The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress
Open accessAbstract
Meditation practices may impact physiological pathways that are modulated by stress and relevant to disease. While much attention has been paid to meditation practices that emphasize calming the mind, improving focused attention, or developing mindfulness, less is known about meditation practices that foster compassion. Accordingly, the current study examined the effect of compassion meditation on innate immune, neuroendocrine and behavioral responses to psychosocial stress and evaluated the degree to which engagement in meditation practice influenced stress reactivity. Sixty-one healthy adults were randomized to 6 weeks of training in compassion meditation (n=33) or participation in a health discussion control group (n=28) followed by exposure to a standardized laboratory stressor (Trier social stress test [TSST]). Physiologic and behavioral responses to the TSST were determined by repeated assessments of plasma concentrations of interleukin (IL)-6 and cortisol as well as total distress scores on the Profile of Mood States (POMS). No main effect of group assignment on TSST responses was found for IL-6, cortisol or POMS scores. However, within the meditation group, increased meditation practice was correlated with decreased TSST-induced IL-6 (r(p)=-0.46, p=0.008) and POMS distress scores (r(p)=-0.43, p=0.014). Moreover, individuals with meditation practice times above the median exhibited lower TSST-induced IL-6 and POMS distress scores compared to individuals below the median, who did not differ from controls. These data suggest that engagement in compassion meditation may reduce stress-induced immune and behavioral responses, although future studies are required to determine whether individuals who engage in compassion meditation techniques are more likely to exhibit reduced stress reactivity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Of the 14 studies with the highest quality ratings, 10 (71%) reported significant positive associations [437–443] or increased immune functions in response to a R/S intervention [444–447].”
From Religion, Spirituality, and Health: The Research and Clinical Implications (2012) · cites this paper as [439]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Other forms of behavioral interventions that have been used for the treatment of fear-and anxiety-based disorder, such as community-based educational intervention, exercise, yoga, and mediation, have also been associated with decreases in inflammation (Bower and Irwin, 2016;Pace et al, 2009;Villablanca et al, 2015).”
From Inflammation in Fear- and Anxiety-Based Disorders: PTSD, GAD, and Beyond (2017) · cites this paper as Pace et al, 2009
Experimental — accuracy not yet measuredIn the citing paper
“While more recent studies have recognized the importance of using social evaluative threat as the stressor rather than a generic emotional film, scripts or slides, (Creswell et al., 2007; Pace et al., 2009; Weinstein et al., 2009), none were intervention studies with clinical samples.”
From Mindfulness-Based Cognitive Therapy Improves Emotional Reactivity to Social Stress: Results from a Randomized Controlled Trial (2012) · cites this paper as Pace et al., 2009
In the citing paper
“These results suggest that CM reduces stress-induced subjective distress and immune response.”
From Loving-Kindness and Compassion Meditation: Potential for Psychological Interventions (2011) · cites this paper as Pace et al., 2009
In the citing paper
“Second, the CM was taught by a highly expert teacher and practitioner with many years of training, whereas the active control was taught by graduate students with certainly little expertise, training or even practice with the protocol.”
From Loving-Kindness and Compassion Meditation: Potential for Psychological Interventions (2011) · cites this paper as Pace et al., 2009
In the citing paper
“However, a major limitation of this study was that the stress test was administered after, rather than before, CM training. Therefore, it is possible that associations between CM practice time and outcome in the stress task might have been due to differences in participants’ stress response rather than due to the practice itself”
From Loving-Kindness and Compassion Meditation: Potential for Psychological Interventions (2011) · cites this paper as Pace et al., 2009
In the citing paper
“First, they do not offer any clear alternative active psychological intervention procedure that has been practiced with the similar rigor of the CM.”
From Loving-Kindness and Compassion Meditation: Potential for Psychological Interventions (2011) · cites this paper as Pace et al., 2009
In the citing paper
“The groups showed no difference in plasma cortisol or interleukin-6 concentration.”
From Loving-Kindness and Compassion Meditation: Potential for Psychological Interventions (2011) · cites this paper as Pace et al., 2009
In the citing paper
“Therefore, the active control condition is hardly better than a treatment-as-usual comparison.”
From Loving-Kindness and Compassion Meditation: Potential for Psychological Interventions (2011) · cites this paper as Pace et al., 2009
In the citing paper
“However, increased meditation practice was associated with decreased stress-induced interleukin-6 and subjective reports of distress in the meditation group.”
