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Cited by 38Schizophrenia research and treatmentSexual function and dysfunction studiesNeurotransmitter Receptor Influence on Behavior

Sexual dysfunction and hormonal changes in first episode psychosis patients on olanzapine or risperidone

van Bruggen, Marion, van Amelsvoort, Thérèse, Wouters, Luuk, Dingemans, Peter, de Haan, Lieuwe, Linszen, Don·2009·Psychoneuroendocrinology
DOI 10.1016/j.psyneuen.2009.01.013
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Abstract

Atypical antipsychotics interfere with central and peripheral neurotransmitter systems and with hormonal production. In this study we compared the effect of olanzapine and risperidone on hormonal state and sexual function (by using the Questionnaire for Sexual Dysfunction, QSD) in 40 patients with a first episode psychosis. Results were compared to those of 34 healthy controls. Patients using risperidone had significant higher prolactin levels than patients using olanzapine. Patients using olanzapine had significantly higher 17beta-estradiol levels than patients using risperidone. Overall satisfaction with sexuality was less in patients compared to controls, but not different between patients using olanzapine and those using risperidone. Problems with sexual arousal were significantly higher in patients using olanzapine compared to patients using risperidone. A significantly higher frequency of problems with ejaculation and problems with insensibility of genitals were found in patients compared to healthy controls. We found no relation between medication, prolactin and 17beta-estradiol levels, frequency of sexual activity, overall satisfaction with sexuality and any of the 18 sexual dysfunctions we investigated. Our results suggests that sexual dysfunction in patients with first episode psychosis might occur despite normal prolactin levels. Also, sexual dysfunction is highly prevalent in healthy controls. Awareness should be raised of potential sexual problems in young adults.

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Authors
van Bruggen, M., van Amelsvoort, T., Wouters, L., Dingemans, P., de Haan, L., & Linszen, D.
Affiliations
Amsterdam UMC Location University of Amsterdam (NL)
ORCID
Wouters, Luuk
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2009-08
Volume
34
Issue
7
Pages
989-995
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/j.psyneuen.2009.01.013
OpenAlex
W2130316627
Cited by
38
References
22
Citations by year
2025: 1 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 3 · 2015: 3 · 2014: 4 · 2013: 3 · 2012: 6
FWCI
2.48
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
sexual dysfunction, first-episode psychosis, olanzapine, risperidone, atypical antipsychotics, prolactin, estradiol, sexual arousal, ejaculatory dysfunction, sexual satisfaction, hormonal changes
MeSH terms
Olanzapine, Benzodiazepines, Cross-Sectional Studies, Estradiol, Female, Humans, Male, Prolactin, Psychotic Disorders, Sexual Dysfunction, Physiological, Antipsychotic Agents, Case-Control Studies, Risperidone, Young Adult

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