, but not in tasks that are less hippocampus dependent, such as delay conditioning (Gould et al., 1999; Shors et al., 2002; Snyder et al., 2005, 2011; Deng et al., 2009; Sahay et al., 2011;”

    From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Gould et al., 1999

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Authors
Gould, E., Beylin, A., Tanapat, P., Reeves, A., & Shors, T. J.
Affiliations
  • Princeton University (US)
  • Rutgers, The State University of New Jersey (US)
Corresponding author
Gould, Elizabeth
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
1999-03
Volume
2
Issue
3
Pages
260-265
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/6365
OpenAlex
W1581458838
Cited by
2,157
References
39
Citations by year
2026: 10 · 2025: 34 · 2024: 21 · 2023: 33 · 2022: 31 · 2021: 37 · 2020: 73 · 2019: 51 · 2018: 59 · 2017: 71 · 2016: 96 · 2015: 69 · 2014: 81 · 2013: 87 · 2012: 89
FWCI
21.30
Type
journal article
Language
en
Update notices
erratum (1999-03-01)
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29mh052423-05)
  • National Institute of Mental Health (MH 52423, MH-59970, R01MH059970)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
adult neurogenesis, hippocampus, dentate gyrus, associative learning, memory formation, BrdU labeling, hippocampus-dependent learning, hippocampal neurons
MeSH terms
Animals, Association Learning, Blinking, Cell Division, Conditioning, Classical, Cues, Learning, Male, Neurons, Physical Conditioning, Animal, Rats, Sprague-Dawley, Maze Learning, Dentate Gyrus, Rats

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