From Loving-Kindness and Compassion Meditation: Potential for Psychological Interventions (2011) · cites this paper as Pace et al., 2009
In the citing paper
“as well as a reduction of interleukin-6 release in response to a psychosocial stressor [23].”
From Short-term compassion training increases prosocial behavior in a newly developed prosocial game (2011) · cites this paper as [23]
In the citing paper
“The more time participants had actually spent training, the stronger the reduction in interleukin-6 release, suggesting a dose-dependent effect of compassion training.”
From Short-term compassion training increases prosocial behavior in a newly developed prosocial game (2011) · cites this paper as [23]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(2008) · Medical Entomology and Zoology · Cited by 7,477
Kirschbaum, C., Pirke, K.-M., & Hellhammer, D. H. (2008) · Neuropsychobiology · doi:10.1159/000119004 · Cited by 6,093
Dickerson, S. S., & Kemeny, M. E. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.3.355 · Cited by 5,881
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850 · cited 4×
“…increased levels of plasma IL-6 (and/or its downstream product c-reactive protein) predict the development of a number of disease states, including vascular disease, diabetes and dementia (Ridker, 2000; Pradhan et al., 2001; Kiecolt-Glaser et al., 2003; Perry et al., 2007; Steptoe et al., 2007).”
BackgroundInfluentialC-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433 · cited 6×
“…data demonstrate that naturalistic life stress increases IL-6 and that elevated plasma levels of IL-6 are a risk factor for the development and/or progression of a number of disease states (Ridker, 2000; Pradhan et al., 2001; Kiecolt-Glaser et al., 2003; Perry et al., 2007; Steptoe et al., 2007).”
BackgroundInfluentialPruessner, J. C., Kirschbaum, C., Meinlschmid, G., & Hellhammer, D. H. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00108-7 · Cited by 3,638 · cited 3×
“…increased levels of plasma IL-6 (and/or its downstream product c-reactive protein) predict the development of a number of disease states, including vascular disease, diabetes and dementia (Ridker, 2000; Pradhan et al., 2001; Kiecolt-Glaser et al., 2003; Perry et al., 2007; Steptoe et al., 2007).”
BackgroundCytokines sing the blues: inflammation and the pathogenesis of depression
Raison, C. L., Capuron, L., & Miller, A. H. (2006) · Trends in Immunology · doi:10.1016/j.it.2005.11.006 · Cited by 3,009 · cited 1×
“Major depression has also been repeatedly associated with increased plasma concentrations of IL-6 (Raison et al., 2006).”
BackgroundSelf-citationAlterations in brain and immune function produced by mindfulness meditation
Davidson, R. J., Kabat-Zinn, J., Schumacher, J., Rosenkranz, M., Muller, D., Santorelli, S. F., Urbanowski, F., Harrington, A., Bonus, K., & Sheridan, J. F. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000077505.67574.e3 · Cited by 2,925 · cited 16×
“reported that training in mindfulness meditation enhanced antibody production following influenza vaccination (Davidson et al., 2003), and Carlson et al.”
BackgroundResultInfluentialAttention regulation and monitoring in meditation
Lutz, A., Slagter, H. A., Dunne, J. D., & Davidson, R. J. (2008) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.01.005 · Cited by 2,659
McNair, D. M. (1992) · Medical Entomology and Zoology · Cited by 2,527
Heim, C. (2000) · JAMA · doi:10.1001/jama.284.5.592 · Cited by 1,968 · cited 1×
“However, responses to laboratory stressors have been cross-sectionally associated with behavioral states such as depression (Heim et al., 2000; Pace et al., 2006), which might affect ability to engage in meditation practice.”
BackgroundCarmody, J., & Baer, R. A. (2008) · Journal of Behavioral Medicine · doi:10.1007/s10865-007-9130-7 · Cited by 1,823
Gilbert, P., & Procter, S. (2006) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.507 · Cited by 1,822 · cited 2×
“Although little is known regarding the effect of compassion meditation (or other compassion training techniques) on stress-related behavioral and neurobiological responses (Carson et al., 2005; Gilbert and Procter, 2006; Lutz et al., 2008a), interest in compassion meditation within the research community has heightene…”
BackgroundLeary, M. R., Tate, E. B., Adams, C. E., Batts Allen, A., & Hancock, J. (2007) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.92.5.887 · Cited by 1,728 · cited 1×
“For example, self-compassion (but not self esteem) was associated with less anxiety in response to a mock job interview and less distress after receiving neutral feedback in response to a videotaped speech performance (Leary et al., 2007; Neff et al., 2007).”
