Cited by 128Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroendocrine regulation and behavior

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Early motherhood in rats is associated with a modification of hippocampal function

Darnaudéry, Muriel, Perez-Martin, Margarita, Del Favero, Fabien, Gomez-Roldan, Carmen, Garcia-Segura, Luis Miguel, Maccari, Stefania·2007·Psychoneuroendocrinology

DOI 10.1016/j.psyneuen.2007.05.012

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Abstract

The transition to motherhood results in a number of hormonal, neurological and behavioral changes necessary to ensure offspring survival. However, little attention has been paid to changes not directly linked to reproductive function in the early mother. In this study, we demonstrate that spatial performances during the learning phase were impaired after the delivery in rats, while spatial retention ability was improved 2 weeks later. In addition, we also report that early motherhood reduced the cell proliferation in the dentate gyrus of the hippocampus without inducing a decrease in the newborn cells 2 weeks later. The decrease of estradiol levels and high levels of glucocorticoids after delivery could in part explain the changes in the hippocampal function. In summary, our findings suggest that early postpartum period is associated with a modification of hippocampal function. This may reflect a homeostatic form of hippocampal plasticity in response to the onset of the maternal experience.

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Authors: Darnaudéry, M., Perez-Martin, M., Del Favero, F., Gomez-Roldan, C., Garcia-Segura, L. M., & Maccari, S.
Affiliations: Université de Lille (FR)
Universidad de Málaga (ES)
Corresponding author: Darnaudéry, Muriel
ORCID: Darnaudéry, Muriel
Maccari, Stefania
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2007-08
Volume: 32
Issue: 7
Pages: 803-812
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/j.psyneuen.2007.05.012
OpenAlex: W2088366321
Cited by: 128
References: 56
Citations by year: 2026: 2 · 2025: 2 · 2024: 9 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 12 · 2018: 8 · 2017: 4 · 2016: 11 · 2015: 10 · 2014: 9 · 2013: 9 · 2012: 4
FWCI: 1.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
Funders: Université de Lille
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: early motherhood, postpartum period, hippocampus, spatial learning, dentate gyrus, cell proliferation, estradiol, glucocorticoids, maternal behavior, hippocampal plasticity, rats
MeSH terms: Animals, Antimetabolites, Bromodeoxyuridine, Cell Survival, Cognition, Corticosterone, Estradiol, Female, Hippocampus, Immunohistochemistry, Mothers, Neuronal Plasticity, Pregnancy, Space Perception, Rats, Sprague-Dawley, Maze Learning, Dentate Gyrus, Cell Proliferation, Rats

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Early motherhood in rats is associated with a modification of hippocampal function

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