BackgroundSelf-compassion and adaptive psychological functioning.
Neff, K. D., Kirkpatrick, K. L., & Rude, S. S. (2007) · Journal of Research in Personality · doi:10.1016/j.jrp.2006.03.004 · Cited by 1,627 · cited 3×
“…in turn, has been associated with a variety of desirable endpoints, including reductions in perceived stress, burnout, depression, and anxiety as well as increases in life satisfaction (Neff et al., 2005; Shapiro et al., 2005; Gilbert et al., 2006; Neff et al., 2007; Shapiro et al., 2007).”
BackgroundShort-term meditation training improves attention and self-regulation
Tang, Y.-Y., Ma, Y., Wang, J., Fan, Y., Feng, S., Lu, Q., Yu, Q., Sui, D., Rothbart, M. K., Fan, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707678104 · Cited by 1,597 · cited 6×
“Increasing evidence suggests that meditation practices may impact physiological pathways, including the immune and neuroendocrine systems, which are modulated by stress and are relevant to disease development and progression (Taylor, 1995; Carlson et al., 2003, 2007; Davidson et al., 2003; Hidderley and Holt, 2004; Os…”
BackgroundInfluentialLong-term meditators self-induce high-amplitude gamma synchrony during mental practice
Lutz, A., Greischar, L. L., Rawlings, N. B., Ricard, M., & Davidson, R. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407401101 · Cited by 1,328 · cited 4×
“…the TSST. Interestingly in this regard, an association between practice time and physiological, behavioral or neural outcomes has been observed in the three prior published studies that have examined compassion-based meditation practices (Lutz et al., 2004; Carson et al., 2005; Lutz et al., 2008b).”
BackgroundResultInfluentialMindfulness-based stress reduction for health care professionals: results from a randomized trial
Shapiro, S. L., Astin, J. A., Bishop, S. R., & Cordova, M. (2005) · International Journal of Stress Management · doi:10.1037/1072-5245.12.2.164 · Cited by 1,323 · cited 5×
“Self-compassion, in turn, has been associated with a variety of desirable endpoints, including reductions in perceived stress, burnout, depression, and anxiety as well as increases in life satisfaction (Neff et al., 2005; Shapiro et al., 2005; Gilbert and Procter, 2006; Neff et al., 2007; Shapiro et al., 2007).”
BackgroundInfluentialInflammation and cancer: how hot is the link?
Aggarwal, B. B., Shishodia, S., Sandur, S. K., Pandey, M. K., & Sethi, G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.06.029 · Cited by 1,312 · cited 2×
“Innate immune inflammatory signaling pathways are increasingly implicated in the pathogenesis of vascular disease (Willerson and Ridker, 2004), cancer (Aggarwal et al., 2006; Hiratsuka et al., 2006), diabetes (Pradhan et al.”
BackgroundInflammation as a Cardiovascular Risk Factor
Willerson, J. T., & Ridker, P. M. (2004) · Circulation · doi:10.1161/01.cir.0000129535.04194.38 · Cited by 1,304 · cited 1×
“Innate immune inflammatory signaling pathways are increasingly implicated in the pathogenesis of vascular disease (Willerson and Ridker, 2004), cancer (Aggarwal et al.”
BackgroundSteptoe, A., Hamer, M., & Chida, Y. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.03.011 · Cited by 1,278 · cited 4×
“…increased levels of plasma IL-6 (and/or its downstream product c-reactive protein) predict the development of a number of disease states, including vascular disease, diabetes and dementia (Ridker, 2000; Pradhan et al., 2001; Kiecolt-Glaser et al., 2003; Perry et al., 2007; Steptoe et al., 2007).”
BackgroundInfluentialChronic stress and age-related increases in the proinflammatory cytokine IL-6.
Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1531903100 · Cited by 1,267 · cited 5×
“…data demonstrate that naturalistic life stress increases IL-6 and that elevated plasma levels of IL-6 are a risk factor for the development and/or progression of a number of disease states (Ridker, 2000; Pradhan et al., 2001; Kiecolt-Glaser et al., 2003; Perry et al., 2007; Steptoe et al., 2007).”
BackgroundInfluentialChildhood maltreatment predicts adult inflammation in a life-course study
Danese, A., Pariante, C. M., Caspi, A., Taylor, A., & Poulton, R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610362104 · Cited by 1,264 · cited 2×
“…that these pathways may be a mechanism by which stress and depression are transduced into medical illness (Lutgendorf et al., 1999; Goebel et al., 2000; Bierhaus et al., 2003; Kiecolt-Glaser et al., 2003; Kiecolt-Glaser et al., 2005; McDade et al., 2006; Pace et al., 2006; Danese et al., 2007).”
BackgroundSelf-compassion, Achievement Goals, and Coping with Academic Failure
Neff, K. D., Hsieh, Y.-P., & Dejitterat, K. (2005) · Self and Identity · doi:10.1080/13576500444000317 · Cited by 1,221 · cited 2×
“…in turn, has been associated with a variety of desirable endpoints, including reductions in perceived stress, burnout, depression, and anxiety as well as increases in life satisfaction (Neff et al., 2005; Shapiro et al., 2005; Gilbert et al., 2006; Neff et al., 2007; Shapiro et al., 2007).”
BackgroundRaison, C. L., & Miller, A. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.9.1554 · Cited by 1,197
Self-citationHandbook of Psychiatric Measures
Salzman, C. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.8.1343 · Cited by 1,172
Shapiro, S. L., Brown, K. W., & Biegel, G. M. (2007) · Training and Education in Professional Psychology · doi:10.1037/1931-3918.1.2.105 · Cited by 1,134 · cited 3×
“Third, metta practices have been shown to increase self-compassion (Shapiro et al., 2005; Shapiro et al., 2007).”
BackgroundHiratsuka, S., Watanabe, A., Aburatani, H., & Maru, Y. (2006) · Nature Cell Biology · doi:10.1038/ncb1507 · Cited by 1,048 · cited 2×
“Innate immune inflammatory signaling pathways are increasingly implicated in the pathogenesis of vascular disease (Willerson and Ridker, 2004), cancer (Aggarwal et al., 2006; Hiratsuka et al., 2006), diabetes (Pradhan et al.”
BackgroundSystemic infections and inflammation affect chronic neurodegeneration
Perry, V. H., Cunningham, C., & Holmes, C. (2007) · Nature Reviews Immunology · doi:10.1038/nri2015 · Cited by 1,027
Lutz, A., Brefczynski-Lewis, J., Johnstone, T., & Davidson, R. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001897 · Cited by 942 · cited 9×
“…that have examined the relative engagement of research subjects in compassion meditation techniques (Carson et al., 2005; Lutz et al., 2008a; Lutz et al., 2008b), we also sought to assess the extent of participation in the compassion meditation program (as reflected by class attendance and…”
BackgroundMethodResultInfluentialA mechanism converting psychosocial stress into mononuclear cell activation
Bierhaus, A., Wolf, J., Andrassy, M., Rohleder, N., Humpert, P. M., Petrov, D., Ferstl, R., von Eynatten, M., Wendt, T., Rudofsky, G., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438019100 · Cited by 927
Handbook of Psychiatric Measures
Rush, A. J., First, M. B., & Blacker, D. (2000) · Medical Entomology and Zoology · Cited by 846
Pace, T. W. W., Mletzko, T. C., Alagbe, O., Musselman, D. L., Nemeroff, C. B., Miller, A. H., & Heim, C. M. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1630 · Cited by 810 · cited 12×
“Interestingly, both stress (acute and chronic) and major depression are also associated with increased activity in innate immune inflammatory pathways, suggesting that these pathways may be a mechanism by which stress and depression are transduced into medical illness (Lutgendorf et al., 1999; Goebel et al., 2000; Bie…”
BackgroundResultInfluentialSelf-citationCarlson, L. E., Speca, M., Patel, K. D., & Goodey, E. (2003) · Psychosomatic Medicine · doi:10.1097/01.psy.0000074003.35911.41 · Cited by 773 · cited 7×
“Increasing evidence suggests that meditation practices may impact physiological pathways, including the immune and neuroendocrine systems, which are modulated by stress and are relevant to disease development and progression (Taylor, 1995; Carlson et al., 2003; Davidson et al., 2003; Hidderley et al., 2004; Carlson et…”
BackgroundInfluentialCarlson, L. E., Speca, M., Patel, K. D., & Goodey, E. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00054-4 · Cited by 756
Hostile Marital Interactions, Proinflammatory Cytokine Production, and Wound Healing
Kiecolt-Glaser, J. K., Loving, T. J., Stowell, J. R., Malarkey, W. B., Lemeshow, S., Dickinson, S. L., & Glaser, R. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.12.1377 · Cited by 715 · cited 2×
“…that these pathways may be a mechanism by which stress and depression are transduced into medical illness (Lutgendorf et al., 1999; Goebel et al., 2000; Bierhaus et al., 2003; Kiecolt-Glaser et al., 2003; Kiecolt-Glaser et al., 2005; McDade et al., 2006; Pace et al., 2006; Danese et al., 2007).”
BackgroundCarlson, L. E., Speca, M., Faris, P., & Patel, K. D. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.04.002 · Cited by 688 · cited 5×
“…pathways, including the immune and neuroendocrine systems, which are modulated by stress and are relevant to disease development and progression (Taylor, 1995; Carlson et al., 2003; Davidson et al., 2003; Hidderley et al., 2004; Carlson et al., 2007; Ospina et al., 2007; Tang et al., 2007).”
BackgroundInfluentialMeditation practices for health: state of the research.
(2007) · PubMed Central · Cited by 516
Neuropsychiatric Adverse Effects of Interferon-??: Recognition and Management
Raison, C. L., Demetrashvili, M., Capuron, L., & Miller, A. H. (2005) · CNS Drugs · doi:10.2165/00023210-200519020-00002 · Cited by 483 · cited 1×
“…the induction of innate immune inflammatory pathways in response to psychosocial stress may also represent a mechanism linking stress to depression, given that humans chronically exposed to innate immune cytokines for therapeutic purposes develop high rates of depression (Raison et al., 2005).”
BackgroundSelf-citationSephton, S. E., Salmon, P., Weissbecker, I., Ulmer, C., Floyd, A., Hoover, K., & Studts, J. L. (2007) · Arthritis Care & Research · doi:10.1002/art.22478 · Cited by 387 · cited 4×
“…to an influenza vaccine in healthy subjects (Davidson et al., 2003) or with a variety of immune, neuroendocrine or behavioral parameters in patients with cancer (Carlson et al., 2003; Carlson et al., 2004) or with depressive symptoms in patients with rheumatoid arthritis (Sephton et al., 2007).”
BackgroundResultInfluentialAcute mental stress elicits delayed increases in circulating inflammatory cytokine levels
STEPTOE, A., WILLEMSEN, G., OWEN, N., FLOWER, L., & MOHAMED-ALI, V. (2001) · Clinical Science · doi:10.1042/cs1010185 · Cited by 354
Shapiro, S. L., Bootzin, R. R., Figueredo, A. J., Lopez, A. M., & Schwartz, G. E. (2003) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(02)00546-9 · Cited by 350 · cited 2×
“…and outcome failed to show an effect of group assignment (i.e. the group randomized to meditation did not separate from that control condition) (Shapiro et al., 2003; Pradhan et al., 2007), whereas several recent studies reporting a significant effect of group assignment found no relationship…”
ResultIL-6 and its circadian secretion in humans
Vgontzas, A. N., Bixler, E. O., Lin, H.-M., Prolo, P., Trakada, G., & Chrousos, G. P. (2005) · Neuroimmunomodulation · doi:10.1159/000084844 · Cited by 338 · cited 1×
“Because cortisol and IL-6 demonstrate circadian variability (Posener et al., 1996; Vgontzas et al., 2005), we also included time of stressor initiation as a covariate in all analyses of these variables.”
BackgroundMcDade, T. W., Hawkley, L. C., & Cacioppo, J. T. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000221371.43607.64 · Cited by 326 · cited 2×
“…that these pathways may be a mechanism by which stress and depression are transduced into medical illness (Lutgendorf et al., 1999; Goebel et al., 2000; Bierhaus et al., 2003; Kiecolt-Glaser et al., 2003; Kiecolt-Glaser et al., 2005; McDade et al., 2006; Pace et al., 2006; Danese et al., 2007).”
BackgroundEffect of Mindfulness‐Based stress reduction in rheumatoid arthritis patients
Pradhan, E. K., Baumgarten, M., Langenberg, P., Handwerger, B., Gilpin, A. K., Magyari, T., Hochberg, M. C., & Berman, B. M. (2007) · Arthritis Care & Research · doi:10.1002/art.23010 · Cited by 309 · cited 10×
“Most of our participants practiced less than the recommendation of one session per day, and less than has been reported in some (Carlson et al., 2003; Carmody and Baer, 2007; Pradhan et al., 2007), but not all (Davidson et al.”
BackgroundResultInfluentialLife stress, mood disturbance, and elevated interleukin-6 in healthy older women
Lutgendorf, S. K., Garand, L., Buckwalter, K. C., Reimer, T. T., Hong, S.-Y., & Lubaroff, D. M. (1999) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/54.9.m434 · Cited by 305
Loving-Kindness Meditation for Chronic Low Back Pain: Results From a Pilot Trial
Carson, J. W., Keefe, F. J., Lynch, T. R., Carson, K. M., Goli, V., Fras, A. M., & Thorp, S. R. (2005) · Journal of Holistic Nursing · doi:10.1177/0898010105277651 · Cited by 299 · cited 5×
“…regarding the effect of compassion meditation (or other compassion training techniques) on stress-related behavioral and neurobiological responses (Carson et al., 2005; Gilbert et al., 2006; Lutz et al., 2008a), interest in compassion meditation within the research community has heightened…”
BackgroundResultInfluentialArterial Stiffness and Stroke in Hypertension
Laurent, S., & Boutouyrie, P. (2005) · CNS Drugs · doi:10.2165/00023210-200519010-00001 · Cited by 237
MacLean, C. R. K., Walton, K. G., Wenneberg, S. R., Levitsky, D. K., Mandarino, J. P., Waziri, R., Hillis, S. L., & Schneider, R. H. (1997) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(97)00003-6 · Cited by 235 · cited 2×
“The current study adds to a conflicting literature on whether meditation affects peripheral cortisol levels, and if so,whether it increases or decreases cortisol release (MacLean et al., 1997; Robinson et al., 2003; Carlson et al., 2004; Robert McComb et al., 2004;Walton et al., 2004; Ospina et al., 2007).”
BackgroundGoebel, M. U., Mills, P. J., Irwin, M. R., & Ziegler, M. G. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200007000-00019 · Cited by 189 · cited 2×
“Interestingly, both stress (acute and chronic) and major depression are also associated with increased activity in innate immune inflammatory pathways, suggesting that these pathways may be a mechanism by which stress and depression are transduced into medical illness (Lutgendorf et al., 1999; Goebel et al., 2000; Bie…”
BackgroundRobinson, F. P., Mathews, H. L., & Witek‐Janusek, L. (2003) · The Journal of Alternative and Complementary Medicine · doi:10.1089/107555303322524535 · Cited by 171 · cited 2×
“The current study adds to a conflicting literature on whether meditation affects peripheral cortisol levels, and if so,whether it increases or decreases cortisol release (MacLean et al., 1997; Robinson et al., 2003; Carlson et al., 2004; Robert McComb et al., 2004;Walton et al., 2004; Ospina et al., 2007).”
BackgroundBower, J. E., Ganz, P. A., Aziz, N., Olmstead, R. E., Irwin, M. R., & Cole, S. W. (2006) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2006.08.001 · Cited by 169 · cited 2×
“Moreover, recent data indicate that cortisol responses to stress maymodulate IL-6 responses and thusmay contribute to long-term effects of stress on disease development via modulatory effects on the innate immune response (Bower et al., 2007).”
BackgroundSelf-citationMcComb, J. J. R., Tacón, A. M., Randolph, P., & Caldera, Y. M. (2004) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2004.10.819 · Cited by 121
Taylor, D. N. (1995) · Psychological Reports · doi:10.2466/pr0.1995.76.2.451 · Cited by 113 · cited 2×
“…pathways, including the immune and neuroendocrine systems, which are modulated by stress and are relevant to disease development and progression (Taylor, 1995; Carlson et al., 2003; Davidson et al., 2003; Hidderley et al., 2004; Carlson et al., 2007; Ospina et al., 2007; Tang et al., 2007).”
BackgroundDepression in the medical setting: biopsychological interactions and treatment considerations.
Evans, D. L., Staab, J. P., Petitto, J. M., Morrison, M. F., Szuba, M. P., Ward, H. E., Wingate, B. J., Luber, M. P., & O’Reardon, J. P. (1999) · PubMed · Cited by 108
Destructive emotions : how can we overcome them? : a scientific dialogue with the Dalai Lama
Goleman, D., Bstan-ʾdzin-rgya-mtsho, D. L. X., & Davidson, R. J. (2003) · Medical Entomology and Zoology · Cited by 98
Hidderley, M., & Holt, M. (2003) · European Journal of Oncology Nursing · doi:10.1016/j.ejon.2003.09.003 · Cited by 74 · cited 2×
“Increasing evidence suggests that meditation practices may impact physiological pathways, including the immune and neuroendocrine systems, which are modulated by stress and are relevant to disease development and progression (Taylor, 1995; Carlson et al., 2003, 2007; Davidson et al., 2003; Hidderley and Holt, 2004; Os…”
BackgroundDiurnal variation of plasma cortisol and homovanillic acid in healthy subjects
Posener, J. A., Schildkraut, J. J., Samson, J. A., & Schatzberg, A. F. (1996) · Psychoneuroendocrinology · doi:10.1016/0306-4530(95)00033-x · Cited by 66 · cited 1×
“Because cortisol and IL-6 demonstrate circadian variability (Posener et al., 1996; Vgontzas et al., 2005), we also included time of stressor initiation as a covariate in all analyses of these variables.”
BackgroundWalton, K. G., Fields, J. Z., Levitsky, D. K., HARRIS, D. A., Pugh, N. D., & Schneider, R. H. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1314.023 · Cited by 57 · cited 2×
“The current study adds to a conflicting literature on whether meditation affects peripheral cortisol levels, and if so,whether it increases or decreases cortisol release (MacLean et al., 1997; Robinson et al., 2003; Carlson et al., 2004; Robert McComb et al., 2004;Walton et al., 2004; Ospina et al., 2007).”
Background
Research works printed but not linked: 1
- Byrom, 2005, A hotline to better data, Good Clin. Pract. J., 12, 1
Cited by
Sorted by citations
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848
Self-citationReligion, Spirituality, and Health: The Research and Clinical Implications
Koenig, H. G. (2012) · ISRN Psychiatry · doi:10.5402/2012/278730 · Cited by 2,423
Slavich, G. M., & Irwin, M. R. (2014) · Psychological Bulletin · doi:10.1037/a0035302 · Cited by 2,206
“Although there were no between-group effects, within the meditation group greater meditation practice was associated with fewer social stressinduced increases in IL-6 and emotional distress (Pace et al., 2009).”
BackgroundWebb, T. L., Miles, E., & Sheeran, P. (2012) · Psychological Bulletin · doi:10.1037/a0027600 · Cited by 2,006
Handbook of Religion and Health
Koenig, H. G., VanderWeele, T. J., & Peteet, J. R. (2023) · doi:10.1093/oso/9780190088859.001.0001 · Cited by 1,160
Metadata
- Authors
- Pace, T. W. W., Negi, L. T., Adame, D. D., Cole, S. P., Sivilli, T. I., Brown, T. D., Issa, M. J., & Raison, C. L.
- Affiliations
- Emory University (US)
- Weill Cornell Medicine (US)
- Corresponding author
- Raison, Charles L.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 34
- Issue
- 1
- Pages
- 87-98
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC2695992
- OpenAlex
- W2101119621
- Cited by
- 748
- References
- 59
- Citations by year
- 2026: 18 · 2025: 29 · 2024: 25 · 2023: 78 · 2022: 41 · 2021: 39 · 2020: 58 · 2019: 50 · 2018: 43 · 2017: 55 · 2016: 43 · 2015: 42 · 2014: 58 · 2013: 45 · 2012: 57
- FWCI
- 24.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Deutsches Krebsforschungszentrum
- National Institutes of Health (UL1TR000454)
- National Institute of Mental Health (K23MH064619)
- National Center for Research Resources (UL1RR025008, M01RR000039, M01-RR-0039)
- National Center for Advancing Translational Sciences
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Health › Religion, Spirituality, and Psychology
- Keywords
- compassion meditation, psychosocial stress, stress reactivity, Trier Social Stress Test, interleukin-6, cortisol, innate immunity, neuroendocrine response
- MeSH terms
- Adolescent, Empathy, Female, Humans, Hydrocortisone, Immunity, Innate, Male, Stress, Physiological, Stress, Psychological, Time Factors, Interleukin-6, Meditation, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
